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Association between race and treatment patterns and survival outcomes in multiple myeloma: A Connect MM Registry analysis.

Publication ,  Journal Article
Ailawadhi, S; Jagannath, S; Lee, HC; Narang, M; Rifkin, RM; Terebelo, HR; Durie, BGM; Toomey, K; Hardin, JW; Gasparetto, CJ; Wagner, L; He, M ...
Published in: Cancer
October 1, 2020

BACKGROUND: Studies have reported racial disparities in access to and use of multiple myeloma (MM) treatments between African American (AA) and White patients. Although AA patients demonstrate longer disease-specific survival, this has not uniformly translated into improved survival over time. The association between race and treatment patterns and survival outcomes was analyzed using data from the Connect MM Registry. METHODS: The Connect MM Registry is a large US, multicenter, prospective observational cohort study of patients with newly diagnosed MM. Patients who received first-line (1L) stem cell transplantation (SCT) or who did not receive SCT (non-SCT or non-stem cell transplantation [NSCT]) were grouped by raceEffects of race and transplantation status on the use of triplet treatment were estimated using logistic regression. RESULTS: Treatment patterns in 1L (types and duration of induction, posttransplantation maintenance) were similar between AA and White patients. SCT rates in 1L (32% vs 36%) and triplet treatment use (AA: 44% for NSCT patients and 72% for SCT patients; and White: 48% for NSCT patients and 72% for SCT patients) during first induction were similar. No significant effect of race or transplantation status on 1L triplet treatment use was observed. Race was not found to be associated with survival outcomes among patients who underwent NSCT; however, AA patients who received SCT had significantly longer overall survival compared with White patients who underwent SCT (not reached vs 88.2 months; hazard ratio, 0.56; 95% CI, 0.35-0.89 [P = .0141]). CONCLUSIONS: AA and White patients were found to have similar treatment patterns in the Connect MM Registry, suggesting that both groups had equal access to health care. In this real-world setting, AA patients received standard-of-care treatment, which might have contributed to better MM-specific survival compared with White patients.

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Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

October 1, 2020

Volume

126

Issue

19

Start / End Page

4332 / 4340

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Survival Analysis
  • Registries
  • Racial Groups
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Multiple Myeloma
  • Middle Aged
  • Male
 

Citation

APA
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ICMJE
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Ailawadhi, S., Jagannath, S., Lee, H. C., Narang, M., Rifkin, R. M., Terebelo, H. R., … Connect MM Registry Investigators, . (2020). Association between race and treatment patterns and survival outcomes in multiple myeloma: A Connect MM Registry analysis. Cancer, 126(19), 4332–4340. https://doi.org/10.1002/cncr.33089
Ailawadhi, Sikander, Sundar Jagannath, Hans C. Lee, Mohit Narang, Robert M. Rifkin, Howard R. Terebelo, Brian G. M. Durie, et al. “Association between race and treatment patterns and survival outcomes in multiple myeloma: A Connect MM Registry analysis.Cancer 126, no. 19 (October 1, 2020): 4332–40. https://doi.org/10.1002/cncr.33089.
Ailawadhi S, Jagannath S, Lee HC, Narang M, Rifkin RM, Terebelo HR, et al. Association between race and treatment patterns and survival outcomes in multiple myeloma: A Connect MM Registry analysis. Cancer. 2020 Oct 1;126(19):4332–40.
Ailawadhi, Sikander, et al. “Association between race and treatment patterns and survival outcomes in multiple myeloma: A Connect MM Registry analysis.Cancer, vol. 126, no. 19, Oct. 2020, pp. 4332–40. Pubmed, doi:10.1002/cncr.33089.
Ailawadhi S, Jagannath S, Lee HC, Narang M, Rifkin RM, Terebelo HR, Durie BGM, Toomey K, Hardin JW, Gasparetto CJ, Wagner L, Omel JL, He M, Yue L, Flick ED, Agarwal A, Abonour R, Connect MM Registry Investigators. Association between race and treatment patterns and survival outcomes in multiple myeloma: A Connect MM Registry analysis. Cancer. 2020 Oct 1;126(19):4332–4340.
Journal cover image

Published In

Cancer

DOI

EISSN

1097-0142

Publication Date

October 1, 2020

Volume

126

Issue

19

Start / End Page

4332 / 4340

Location

United States

Related Subject Headings

  • Young Adult
  • United States
  • Survival Analysis
  • Registries
  • Racial Groups
  • Prospective Studies
  • Oncology & Carcinogenesis
  • Multiple Myeloma
  • Middle Aged
  • Male