Cristina Gasparetto | Scholars@Duke

Cristina Gasparetto
Professor of Medicine

Dr. Gasparetto performs both laboratory and clinical research in the field of multiple myeloma. Her primary research interests are in developing immunotherapy approaches to treating multiple myeloma particularly in conjunction with hematopoietic stem cell transplantation. Ongoing laboratory research projects include the development of dendritic cell vaccines and antibody therapies. Clinical studies include a recently approved trial involving vaccination with autologous dendritic cells pulsed with idiotypic protein following high dose chemotherapy and autologous peripheral blood stem cells transplant. Upcoming trials include novel antibody therapies for multiple myeloma. Dr. Gasparetto is also an investigator on several other clinical trials for myeloma including non-myeloablative allogeneic transplantation, high dose sequential chemotherapy and autologous peripheral blood stem cell transplantation and transplantation of partially HLA matched unrelated cord blood.

Current Appointments & Affiliations

Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2018
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1993

Contact Information

2400 Pratt St Suite 5000, DUMC Box 3961, Durham, NC 27710
DUMC Box 3961, Durham, NC 27710
gaspa001@mc.duke.edu (919) 668-1000

Background
Education, Training, & Certifications
- Fellow in Hematology/Oncology, Medicine, Duke University 1996 - 1999
- Medical Resident, Medicine, Duke University 1993 - 1996
- M.D., Sapienza University of Rome (Italy) 1986
Duke Appointment History
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2012 - 2018
- Associate Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2008 - 2012
- Assistant Professor of Medicine, Medicine, Hematologic Malignancies and Cellular Therapy, Medicine 2002 - 2008
- Associate in the Department of Medicine, Medicine, Medical Oncology, Medicine 1999 - 2002
- Instructor, Temporary in the Department of Medicine, Medicine, Medical Oncology, Medicine 1999
Research
Selected Grants
External Relationships
- AbbVie
- Amgen, Inc.
- Bristol-Myers Squibb
- Celgene Corporation
- GlaxoSmithKline
- Janssen AI (Johnson & Johnson)
- Karyopharm Therapeutics Inc
- Millennium Pharmaceuticals, Inc. (Takeda)
- Sanofi
- adaptive biotechnology corporation
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Abonour, Rafat, Robert M. Rifkin, Cristina Gasparetto, Kathleen Toomey, Brian G. M. Durie, James W. Hardin, Howard R. Terebelo, et al. “Effect of initial treatment on health-related quality of life in patients with newly diagnosed multiple myeloma without immediate stem cell transplant intent: results from the Connect® MM Registry.” Br J Haematol, October 29, 2020. https://doi.org/10.1111/bjh.17131.
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  - Smith, Patrick, Jillian C. Thompson, Elena Perea, Brian Wasserman, Lauren Bohannon, Alessandro Racioppi, Taewoong Choi, et al. “Clinical and Neuroimaging Correlates of Post-Transplant Delirium.” Biol Blood Marrow Transplant, September 19, 2020. https://doi.org/10.1016/j.bbmt.2020.09.016.
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  - Gavriatopoulou, Maria, Ajai Chari, Christine Chen, Nizar Bahlis, Dan T. Vogl, Andrzej Jakubowiak, David Dingli, et al. “Integrated safety profile of selinexor in multiple myeloma: experience from 437 patients enrolled in clinical trials.” Leukemia 34, no. 9 (September 2020): 2430–40. https://doi.org/10.1038/s41375-020-0756-6.
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  - Chari, Ajai, Robert F. Cornell, Cristina Gasparetto, Chatchada Karanes, Jeffrey V. Matous, Ruben Niesvizky, Matthew Lunning, et al. “Final analysis of a phase 1/2b study of ibrutinib combined with carfilzomib/dexamethasone in patients with relapsed/refractory multiple myeloma.” Hematological Oncology 38, no. 3 (August 2020): 353–62. https://doi.org/10.1002/hon.2723.
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  - Ailawadhi, Sikander, Sundar Jagannath, Hans C. Lee, Mohit Narang, Robert M. Rifkin, Howard R. Terebelo, Brian G. M. Durie, et al. “Association between race and treatment patterns and survival outcomes in multiple myeloma: A Connect MM Registry analysis.” Cancer, July 24, 2020. https://doi.org/10.1002/cncr.33089.
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  - Maung, Ko K., Benny J. Chen, Ian Barak, Zhiguo Li, David A. Rizzieri, Cristina Gasparetto, Keith M. Sullivan, et al. “Phase I dose escalation study of naive T-cell depleted donor lymphocyte infusion following allogeneic stem cell transplantation.” Bone Marrow Transplant, July 5, 2020. https://doi.org/10.1038/s41409-020-0991-5.
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  - Jagannath, Sundar, Robert M. Rifkin, Cristina J. Gasparetto, Kathleen Toomey, Brian G. M. Durie, James W. Hardin, Howard R. Terebelo, et al. “Treatment Journeys of Patients With Newly Diagnosed Multiple Myeloma (NDMM): Results From The Connect MM Registry.” Clin Lymphoma Myeloma Leuk 20, no. 5 (May 2020): 272–76. https://doi.org/10.1016/j.clml.2019.10.002.
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  - Ailawadhi, Sikander, Sundar Jagannath, Mohit Narang, Robert M. Rifkin, Howard R. Terebelo, Kathleen Toomey, Brian G. M. Durie, et al. “Connect MM Registry as a national reference for United States multiple myeloma patients.” Cancer Med 9, no. 1 (January 2020): 35–42. https://doi.org/10.1002/cam4.2656.
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  - Maung, Ko, Sendhilnathan Ramalingam, Mohammad Chaudhry, Yi Ren, Sin-Ho Jung, Kristi Romero, Kelly Corbet, et al. “Pre-transplant hepatic steatosis (fatty liver) is associated with chronic graft-vs-host disease but not mortality.” Plos One 15, no. 9 (2020): e0238824. https://doi.org/10.1371/journal.pone.0238824.
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  - Terebelo, Howard R., Rafat Abonour, Cristina J. Gasparetto, Kathleen Toomey, Brian G. M. Durie, James W. Hardin, Sundar Jagannath, et al. “Development of a prognostic model for overall survival in multiple myeloma using the Connect® MM Patient Registry.” Br J Haematol 187, no. 5 (December 2019): 602–14. https://doi.org/10.1111/bjh.16139.
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  - Gopalakrishnan, Sathish, Anita D’Souza, Emma Scott, Raphael Fraser, Omar Davila, Nina Shah, Robert Peter Gale, et al. “Revised International Staging System Is Predictive and Prognostic for Early Relapse (<24 months) after Autologous Transplantation for Newly Diagnosed Multiple Myeloma.” Biol Blood Marrow Transplant 25, no. 4 (April 2019): 683–88. https://doi.org/10.1016/j.bbmt.2018.12.141.
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  - Stadtmauer, Edward A., Marcelo C. Pasquini, Beth Blackwell, Parameswaran Hari, Asad Bashey, Steven Devine, Yvonne Efebera, et al. “Autologous Transplantation, Consolidation, and Maintenance Therapy in Multiple Myeloma: Results of the BMT CTN 0702 Trial.” J Clin Oncol 37, no. 7 (March 1, 2019): 589–97. https://doi.org/10.1200/JCO.18.00685.
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  - Zheng, Jing, Yonggang Sha, Logan Roof, Oded Foreman, John Lazarchick, Jagadish Kummetha Venkta, Cleopatra Kozlowski, et al. “Pan-PIM kinase inhibitors enhance Lenalidomide's anti-myeloma activity via cereblon-IKZF1/3 cascade.” Cancer Lett 440–441 (January 2019): 1–10. https://doi.org/10.1016/j.canlet.2018.10.003.
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  - Bahlis, Nizar J., Heather Sutherland, Darrell White, Michael Sebag, Suzanne Lentzsch, Rami Kotb, Christopher P. Venner, et al. “Selinexor plus low-dose bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma.” Blood 132, no. 24 (December 13, 2018): 2546–54. https://doi.org/10.1182/blood-2018-06-858852.
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  - Abonour, Rafat, Lynne Wagner, Brian G. M. Durie, Sundar Jagannath, Mohit Narang, Howard R. Terebelo, Cristina J. Gasparetto, et al. “Impact of post-transplantation maintenance therapy on health-related quality of life in patients with multiple myeloma: data from the Connect® MM Registry.” Ann Hematol 97, no. 12 (December 2018): 2425–36. https://doi.org/10.1007/s00277-018-3446-y.
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  - Sivaraj, Dharshan, Michael M. Green, Yubin Kang, Gwynn D. Long, David A. Rizzieri, Zhiguo Li, Anderson H. Garrett, Jackie L. McIntyre, Nelson J. Chao, and Cristina Gasparetto. “Bendamustine, pomalidomide, and dexamethasone for relapsed and/or refractory multiple myeloma.” Blood Cancer J 8, no. 8 (July 31, 2018): 71. https://doi.org/10.1038/s41408-018-0104-5.
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  - Jagannath, Sundar, Rafat Abonour, Brian G. M. Durie, Mohit Narang, Howard R. Terebelo, Cristina J. Gasparetto, Kathleen Toomey, et al. “Impact of post-ASCT maintenance therapy on outcomes in patients with newly diagnosed multiple myeloma in Connect MM.” Blood Adv 2, no. 13 (July 10, 2018): 1608–15. https://doi.org/10.1182/bloodadvances.2018017186.
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  - Jagannath, Sundar, Rafat Abonour, Brian G. M. Durie, Cristina Gasparetto, James W. Hardin, Mohit Narang, Howard R. Terebelo, et al. “Heterogeneity of Second-Line Treatment for Patients With Multiple Myeloma in the Connect MM Registry (2010-2016).” Clin Lymphoma Myeloma Leuk 18, no. 7 (July 2018): 480-485.e3. https://doi.org/10.1016/j.clml.2018.04.007.
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  - Rifkin, Robert M., Sundar Jagannath, Brian G. M. Durie, Mohit Narang, Howard R. Terebelo, Cristina J. Gasparetto, Kathleen Toomey, et al. “Treatment Outcomes and Health Care Resource Utilization in Patients With Newly Diagnosed Multiple Myeloma Receiving Lenalidomide-only Maintenance, Any Maintenance, or No Maintenance: Results from the Connect MM Registry.” Clin Ther 40, no. 7 (July 2018): 1193-1202.e1. https://doi.org/10.1016/j.clinthera.2018.05.017.
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  - Kumar, S. K., A. Dispenzieri, R. Fraser, F. Mingwei, G. Akpek, R. Cornell, M. Kharfan-Dabaja, et al. “Early relapse after autologous hematopoietic cell transplantation remains a poor prognostic factor in multiple myeloma but outcomes have improved over time.” Leukemia 32, no. 4 (April 2018): 986–95. https://doi.org/10.1038/leu.2017.331.
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  - Htut, Myo, Anita D’Souza, Amrita Krishnan, Benedetto Bruno, Mei-Jie Zhang, Mingwei Fei, Miguel Angel Diaz, et al. “Autologous/Allogeneic Hematopoietic Cell Transplantation versus Tandem Autologous Transplantation for Multiple Myeloma: Comparison of Long-Term Postrelapse Survival.” Biol Blood Marrow Transplant 24, no. 3 (March 2018): 478–85. https://doi.org/10.1016/j.bbmt.2017.10.024.
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  - Zheng, Zhihong, Shengjun Fan, Jing Zheng, Wei Huang, Cristina Gasparetto, Nelson J. Chao, Jianda Hu, and Yubin Kang. “Inhibition of thioredoxin activates mitophagy and overcomes adaptive bortezomib resistance in multiple myeloma.” Journal of Hematology & Oncology 11, no. 1 (February 27, 2018): 29. https://doi.org/10.1186/s13045-018-0575-7.
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  - Sivaraj, D., W. Bacon, G. D. Long, D. A. Rizzieri, M. E. Horwitz, K. M. Sullivan, Y. Kang, Z. Li, N. J. Chao, and C. Gasparetto. “High-dose BCNU/Melphalan conditioning regimen before autologous stem cell transplantation in newly diagnosed multiple myeloma.” Bone Marrow Transplantation 53, no. 1 (January 2018): 34–38. https://doi.org/10.1038/bmt.2017.208.
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  - Huang, Li-Wen, Wendi Bacon, Constance Cirrincione, Bercedis Peterson, Gwynn Long, David Rizzieri, Keith M. Sullivan, et al. “Efficacy and safety of high-dose chemotherapy with autologous stem cell transplantation in senior versus younger adults with newly diagnosed multiple myeloma.” Hematol Oncol 35, no. 4 (December 2017): 752–59. https://doi.org/10.1002/hon.2379.
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  - Shah, Jatin J., Rafat Abonour, Christina Gasparetto, James W. Hardin, Kathleen Toomey, Mohit Narang, Shankar Srinivasan, et al. “Analysis of Common Eligibility Criteria of Randomized Controlled Trials in Newly Diagnosed Multiple Myeloma Patients and Extrapolating Outcomes.” Clin Lymphoma Myeloma Leuk 17, no. 9 (September 2017): 575-583.e2. https://doi.org/10.1016/j.clml.2017.06.013.
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  - Terebelo, Howard, Shankar Srinivasan, Mohit Narang, Rafat Abonour, Cristina Gasparetto, Kathleen Toomey, James W. Hardin, et al. “Recognition of early mortality in multiple myeloma by a prediction matrix.” Am J Hematol 92, no. 9 (September 2017): 915–23. https://doi.org/10.1002/ajh.24796.
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  - Vogl, Dan T., Thomas G. Martin, Ravi Vij, Parameswaran Hari, Joseph R. Mikhael, David Siegel, Ka Lung Wu, Michel Delforge, and Cristina Gasparetto. “Phase I/II study of the novel proteasome inhibitor delanzomib (CEP-18770) for relapsed and refractory multiple myeloma.” Leuk Lymphoma 58, no. 8 (August 2017): 1872–79. https://doi.org/10.1080/10428194.2016.1263842.
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  - Anand, Sarah, Samantha Thomas, Terry Hyslop, Janet Adcock, Kelly Corbet, Cristina Gasparetto, Richard Lopez, et al. “Transplantation of Ex Vivo Expanded Umbilical Cord Blood (NiCord) Decreases Early Infection and Hospitalization.” Biol Blood Marrow Transplant 23, no. 7 (July 2017): 1151–57. https://doi.org/10.1016/j.bbmt.2017.04.001.
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  - Voorhees, Peter M., Cristina Gasparetto, Dominic T. Moore, Diane Winans, Robert Z. Orlowski, and David D. Hurd. “Final Results of a Phase 1 Study of Vorinostat, Pegylated Liposomal Doxorubicin, and Bortezomib in Relapsed or Refractory Multiple Myeloma.” Clin Lymphoma Myeloma Leuk 17, no. 7 (July 2017): 424–32. https://doi.org/10.1016/j.clml.2017.05.007.
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  - Sivaraj, Dharshan, Michael M. Green, and Cristina Gasparetto. “Panobinostat for the management of multiple myeloma.” Future Oncol 13, no. 6 (March 2017): 477–88. https://doi.org/10.2217/fon-2016-0329.
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  - Sivaraj, Dharshan, Michael M. Green, Zhiguo Li, Anthony D. Sung, Stefanie Sarantopoulos, Yubin Kang, Gwynn D. Long, et al. “Outcomes of Maintenance Therapy with Bortezomib after Autologous Stem Cell Transplantation for Patients with Multiple Myeloma.” Biol Blood Marrow Transplant 23, no. 2 (February 2017): 262–68. https://doi.org/10.1016/j.bbmt.2016.11.010.
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  - LeBlanc, T. W., A. Howson, W. Turell, P. Sheldon, S. C. Locke, S. A. Tuchman, C. Gasparetto, S. Kaura, Z. M. Khan, and A. P. Abernethy. “Risk stratification, treatment selection, and transplant eligibility in multiple myeloma: a qualitative study of the perspectives and self-reported practices of oncologists.” Curr Oncol 23, no. 6 (December 2016): e598–604. https://doi.org/10.3747/co.23.3298.
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  - Sung, Anthony D., Julia A. M. Sung, Samantha Thomas, Terry Hyslop, Cristina Gasparetto, Gwynn Long, David Rizzieri, et al. “Universal Mask Usage for Reduction of Respiratory Viral Infections After Stem Cell Transplant: A Prospective Trial.” Clin Infect Dis 63, no. 8 (October 15, 2016): 999–1006. https://doi.org/10.1093/cid/ciw451.
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  - Scott, Emma C., Parameswaran Hari, Manish Sharma, Jennifer Le-Rademacher, Jiaxing Huang, Dan Vogl, Muneer Abidi, et al. “Post-Transplant Outcomes in High-Risk Compared with Non-High-Risk Multiple Myeloma: A CIBMTR Analysis.” Biol Blood Marrow Transplant 22, no. 10 (October 2016): 1893–99. https://doi.org/10.1016/j.bbmt.2016.07.007.
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  - Rifkin, Robert M., Rafat Abonour, Jatin J. Shah, Jayesh Mehta, Mohit Narang, Howard Terebelo, Cristina Gasparetto, et al. “Connect MM® - the Multiple Myeloma Disease Registry: incidence of second primary malignancies in patients treated with lenalidomide.” Leuk Lymphoma 57, no. 9 (September 2016): 2228–31. https://doi.org/10.3109/10428194.2015.1132419.
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  - Green, Michael M. B., Nelson Chao, Saurabh Chhabra, Kelly Corbet, Cristina Gasparetto, Ari Horwitz, Zhiguo Li, et al. “Plerixafor (a CXCR4 antagonist) following myeloablative allogeneic hematopoietic stem cell transplantation enhances hematopoietic recovery.” J Hematol Oncol 9, no. 1 (August 17, 2016): 71. https://doi.org/10.1186/s13045-016-0301-2.
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  - Sivaraj, Dharshan, Michael Martin Green, Abdullah Mucahit Ciftci, Mohammad Faizan Zahid, Angela Anne Johns, Maureen Ross, and Cristina Gasparetto. “Can We Cure Light Chain Deposition Disease of the Kidneys?-A Review and Case Report of a Patient Treated With a Triple Transplant Approach.” Clin Lymphoma Myeloma Leuk 16, no. 6 (June 2016): e95–100. https://doi.org/10.1016/j.clml.2016.03.002.
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  - Anderson, Kenneth C., Melissa Alsina, Djordje Atanackovic, J Sybil Biermann, Jason C. Chandler, Caitlin Costello, Benjamin Djulbegovic, et al. “NCCN Guidelines Insights: Multiple Myeloma, Version 3.2016.” J Natl Compr Canc Netw 14, no. 4 (April 2016): 389–400. https://doi.org/10.6004/jnccn.2016.0046.
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  - Shah, Jatin J., Edward A. Stadtmauer, Rafat Abonour, Adam D. Cohen, William I. Bensinger, Cristina Gasparetto, Jonathan L. Kaufman, et al. “Carfilzomib, pomalidomide, and dexamethasone for relapsed or refractory myeloma.” Blood 126, no. 20 (November 12, 2015): 2284–90. https://doi.org/10.1182/blood-2015-05-643320.
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  - Rifkin, Robert M., Rafat Abonour, Howard Terebelo, Jatin J. Shah, Cristina Gasparetto, James Hardin, Shankar Srinivasan, Rosanna Ricafort, Yasir Nagarwala, and Brian G. M. Durie. “Connect MM Registry: The Importance of Establishing Baseline Disease Characteristics.” Clin Lymphoma Myeloma Leuk 15, no. 6 (June 2015): 368–76. https://doi.org/10.1016/j.clml.2014.12.002.
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  - Tuchman, Sascha A., Wendi A. Bacon, Li-Wen Huang, Gwynn Long, David Rizzieri, Mitchell Horwitz, John P. Chute, et al. “Cyclophosphamide-based hematopoietic stem cell mobilization before autologous stem cell transplantation in newly diagnosed multiple myeloma.” J Clin Apher 30, no. 3 (June 2015): 176–82. https://doi.org/10.1002/jca.21360.
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  - Tuchman, Sascha A., Amy Lane, Whitney E. Hornsby, Caroline Bishop, Samantha Thomas, James E. Herndon, Gwynn Long, Cristina Gasparetto, and Lee W. Jones. “Quantitative measures of physical functioning after autologous hematopoietic stem cell transplantation in multiple myeloma: a feasibility study.” Clin Lymphoma Myeloma Leuk 15, no. 2 (February 2015): 103–9. https://doi.org/10.1016/j.clml.2014.09.002.
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  - Sharma, Manish, Mei-Jie Zhang, Xiaobo Zhong, Muneer H. Abidi, Görgün Akpek, Ulrike Bacher, Natalie S. Callander, et al. “Older patients with myeloma derive similar benefit from autologous transplantation.” Biol Blood Marrow Transplant 20, no. 11 (November 2014): 1796–1803. https://doi.org/10.1016/j.bbmt.2014.07.013.
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  - Horwitz, Mitchell E., Nelson J. Chao, David A. Rizzieri, Gwynn D. Long, Keith M. Sullivan, Cristina Gasparetto, John P. Chute, et al. “Umbilical cord blood expansion with nicotinamide provides long-term multilineage engraftment.” J Clin Invest 124, no. 7 (July 2014): 3121–28. https://doi.org/10.1172/JCI74556.
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  - Saad, Ayman, Anuj Mahindra, Mei-Jie Zhang, Xiaobo Zhong, Luciano J. Costa, Angela Dispenzieri, William R. Drobyski, et al. “Hematopoietic cell transplant comorbidity index is predictive of survival after autologous hematopoietic cell transplantation in multiple myeloma.” Biol Blood Marrow Transplant 20, no. 3 (March 2014): 402-408.e1. https://doi.org/10.1016/j.bbmt.2013.12.557.
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  - Kanda, Junya, Gwynn D. Long, Cristina Gasparetto, Mitchell E. Horwitz, Keith M. Sullivan, John P. Chute, Ashley Morris, et al. “Reduced-intensity allogeneic transplantation using alemtuzumab from HLA-matched related, unrelated, or haploidentical related donors for patients with hematologic malignancies.” Biol Blood Marrow Transplant 20, no. 2 (February 2014): 257–63. https://doi.org/10.1016/j.bbmt.2013.11.010.
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  - Saad, A., A. Mahindra, M. -. J. Zhang, X. Zhong, L. J. Costa, A. Dispenzieri, W. R. Drobyski, et al. “Hematopoietic cell transplant comorbidity index is predictive of survival after autologous hematopoietic cell transplantation in multiple myeloma.” Biology of Blood and Marrow Transplantation 20, no. 3 (2014): 402–8.
  - Kanda, J., L. Kaynar, Y. Kanda, V. K. Prasad, S. H. Parikh, L. Lan, T. Shen, et al. “Pre-engraftment syndrome after myeloablative dual umbilical cord blood transplantation: risk factors and response to treatment.” Bone Marrow Transplant 48, no. 7 (July 2013): 926–31. https://doi.org/10.1038/bmt.2012.279.
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  - Held, Lauren A., David Rizzieri, Gwynn D. Long, Jon P. Gockerman, Louis F. Diehl, Carlos M. de Castro, Joseph O. Moore, Mitchell E. Horwitz, Nelson J. Chao, and Cristina Gasparetto. “A Phase I study of arsenic trioxide (Trisenox), ascorbic acid, and bortezomib (Velcade) combination therapy in patients with relapsed/refractory multiple myeloma.” Cancer Invest 31, no. 3 (March 2013): 172–76. https://doi.org/10.3109/07357907.2012.756109.
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  - Anderson, Kenneth C., Melissa Alsina, William Bensinger, J Sybil Biermann, Adam D. Cohen, Steven Devine, Benjamin Djulbegovic, et al. “Multiple myeloma, version 1.2013.” Journal of the National Comprehensive Cancer Network : Jnccn 11, no. 1 (January 2013): 11–17. https://doi.org/10.6004/jnccn.2013.0004.
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  - Kanda, Junya, Lun-Wei Chiou, Paul Szabolcs, Gregory D. Sempowski, David A. Rizzieri, Gwynn D. Long, Keith M. Sullivan, et al. “Immune recovery in adult patients after myeloablative dual umbilical cord blood, matched sibling, and matched unrelated donor hematopoietic cell transplantation.” Biol Blood Marrow Transplant 18, no. 11 (November 2012): 1664-1676.e1. https://doi.org/10.1016/j.bbmt.2012.06.005.
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  - Spasojevic, Ivan, Ligia R. S. da Costa, Mitchell E. Horwitz, Gwynn D. Long, Keith M. Sullivan, John P. Chute, Cristina Gasparetto, Ashley Morris, Nelson J. Chao, and David A. Rizzieri. “Mini test dose of intravenous busulfan (busulfex(®)) in allogeneic non-myeloablative stem cell transplantation, followed by liquid chromatography tandem-mass spectrometry.” Cancer Invest 30, no. 9 (November 2012): 679–82. https://doi.org/10.3109/07357907.2012.726386.
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  - Anderson, Kenneth C., Melissa Alsina, William Bensinger, J Sybil Biermann, Adam D. Cohen, Steven Devine, Benjamin Djulbegovic, et al. “Waldenström's macroglobulinemia/lymphoplasmacytic lymphoma, version 2.2013.” J Natl Compr Canc Netw 10, no. 10 (October 1, 2012): 1211–19. https://doi.org/10.6004/jnccn.2012.0128.
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  - Horwitz, M. E., J. P. Chute, C. Gasparetto, G. D. Long, C. McDonald, A. Morris, D. A. Rizzieri, K. M. Sullivan, and N. J. Chao. “Preemptive dosing of plerixafor given to poor stem cell mobilizers on day 5 of G-CSF administration.” Bone Marrow Transplant 47, no. 8 (August 2012): 1051–55. https://doi.org/10.1038/bmt.2011.217.
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  - Chen, D. -. F., V. K. Prasad, G. Broadwater, N. L. Reinsmoen, A. DeOliveira, A. Clark, K. M. Sullivan, et al. “Differential impact of inhibitory and activating Killer Ig-Like Receptors (KIR) on high-risk patients with myeloid and lymphoid malignancies undergoing reduced intensity transplantation from haploidentical related donors.” Bone Marrow Transplant 47, no. 6 (June 2012): 817–23. https://doi.org/10.1038/bmt.2011.181.
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  - Kanda, J., M. E. Horwitz, G. D. Long, C. Gasparetto, K. M. Sullivan, J. P. Chute, A. Morris, et al. “Outcomes of a 1-day nonmyeloablative salvage regimen for patients with primary graft failure after allogeneic hematopoietic cell transplantation.” Bone Marrow Transplant 47, no. 5 (May 2012): 700–705. https://doi.org/10.1038/bmt.2011.158.
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  - Tuchman, S. A., N. J. Chao, and C. G. Gasparetto. “Lenalidomide before and after Autologous Hematopoietic Stem Cell Transplantation in Multiple Myeloma.” Adv Hematol 2012 (2012): 712613. https://doi.org/10.1155/2012/712613.
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  - Anderson, Kenneth C., Melissa Alsina, William Bensinger, J Sybil Biermann, Asher Chanan-Khan, Adam D. Cohen, Steven Devine, et al. “Multiple myeloma.” J Natl Compr Canc Netw 9, no. 10 (October 2011): 1146–83. https://doi.org/10.6004/jnccn.2011.0095.
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  - Kanda, Junya, David A. Rizzieri, Cristina Gasparetto, Gwynn D. Long, John P. Chute, Keith M. Sullivan, Ashley Morris, et al. “Adult dual umbilical cord blood transplantation using myeloablative total body irradiation (1350 cGy) and fludarabine conditioning.” Biol Blood Marrow Transplant 17, no. 6 (June 2011): 867–74. https://doi.org/10.1016/j.bbmt.2010.09.009.
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  - Lokhorst, H., H. Einsele, D. Vesole, B. Bruno, J. San Miguel, J. A. Perez-Simon, N. M. Kröger, et al. “Reply to A. Gratwohl.” Journal of Clinical Oncology 29, no. 16 (June 1, 2011). https://doi.org/10.1200/JCO.2011.34.6718.
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  - Craciunescu, Oana I., Beverly A. Steffey, Chris R. Kelsey, Nicole A. Larrier, Cathy J. Paarz-Largay, Robert G. Prosnitz, Nelson Chao, et al. “Renal shielding and dosimetry for patients with severe systemic sclerosis receiving immunoablation with total body irradiation in the scleroderma: cyclophosphamide or transplantation trial.” Int J Radiat Oncol Biol Phys 79, no. 4 (March 15, 2011): 1248–55. https://doi.org/10.1016/j.ijrobp.2010.05.036.
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  - Rizzieri, David A., Christopher Crout, Robert Storms, Jared Golob, Gwynn D. Long, Cristina Gasparetto, Keith M. Sullivan, et al. “Feasibility of low-dose interleukin-2 therapy following T-cell-depleted nonmyeloablative allogeneic hematopoietic stem cell transplantation from HLA-matched or -mismatched family member donors.” Cancer Invest 29, no. 1 (January 2011): 56–61. https://doi.org/10.3109/07357907.2010.535055.
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  - Lokhorst, Henk, Hermann Einsele, David Vesole, Benedetto Bruno, Jesus San Miguel, Jose A. Pérez-Simon, Nicolaus Kröger, et al. “International Myeloma Working Group consensus statement regarding the current status of allogeneic stem-cell transplantation for multiple myeloma.” J Clin Oncol 28, no. 29 (October 10, 2010): 4521–30. https://doi.org/10.1200/JCO.2010.29.7929.
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  - Rizzieri, David A., Robert Storms, Dong-Feng Chen, Gwynn Long, Yiping Yang, Daniel A. Nikcevich, Cristina Gasparetto, et al. “Natural killer cell-enriched donor lymphocyte infusions from A 3-6/6 HLA matched family member following nonmyeloablative allogeneic stem cell transplantation.” Biol Blood Marrow Transplant 16, no. 8 (August 2010): 1107–14. https://doi.org/10.1016/j.bbmt.2010.02.018.
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  - Crout, Christopher A., Liang-Piu Koh, Jon P. Gockerman, Joseph O. Moore, Carlos Decastro, Gwynn D. Long, Louis Diehl, et al. “Overcoming drug resistance in mantle cell lymphoma using a combination of dose-dense and intense therapy.” Cancer Invest 28, no. 6 (July 2010): 654–60. https://doi.org/10.3109/07357901003631015.
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  - Kumar, S. K., I. Flinn, S. J. Noga, P. Hari, R. Rifkin, N. Callander, M. Bhandari, et al. “Bortezomib, dexamethasone, cyclophosphamide and lenalidomide combination for newly diagnosed multiple myeloma: phase 1 results from the multicenter EVOLUTION study.” Leukemia 24, no. 7 (July 2010): 1350–56. https://doi.org/10.1038/leu.2010.116.
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  - Gasparetto, Cristina, Jon P. Gockerman, Louis F. Diehl, Carlos M. de Castro, Joseph O. Moore, Gwynn D. Long, Mitchell E. Horwitz, et al. “"Short course" bortezomib plus melphalan and prednisone as induction prior to transplant or as frontline therapy for nontransplant candidates in patients with previously untreated multiple myeloma.” Biol Blood Marrow Transplant 16, no. 1 (January 2010): 70–77. https://doi.org/10.1016/j.bbmt.2009.08.017.
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  - Anderson, Kenneth C., Melissa Alsina, William Bensinger, J Sybil Biermann, Asher Chanan-Khan, Adam D. Cohen, Steven Devine, et al. “NCCN clinical practice guidelines in oncology: multiple myeloma.” J Natl Compr Canc Netw 7, no. 9 (October 2009): 908–42. https://doi.org/10.6004/jnccn.2009.0061.
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  - Anguiano, Ariel, Sascha A. Tuchman, Chaitanya Acharya, Kelly Salter, Cristina Gasparetto, Fenghuang Zhan, Madhav Dhodapkar, et al. “Gene expression profiles of tumor biology provide a novel approach to prognosis and may guide the selection of therapeutic targets in multiple myeloma.” J Clin Oncol 27, no. 25 (September 1, 2009): 4197–4203. https://doi.org/10.1200/JCO.2008.19.1916.
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  - Rizzieri, D. A., P. Dev, G. D. Long, C. Gasparetto, K. M. Sullivan, Ml Horwitz, J. Chute, and N. J. Chao. “Response and toxicity of donor lymphocyte infusions following T-cell depleted non-myeloablative allogeneic hematopoietic SCT from 3-6/6 HLA matched donors.” Bone Marrow Transplant 43, no. 4 (February 2009): 327–33. https://doi.org/10.1038/bmt.2008.321.
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  - Horwitz, Mitchell E., Ashley Morris, Cristina Gasparetto, Keith Sullivan, Gwynn Long, John Chute, David Rizzieri, Jackie McPherson, and Nelson Chao. “Myeloablative intravenous busulfan/fludarabine conditioning does not facilitate reliable engraftment of dual umbilical cord blood grafts in adult recipients.” Biol Blood Marrow Transplant 14, no. 5 (May 2008): 591–94. https://doi.org/10.1016/j.bbmt.2008.02.016.
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  - Byrne, B. J., M. Horwitz, G. D. Long, C. Gasparetto, K. M. Sullivan, J. Chute, N. J. Chao, and D. A. Rizzieri. “Outcomes of a second non-myeloablative allogeneic stem cell transplantation following graft rejection.” Bone Marrow Transplant 41, no. 1 (January 2008): 39–43. https://doi.org/10.1038/sj.bmt.1705882.
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  - Horwitz, Mitchell E., Ivan Spasojevic, Ashley Morris, Marilyn Telen, James Essell, Cristina Gasparetto, Keith Sullivan, et al. “Fludarabine-based nonmyeloablative stem cell transplantation for sickle cell disease with and without renal failure: clinical outcome and pharmacokinetics.” Biol Blood Marrow Transplant 13, no. 12 (December 2007): 1422–26. https://doi.org/10.1016/j.bbmt.2007.08.050.
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  - Rizzieri, David A., Liang Piu Koh, Gwynn D. Long, Cristina Gasparetto, Keith M. Sullivan, Mitchell Horwitz, John Chute, et al. “Partially matched, nonmyeloablative allogeneic transplantation: clinical outcomes and immune reconstitution.” J Clin Oncol 25, no. 6 (February 20, 2007): 690–97. https://doi.org/10.1200/JCO.2006.07.0953.
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  - Lagoo, Anand S., Jerald Z. Gong, Timothy T. Stenzel, Barbara K. Goodman, Patrick J. Buckley, Nelson J. Chao, Cristina Gasparetto, Gwynn D. Long, and David A. Rizzieri. “Morphologic examination of sequential bone marrow biopsies after nonmyeloablative stem cell transplantation complements molecular studies of donor engraftment.” Arch Pathol Lab Med 130, no. 10 (October 2006): 1479–88. https://doi.org/10.1043/1543-2165(2006)130[1479:MEOSBM]2.0.CO;2.
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  - Nieto, Yago, James J. Vredenburgh, Elizabeth J. Shpall, Scott I. Bearman, Peter A. McSweeney, Nelson Chao, David Rizzieri, et al. “Phase II feasibility and pharmacokinetic study of concurrent administration of trastuzumab and high-dose chemotherapy in advanced HER2+ breast cancer.” Clin Cancer Res 10, no. 21 (November 1, 2004): 7136–43. https://doi.org/10.1158/1078-0432.CCR-04-0891.
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  - Chao, Nelson J., Liang-Piu Koh, Gwynn D. Long, Cristina Gasparetto, Mitchell Horwitz, Ashley Morris, Martha Lassiter, Keith M. Sullivan, and David A. Rizzieri. “Adult recipients of umbilical cord blood transplants after nonmyeloablative preparative regimens.” Biol Blood Marrow Transplant 10, no. 8 (August 2004): 569–75. https://doi.org/10.1016/j.bbmt.2004.05.001.
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  - Rizzieri, David A., Gamal Akabani, Michael R. Zalutsky, R Edward Coleman, Scott D. Metzler, James E. Bowsher, Bonnie Toaso, et al. “Phase 1 trial study of 131I-labeled chimeric 81C6 monoclonal antibody for the treatment of patients with non-Hodgkin lymphoma.” Blood 104, no. 3 (August 1, 2004): 642–48. https://doi.org/10.1182/blood-2003-12-4264.
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  - Rizzieri, David A., Gregory J. Sand, Dean McGaughey, Joseph O. Moore, Carlos DeCastro, Nelson J. Chao, James J. Vredenburgh, et al. “Low-dose weekly paclitaxel for recurrent or refractory aggressive non-Hodgkin lymphoma.” Cancer 100, no. 11 (June 1, 2004): 2408–14. https://doi.org/10.1002/cncr.20245.
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  - Snyder, Matthew J., Timothy T. Stenzel, Patrick J. Buckley, Anand S. Lagoo, David A. Rizzieri, Cristina Gasparetto, James J. Vredenburgh, Nelson J. Chao, and Jerald Z. Gong. “Posttransplant lymphoproliferative disorder following nonmyeloablative allogeneic stem cell transplantation.” Am J Surg Pathol 28, no. 6 (June 2004): 794–800. https://doi.org/10.1097/01.pas.0000126052.88174.f.
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  - Gasparetto, Cristina. “Stem cell transplantation for multiple myeloma.” Cancer Control 11, no. 2 (March 2004): 119–29. https://doi.org/10.1177/107327480401100218.
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  - Long, Gwynn D., Mary Laughlin, Bella Madan, Joanne Kurtzberg, Cristina Gasparetto, Ashley Morris, David Rizzieri, et al. “Unrelated umbilical cord blood transplantation in adult patients.” Biol Blood Marrow Transplant 9, no. 12 (December 2003): 772–80. https://doi.org/10.1016/j.bbmt.2003.08.007.
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  - Rizzieri, David A., Jeffrey T. Talbot, Gwynn D. Long, James J. Vredenburgh, Christina Gasparetto, Clayton S. Smith, Michael O. Colvin, et al. “4-hydroperoxycyclophosphamide--purged peripheral blood stem cells for autologous transplantation in patients with acute myeloid leukemia.” Biol Blood Marrow Transplant 9, no. 3 (March 2003): 183–88. https://doi.org/10.1053/bbmt.2003.50011.
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  - Rizzieri, David A., Valerie K. Ibom, Joseph O. Moore, Carlos M. DeCastro, Gary L. Rosner, David J. Adams, Traci Foster, et al. “Phase I evaluation of prolonged-infusion gemcitabine with fludarabine for relapsed or refractory acute myelogenous leukemia.” Clin Cancer Res 9, no. 2 (February 2003): 663–68.
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  - McCune, Steven L., Jon P. Gockerman, Joseph O. Moore, Carlos M. Decastro, Adam J. Bass, Nelson J. Chao, Gwynn D. Long, et al. “Alemtuzumab in relapsed or refractory chronic lymphocytic leukemia and prolymphocytic leukemia.” Leuk Lymphoma 43, no. 5 (May 2002): 1007–11. https://doi.org/10.1080/10428190290021597.
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  - Gasparetto, Cristina, Maura Gasparetto, Michael Morse, Barbara Rooney, James J. Vredenburgh, Gwynn D. Long, David A. Rizzieri, Jennifer Loftis, Nelson J. Chao, and Clay Smith. “Mobilization of dendritic cells from patients with breast cancer into peripheral blood stem cell leukapheresis samples using Flt-3-Ligand and G-CSF or GM-CSF.” Cytokine 18, no. 1 (April 7, 2002): 8–19. https://doi.org/10.1006/cyto.2002.1009.
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  - Chao, Nelson J., Cong X. Liu, Barbara Rooney, Benny J. Chen, Gwynn D. Long, James J. Vredenburgh, Ashley Morris, Cristina Gasparetto, and David A. Rizzieri. “Nonmyeloablative regimen preserves "niches" allowing for peripheral expansion of donor T-cells.” Biol Blood Marrow Transplant 8, no. 5 (2002): 249–56. https://doi.org/10.1053/bbmt.2002.v8.pm12064361.
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  - Rizzieri, D. A., G. D. Long, J. J. Vredenburgh, C. Gasparetto, A. Morris, T. T. Stenzel, P. Davis, and N. J. Chao. “Successful allogeneic engraftment of mismatched unrelated cord blood following a nonmyeloablative preparative regimen.” Blood 98, no. 12 (December 1, 2001): 3486–88. https://doi.org/10.1182/blood.v98.12.3486.
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  - Gasparetto, C., C. Smith, A. Gillio, A. M. Stoppa, M. A. Moore, and R. J. O’Reilly. “Enrichment of peripheral blood stem cells in a primate model following administration of a single dose of rh-IL-1 beta.” Bone Marrow Transplant 14, no. 5 (November 1994): 717–23.
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  - Dennig, D., J. Lacerda, Y. Yan, C. Gasparetto, and R. J. O’Reilly. “ICAM-1 (CD54) expression on B lymphocytes is associated with their costimulatory function and can be increased by coactivation with IL-1 and IL-7.” Cell Immunol 156, no. 2 (July 1994): 414–23. https://doi.org/10.1006/cimm.1994.1186.
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  - Gasparetto, C., C. Smith, M. Firpo, D. Dennig, T. Small, A. P. Gillio, R. Lichtenberg, R. J. O’Reilly, and M. A. Moore. “Dyshematopoiesis in combined immune deficiency with congenital neutropenia.” Am J Hematol 45, no. 1 (January 1994): 63–72. https://doi.org/10.1002/ajh.2830450110.
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  - Muench, M. O., C. Gasparetto, and M. A. Moore. “The in vitro growth of murine high proliferative potential-colony forming cells is not enhanced by growth in a low oxygen atmosphere.” Cytokine 4, no. 6 (November 1992): 488–94. https://doi.org/10.1016/1043-4666(92)90009-g.
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  - Crown, J., A. Jakubowski, N. Kemeny, M. Gordon, C. Gasparetto, G. Wong, C. Sheridan, G. Toner, B. Meisenberg, and J. Botet. “A phase I trial of recombinant human interleukin-1 beta alone and in combination with myelosuppressive doses of 5-fluorouracil in patients with gastrointestinal cancer.” Blood 78, no. 6 (September 15, 1991): 1420–27.
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  - Smith, C., C. Gasparetto, N. Collins, A. Gillio, M. O. Muench, R. J. O’Reilly, and M. A. Moore. “Purification and partial characterization of a human hematopoietic precursor population.” Blood 77, no. 10 (May 15, 1991): 2122–28.
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  - Lemoli, R. M., C. Gasparetto, D. A. Scheinberg, M. A. Moore, B. D. Clarkson, and S. C. Gulati. “Autologous bone marrow transplantation in acute myelogenous leukemia: in vitro treatment with myeloid-specific monoclonal antibodies and drugs in combination.” Blood 77, no. 8 (April 15, 1991): 1829–36.
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  - Gillio, A. P., C. Gasparetto, J. Laver, M. Abboud, M. A. Bonilla, M. B. Garnick, and R. J. O’Reilly. “Effects of interleukin-3 on hematopoietic recovery after 5-fluorouracil or cyclophosphamide treatment of cynomolgus primates.” J Clin Invest 85, no. 5 (May 1990): 1560–65. https://doi.org/10.1172/JCI114605.
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  - Laver, J., E. Duncan, M. Abboud, C. Gasparetto, I. Sahdev, D. Warren, J. Bussel, P. Auld, R. J. O’Reilly, and M. A. Moore. “High levels of granulocyte and granulocyte-macrophage colony-stimulating factors in cord blood of normal full-term neonates.” J Pediatr 116, no. 4 (April 1990): 627–32. https://doi.org/10.1016/s0022-3476(05)81617-8.
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  - O’Reilly, R. J., A. Gillio, and C. Gasparetto. “Effects of hematopoietic growth factors following myeloablation in a primate model.” Int J Cell Cloning 8 Suppl 1 (January 1990): 262–67. https://doi.org/10.1002/stem.5530080724.
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  - Gasparetto, C., J. Laver, M. Abboud, A. Gillio, C. Smith, R. J. O’Reilly, and M. A. Moore. “Effects of interleukin-1 on hematopoietic progenitors: evidence of stimulatory and inhibitory activities in a primate model.” Blood 74, no. 2 (August 1, 1989): 547–50.
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  - Laver, J., M. Abboud, C. Gasparetto, A. Gillio, C. Smith, R. J. O’Reilly, and M. A. Moore. “Effects of IL-1 on hematopoietic progenitors after myelosuppressive chemoradiotherapy.” Biotherapy 1, no. 4 (1989): 293–300. https://doi.org/10.1007/BF02171005.
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- Conference Papers
  - Abonour, R., R. M. Rifkin, C. Gasparetto, K. Toomey, B. G. M. Durie, J. W. Hardin, H. R. Terebelo, et al. “Impact of initial treatment (tx) on HRQoL and outcomes in patients (pts) with newly diagnosed multiple myeloma (NDMM) without intent for immediate transplant (SCT): Results from the Connect® MM registry.” In Ann Oncol, 29 Suppl 8:viii360, 2018. https://doi.org/10.1093/annonc/mdy286.003.
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  - Anand, Sarah, Samantha Thomas, Kelly Corbet, Cristina Gasparetto, Gwynn D. Long, Richard Lopez, Ashley K. Morris, et al. “Adult Umbilical Cord Blood Transplantation Using Myeloablative Thiotepa, Total Body Irradiation, and Fludarabine Conditioning.” In Biol Blood Marrow Transplant, 23:1949–54, 2017. https://doi.org/10.1016/j.bbmt.2017.06.027.
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  - Richardson, Paul G., Robert L. Schlossman, Melissa Alsina, Donna M. Weber, Steven E. Coutre, Cristina Gasparetto, Sutapa Mukhopadhyay, et al. “PANORAMA 2: panobinostat in combination with bortezomib and dexamethasone in patients with relapsed and bortezomib-refractory myeloma.” In Blood, 122:2331–37, 2013. https://doi.org/10.1182/blood-2013-01-481325.
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