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The Calpain Gene is Correlated With Metal-on-Metal Hip Replacement Failures.

Publication ,  Journal Article
Kavolus, JJ; Lazarides, AL; Moore, C; Seyler, TM; Wellman, SS; Attarian, DE; Bolognesi, MP; Alman, BA
Published in: J Arthroplasty
January 2021

BACKGROUND: Metal-on-metal (MOM) total hip arthroplasty is associated with unacceptable failure rates secondary to metal ion reactions. Efforts to identify which patients will go on to failure have been limited; recently, there has been a suggestion for a potential genetic basis for the increased risk of revision in MOM hip replacements (MOMHRs). The purpose of this study is to determine whether certain immunologic genotypes are predictive of the need for revision in patients with MOM total hip implants. METHODS: This is a case-control study of all patients undergoing primary MOMHR between September 2002 and January 2012 with a minimum of 5-year follow-up. Our investigational "case" cohort was comprised of patients who underwent revision for MOMHR for a reason other than infection. A single-nucleotide polymorphism (SNP) array analysis was performed to identify a potential genetic basis for failure. RESULTS: Thirty-two patients (15 case and 17 control) were included in our analysis. All patients in the revision group had a chief complain of pain; revision patients were more likely to have a posterior approach (P = .01) and larger head size (P = .04) than nonrevision patients. No patient or implant characteristics were independently associated with revision in a multivariate analysis. Patients with SNP kgp9316441 were identified as having an increased odds of revision for MOM failure (P < .001). CONCLUSION: This study identified an SNP, kgp9316441, encoding proteins associated with inflammation and macrophage activation. This SNP was associated with significantly increased odds of revision for MOMHR. Future studies are warranted to validate this gene target both in vitro and in vivo. LEVEL OF EVIDENCE: III.

Duke Scholars

Published In

J Arthroplasty

DOI

EISSN

1532-8406

Publication Date

January 2021

Volume

36

Issue

1

Start / End Page

236 / 241.e3

Location

United States

Related Subject Headings

  • Risk Factors
  • Reoperation
  • Prosthesis Failure
  • Prosthesis Design
  • Orthopedics
  • Metal-on-Metal Joint Prostheses
  • Humans
  • Hip Prosthesis
  • Case-Control Studies
  • Calpain
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kavolus, J. J., Lazarides, A. L., Moore, C., Seyler, T. M., Wellman, S. S., Attarian, D. E., … Alman, B. A. (2021). The Calpain Gene is Correlated With Metal-on-Metal Hip Replacement Failures. J Arthroplasty, 36(1), 236-241.e3. https://doi.org/10.1016/j.arth.2020.07.054
Kavolus, Joseph J., Alexander L. Lazarides, Christina Moore, Thorsten M. Seyler, Samuel S. Wellman, David E. Attarian, Michael P. Bolognesi, and Benjamin A. Alman. “The Calpain Gene is Correlated With Metal-on-Metal Hip Replacement Failures.J Arthroplasty 36, no. 1 (January 2021): 236-241.e3. https://doi.org/10.1016/j.arth.2020.07.054.
Kavolus JJ, Lazarides AL, Moore C, Seyler TM, Wellman SS, Attarian DE, et al. The Calpain Gene is Correlated With Metal-on-Metal Hip Replacement Failures. J Arthroplasty. 2021 Jan;36(1):236-241.e3.
Kavolus, Joseph J., et al. “The Calpain Gene is Correlated With Metal-on-Metal Hip Replacement Failures.J Arthroplasty, vol. 36, no. 1, Jan. 2021, pp. 236-241.e3. Pubmed, doi:10.1016/j.arth.2020.07.054.
Kavolus JJ, Lazarides AL, Moore C, Seyler TM, Wellman SS, Attarian DE, Bolognesi MP, Alman BA. The Calpain Gene is Correlated With Metal-on-Metal Hip Replacement Failures. J Arthroplasty. 2021 Jan;36(1):236-241.e3.
Journal cover image

Published In

J Arthroplasty

DOI

EISSN

1532-8406

Publication Date

January 2021

Volume

36

Issue

1

Start / End Page

236 / 241.e3

Location

United States

Related Subject Headings

  • Risk Factors
  • Reoperation
  • Prosthesis Failure
  • Prosthesis Design
  • Orthopedics
  • Metal-on-Metal Joint Prostheses
  • Humans
  • Hip Prosthesis
  • Case-Control Studies
  • Calpain