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Controlled Lengthwise Assembly of Helical Peptide Nanofibers to Modulate CD8+ T-Cell Responses.

Publication ,  Journal Article
Fries, CN; Wu, Y; Kelly, SH; Wolf, M; Votaw, NL; Zauscher, S; Collier, JH
Published in: Advanced materials (Deerfield Beach, Fla.)
October 2020

Peptide nanofibers are useful for many biological applications, including immunotherapy, tissue engineering, and drug delivery. The robust lengthwise assembly of these peptides into nanofibers is typically difficult to control, resulting in polydisperse fiber lengths and an incomplete understanding of how nanofiber length affects biological responses. Here, rationally designed capping peptides control the length of helical peptide nanofibers with unique precision. These designed peptides bind the tips of elongated nanofibers to shorten and narrow their length distributions. Demonstrating their use as immunotherapies, capped nanofibers are preferentially cross-presented by dendritic cells compared to uncapped nanofibers. Due to increased cross-presentation, these capped nanofibers trigger stronger CD8+ T-cell responses in mice than uncapped nanofibers. This strategy illustrates a means for controlling the length of supramolecular peptide nanofibers to modulate their immunogenicity in the context of immunotherapies.

Duke Scholars

Published In

Advanced materials (Deerfield Beach, Fla.)

DOI

EISSN

1521-4095

ISSN

0935-9648

Publication Date

October 2020

Volume

32

Issue

39

Start / End Page

e2003310

Related Subject Headings

  • Protein Conformation, alpha-Helical
  • Peptides
  • Nanoscience & Nanotechnology
  • Nanofibers
  • Mice
  • Immunologic Factors
  • CD8-Positive T-Lymphocytes
  • Animals
  • 51 Physical sciences
  • 40 Engineering
 

Citation

APA
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ICMJE
MLA
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Fries, C. N., Wu, Y., Kelly, S. H., Wolf, M., Votaw, N. L., Zauscher, S., & Collier, J. H. (2020). Controlled Lengthwise Assembly of Helical Peptide Nanofibers to Modulate CD8+ T-Cell Responses. Advanced Materials (Deerfield Beach, Fla.), 32(39), e2003310. https://doi.org/10.1002/adma.202003310
Fries, Chelsea N., Yaoying Wu, Sean H. Kelly, Michelle Wolf, Nicole L. Votaw, Stefan Zauscher, and Joel H. Collier. “Controlled Lengthwise Assembly of Helical Peptide Nanofibers to Modulate CD8+ T-Cell Responses.Advanced Materials (Deerfield Beach, Fla.) 32, no. 39 (October 2020): e2003310. https://doi.org/10.1002/adma.202003310.
Fries CN, Wu Y, Kelly SH, Wolf M, Votaw NL, Zauscher S, et al. Controlled Lengthwise Assembly of Helical Peptide Nanofibers to Modulate CD8+ T-Cell Responses. Advanced materials (Deerfield Beach, Fla). 2020 Oct;32(39):e2003310.
Fries, Chelsea N., et al. “Controlled Lengthwise Assembly of Helical Peptide Nanofibers to Modulate CD8+ T-Cell Responses.Advanced Materials (Deerfield Beach, Fla.), vol. 32, no. 39, Oct. 2020, p. e2003310. Epmc, doi:10.1002/adma.202003310.
Fries CN, Wu Y, Kelly SH, Wolf M, Votaw NL, Zauscher S, Collier JH. Controlled Lengthwise Assembly of Helical Peptide Nanofibers to Modulate CD8+ T-Cell Responses. Advanced materials (Deerfield Beach, Fla). 2020 Oct;32(39):e2003310.
Journal cover image

Published In

Advanced materials (Deerfield Beach, Fla.)

DOI

EISSN

1521-4095

ISSN

0935-9648

Publication Date

October 2020

Volume

32

Issue

39

Start / End Page

e2003310

Related Subject Headings

  • Protein Conformation, alpha-Helical
  • Peptides
  • Nanoscience & Nanotechnology
  • Nanofibers
  • Mice
  • Immunologic Factors
  • CD8-Positive T-Lymphocytes
  • Animals
  • 51 Physical sciences
  • 40 Engineering