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Joel Collier

Theodore Kennedy Professor of Biomedical Engineering
Biomedical Engineering

Overview


The Collier Lab designs biomaterials for a range of biomedical applications, with a focus on understanding and controlling adaptive immune responses.  Most materials investigated are created from molecular assemblies- proteins, peptides or bioconjugates that self-organize into useful structures such as nanofibers, gels, and particles. 

These biomaterials are being developed as novel treatments for infectious diseases, cancer, wound healing, and chronic inflammation.  Additionally, as these strategies are developed, basic insights into how materials engage the immune system are uncovered.

Current Appointments & Affiliations


Theodore Kennedy Professor of Biomedical Engineering · 2021 - Present Biomedical Engineering, Pratt School of Engineering
Professor of Biomedical Engineering · 2021 - Present Biomedical Engineering, Pratt School of Engineering
Associate Dean for Doctoral Education in the Pratt School of Engineering · 2023 - Present Pratt School of Engineering
Associate Professor in Integrative Immunobiology · 2016 - Present Integrative Immunobiology, Basic Science Departments

In the News


Published September 15, 2023
Duke Companies and Faculty Share Ideas with Investors at Triangle Venture Day
Published June 1, 2021
Six New Bass Fellows Honored for Excellence in Research and Outstanding Undergraduate Teaching

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Recent Publications


Anti-Cytokine Active Immunotherapy Based on Supramolecular Peptides for Alleviating IL-1β-Mediated Inflammation.

Journal Article Advanced healthcare materials · February 2025 IL-1β is a principal proinflammatory cytokine underlying multiple local and systemic chronic inflammatory conditions including psoriasis, rheumatoid arthritis, inflammatory bowel disease, and type 2 diabetes. Passive immunotherapies and biologic drugs targ ... Full text Open Access Cite

Multi-Target Peptide Nanofiber Immunotherapy Diminishes Complement Anaphylatoxin Activity in Acute Inflammation.

Journal Article Advanced healthcare materials · January 2025 The anaphylatoxins C3a and C5a are products of the complement cascade that play important and interrelated roles in health and disease. Both are potential targets for anti-inflammatory active immunotherapies in which a patient's own immune system is stimul ... Full text Cite

Tuning Helical Peptide Nanofibers as a Sublingual Vaccine Platform for a Variety of Peptide Epitopes.

Journal Article Advanced healthcare materials · January 2025 Mucosal immune responses to vaccination are essential for achieving full protection against pathogens entering their host at mucosal sites. However, traditional parenteral immunization routes commonly fail to raise significant mucosal immunity. Sublingual ... Full text Cite
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Recent Grants


University Training Program in Biomolecular and Tissue Engineering

Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2027

Supramolecular biomaterials for tuning the inflammatory properties of the complement system

ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2022 - 2027

Sublingual Supramolecular Vaccines and Immunotherapies

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2026

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Education, Training & Certifications


Northwestern University · 2003 Ph.D.