Overview
The Collier Lab designs biomaterials for a range of biomedical applications, with a focus on understanding and controlling adaptive immune responses. Most materials investigated are created from molecular assemblies- proteins, peptides or bioconjugates that self-organize into useful structures such as nanofibers, gels, and particles.
These biomaterials are being developed as novel treatments for infectious diseases, cancer, wound healing, and chronic inflammation. Additionally, as these strategies are developed, basic insights into how materials engage the immune system are uncovered.
These biomaterials are being developed as novel treatments for infectious diseases, cancer, wound healing, and chronic inflammation. Additionally, as these strategies are developed, basic insights into how materials engage the immune system are uncovered.
Current Appointments & Affiliations
Theodore Kennedy Professor of Biomedical Engineering
·
2021 - Present
Biomedical Engineering,
Pratt School of Engineering
Professor of Biomedical Engineering
·
2021 - Present
Biomedical Engineering,
Pratt School of Engineering
Associate Dean for Doctoral Education in the Pratt School of Engineering
·
2023 - Present
Pratt School of Engineering
Associate Professor in Integrative Immunobiology
·
2016 - Present
Integrative Immunobiology,
Basic Science Departments
Recent Publications
Anti-Cytokine Active Immunotherapy Based on Supramolecular Peptides for Alleviating IL-1β-Mediated Inflammation.
Journal Article Advanced healthcare materials · February 2025 IL-1β is a principal proinflammatory cytokine underlying multiple local and systemic chronic inflammatory conditions including psoriasis, rheumatoid arthritis, inflammatory bowel disease, and type 2 diabetes. Passive immunotherapies and biologic drugs targ ... Full text Open Access CiteMulti-Target Peptide Nanofiber Immunotherapy Diminishes Complement Anaphylatoxin Activity in Acute Inflammation.
Journal Article Advanced healthcare materials · January 2025 The anaphylatoxins C3a and C5a are products of the complement cascade that play important and interrelated roles in health and disease. Both are potential targets for anti-inflammatory active immunotherapies in which a patient's own immune system is stimul ... Full text CiteTuning Helical Peptide Nanofibers as a Sublingual Vaccine Platform for a Variety of Peptide Epitopes.
Journal Article Advanced healthcare materials · January 2025 Mucosal immune responses to vaccination are essential for achieving full protection against pathogens entering their host at mucosal sites. However, traditional parenteral immunization routes commonly fail to raise significant mucosal immunity. Sublingual ... Full text CiteRecent Grants
University Training Program in Biomolecular and Tissue Engineering
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2027Supramolecular biomaterials for tuning the inflammatory properties of the complement system
ResearchPrincipal Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2022 - 2027Sublingual Supramolecular Vaccines and Immunotherapies
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2026View All Grants
Education, Training & Certifications
Northwestern University ·
2003
Ph.D.