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Joel Collier

Theodore Kennedy Professor of Biomedical Engineering
Biomedical Engineering

Selected Publications


Self-Assembling Allergen Vaccine Platform Raises Therapeutic Allergen-Specific IgG Responses without Induction of Systemic Allergic Responses.

Journal Article ACS biomaterials science & engineering · March 2024 Allergen immunotherapies are often successful at desensitizing allergic patients but can require life-long dosing and suffer from frequent adverse events including instances of systemic anaphylaxis, leading to poor patient compliance and high cost. Allerge ... Full text Cite

Engaging natural antibody responses for the treatment of inflammatory bowel disease via phosphorylcholine-presenting nanofibres.

Journal Article Nat Biomed Eng · November 27, 2023 Inflammatory bowel disease lacks a long-lasting and broadly effective therapy. Here, by taking advantage of the anti-infection and anti-inflammatory properties of natural antibodies against the small-molecule epitope phosphorylcholine (PC), we show in mult ... Full text Link to item Cite

Immune-active polymeric materials for the treatment of inflammatory diseases

Journal Article Current Opinion in Colloid and Interface Science · October 1, 2023 In recent years, a growing understanding of the underlying mechanisms of autoinflammatory and autoimmune disease has enabled significant advances in biomaterial therapeutics for their treatment and prevention. Drug-free or immune-active polymeric materials ... Full text Cite

Lung cDC1 and cDC2 dendritic cells priming naive CD8+ T cells in situ prior to migration to draining lymph nodes.

Journal Article Cell reports · October 2023 The current paradigm indicates that naive T cells are primed in secondary lymphoid organs. Here, we present evidence that intranasal administration of peptide antigens appended to nanofibers primes naive CD8+ T cells in the lung independently an ... Full text Cite

A Balance between Pro-Inflammatory and Pro-Reparative Macrophages is Observed in Regenerative D-MAPS.

Journal Article Advanced science (Weinheim, Baden-Wurttemberg, Germany) · April 2023 Microporous annealed particle scaffolds (MAPS) are a new class of granular materials generated through the interlinking of tunable microgels, which produce an interconnected network of void space. These microgel building blocks can be designed with differe ... Full text Cite

An injectable PEG-like conjugate forms a subcutaneous depot and enables sustained delivery of a peptide drug.

Journal Article Biomaterials · March 2023 Many biologics have a short plasma half-life, and their conjugation to polyethylene glycol (PEG) is commonly used to solve this problem. However, the improvement in the plasma half-life of PEGylated drugs' is at an asymptote because the development of bran ... Full text Link to item Cite

Expanding opportunities to engineer mucosal vaccination with biomaterials.

Journal Article Biomaterials science · February 2023 Mucosal vaccines are receiving increasing interest both for protecting against infectious diseases and for inducing therapeutic immune responses to treat non-infectious diseases. However, the mucosal barriers of the lungs, gastrointestinal tract, genitouri ... Full text Cite

A sublingual nanofiber vaccine to prevent urinary tract infections.

Journal Article Science advances · November 2022 Urinary tract infections (UTIs) are a major public health problem affecting millions of individuals each year. Recurrent UTIs are managed by long-term antibiotic use, making the alarming rise of antibiotic resistance a substantial threat to future UTI trea ... Full text Cite

Self-assembling peptide nanofiber HIV vaccine elicits robust vaccine-induced antibody functions and modulates Fc glycosylation.

Journal Article Sci Adv · September 23, 2022 To develop vaccines for certain key global pathogens such as HIV, it is crucial to elicit both neutralizing and non-neutralizing Fc-mediated effector antibody functions. Clinical evidence indicates that non-neutralizing antibody functions including antibod ... Full text Link to item Cite

Multiepitope supramolecular peptide nanofibers eliciting coordinated humoral and cellular antitumor immune responses.

Journal Article Sci Adv · July 22, 2022 Featured Publication Subunit vaccines inducing antibodies against tumor-specific antigens have yet to be clinically successful. Here, we use a supramolecular α-helical peptide nanofiber approach to design epitope-specific vaccines raising simultaneous B cell, CD8+ T cell, and ... Full text Link to item Cite

Polyethylene Glycol-Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart.

Journal Article Adv Sci (Weinh) · April 2022 Protein therapeutics, except for antibodies, have a short plasma half-life and poor stability in circulation. Covalent coupling of polyethylene glycol (PEG) to protein drugs addresses this limitation. However, unlike previously thought, PEG is immunogenic. ... Full text Link to item Cite

HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth.

Journal Article Scientific reports · July 2021 Featured Publication A major challenge in developing an effective vaccine against HIV-1 is the genetic diversity of its viral envelope. Because of the broad range of sequences exhibited by HIV-1 strains, protective antibodies must be able to bind and neutralize a widely mutate ... Full text Cite

Randomized peptide assemblies for enhancing immune responses to nanomaterials.

Journal Article Biomaterials · June 2021 Featured Publication Biomaterials capable of inducing immune responses with minimal associated inflammation are of interest in applications ranging from tissue repair to vaccines. Here we report the design of self-assembling randomized polypeptide nanomaterials inspired by gla ... Full text Cite

Intranasal Subunit Vaccination Strategies Employing Nanomaterials and Biomaterials.

Journal Article ACS biomaterials science & engineering · May 2021 Intranasal vaccines offer key advantages over traditional needle-based vaccines. They are simple to administer and painless and establish local immunity at mucosal surfaces. Owing to these advantages, they are particularly attractive for use in resource-li ... Full text Cite

Titrating Polyarginine into Nanofibers Enhances Cyclic-Dinucleotide Adjuvanticity in Vitro and after Sublingual Immunization.

Journal Article ACS biomaterials science & engineering · May 2021 Effective sublingual peptide immunization requires overcoming challenges of both delivery and immunogenicity. Mucosal adjuvants, such as cyclic-dinucleotides (CDN), can promote sublingual immune responses but must be codelivered with the antigen to the epi ... Full text Cite

Advances in nanomaterial vaccine strategies to address infectious diseases impacting global health.

Journal Article Nat Nanotechnol · April 2021 Featured Publication Despite the overwhelming success of vaccines in preventing infectious diseases, there remain numerous globally devastating diseases without fully protective vaccines, particularly human immunodeficiency virus (HIV), malaria and tuberculosis. Nanotechnology ... Full text Link to item Cite

Modular complement assemblies for mitigating inflammatory conditions.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · April 2021 Featured Publication Complement protein C3dg, a key linkage between innate and adaptive immunity, is capable of stimulating both humoral and cell-mediated immune responses, leading to considerable interest in its use as a molecular adjuvant. However, the potential of C3dg as a ... Full text Cite

Tabletized Supramolecular Assemblies for Sublingual Peptide Immunization.

Journal Article Advanced healthcare materials · March 2021 Featured Publication Widespread vaccination is essential to global health. Significant barriers exist to improving vaccine coverage in lower- and middle-income countries, including the costly requirements for cold-chain distribution and trained medical personnel to administer ... Full text Cite

Injectable non-immunogenic PEG-like conjugate that forms a subcutaneous depot and enables sustained delivery of a peptide drug

Journal Article · 2021 Many biologics have a short plasma half-life, and their conjugation to polyethylene glycol (PEG) is commonly used to solve this problem. Unfortunately, PEG is immunogenic and forms vacuoles, and improvement in PEGylated drugs' half-life is at an asymptote. ... Full text Cite

Controlled Lengthwise Assembly of Helical Peptide Nanofibers to Modulate CD8+ T-Cell Responses.

Journal Article Advanced materials (Deerfield Beach, Fla.) · October 2020 Featured Publication Peptide nanofibers are useful for many biological applications, including immunotherapy, tissue engineering, and drug delivery. The robust lengthwise assembly of these peptides into nanofibers is typically difficult to control, resulting in polydisperse fi ... Full text Cite

Self-Assembling Allergen Vaccine Platform Raises Therapeutic Allergen-Specific IgG Responses without Induction of Systemic Allergic Responses.

Journal Article ACS biomaterials science & engineering · March 2024 Allergen immunotherapies are often successful at desensitizing allergic patients but can require life-long dosing and suffer from frequent adverse events including instances of systemic anaphylaxis, leading to poor patient compliance and high cost. Allerge ... Full text Cite

Engaging natural antibody responses for the treatment of inflammatory bowel disease via phosphorylcholine-presenting nanofibres.

Journal Article Nat Biomed Eng · November 27, 2023 Inflammatory bowel disease lacks a long-lasting and broadly effective therapy. Here, by taking advantage of the anti-infection and anti-inflammatory properties of natural antibodies against the small-molecule epitope phosphorylcholine (PC), we show in mult ... Full text Link to item Cite

Immune-active polymeric materials for the treatment of inflammatory diseases

Journal Article Current Opinion in Colloid and Interface Science · October 1, 2023 In recent years, a growing understanding of the underlying mechanisms of autoinflammatory and autoimmune disease has enabled significant advances in biomaterial therapeutics for their treatment and prevention. Drug-free or immune-active polymeric materials ... Full text Cite

Lung cDC1 and cDC2 dendritic cells priming naive CD8+ T cells in situ prior to migration to draining lymph nodes.

Journal Article Cell reports · October 2023 The current paradigm indicates that naive T cells are primed in secondary lymphoid organs. Here, we present evidence that intranasal administration of peptide antigens appended to nanofibers primes naive CD8+ T cells in the lung independently an ... Full text Cite

A Balance between Pro-Inflammatory and Pro-Reparative Macrophages is Observed in Regenerative D-MAPS.

Journal Article Advanced science (Weinheim, Baden-Wurttemberg, Germany) · April 2023 Microporous annealed particle scaffolds (MAPS) are a new class of granular materials generated through the interlinking of tunable microgels, which produce an interconnected network of void space. These microgel building blocks can be designed with differe ... Full text Cite

An injectable PEG-like conjugate forms a subcutaneous depot and enables sustained delivery of a peptide drug.

Journal Article Biomaterials · March 2023 Many biologics have a short plasma half-life, and their conjugation to polyethylene glycol (PEG) is commonly used to solve this problem. However, the improvement in the plasma half-life of PEGylated drugs' is at an asymptote because the development of bran ... Full text Link to item Cite

Expanding opportunities to engineer mucosal vaccination with biomaterials.

Journal Article Biomaterials science · February 2023 Mucosal vaccines are receiving increasing interest both for protecting against infectious diseases and for inducing therapeutic immune responses to treat non-infectious diseases. However, the mucosal barriers of the lungs, gastrointestinal tract, genitouri ... Full text Cite

A sublingual nanofiber vaccine to prevent urinary tract infections.

Journal Article Science advances · November 2022 Urinary tract infections (UTIs) are a major public health problem affecting millions of individuals each year. Recurrent UTIs are managed by long-term antibiotic use, making the alarming rise of antibiotic resistance a substantial threat to future UTI trea ... Full text Cite

Self-assembling peptide nanofiber HIV vaccine elicits robust vaccine-induced antibody functions and modulates Fc glycosylation.

Journal Article Sci Adv · September 23, 2022 To develop vaccines for certain key global pathogens such as HIV, it is crucial to elicit both neutralizing and non-neutralizing Fc-mediated effector antibody functions. Clinical evidence indicates that non-neutralizing antibody functions including antibod ... Full text Link to item Cite

Multiepitope supramolecular peptide nanofibers eliciting coordinated humoral and cellular antitumor immune responses.

Journal Article Sci Adv · July 22, 2022 Featured Publication Subunit vaccines inducing antibodies against tumor-specific antigens have yet to be clinically successful. Here, we use a supramolecular α-helical peptide nanofiber approach to design epitope-specific vaccines raising simultaneous B cell, CD8+ T cell, and ... Full text Link to item Cite

Polyethylene Glycol-Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart.

Journal Article Adv Sci (Weinh) · April 2022 Protein therapeutics, except for antibodies, have a short plasma half-life and poor stability in circulation. Covalent coupling of polyethylene glycol (PEG) to protein drugs addresses this limitation. However, unlike previously thought, PEG is immunogenic. ... Full text Link to item Cite

HIV envelope antigen valency on peptide nanofibers modulates antibody magnitude and binding breadth.

Journal Article Scientific reports · July 2021 Featured Publication A major challenge in developing an effective vaccine against HIV-1 is the genetic diversity of its viral envelope. Because of the broad range of sequences exhibited by HIV-1 strains, protective antibodies must be able to bind and neutralize a widely mutate ... Full text Cite

Randomized peptide assemblies for enhancing immune responses to nanomaterials.

Journal Article Biomaterials · June 2021 Featured Publication Biomaterials capable of inducing immune responses with minimal associated inflammation are of interest in applications ranging from tissue repair to vaccines. Here we report the design of self-assembling randomized polypeptide nanomaterials inspired by gla ... Full text Cite

Intranasal Subunit Vaccination Strategies Employing Nanomaterials and Biomaterials.

Journal Article ACS biomaterials science & engineering · May 2021 Intranasal vaccines offer key advantages over traditional needle-based vaccines. They are simple to administer and painless and establish local immunity at mucosal surfaces. Owing to these advantages, they are particularly attractive for use in resource-li ... Full text Cite

Titrating Polyarginine into Nanofibers Enhances Cyclic-Dinucleotide Adjuvanticity in Vitro and after Sublingual Immunization.

Journal Article ACS biomaterials science & engineering · May 2021 Effective sublingual peptide immunization requires overcoming challenges of both delivery and immunogenicity. Mucosal adjuvants, such as cyclic-dinucleotides (CDN), can promote sublingual immune responses but must be codelivered with the antigen to the epi ... Full text Cite

Advances in nanomaterial vaccine strategies to address infectious diseases impacting global health.

Journal Article Nat Nanotechnol · April 2021 Featured Publication Despite the overwhelming success of vaccines in preventing infectious diseases, there remain numerous globally devastating diseases without fully protective vaccines, particularly human immunodeficiency virus (HIV), malaria and tuberculosis. Nanotechnology ... Full text Link to item Cite

Modular complement assemblies for mitigating inflammatory conditions.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · April 2021 Featured Publication Complement protein C3dg, a key linkage between innate and adaptive immunity, is capable of stimulating both humoral and cell-mediated immune responses, leading to considerable interest in its use as a molecular adjuvant. However, the potential of C3dg as a ... Full text Cite

Tabletized Supramolecular Assemblies for Sublingual Peptide Immunization.

Journal Article Advanced healthcare materials · March 2021 Featured Publication Widespread vaccination is essential to global health. Significant barriers exist to improving vaccine coverage in lower- and middle-income countries, including the costly requirements for cold-chain distribution and trained medical personnel to administer ... Full text Cite

Injectable non-immunogenic PEG-like conjugate that forms a subcutaneous depot and enables sustained delivery of a peptide drug

Journal Article · 2021 Many biologics have a short plasma half-life, and their conjugation to polyethylene glycol (PEG) is commonly used to solve this problem. Unfortunately, PEG is immunogenic and forms vacuoles, and improvement in PEGylated drugs' half-life is at an asymptote. ... Full text Cite

Controlled Lengthwise Assembly of Helical Peptide Nanofibers to Modulate CD8+ T-Cell Responses.

Journal Article Advanced materials (Deerfield Beach, Fla.) · October 2020 Featured Publication Peptide nanofibers are useful for many biological applications, including immunotherapy, tissue engineering, and drug delivery. The robust lengthwise assembly of these peptides into nanofibers is typically difficult to control, resulting in polydisperse fi ... Full text Cite

Adjuvant-free nanofiber vaccine induces in situ lung dendritic cell activation and TH17 responses.

Journal Article Science advances · August 2020 The current paradigm that subunit vaccines require adjuvants to optimally activate innate immunity implies that increased vaccine reactogenicity will invariably be linked to improved immunogenicity. Countering this paradigm, nanoparticulate vaccines have b ... Full text Cite

Comparative study of α-helical and β-sheet self-assembled peptide nanofiber vaccine platforms: influence of integrated T-cell epitopes.

Journal Article Biomater Sci · June 21, 2020 Featured Publication Several different self-assembling peptide systems that form nanofibers have been investigated as vaccine platforms, but design principles for adjusting the character of the immune responses they raise have yet to be well articulated. Here we compared the i ... Full text Link to item Cite

Enabling sublingual peptide immunization with molecular self-assemblies.

Journal Article Biomaterials · May 2020 Featured Publication Short peptides are poorly immunogenic when delivered sublingually - under the tongue. Nanomaterial delivery of peptides could be utilized to improve immunogenicity towards designed sublingual vaccines, but nanomaterials have not been widely successful in s ... Full text Cite

Multifactorial Design of a Supramolecular Peptide Anti-IL-17 Vaccine Toward the Treatment of Psoriasis.

Journal Article Front Immunol · 2020 Featured Publication Current treatments for chronic immune-mediated diseases such as psoriasis, rheumatoid arthritis, or Crohn's disease commonly rely on cytokine neutralization using monoclonal antibodies; however, such approaches have drawbacks. Frequent repeated dosing can ... Full text Link to item Cite

Long-Term Evaluation of AAV-CRISPR Genome Editing for Duchenne Muscular Dystrophy

Conference MOLECULAR THERAPY · April 22, 2019 Featured Publication Link to item Cite

Long-term evaluation of AAV-CRISPR genome editing for Duchenne muscular dystrophy.

Journal Article Nat Med · March 2019 Duchenne muscular dystrophy (DMD) is a monogenic disorder and a candidate for therapeutic genome editing. There have been several recent reports of genome editing in preclinical models of Duchenne muscular dystrophy1-6, however, the long-term persistence a ... Full text Link to item Cite

Biomaterial interactions with the immune system.

Journal Article Biomaterials science · February 2019 Full text Cite

Self-Assembling Peptide Gels for 3D Prostate Cancer Spheroid Culture.

Journal Article Macromolecular bioscience · January 2019 Progress in prostate cancer research is presently limited by a shortage of reliable in vitro model systems. The authors describe a novel self-assembling peptide, bQ13, which forms nanofibers and gels useful for the 3D culture of prostate cancer spheroids, ... Full text Cite

Modular complement assemblies as defined active immunotherapies

Conference Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium · January 1, 2019 Statement of Purpose: Induction of a tunable humoral response is essential for the success of a variety of immunotherapies including vaccines against infectious diseases and active immunotherapies against autologous targets. These therapies often require a ... Cite

Injectable tissue integrating networks from recombinant polypeptides with tunable order.

Journal Article Nat Mater · December 2018 Emergent properties of natural biomaterials result from the collective effects of nanoscale interactions among ordered and disordered domains. Here, using recombinant sequence design, we have created a set of partially ordered polypeptides to study emergen ... Full text Link to item Cite

Author Correction: Injectable tissue integrating networks from recombinant polypeptides with tunable order.

Journal Article Nat Mater · December 2018 In the version of this Article originally published, one of the authors' names was incorrectly given as Jeffery Schaal; it should have been Jeffrey L. Schaal. This has been corrected in all versions of the Article. ... Full text Link to item Cite

Intranasal delivery of adjuvant-free peptide nanofibers elicits resident CD8+ T cell responses.

Journal Article Journal of controlled release : official journal of the Controlled Release Society · July 2018 Featured Publication Influenza vaccines that can be administered intranasally or by other needle-free delivery routes have potential advantages over injected formulations in terms of patient compliance, cost, and ease of global distribution. Supramolecular peptide nanofibers h ... Full text Cite

Progress Toward the Clinical Translation of Bioinspired Peptide and Protein Assemblies.

Journal Article Advanced healthcare materials · March 2018 Featured Publication Supramolecular materials composed of proteins and peptides have been receiving considerable attention toward a range of diseases and conditions from vaccines to drug delivery. Owing to the relative newness of this class of materials, the bulk of work to da ... Full text Cite

MyD88 in antigen-presenting cells is not required for CD4+ T-cell responses during peptide nanofiber vaccination.

Journal Article MedChemComm · January 2018 Featured Publication Self-assembled peptide nanofibers raise significant antibody and T cell responses without adjuvants, but the mechanism by which they achieve this has not been fully elucidated. Myeloid differentiation primary response gene 88 (MyD88) previously has been sh ... Full text Cite

Practical Considerations in the Design and Use of Immunologically Active Fibrillar Peptide Assemblies.

Journal Article Methods in molecular biology (Clifton, N.J.) · January 2018 Featured Publication The design, formulation, and immunological evaluation of self-assembling peptide materials is relatively straightforward. Indeed, one of the advantages of synthetic self-assembling peptides is that one can progress from initial concept to in vivo testing i ... Full text Cite

A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers.

Journal Article ACS Biomater Sci Eng · December 11, 2017 Featured Publication A supramolecular peptide vaccine system was designed in which epitope-bearing peptides self-assemble into elongated nanofibers composed almost entirely of alpha-helical structure. The nanofibers were readily internalized by antigen presenting cells and pro ... Full text Link to item Cite

Active immunotherapy for TNF-mediated inflammation using self-assembled peptide nanofibers.

Journal Article Biomaterials · December 2017 Featured Publication Active immunotherapies raising antibody responses against autologous targets are receiving increasing interest as alternatives to the administration of manufactured antibodies. The challenge in such an approach is generating protective and adjustable level ... Full text Cite

Biomaterial strategies for generating therapeutic immune responses.

Journal Article Advanced drug delivery reviews · May 2017 Featured Publication Biomaterials employed to raise therapeutic immune responses have become a complex and active field. Historically, vaccines have been developed primarily to fight infectious diseases, but recent years have seen the development of immunologically active biom ... Full text Cite

α-Helical coiled-coil peptide materials for biomedical applications.

Journal Article Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · March 2017 Featured Publication Self-assembling coiled coils, which occur commonly in native proteins, have received significant interest for the design of new biomaterials-based medical therapies. Considerable effort over recent years has led to a detailed understanding of the self-asse ... Full text Cite

Editorial: Special Issue on Biomaterials for Immunoengineering.

Journal Article ACS biomaterials science & engineering · February 2017 Full text Cite

2.4 Self-assembling biomaterials

Chapter · January 1, 2017 Self-assembly has become a useful way of constructing biomaterials for a variety of applications ranging from cell culture to tissue engineering. Attractive features of self-assembled biomaterials include chemical definition, modularity, stimulus-sensitivi ... Full text Cite

Switching the Immunogenicity of Peptide Assemblies Using Surface Properties.

Journal Article ACS nano · October 2016 Featured Publication Biomaterials created from supramolecular peptides, proteins, and their derivatives have been receiving increasing interest for both immunological applications, such as vaccines and immunotherapies, as well as ostensibly nonimmunological applications, such ... Full text Cite

This paper is the winner of an SFB Award in the Hospital Intern, Residency category: Peptide biomaterials raising adaptive immune responses in wound healing contexts.

Journal Article Journal of biomedical materials research. Part A · August 2016 Featured Publication Biomaterials used in the context of tissue engineering or wound repair are commonly designed to be "nonimmunogenic." However, previously it has been observed that self-assembled peptide nanofiber materials are noninflammatory despite their immunogenicity, ... Full text Cite

Methods and compositions related to immunogenic fibrils

Other US Patent No. 9,241,987 · January 26, 2016 Cite

Thermal stability of self-assembled peptide vaccine materials.

Journal Article Acta biomaterialia · January 2016 Featured Publication The majority of current vaccines depend on a continuous "cold chain" of storage and handling between 2 and 8°C. Vaccines experiencing temperature excursions outside this range can suffer from reduced potency. This thermal sensitivity results in significant ... Full text Cite

Methods and compositions involving fibrillizing polypeptides for nanofibers

Other US Patent No. 9,200,082 B2 · December 1, 2015 Cite

Self-assembled glycopeptide nanofibers as modulators of galectin-1 bioactivity.

Journal Article Cellular and molecular bioengineering · September 2015 Galectins are carbohydrate-binding proteins that act as extracellular signaling molecules in various normal and pathological processes. Galectin bioactivity is mediated by specific non-covalent interactions with cell-surface and extracellular matrix (ECM) ... Full text Cite

Supramolecular peptide vaccines: tuning adaptive immunity.

Journal Article Current opinion in immunology · August 2015 Featured Publication Successful immunotherapies must be designed to elicit targeted immune responses having a specifiable phenotype across many dimensions, including the phenotypes of T cells, B cells, antigen-presenting cells, and others. For synthetic or subunit vaccines, st ... Full text Cite

Titrating T-cell epitopes within self-assembled vaccines optimizes CD4+ helper T cell and antibody outputs.

Journal Article Advanced healthcare materials · November 2014 Featured Publication Epitope content plays a critical role in determining T-cell and antibody responses to vaccines, biomaterials, and protein therapeutics, but its effects are nonlinear and difficult to isolate. Here, molecular self-assembly is used to build a vaccine with pr ... Full text Cite

Gradated assembly of multiple proteins into supramolecular nanomaterials.

Journal Article Nature materials · August 2014 Featured Publication Biomaterials exhibiting precise ratios of different bioactive protein components are critical for applications ranging from vaccines to regenerative medicine, but their design is often hindered by limited choices and cross-reactivity of protein conjugation ... Full text Cite

Engaging adaptive immunity with biomaterials.

Journal Article Journal of materials chemistry. B · May 2014 Featured Publication Adaptive immune responses, characterized by T cells and B cells engaging and responding to specific antigens, can be raised by biomaterials containing proteins, peptides, and other biomolecules. How does one avoid, control, or exploit such responses? This ... Full text Cite

Phosphate-containing polyethylene glycol polymers prevent lethal sepsis by multidrug-resistant pathogens.

Journal Article Antimicrobial agents and chemotherapy · January 2014 Antibiotic resistance among highly pathogenic strains of bacteria and fungi is a growing concern in the face of the ability to sustain life during critical illness with advancing medical interventions. The longer patients remain critically ill, the more li ... Full text Cite

The use of self-adjuvanting nanofiber vaccines to elicit high-affinity B cell responses to peptide antigens without inflammation.

Journal Article Biomaterials · November 2013 Featured Publication Balancing immunogenicity with inflammation is a central tenet of vaccine design, especially for subunit vaccines that utilize traditional pro-inflammatory adjuvants. Here we report that by using a nanoparticulate peptide-based vaccine, immunogenicity and l ... Full text Cite

Controllably degradable β-sheet nanofibers and gels from self-assembling depsipeptides.

Journal Article Biomaterials science · October 2013 Featured Publication Self-assembled peptide materials have received considerable interest for a range of applications, including 3D cell culture, tissue engineering, and the delivery of cells and drugs. One challenge in applying such materials within these areas has been the e ... Full text Cite

A self-adjuvanting supramolecular vaccine carrying a folded protein antigen.

Journal Article Advanced healthcare materials · August 2013 Featured Publication This work illustrates a strategy for the design of molecularly defined immunotherapies, using a blend of supramolecular peptide self-assembly and active site-directed protein capture. ... Full text Cite

Tangled up in nanofibers

Journal Article Science Translational Medicine · February 6, 2013 Full text Cite

Inspired by Porcupines

Journal Article Science Translational Medicine · January 9, 2013 Full text Cite

Driving a wedge into acute allergic responses

Journal Article Science Translational Medicine · December 5, 2012 Full text Cite

Taking a bite out of pain

Journal Article Science Translational Medicine · November 7, 2012 Full text Cite

There's node place like home

Journal Article Science Translational Medicine · October 10, 2012 Full text Cite

Merging electronics and engineered tissues

Journal Article Science Translational Medicine · September 12, 2012 Full text Cite

Self-assembled peptide nanofibers raising durable antibody responses against a malaria epitope.

Journal Article Biomaterials · September 2012 Biomaterials that modulate innate and adaptive immune responses are receiving increasing interest as adjuvants for eliciting protective immunity against a variety of diseases. Previous results have indicated that self-assembling β-sheet peptides, when fuse ... Full text Cite

A sweet way to construct vascular networks

Journal Article Science Translational Medicine · August 22, 2012 Full text Cite

Diminishing returns

Journal Article Science Translational Medicine · July 18, 2012 Full text Cite

A steps toward a universal flu vaccine

Journal Article Science Translational Medicine · June 20, 2012 Full text Cite

Abandonment complexes

Journal Article Science Translational Medicine · May 23, 2012 Full text Cite

Carrier and therapeutic in one

Journal Article Science Translational Medicine · April 25, 2012 Full text Cite

Nanomedicine: Nanoscale mimics of mast cell messengers

Journal Article Science Translational Medicine · March 28, 2012 Full text Cite

Some disassembly required

Journal Article Science Translational Medicine · February 29, 2012 Full text Cite

Modulating adaptive immune responses to peptide self-assemblies.

Journal Article ACS nano · February 2012 Self-assembling peptides and peptide derivatives have received significant interest for several biomedical applications, including tissue engineering, wound healing, cell delivery, drug delivery, and vaccines. This class of materials has exhibited signific ... Full text Cite

Regulation of endothelial cell activation and angiogenesis by injectable peptide nanofibers.

Journal Article Acta biomaterialia · January 2012 RAD16-II peptide nanofibers are promising for vascular tissue engineering and were shown to enhance angiogenesis in vitro and in vivo, although the mechanism remains unknown. We hypothesized that the pro-angiogenic effect of RAD16-II results from low-affin ... Full text Cite

Directed intermixing in multicomponent self-assembling biomaterials.

Journal Article Biomacromolecules · October 2011 The noncovalent coassembly of multiple different peptides can be a useful route for producing multifunctional biomaterials. However, to date, such materials have almost exclusively been investigated as homogeneous self-assemblies, having functional compone ... Full text Cite

Self-assembling biomaterials

Chapter · October 1, 2011 Self-assembly has become a useful way of constructing biomaterials for a variety of applications ranging from cell culture to tissue engineering. Attractive features of self-assembled biomaterials include chemical definition, modularity, stimulus-sensitivi ... Cite

Multifactorial optimization of endothelial cell growth using modular synthetic extracellular matrices.

Journal Article Integrative biology : quantitative biosciences from nano to macro · March 2011 Featured Publication Extracellular matrices (ECMs) are complex materials, containing at least dozens of different macromolecules that are assembled together, thus complicating their optimization towards applications in 3D cell culture or tissue engineering. The natural complex ... Full text Cite

Fibrillized peptide microgels for cell encapsulation and 3D cell culture.

Journal Article Soft matter · January 2011 One of the advantages of materials produced by self-assembly is that in principle they can be formed in any given container to produce materials of predetermined shapes and sizes. Here, we developed a method for triggering peptide self-assembly within the ... Full text Cite

Immune responses to coiled coil supramolecular biomaterials.

Journal Article Biomaterials · November 2010 Self-assembly has been increasingly utilized in recent years to create peptide-based biomaterials for 3D cell culture, tissue engineering, and regenerative medicine, but the molecular determinants of these materials' immunogenicity have remained largely un ... Full text Cite

Multi-component extracellular matrices based on peptide self-assembly.

Journal Article Chemical Society reviews · September 2010 Extracellular matrices (ECMs) are challenging design targets for materials synthesis because they serve multiple biological roles, and they are composed of multiple molecular constituents. In addition, their composition and activities are dynamic and varia ... Full text Cite

Fibrillar peptide gels in biotechnology and biomedicine.

Journal Article Biopolymers · January 2010 Peptides, peptidomimetics, and peptide derivatives that self-assemble into fibrillar gels have received increasing interest as synthetic extracellular matrices for applications in 3D cell culture and regenerative medicine. Recently, several of these fibril ... Full text Cite

A self-assembling peptide acting as an immune adjuvant.

Journal Article Proceedings of the National Academy of Sciences of the United States of America · January 2010 Featured Publication The development of vaccines and other immunotherapies has been complicated by heterogeneous antigen display and the use of incompletely defined immune adjuvants with complex mechanisms of action. We have observed strong antibody responses in mice without t ... Full text Cite

Nanostructured materials constructed from polypeptides

Chapter · December 1, 2009 This chapter describes peptide design strategies for the construction of nanostructured materials. It begins with a brief tutorial of amino acid structure and function and then describes higher-order assemblies of peptides and peptidomimetics. Primarily β- ... Full text Cite

Co-assembling peptides as defined matrices for endothelial cells.

Journal Article Biomaterials · April 2009 Self-assembling peptides and peptide derivatives bearing cell-binding ligands are increasingly being investigated as defined cell culture matrices and as scaffolds for regenerative medicine. In order to systematically refine such scaffolds to elicit specif ... Full text Cite

Sequence- or position-specific mutations in the carboxyl-terminal FL motif of the kidney sodium bicarbonate cotransporter (NBC1) disrupt its basolateral targeting and alpha-helical structure.

Journal Article The Journal of membrane biology · March 2009 The sodium-bicarbonate cotransporter NBC1 is targeted exclusively at the basolateral membrane. Mutagenesis of a dihydrophobic FL motif (residues 1013-1014) in the C-terminal domain disrupts the targeting of NBC1. In the present study, we determined the pre ... Full text Cite

Chemoselective stiffening of self-assembled matrices via native chemical ligation

Conference 8th World Biomaterials Congress 2008 · December 1, 2008 Cite

Ultrasound-mediated release of hydrophilic and lipophilic agents from echogenic liposomes.

Journal Article Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · November 2008 ObjectiveTo achieve ultrasound-controlled drug delivery using echogenic liposomes (ELIPs), we assessed ultrasound-triggered release of hydrophilic and lipophilic agents in vitro using color Doppler ultrasound delivered with a clinical 6-MHz compac ... Full text Cite

Self-assembling peptide-polymer hydrogels designed from the coiled coil region of fibrin.

Journal Article Biomacromolecules · September 2008 Biomaterials constructed from self-assembling peptides, peptide derivatives, and peptide-polymer conjugates are receiving increasing attention as defined matrices for tissue engineering, controlled therapeutic release, and in vitro cell expansion, but many ... Full text Cite

Modulating the mechanical properties of self-assembled peptide hydrogels via native chemical ligation.

Journal Article Biomaterials · May 2008 Hydrogels produced from self-assembling peptides and peptide derivatives are being investigated as synthetic extracellular matrices for defined cell culture substrates and scaffolds for regenerative medicine. In many cases, however, they are less stiff tha ... Full text Cite

Modular self-assembling biomaterials for directing cellular responses.

Journal Article Soft matter · January 2008 Self-assembling biomaterials are promising as cell-interactive matrices because they can be constructed in a modular fashion, which enables the independent and simultaneous tuning of several of their physicochemical and biological properties. Such modulari ... Full text Cite

Epithelialization of hydrogels achieved by amine functionalization and co-culture with stromal cells.

Journal Article Biomaterials · December 2007 The aim of this study was to develop a hydrogel which would be suitable for corneal cell re-epithelialization when used as a corneal implant. To achieve this, a series of hydrogels were functionalized with primary amines by post-polymerization reactions be ... Full text Cite

Self-assembling polymer-peptide conjugates: Toward scaffolds for regenerative medicine

Journal Article ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY · August 19, 2007 Link to item Cite

The reproducibility of endometrial volume acquisition and measurement with the VOCAL-imaging program.

Journal Article Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · January 2002 ObjectivesTo determine the intraobserver reproducibility of volume acquisition and repeatability of endometrial volume measurements using the VOCAL-imaging program (Virtual Organ Computer-aided AnaLysis).MethodsTen three-dimensional (3D) ... Full text Cite

Modification of electroactive biomaterials for neural engineering applications

Journal Article ACS Symposium Series · January 1, 2002 New tissue engineering technologies will rely increasingly more on interactive biomaterials that can both physically support tissue growth and stimulate specific cell functions. In our research, we have focused on a biomaterial with electrical properties ( ... Full text Cite

Biodegradable poly(α-hydroxy ester) thin films as temporary substrates for retinal pigment epithelium cell transplantation

Conference American Society of Mechanical Engineers, Bioengineering Division (Publication) BED · January 1, 1995 A solvent casting technique was developed to produce thin films of four poly(alpha-hydroxy esters) with various thicknesses. These films were characterized with respect to surface morphology, porosity, and flexibility using scanning electron microscope, me ... Cite