A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers.
Publication
, Journal Article
Wu, Y; Norberg, PK; Reap, EA; Congdon, KL; Fries, CN; Kelly, SH; Sampson, JH; Conticello, VP; Collier, JH
Published in: ACS Biomater Sci Eng
December 11, 2017
A supramolecular peptide vaccine system was designed in which epitope-bearing peptides self-assemble into elongated nanofibers composed almost entirely of alpha-helical structure. The nanofibers were readily internalized by antigen presenting cells and produced robust antibody, CD4+ T-cell, and CD8+ T-cell responses without supplemental adjuvants in mice. Epitopes studied included a cancer B-cell epitope from the epidermal growth factor receptor class III variant (EGFRvIII), the universal CD4+ T-cell epitope PADRE, and the model CD8+ T-cell epitope SIINFEKL, each of which could be incorporated into supramolecular multi-epitope nanofibers in a modular fashion.
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Published In
ACS Biomater Sci Eng
DOI
ISSN
2373-9878
Publication Date
December 11, 2017
Volume
3
Issue
12
Start / End Page
3128 / 3132
Location
United States
Related Subject Headings
- 4003 Biomedical engineering
- 0903 Biomedical Engineering
Citation
APA
Chicago
ICMJE
MLA
NLM
Wu, Y., Norberg, P. K., Reap, E. A., Congdon, K. L., Fries, C. N., Kelly, S. H., … Collier, J. H. (2017). A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers. ACS Biomater Sci Eng, 3(12), 3128–3132. https://doi.org/10.1021/acsbiomaterials.7b00561
Wu, Yaoying, Pamela K. Norberg, Elizabeth A. Reap, Kendra L. Congdon, Chelsea N. Fries, Sean H. Kelly, John H. Sampson, Vincent P. Conticello, and Joel H. Collier. “A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers.” ACS Biomater Sci Eng 3, no. 12 (December 11, 2017): 3128–32. https://doi.org/10.1021/acsbiomaterials.7b00561.
Wu Y, Norberg PK, Reap EA, Congdon KL, Fries CN, Kelly SH, et al. A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers. ACS Biomater Sci Eng. 2017 Dec 11;3(12):3128–32.
Wu, Yaoying, et al. “A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers.” ACS Biomater Sci Eng, vol. 3, no. 12, Dec. 2017, pp. 3128–32. Pubmed, doi:10.1021/acsbiomaterials.7b00561.
Wu Y, Norberg PK, Reap EA, Congdon KL, Fries CN, Kelly SH, Sampson JH, Conticello VP, Collier JH. A Supramolecular Vaccine Platform Based on α-Helical Peptide Nanofibers. ACS Biomater Sci Eng. 2017 Dec 11;3(12):3128–3132.
Published In
ACS Biomater Sci Eng
DOI
ISSN
2373-9878
Publication Date
December 11, 2017
Volume
3
Issue
12
Start / End Page
3128 / 3132
Location
United States
Related Subject Headings
- 4003 Biomedical engineering
- 0903 Biomedical Engineering