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Self-Assembling Allergen Vaccine Platform Raises Therapeutic Allergen-Specific IgG Responses without Induction of Systemic Allergic Responses.

Publication ,  Journal Article
Cossette, BJ; Shetty, S; Issah, LA; Collier, JH
Published in: ACS biomaterials science & engineering
March 2024

Allergen immunotherapies are often successful at desensitizing allergic patients but can require life-long dosing and suffer from frequent adverse events including instances of systemic anaphylaxis, leading to poor patient compliance and high cost. Allergen vaccines, in turn, can generate more durable immunological allergen desensitization with far fewer doses. However, like immunotherapies, allergen vaccines are often highly reactogenic in allergic patients, hampering their use in therapeutic settings. In this work, we utilize a peptide-based self-assembling nanofiber platform to design allergen vaccines against allergen B-cell epitopes that do not elicit systemic anaphylaxis when administered subcutaneously to allergic mice. We show that, in contrast to protein vaccines, nanofiber vaccines prevent leakage of allergen material into the vascular compartment, a feature that likely underpins their reduced systemic reactogenicity. Further, we show that our allergen vaccine platform elicits therapeutic IgG antibody responses capable of desensitizing allergic mice to allergen-induced Type I hypersensitivity reactions. Finally, we have demonstrated a proof-of-concept for the therapeutic potential of nanofiber-based peanut allergen vaccines directed against peanut allergen-derived epitopes.

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Published In

ACS biomaterials science & engineering

DOI

EISSN

2373-9878

ISSN

2373-9878

Publication Date

March 2024

Volume

10

Issue

3

Start / End Page

1819 / 1829

Related Subject Headings

  • Vaccines
  • Mice
  • Immunoglobulin G
  • Humans
  • Desensitization, Immunologic
  • Animals
  • Anaphylaxis
  • Allergens
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering
 

Citation

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Cossette, B. J., Shetty, S., Issah, L. A., & Collier, J. H. (2024). Self-Assembling Allergen Vaccine Platform Raises Therapeutic Allergen-Specific IgG Responses without Induction of Systemic Allergic Responses. ACS Biomaterials Science & Engineering, 10(3), 1819–1829. https://doi.org/10.1021/acsbiomaterials.3c01945
Cossette, Benjamin J., Shamitha Shetty, Luqman A. Issah, and Joel H. Collier. “Self-Assembling Allergen Vaccine Platform Raises Therapeutic Allergen-Specific IgG Responses without Induction of Systemic Allergic Responses.ACS Biomaterials Science & Engineering 10, no. 3 (March 2024): 1819–29. https://doi.org/10.1021/acsbiomaterials.3c01945.
Cossette BJ, Shetty S, Issah LA, Collier JH. Self-Assembling Allergen Vaccine Platform Raises Therapeutic Allergen-Specific IgG Responses without Induction of Systemic Allergic Responses. ACS biomaterials science & engineering. 2024 Mar;10(3):1819–29.
Cossette, Benjamin J., et al. “Self-Assembling Allergen Vaccine Platform Raises Therapeutic Allergen-Specific IgG Responses without Induction of Systemic Allergic Responses.ACS Biomaterials Science & Engineering, vol. 10, no. 3, Mar. 2024, pp. 1819–29. Epmc, doi:10.1021/acsbiomaterials.3c01945.
Cossette BJ, Shetty S, Issah LA, Collier JH. Self-Assembling Allergen Vaccine Platform Raises Therapeutic Allergen-Specific IgG Responses without Induction of Systemic Allergic Responses. ACS biomaterials science & engineering. 2024 Mar;10(3):1819–1829.
Journal cover image

Published In

ACS biomaterials science & engineering

DOI

EISSN

2373-9878

ISSN

2373-9878

Publication Date

March 2024

Volume

10

Issue

3

Start / End Page

1819 / 1829

Related Subject Headings

  • Vaccines
  • Mice
  • Immunoglobulin G
  • Humans
  • Desensitization, Immunologic
  • Animals
  • Anaphylaxis
  • Allergens
  • 4003 Biomedical engineering
  • 0903 Biomedical Engineering