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Supramolecular peptide vaccines: tuning adaptive immunity.

Publication ,  Journal Article
Wen, Y; Collier, JH
Published in: Current opinion in immunology
August 2015

Successful immunotherapies must be designed to elicit targeted immune responses having a specifiable phenotype across many dimensions, including the phenotypes of T cells, B cells, antigen-presenting cells, and others. For synthetic or subunit vaccines, stimulation of strong enough immune responses usually requires adjuvants, which can cause local inflammation and complicate the targeting of such phenotypes. Supramolecular materials provide routes for reducing or eliminating supplemental adjuvants. Owing to their compositional controllability, supramolecular assemblies show promise for fine-tuning immune responses by adjusting combinations of material attributes including epitope content, multivalency, size, dose, and small quantities of specific adjuvants. Here we focus on supramolecular vaccines incorporating multiple epitopes in precise ratios, with an emphasis on peptides that form high-aspect ratio (i.e. fibrillar) structures.

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Published In

Current opinion in immunology

DOI

EISSN

1879-0372

ISSN

0952-7915

Publication Date

August 2015

Volume

35

Start / End Page

73 / 79

Related Subject Headings

  • Vaccines, Subunit
  • T-Lymphocytes
  • Protein Conformation
  • Peptides
  • Immunotherapy
  • Immunology
  • Humans
  • Epitopes
  • Dendritic Cells
  • B-Lymphocytes
 

Citation

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Wen, Y., & Collier, J. H. (2015). Supramolecular peptide vaccines: tuning adaptive immunity. Current Opinion in Immunology, 35, 73–79. https://doi.org/10.1016/j.coi.2015.06.007
Wen, Yi, and Joel H. Collier. “Supramolecular peptide vaccines: tuning adaptive immunity.Current Opinion in Immunology 35 (August 2015): 73–79. https://doi.org/10.1016/j.coi.2015.06.007.
Wen Y, Collier JH. Supramolecular peptide vaccines: tuning adaptive immunity. Current opinion in immunology. 2015 Aug;35:73–9.
Wen, Yi, and Joel H. Collier. “Supramolecular peptide vaccines: tuning adaptive immunity.Current Opinion in Immunology, vol. 35, Aug. 2015, pp. 73–79. Epmc, doi:10.1016/j.coi.2015.06.007.
Wen Y, Collier JH. Supramolecular peptide vaccines: tuning adaptive immunity. Current opinion in immunology. 2015 Aug;35:73–79.
Journal cover image

Published In

Current opinion in immunology

DOI

EISSN

1879-0372

ISSN

0952-7915

Publication Date

August 2015

Volume

35

Start / End Page

73 / 79

Related Subject Headings

  • Vaccines, Subunit
  • T-Lymphocytes
  • Protein Conformation
  • Peptides
  • Immunotherapy
  • Immunology
  • Humans
  • Epitopes
  • Dendritic Cells
  • B-Lymphocytes