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Engaging natural antibody responses for the treatment of inflammatory bowel disease via phosphorylcholine-presenting nanofibres.

Publication ,  Journal Article
Curvino, EJ; Roe, EF; Freire Haddad, H; Anderson, AR; Woodruff, ME; Votaw, NL; Segura, T; Hale, LP; Collier, JH
Published in: Nat Biomed Eng
November 27, 2023

Inflammatory bowel disease lacks a long-lasting and broadly effective therapy. Here, by taking advantage of the anti-infection and anti-inflammatory properties of natural antibodies against the small-molecule epitope phosphorylcholine (PC), we show in multiple mouse models of colitis that immunization of the animals with self-assembling supramolecular peptide nanofibres bearing PC epitopes induced sustained levels of anti-PC antibodies that were both protective and therapeutic. The strength and type of immune responses elicited by the nanofibres could be controlled through the relative valency of PC epitopes and exogenous T-cell epitopes on the nanofibres and via the addition of the adjuvant CpG. The nanomaterial-assisted induction of the production of therapeutic antibodies may represent a durable therapy for inflammatory bowel disease.

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Published In

Nat Biomed Eng

DOI

EISSN

2157-846X

Publication Date

November 27, 2023

Location

England

Related Subject Headings

  • 4003 Biomedical engineering
 

Citation

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Curvino, E. J., Roe, E. F., Freire Haddad, H., Anderson, A. R., Woodruff, M. E., Votaw, N. L., … Collier, J. H. (2023). Engaging natural antibody responses for the treatment of inflammatory bowel disease via phosphorylcholine-presenting nanofibres. Nat Biomed Eng. https://doi.org/10.1038/s41551-023-01139-6
Curvino, Elizabeth J., Emily F. Roe, Helena Freire Haddad, Alexa R. Anderson, Mia E. Woodruff, Nicole L. Votaw, Tatiana Segura, Laura P. Hale, and Joel H. Collier. “Engaging natural antibody responses for the treatment of inflammatory bowel disease via phosphorylcholine-presenting nanofibres.Nat Biomed Eng, November 27, 2023. https://doi.org/10.1038/s41551-023-01139-6.
Curvino EJ, Roe EF, Freire Haddad H, Anderson AR, Woodruff ME, Votaw NL, et al. Engaging natural antibody responses for the treatment of inflammatory bowel disease via phosphorylcholine-presenting nanofibres. Nat Biomed Eng. 2023 Nov 27;
Curvino, Elizabeth J., et al. “Engaging natural antibody responses for the treatment of inflammatory bowel disease via phosphorylcholine-presenting nanofibres.Nat Biomed Eng, Nov. 2023. Pubmed, doi:10.1038/s41551-023-01139-6.
Curvino EJ, Roe EF, Freire Haddad H, Anderson AR, Woodruff ME, Votaw NL, Segura T, Hale LP, Collier JH. Engaging natural antibody responses for the treatment of inflammatory bowel disease via phosphorylcholine-presenting nanofibres. Nat Biomed Eng. 2023 Nov 27;

Published In

Nat Biomed Eng

DOI

EISSN

2157-846X

Publication Date

November 27, 2023

Location

England

Related Subject Headings

  • 4003 Biomedical engineering