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A Balance between Pro-Inflammatory and Pro-Reparative Macrophages is Observed in Regenerative D-MAPS.

Publication ,  Journal Article
Liu, Y; Suarez-Arnedo, A; Shetty, S; Wu, Y; Schneider, M; Collier, JH; Segura, T
Published in: Advanced science (Weinheim, Baden-Wurttemberg, Germany)
April 2023

Microporous annealed particle scaffolds (MAPS) are a new class of granular materials generated through the interlinking of tunable microgels, which produce an interconnected network of void space. These microgel building blocks can be designed with different mechanical or bio-active parameters to facilitate cell infiltration and modulate host response. Previously, changing the chirality of the microgel crosslinking peptides from L- to D-amino acids led to significant tissue regeneration and functional recovery in D-MAPS-treated cutaneous wounds. In this study, the immunomodulatory effect of D-MAPS in a subcutaneous implantation model is investigated. How macrophages are the key antigen-presenting cells to uptake and present these biomaterials to the adaptive immune system is uncovered. A robust linker-specific IgG2b/IgG1 response to D-MAPS is detected as early as 14 days post-implantation. The fine balance between pro-regenerative and pro-inflammatory macrophage phenotypes is observed in D-MAPS as an indicator for regenerative scaffolds. The work offers valuable insights into the temporal cellular response to synthetic porous scaffolds and establishes a foundation for further optimization of immunomodulatory pro-regenerative outcomes.

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Published In

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

DOI

EISSN

2198-3844

ISSN

2198-3844

Publication Date

April 2023

Volume

10

Issue

11

Start / End Page

e2204882

Related Subject Headings

  • Tissue Scaffolds
  • Phenotype
  • Microgels
  • Macrophages
  • Biocompatible Materials
 

Citation

APA
Chicago
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MLA
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Liu, Y., Suarez-Arnedo, A., Shetty, S., Wu, Y., Schneider, M., Collier, J. H., & Segura, T. (2023). A Balance between Pro-Inflammatory and Pro-Reparative Macrophages is Observed in Regenerative D-MAPS. Advanced Science (Weinheim, Baden-Wurttemberg, Germany), 10(11), e2204882. https://doi.org/10.1002/advs.202204882
Liu, Yining, Alejandra Suarez-Arnedo, Shamitha Shetty, Yaoying Wu, Michelle Schneider, Joel H. Collier, and Tatiana Segura. “A Balance between Pro-Inflammatory and Pro-Reparative Macrophages is Observed in Regenerative D-MAPS.Advanced Science (Weinheim, Baden-Wurttemberg, Germany) 10, no. 11 (April 2023): e2204882. https://doi.org/10.1002/advs.202204882.
Liu Y, Suarez-Arnedo A, Shetty S, Wu Y, Schneider M, Collier JH, et al. A Balance between Pro-Inflammatory and Pro-Reparative Macrophages is Observed in Regenerative D-MAPS. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023 Apr;10(11):e2204882.
Liu, Yining, et al. “A Balance between Pro-Inflammatory and Pro-Reparative Macrophages is Observed in Regenerative D-MAPS.Advanced Science (Weinheim, Baden-Wurttemberg, Germany), vol. 10, no. 11, Apr. 2023, p. e2204882. Epmc, doi:10.1002/advs.202204882.
Liu Y, Suarez-Arnedo A, Shetty S, Wu Y, Schneider M, Collier JH, Segura T. A Balance between Pro-Inflammatory and Pro-Reparative Macrophages is Observed in Regenerative D-MAPS. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 2023 Apr;10(11):e2204882.
Journal cover image

Published In

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

DOI

EISSN

2198-3844

ISSN

2198-3844

Publication Date

April 2023

Volume

10

Issue

11

Start / End Page

e2204882

Related Subject Headings

  • Tissue Scaffolds
  • Phenotype
  • Microgels
  • Macrophages
  • Biocompatible Materials