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Fibrillar peptide gels in biotechnology and biomedicine.

Publication ,  Journal Article
Jung, JP; Gasiorowski, JZ; Collier, JH
Published in: Biopolymers
January 2010

Peptides, peptidomimetics, and peptide derivatives that self-assemble into fibrillar gels have received increasing interest as synthetic extracellular matrices for applications in 3D cell culture and regenerative medicine. Recently, several of these fibrillizing molecules have been functionalized with bioactive components and chemical features such as cell-binding ligands, degradable sequences, drug eluting compounds, and cross-linkable groups, thereby producing gels that can reliably display multiple factors simultaneously. This capacity for incorporating precise levels of many different biological and chemical factors is advantageous given the natural complexity of cell-matrix interactions that many current biomaterial strategies seek to mimic. In this review, recent efforts in the area of fibril-forming peptide materials are described, and advantages of biomaterials containing multiple modular elements are outlined. In addition, a few hurdles and open questions surrounding fibrillar peptide gels are discussed, including issues of the materials' structural heterogeneity, challenges in fully characterizing the diversity of their self-assembled structures, and incomplete knowledge of how the materials are processed in vivo.

Duke Scholars

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Published In

Biopolymers

DOI

EISSN

1097-0282

ISSN

0006-3525

Publication Date

January 2010

Volume

94

Issue

1

Start / End Page

49 / 59

Related Subject Headings

  • Proteins
  • Protein Conformation
  • Peptides
  • Molecular Structure
  • Humans
  • Gels
  • Extracellular Matrix
  • Biotechnology
  • Biophysics
  • Biomedical Engineering
 

Citation

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Jung, J. P., Gasiorowski, J. Z., & Collier, J. H. (2010). Fibrillar peptide gels in biotechnology and biomedicine. Biopolymers, 94(1), 49–59. https://doi.org/10.1002/bip.21326
Jung, Jangwook P., Joshua Z. Gasiorowski, and Joel H. Collier. “Fibrillar peptide gels in biotechnology and biomedicine.Biopolymers 94, no. 1 (January 2010): 49–59. https://doi.org/10.1002/bip.21326.
Jung JP, Gasiorowski JZ, Collier JH. Fibrillar peptide gels in biotechnology and biomedicine. Biopolymers. 2010 Jan;94(1):49–59.
Jung, Jangwook P., et al. “Fibrillar peptide gels in biotechnology and biomedicine.Biopolymers, vol. 94, no. 1, Jan. 2010, pp. 49–59. Epmc, doi:10.1002/bip.21326.
Jung JP, Gasiorowski JZ, Collier JH. Fibrillar peptide gels in biotechnology and biomedicine. Biopolymers. 2010 Jan;94(1):49–59.
Journal cover image

Published In

Biopolymers

DOI

EISSN

1097-0282

ISSN

0006-3525

Publication Date

January 2010

Volume

94

Issue

1

Start / End Page

49 / 59

Related Subject Headings

  • Proteins
  • Protein Conformation
  • Peptides
  • Molecular Structure
  • Humans
  • Gels
  • Extracellular Matrix
  • Biotechnology
  • Biophysics
  • Biomedical Engineering