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Formation of NPR1 Condensates Promotes Cell Survival during the Plant Immune Response.

Publication ,  Journal Article
Zavaliev, R; Mohan, R; Chen, T; Dong, X
Published in: Cell
September 2020

In plants, pathogen effector-triggered immunity (ETI) often leads to programmed cell death, which is restricted by NPR1, an activator of systemic acquired resistance. However, the biochemical activities of NPR1 enabling it to promote defense and restrict cell death remain unclear. Here we show that NPR1 promotes cell survival by targeting substrates for ubiquitination and degradation through formation of salicylic acid-induced NPR1 condensates (SINCs). SINCs are enriched with stress response proteins, including nucleotide-binding leucine-rich repeat immune receptors, oxidative and DNA damage response proteins, and protein quality control machineries. Transition of NPR1 into condensates is required for formation of the NPR1-Cullin 3 E3 ligase complex to ubiquitinate SINC-localized substrates, such as EDS1 and specific WRKY transcription factors, and promote cell survival during ETI. Our analysis of SINCs suggests that NPR1 is centrally integrated into the cell death or survival decisions in plant immunity by modulating multiple stress-responsive processes in this quasi-organelle.

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Published In

Cell

DOI

EISSN

1097-4172

ISSN

0092-8674

Publication Date

September 2020

Volume

182

Issue

5

Start / End Page

1093 / 1108.e18

Related Subject Headings

  • Ubiquitination
  • Salicylic Acid
  • Plant Immunity
  • Gene Expression Regulation, Plant
  • Developmental Biology
  • Cell Survival
  • Arabidopsis Proteins
  • Arabidopsis
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

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Zavaliev, R., Mohan, R., Chen, T., & Dong, X. (2020). Formation of NPR1 Condensates Promotes Cell Survival during the Plant Immune Response. Cell, 182(5), 1093-1108.e18. https://doi.org/10.1016/j.cell.2020.07.016
Zavaliev, Raul, Rajinikanth Mohan, Tianyuan Chen, and Xinnian Dong. “Formation of NPR1 Condensates Promotes Cell Survival during the Plant Immune Response.Cell 182, no. 5 (September 2020): 1093-1108.e18. https://doi.org/10.1016/j.cell.2020.07.016.
Zavaliev R, Mohan R, Chen T, Dong X. Formation of NPR1 Condensates Promotes Cell Survival during the Plant Immune Response. Cell. 2020 Sep;182(5):1093-1108.e18.
Zavaliev, Raul, et al. “Formation of NPR1 Condensates Promotes Cell Survival during the Plant Immune Response.Cell, vol. 182, no. 5, Sept. 2020, pp. 1093-1108.e18. Epmc, doi:10.1016/j.cell.2020.07.016.
Zavaliev R, Mohan R, Chen T, Dong X. Formation of NPR1 Condensates Promotes Cell Survival during the Plant Immune Response. Cell. 2020 Sep;182(5):1093-1108.e18.
Journal cover image

Published In

Cell

DOI

EISSN

1097-4172

ISSN

0092-8674

Publication Date

September 2020

Volume

182

Issue

5

Start / End Page

1093 / 1108.e18

Related Subject Headings

  • Ubiquitination
  • Salicylic Acid
  • Plant Immunity
  • Gene Expression Regulation, Plant
  • Developmental Biology
  • Cell Survival
  • Arabidopsis Proteins
  • Arabidopsis
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences