Xinnian Dong | Scholars@Duke

Xinnian Dong
Arts and Sciences Professor of Biology in the Trinity College of Arts and Sciences

Using Arabidopsis thaliana as a model system, my laboratory studies the mechanisms of plant defense against microbial pathogens. We focus on a specific response known as systemic acquired resistance (SAR). SAR, which can be induced by a local infection, provides the plants with long lasting, systemic resistance against a broad spectrum of pathogens. Salicylic acid (SA; an active ingredient of aspirin) has been found to be the endogenous signal of SAR. Using a genetic approach, our laboratory identified genes involved in the regulation of SAR. Molecular and genetic analyses are being carried out to understand the gene function and to elucidate the SAR signaling pathway. These SAR-regulating genes are also favorite targets for molecular engineering of disease-resistance crops.

Current Appointments & Affiliations

Arts and Sciences Professor of Biology in the Trinity College of Arts and Sciences, Biology, Trinity College of Arts & Sciences 2007
Professor of Biology, Biology, Trinity College of Arts & Sciences 2004

Contact Information

4213 French Family Science Center, Durham, NC 27708
Box 90338, Durham, NC 27708-1000
xdong@duke.edu (919) 613-8176
Dong lab website

Background
Education, Training, & Certifications
- Ph.D., Northwestern University 1988
- B.S., National Wuhan University 1982
Duke Appointment History
- Associate Professor of Biology, Biology, Trinity College of Arts & Sciences 2000 - 2004
- Associate Professor of Botany, Biology, Trinity College of Arts & Sciences 1999 - 2000
- Assistant Professor, Biology, Trinity College of Arts & Sciences 1992 - 1998
Recognition
In the News
- JUN 22, 2015
  
  Dual Internal Clocks Keep Plant Defenses on Schedule
Awards & Honors
Research
Selected Grants
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2022
- Elucidation of translational regulatory mechanisms of plant immune responses awarded by National Science Foundation 2017 - 2021
- Salicylic acid in immunity and health: A small phytohormone with big physiological impacts awarded by National Institutes of Health 2016 - 2021
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Characterization of the Arabidopsis tRNAome in Pathogen Triggered Immunity awarded by National Institutes of Health 2017 - 2019
- Innovation Corps - National Innovation Network Teams Program (I-CorpsTM Teams) awarded by National Science Foundation 2017 - 2018
- Dynamic regulation of salicylic acid biosynthesis & perception in plant immunity awarded by National Institutes of Health 2004 - 2018
- Gordon and Betty Moore Foundation awarded by Gordon & Betty Moore Foundation 2011 - 2017
- The Interplay Between the Circadian Clock and Plant Immune Mechanisms awarded by National Institutes of Health 2012 - 2017
- Intercellular signal transport in plant immune response awarded by US-Israel Binational Agricultural R&D Fund 2014 - 2016
- Arabidopsis 2010: Global Analysis of Plant Disease Resistance Pathways awarded by National Science Foundation 2001 - 2015
- The 22nd International Conference on Arabidopsis Research awarded by National Science Foundation 2011 - 2012
- The Arabidopsis SNI1 complex regulate both gene transcription an awarded by National Science Foundation 2008 - 2012
- A Systems Approach to Broad-Spectrum Disease Resistance Using NPR1-Mediated Gene Expression awarded by Department of Agriculture 2007 - 2010
- Chromosome Modification and Transcription Repression in Regulation of Systemic Acquired Resistance awarded by National Science Foundation 2005 - 2009
- Characterization of the direct-target genes of NPR1 in systemic acquired resistance awarded by Department of Agriculture 2003 - 2007
- Characterization of Negative Regulators of NPR1-Mediated Systemic Acquired Resistance awarded by National Science Foundation 1998 - 2006
- Identification of Signaling Components in NPR1-independent Resistance awarded by Department of Agriculture 2000 - 2004
- (98-0421) Further Dissection of Signalling Pathways Leading To Disease Resistance awarded by Cooperative State Research Service (CSRS) 1998 - 2001
- Function of NPR1 in Plant Disease Resistance awarded by National Institutes of Health 1998 - 2000
- (97-0776) Molecular and Genetic Studies of Mutants Insensitive to SAR-inducing Signals awarded by Department of Agriculture 1995 - 1998
- (96-0762) Molecular and Genetic Studies of Mutants Insensitive to SAR-inducing Signals awarded by Department of Agriculture 1995 - 1997
- (95-0298) Molecular and Genetic Studies of Mutants Insensitive to SAR-inducing Signals awarded by Department of Agriculture 1995 - 1996
- (93-0420) Molecular Genetic Analysis of Systemic Acquired Resistance in A. thaliana awarded by Cooperative State Research Service (CSRS) 1993 - 1995
Publications & Artistic Works
Selected Publications
- Conference Papers
  - DONG, X, BOWLING, SA, and CAO, H. "GENETIC DISSECTION OF THE SAR SIGNAL-TRANSDUCTION PATHWAY(S) IN ARABIDOPSIS." March 10, 1995. Link to Item
- Journal Articles
  - Karapetyan, S, and Dong, X. "Redox and the circadian clock in plant immunity: A balancing act." Free radical biology & medicine (December 19, 2017). (Review) Full Text
  - Gu, Y, Zavaliev, R, and Dong, X. "Membrane Trafficking in Plant Immunity." Molecular plant 10, no. 8 (August 2017): 1026-1034. (Review) Full Text Open Access Copy
  - Withers, J, and Dong, X. "Post-translational regulation of plant immunity." Current opinion in plant biology 38 (August 2017): 124-132. (Review) Full Text Open Access Copy
  - Xu, G, Greene, GH, Yoo, H, Liu, L, Marqués, J, Motley, J, and Dong, X. "Global translational reprogramming is a fundamental layer of immune regulation in plants." Nature 545, no. 7655 (May 17, 2017): 487-490. Full Text Open Access Copy
  - Xu, G, Yuan, M, Ai, C, Liu, L, Zhuang, E, Karapetyan, S, Wang, S, and Dong, X. "uORF-mediated translation allows engineered plant disease resistance without fitness costs." Nature 545, no. 7655 (May 17, 2017): 491-494. Full Text
  - Mwimba, M, and Dong, X. "The CAT(2) Comes Back." Cell host & microbe 21, no. 2 (February 2017): 125-127. Full Text
  - Liu, L, Sonbol, F-M, Huot, B, Gu, Y, Withers, J, Mwimba, M, Yao, J, He, SY, and Dong, X. "Salicylic acid receptors activate jasmonic acid signalling through a non-canonical pathway to promote effector-triggered immunity." Nature communications 7 (October 11, 2016): 13099-. Full Text
  - Zavaliev, R, Dong, X, and Epel, BL. "Glycosylphosphatidylinositol (GPI) Modification Serves as a Primary Plasmodesmal Sorting Signal." Plant physiology 172, no. 2 (October 2016): 1061-1073. Full Text
  - Gu, Y, Zebell, SG, Liang, Z, Wang, S, Kang, B-H, and Dong, X. "Nuclear Pore Permeabilization Is a Convergent Signaling Event in Effector-Triggered Immunity." Cell 166, no. 6 (September 2016): 1526-1538.e11. Full Text
  - Withers, J, and Dong, X. "Posttranslational Modifications of NPR1: A Single Protein Playing Multiple Roles in Plant Immunity and Physiology." PLoS pathogens 12, no. 8 (August 11, 2016): e1005707-. (Review) Full Text
  - Saleh, A, Withers, J, Mohan, R, Marqués, J, Gu, Y, Yan, S, Zavaliev, R, Nomoto, M, Tada, Y, and Dong, X. "Erratum: Posttranslational Modifications of the Master Transcriptional Regulator NPR1 Enable Dynamic but Tight Control of Plant Immune Responses (Cell Host and Microbe (2015) 18 (169-182))." Cell Host and Microbe 19, no. 1 (January 13, 2016): 127-130. Full Text
  - Zebell, SG, and Dong, X. "Cell-Cycle Regulators and Cell Death in Immunity." Cell host & microbe 18, no. 4 (October 2015): 402-407. (Review) Full Text
  - Yang, L, Li, B, Zheng, X-Y, Li, J, Yang, M, Dong, X, He, G, An, C, and Deng, XW. "Corrigendum: Salicylic acid biosynthesis is enhanced and contributes to increased biotrophic pathogen resistance in Arabidopsis hybrids." Nature Communications 6 (August 12, 2015): 8145-8145. Full Text
  - Saleh, A, Withers, J, Mohan, R, Marqués, J, Gu, Y, Yan, S, Zavaliev, R, Nomoto, M, Tada, Y, and Dong, X. "Posttranslational Modifications of the Master Transcriptional Regulator NPR1 Enable Dynamic but Tight Control of Plant Immune Responses." Cell host & microbe 18, no. 2 (August 2015): 169-182. Full Text
  - Zheng, X-Y, Zhou, M, Yoo, H, Pruneda-Paz, JL, Spivey, NW, Kay, SA, and Dong, X. "Spatial and temporal regulation of biosynthesis of the plant immune signal salicylic acid." Proceedings of the National Academy of Sciences of the United States of America 112, no. 30 (July 2, 2015): 9166-9173. Full Text
  - Gu, Y, and Dong, X. "Stromules: Signal Conduits for Plant Immunity." Developmental cell 34, no. 1 (July 2015): 3-4. Full Text
  - Zhou, M, Wang, W, Karapetyan, S, Mwimba, M, Marqués, J, Buchler, NE, and Dong, X. "Redox rhythm reinforces the circadian clock to gate immune response." Nature 523, no. 7561 (July 2015): 472-476. Full Text Open Access Copy
  - Yang, L, Li, B, Zheng, X-Y, Li, J, Yang, M, Dong, X, He, G, An, C, and Deng, XW. "Salicylic acid biosynthesis is enhanced and contributes to increased biotrophic pathogen resistance in Arabidopsis hybrids." Nature communications 6 (June 12, 2015): 7309-. Full Text Open Access Copy
  - Mammarella, ND, Cheng, Z, Fu, ZQ, Daudi, A, Bolwell, GP, Dong, X, and Ausubel, FM. "Apoplastic peroxidases are required for salicylic acid-mediated defense against Pseudomonas syringae." Phytochemistry 112 (April 2015): 110-121. Full Text
  - Mammarella, ND, Cheng, Z, Fu, ZQ, Daudi, A, Bolwell, GP, Dong, X, and Ausubel, FM. "Apoplastic peroxidases are required for salicylic acid-mediated defense against Pseudomonas syringae." Phytochemistry 112, no. 1 (2015): 110-121. Full Text
  - Wang, S, Gu, Y, Zebell, SG, Anderson, LK, Wang, W, Mohan, R, and Dong, X. "A noncanonical role for the CKI-RB-E2F cell-cycle signaling pathway in plant effector-triggered immunity." Cell host & microbe 16, no. 6 (December 2014): 787-794. Full Text
  - Yan, S, and Dong, X. "Perception of the plant immune signal salicylic acid." Current opinion in plant biology 20 (August 2014): 64-68. (Review) Full Text
  - Fonseca, JP, and Dong, X. "Functional characterization of a Nudix hydrolase AtNUDX8 upon pathogen attack indicates a positive role in plant immune responses." PloS one 9, no. 12 (January 2014): e114119-. Full Text
  - Yan, S, Wang, W, Marqués, J, Mohan, R, Saleh, A, Durrant, WE, Song, J, and Dong, X. "Salicylic acid activates DNA damage responses to potentiate plant immunity." Molecular Cell 52, no. 4 (November 21, 2013): 602-610. Full Text
  - Chen, X, Barnaby, JY, Sreedharan, A, Huang, X, Orbović, V, Grosser, JW, Wang, N, Dong, X, and Song, W-Y. "Over-expression of the citrus gene CtNH1 confers resistance to bacterial canker disease." Physiological and Molecular Plant Pathology 84, no. 1 (2013): 115-122. Full Text
  - Fu, ZQ, and Dong, X. "Systemic acquired resistance: turning local infection into global defense." Annu Rev Plant Biol 64 (2013): 839-863. (Review) Full Text Link to Item
  - Yan, S, Wang, W, Marqués, J, Mohan, R, Saleh, A, Durrant, W, Song, J, and Dong, X. "Salicylic Acid Activates DNA Damage Responses to Potentiate Plant Immunity." Molecular Cell (2013).
  - Zheng, X-Y, Spivey, NW, Zeng, W, Liu, P-P, Fu, ZQ, Klessig, DF, He, SY, and Dong, X. "Coronatine promotes Pseudomonas syringae virulence in plants by activating a signaling cascade that inhibits salicylic acid accumulation." Cell Host Microbe 11, no. 6 (June 14, 2012): 587-596. Full Text Link to Item
  - Fu, ZQ, Yan, S, Saleh, A, Wang, W, Ruble, J, Oka, N, Mohan, R, Spoel, SH, Tada, Y, Zheng, N, and Dong, X. "NPR3 and NPR4 are receptors for the immune signal salicylic acid in plants. (Published online)" Nature 486, no. 7402 (May 16, 2012): 228-232. Full Text Link to Item
  - Pajerowska-Mukhtar, KM, Wang, W, Tada, Y, Oka, N, Tucker, CL, Fonseca, JP, and Dong, X. "The HSF-like transcription factor TBF1 is a major molecular switch for plant growth-to-defense transition." Curr Biol 22, no. 2 (January 24, 2012): 103-112. Full Text Link to Item
  - Moreno, AA, Mukhtar, MS, Blanco, F, Boatwright, JL, Moreno, I, Jordan, MR, Chen, Y, Brandizzi, F, Dong, X, Orellana, A, and Pajerowska-Mukhtar, KM. "IRE1/bZIP60-mediated unfolded protein response plays distinct roles in plant immunity and abiotic stress responses." PLoS ONE 7, no. 2 (2012). Full Text
  - Spoel, SH, and Dong, X. "How do plants achieve immunity? Defence without specialized immune cells." Nature Reviews Immunology 12, no. 2 (2012): 89-100. Full Text
  - Song, J, Durrant, WE, Wang, S, Yan, S, Tan, EH, and Dong, X. "DNA repair proteins are directly involved in regulation of gene expression during plant immune response." Cell Host Microbe 9, no. 2 (February 17, 2011): 115-124. Full Text Link to Item
  - Wang, W, Barnaby, JY, Tada, Y, Li, H, Tör, M, Caldelari, D, Lee, D-U, Fu, X-D, and Dong, X. "Timing of plant immune responses by a central circadian regulator." Nature 470, no. 7332 (February 3, 2011): 110-114. Full Text Link to Item
  - Caldelari, D, Wang, G, Farmer, EE, and Dong, X. "Inflorescence meristem arrest defects and male infertility in Arabidopsis lox3 lox4 double mutants." Plant Molecular Biology 75 (2011): 25-33. (Academic Article)
  - Caldelari, D, Wang, G, Farmer, EE, and Dong, X. "Arabidopsis lox3 lox4 double mutants are male sterile and defective in global proliferative arrest." Plant Mol Biol 75, no. 1-2 (January 2011): 25-33. Full Text Link to Item
  - Cheng, YT, Li, Y, Huang, S, Huang, Y, Dong, X, Zhang, Y, and Li, X. "Stability of plant immune-receptor resistance proteins is controlled by SKP1-CULLIN1-F-box (SCF)-mediated protein degradation." Proceedings of the National Academy of Sciences of the United States of America 108, no. 35 (2011): 14694-14699. Full Text
  - Wang, D, and Dong, X. "A highway for war and peace: The secretory pathway in plant-microbe interactions." Molecular Plant 4, no. 4 (2011): 581-587. Full Text
  - Wang, S, Durrant, WE, Song, J, Spivey, NW, and Dong, X. "Arabidopsis BRCA2 and RAD51 proteins are specifically involved in defense gene transcription during plant immune responses." Proc Natl Acad Sci U S A 107, no. 52 (December 28, 2010): 22716-22721. Full Text Link to Item
  - Pajerowska-Mukhtar, K, and Dong, X. "A kiss of death--proteasome-mediated membrane fusion and programmed cell death in plant defense against bacterial infection." Genes Dev 23, no. 21 (November 1, 2009): 2449-2454. Full Text Link to Item
  - Spoel, SH, Mou, Z, Tada, Y, Spivey, NW, Genschik, P, and Dong, X. "Proteasome-mediated turnover of the transcription coactivator NPR1 plays dual roles in regulating plant immunity." Cell 137, no. 5 (May 29, 2009): 860-872. Full Text Link to Item
  - Dong, X, and Kahmann, R. "Battle for survival: plants and their allies and enemies." Current Opinion in Plant Biology 12, no. 4 (2009): 387-389. Full Text
  - Saijo, Y, Tintor, N, Lu, X, Rauf, P, Pajerowska-Mukhtar, K, Häweker, H, Dong, X, Robatzek, S, and Schulze-Lefert, P. "Receptor quality control in the endoplasmic reticulum for plant innate immunity." EMBO Journal 28, no. 21 (2009): 3439-3449. Full Text
  - Tada, Y, Spoel, SH, Pajerowska-Mukhtar, K, Mou, Z, Song, J, Wang, C, Zuo, J, and Dong, X. "Plant immunity requires conformational changes [corrected] of NPR1 via S-nitrosylation and thioredoxins." Science 321, no. 5891 (August 15, 2008): 952-956. Full Text Link to Item
  - Spoel, SH, and Dong, X. "Making sense of hormone crosstalk during plant." Cell Host & Microbe 3 (2008): 348-351. (Academic Article)
  - Spoel, SH, Johnson, JS, and Dong, X. "Regulation of tradeoffs between plant defenses against pathogens with different lifestyles." Proc Natl Acad Sci U S A 104, no. 47 (November 20, 2007): 18842-18847. Full Text Link to Item
  - Wang, D, Pajerowska-Mukhtar, K, Culler, AH, and Dong, X. "Salicylic acid inhibits pathogen growth in plants through repression of the auxin signaling pathway." Curr Biol 17, no. 20 (October 23, 2007): 1784-1790. Full Text Link to Item
  - Xue, C, Tada, Y, Dong, X, and Heitman, J. "The human fungal pathogen Cryptococcus can complete its sexual cycle during a pathogenic association with plants." Cell Host Microbe 1, no. 4 (June 14, 2007): 263-273. Full Text Link to Item
  - Kesarwani, M, Yoo, J, and Dong, X. "Genetic interactions of TGA transcription factors in the regulation of pathogenesis-related genes and disease resistance in Arabidopsis." Plant Physiol 144, no. 1 (May 2007): 336-346. Full Text Link to Item
  - Durrant, WE, Wang, S, and Dong, X. "Arabidopsis SNI1 and RAD51D regulate both gene transcription and DNA recombination during the defense response." Proc Natl Acad Sci U S A 104, no. 10 (March 6, 2007): 4223-4227. Full Text Link to Item
  - Durrant, WE, Wang, S, and Dong, X. "Erratum: Arabidopsis SNI1 and RAD51D regulate both gene transcription and DNA recombination during the defense response (Proceedings of the National Academy of Sciences of the United States of America (2007) 104, 10, (4223-4227) DOI: 10.1073/pnas.0609357104)." Proceedings of the National Academy of Sciences of the United States of America 104, no. 17 (2007): 7307--. Full Text
  - Zhang, X, Dai, Y, Xiong, Y, DeFraia, C, Li, J, Dong, X, and Mou, Z. "Overexpression of Arabidopsis MAP kinase kinase 7 leads to activation of plant basal and systemic acquired resistance." Plant Journal 52, no. 6 (2007): 1066-1079. Full Text
  - Wang, D, Amornsiripanitch, N, and Dong, X. "A genomic approach to identify regulatory nodes in the transcriptional network of systemic acquired resistance in plants." PLoS Pathog 2, no. 11 (November 2006): e123-. Full Text Link to Item
  - Heidel, AJ, and Dong, X. "Fitness benefits of systemic acquired resistance during Hyaloperonospora parasitica infection in Arabidopsis thaliana." Genetics 173, no. 3 (July 2006): 1621-1628. Full Text Link to Item
  - Mosher, RA, Durrant, WE, Wang, D, Song, J, and Dong, X. "A comprehensive structure-function analysis of Arabidopsis SNI1 defines essential regions and transcriptional repressor activity." Plant Cell 18, no. 7 (July 2006): 1750-1765. Full Text Link to Item
  - Wang, D, Amornsiripanitch, N, and Dong, X. "A genomic approach to identify regulatory nodes in the transcriptional network of systemic acquired resistance in plants." PLoS pathogens 2, no. 11 (2006): e123-. Full Text
  - Wang, D, Weaver, ND, Kesarwani, M, and Dong, X. "Induction of protein secretory pathway is required for systemic acquired resistance." Science 308, no. 5724 (May 13, 2005): 1036-1040. Full Text Link to Item
  - Heidel, AJ, Clarke, JD, Antonovics, J, and Dong, X. "Fitness costs of mutations affecting the systemic acquired resistance pathway in Arabidopsis thaliana." Genetics 168, no. 4 (December 2004): 2197-2206. Full Text Link to Item
  - Dong, X. "NPR1, all things considered." Curr Opin Plant Biol 7, no. 5 (October 2004): 547-552. (Review) Full Text Link to Item
  - Dong, X. "The role of membrane-bound ankyrin-repeat protein ACD6 in programmed cell death and plant defense. (Published online)" Sci STKE 2004, no. 221 (February 17, 2004): pe6-. (Review) Full Text Link to Item
  - Dong, X. "Pathogen-induced systemic DNA rearrangement in plants." Trends Plant Sci 9, no. 2 (February 2004): 60-61. (Review) Full Text Link to Item
  - Dong, X. "ACD6, an ankryn-repeat protein that both regulates and is regulated by the plant hormone salicylic acid helps plants defend against pathogens." Science's STKE (February 2004). (Academic Article) Link to Item
  - Durrant, WE, and Dong, X. "Systemic acquired resistance." Annu Rev Phytopathol 42 (2004): 185-209. (Review) Full Text Link to Item
  - Mou, Z, Fan, W, and Dong, X. "Inducers of plant systemic acquired resistance regulate NPR1 function through redox changes." Cell 113, no. 7 (June 27, 2003): 935-944. Link to Item
  - Spoel, SH, Koornneef, A, Claessens, SMC, Korzelius, JP, Pelt, JAV, Mueller, MJ, Buchala, AJ, Métraux, J-P, Brown, R, Kazan, K, Loon, LCV, Dong, X, and Pieterse, CMJ. "NPR1 modulates cross-talk between salicylate- and jasmonate-dependent defense pathways through a novel function in the cytosol." Plant Cell 15, no. 3 (2003): 760-770. Full Text
  - Zhang, Y, Goritschnig, S, Dong, X, and Li, X. "A Gain-of-Function Mutation in a Plant Disease Resistance Gene Leads to Constitutive Activation of Downstream Signal Transduction Pathways in suppressor of npr1-1, constitutive 1." Plant Cell 15, no. 11 (2003): 2636-2646. Full Text
  - Fan, W, and Dong, X. "In vivo interaction between NPR1 and transcription factor TGA2 leads to salicylic acid-mediated gene activation in Arabidopsis." Plant Cell 14, no. 6 (June 2002): 1377-1389. Link to Item
  - Fan, W, and Dong, X. "In Vivo Interaction between NPR1 and transcription." Plant Cell 14 (2002): 1377-. (Academic Article)
  - Li, X, Clarke, JD, Zhang, Y, and Dong, X. "Activation of an EDS1-mediated R-gene pathway in the snc1 mutant leads to constitutive, NPR1-independent pathogen resistance." Mol Plant Microbe Interact 14, no. 10 (October 2001): 1131-1139. Full Text Link to Item
  - Dong, X. "Genetic dissection of systemic acquired resistance." Curr Opin Plant Biol 4, no. 4 (August 2001): 309-314. (Review) Link to Item
  - Clarke, JD, Aarts, N, Feys, BJ, Dong, X, and Parker, JE. "Constitutive disease resistance requires EDS1 in the Arabidopsis mutants cpr1 and cpr6 and is partially EDS1-dependent in cpr5." Plant J 26, no. 4 (May 2001): 409-420. Link to Item
  - Chern, M-S, Fitzgerald, HA, Yadav, RC, Canlas, PE, Dong, X, and Ronald, PC. "Evidence for a disease-resistance pathway in rice similar to the NPR1-mediated signaling pathway in Arabidopsis." Plant Journal 27, no. 2 (2001): 101-113. Full Text
  - Dong, X, Braun, EL, and Grotewold, E. "Functional conservation of plant secondary metabolic enzymes revealed by complementation of Arabidopsis flavonoid mutants with maize genes." Plant Physiology 127, no. 1 (2001): 46-57. Full Text
  - Dong, X, Li, X, Zhang, Y, Fan, W, Kinkema, M, and Clarke, J. "Regulation of systemic acquired resistance by NPR1 and its partners." Novartis Found Symp 236 (2001): 165-173. Link to Item
  - Jirage, D, Zhou, N, Cooper, B, Clarke, JD, Dong, X, and Glazebrook, J. "Constitutive salicylic acid-dependent signaling in cpr1 and cpr6 mutants requires PAD4." Plant Journal 26, no. 4 (2001): 395-407. Full Text
  - Li, X, Song, Y, Century, K, Straight, S, Ronald, P, Dong, X, Lassner, M, and Zhang, Y. "A fast neutron deletion mutagenesis-based reverse genetics system for plants." Plant Journal 27, no. 3 (2001): 235-242. Full Text
  - Kinkema, M, Fan, W, and Dong, X. "Nuclear localization of NPR1 is required for activation of PR gene expression." Plant Cell 12, no. 12 (December 2000): 2339-2350. Link to Item
  - Clarke, JD, Volko, SM, Ledford, H, Ausubel, FM, and Dong, X. "Roles of salicylic acid, jasmonic acid, and ethylene in cpr-induced resistance in arabidopsis." Plant Cell 12, no. 11 (November 2000): 2175-2190. Link to Item
  - Li, X, Zhang, Y, Clarke, JD, Li, Y, and Dong, X. "Identification and cloning of a negative regulator of systemic acquired resistance, SNI1, through a screen for suppressors of npr1-1." Cell 98, no. 3 (August 6, 1999): 329-339. Link to Item
  - Zhang, Y, Fan, W, Kinkema, M, Li, X, and Dong, X. "Interaction of NPR1 with basic leucine zipper protein transcription factors that bind sequences required for salicylic acid induction of the PR-1 gene." Proc Natl Acad Sci U S A 96, no. 11 (May 25, 1999): 6523-6528. Link to Item
  - Dong, X. "SA, JA, ethylene, and disease resistance in plants." Curr Opin Plant Biol 1, no. 4 (August 1998): 316-323. (Review) Link to Item
  - Cao, H, Li, X, and Dong, X. "Generation of broad-spectrum disease resistance by overexpression of an essential regulatory gene in systemic acquired resistance." Proc Natl Acad Sci U S A 95, no. 11 (May 26, 1998): 6531-6536. Link to Item
  - Clarke, JD, Liu, Y, Klessig, DF, and Dong, X. "Uncoupling PR gene expression from NPR1 and bacterial resistance: characterization of the dominant Arabidopsis cpr6-1 mutant." Plant Cell 10, no. 4 (April 1998): 557-569. Link to Item
  - Bowling, SA, Clarke, JD, Liu, Y, Klessig, DF, and Dong, X. "The cpr5 mutant of Arabidopsis expresses both NPR1-dependent and NPR1-independent resistance." Plant Cell 9, no. 9 (September 1997): 1573-1584. Full Text Link to Item
  - Cao, H, Glazebrook, J, Clarke, JD, Volko, S, and Dong, X. "The Arabidopsis NPR1 gene that controls systemic acquired resistance encodes a novel protein containing ankyrin repeats." Cell 88, no. 1 (January 10, 1997): 57-63. Link to Item
  - Dong, X. "Finding the missing pieces in the puzzle of plant disease resistance." Proc Natl Acad Sci U S A 92, no. 16 (August 1, 1995): 7137-7139. Link to Item
  - Bowling, SA, Guo, A, Cao, H, Gordon, AS, Klessig, DF, and Dong, X. "A mutation in Arabidopsis that leads to constitutive expression of systemic acquired resistance." Plant Cell 6, no. 12 (December 1994): 1845-1857. Full Text Link to Item
  - Cao, H, Bowling, SA, Gordon, AS, and Dong, X. "Characterization of an Arabidopsis Mutant That Is Nonresponsive to Inducers of Systemic Acquired Resistance." Plant Cell 6, no. 11 (November 1994): 1583-1592. Full Text Link to Item
  - Melan, MA, Dong, X, Endara, ME, Davis, KR, Ausubel, FM, and Peterman, TK. "An Arabidopsis thaliana lipoxygenase gene can be induced by pathogens, abscisic acid, and methyl jasmonate." Plant Physiology 101, no. 2 (1993): 441-450.
  - Dong, X, Mindrinos, M, Davis, KR, and Ausubel, FM. "Induction of Arabidopsis defense genes by virulent and avirulent Pseudomonas syringae strains and by a cloned avirulence gene." Plant Cell 3, no. 1 (1991): 61-72. Full Text
  - Keith, B, Dong, X, Ausubel, FM, and Fink, GR. "Differential induction of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase genes in Arabidopsis thaliana by wounding and pathogenic attack." Proceedings of the National Academy of Sciences of the United States of America 88, no. 19 (1991): 8821-8825. Full Text
  - Dong, XN, Rouillard, KP, Womble, DD, and Rownd, RH. "DNA bending near the replication origin of IncFII plasmid NR1." Journal of Bacteriology 171, no. 2 (1989): 703-707.
  - Dong, X, Womble, DD, and Rownd, RH. "In-vivo studies on the cis-acting replication initiator protein of IncFII plasmid NR1." Journal of Molecular Biology 202, no. 3 (1988): 495-509.
  - Dong, XN, Womble, DD, and Rownd, RH. "Transcriptional pausing in a region important for plasmid NR1 replication control." Journal of bacteriology 169, no. 12 (December 1987): 5353-5363. Full Text
  - Dong, X, Womble, DD, and Rownd, RH. "Transcriptional pausing in a region important for plasmid NR1 replication control." J. Bacteriol. 169 (1987): 353-363. (Academic Article)
  - Dong, X, Womble, DD, Luckow, VA, and Rownd, RH. "Regulation of transcription of the repA1 gene in the replication control region of IncFII plasmid NR1 by gene dosage of the repA2 transcription repressor protein." Journal of Bacteriology 161, no. 2 (1985): 544-551.
  - Rownd, RH, Womble, DD, Dong, XN, Luckow, VA, and Wu, RP. "Incompatibility and IncFII plasmid replication control." Basic life sciences 30 (1985): 335-354.
  - Womble, DD, Dong, X, Luckow, VA, Wu, RP, and Rownd, RH. "Analysis of the individual regulatory components of the IncFII plasmid replication control system." Journal of Bacteriology 161, no. 2 (1985): 534-543.
  - Womble, DD, Dong, X, Wu, RP, Luckow, VA, Martinez, AF, and Rownd, RH. "IncFII plasmid incompatibility product and its target are both RNA transcripts." Journal of Bacteriology 160, no. 1 (1984): 28-35.
Teaching & Mentoring
Recent Courses
- BIOLOGY 212L: General Microbiology 2018
- BIOLOGY 293: Research Independent Study 2018
- BIOLOGY 493: Research Independent Study 2018
- BIOLOGY 718S: Developmental, Cellular, and Molecular Biology Seminar 2018
- BIOLOGY 792: Research 2018
- BIOLOGY 791T: Tutorial 2017
Scholarly, Clinical, & Service Activities
Presentations & Appearances
Outreach & Engaged Scholarship
Service to the Profession

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Education, Training, & Certifications

Duke Appointment History

In the News

Awards & Honors

Selected Grants

Selected Publications

Conference Papers

Journal Articles

Recent Courses

Presentations & Appearances

Outreach & Engaged Scholarship

Service to the Profession