VisTCR: An Interactive Software for T Cell Repertoire Sequencing Data Analysis.

Journal Article (Journal Article)

Recent progress in high throughput sequencing technologies has provided an opportunity to probe T cell receptor (TCR) repertoire, bringing about an explosion of TCR sequencing data and analysis tools. For easier and more heuristic analysis TCR sequencing data, we developed a client-based HTML program (VisTCR). It has a data storage module and a data analysis module that integrate multiple cutting-edge analysis algorithms in a hierarchical fashion. Researchers can group and re-group samples for different analysis purposes by customized "Experiment Design File." Moreover, the VisTCR provides a user-friendly interactive interface, by all the TCR analysis methods and visualization results can be accessed and saved as tables or graphs in the process of analysis. The source code is freely available at https://github.com/qingshanni/VisTCR.

Full Text

Duke Authors

Cited Authors

  • Ni, Q; Zhang, J; Zheng, Z; Chen, G; Christian, L; Grönholm, J; Yu, H; Zhou, D; Zhuang, Y; Li, Q-J; Wan, Y

Published Date

  • 2020

Published In

Volume / Issue

  • 11 /

Start / End Page

  • 771 -

PubMed ID

  • 32849789

Pubmed Central ID

  • PMC7416706

International Standard Serial Number (ISSN)

  • 1664-8021

Digital Object Identifier (DOI)

  • 10.3389/fgene.2020.00771

Language

  • eng

Conference Location

  • Switzerland