Yuan Zhuang | Scholars@Duke

Yuan Zhuang
Professor of Integrative Immunobiology

Research in our laboratory focuses on molecular mechanism of lymphocyte development and genetic basis of lymphoid diseases such as leukemia and autoimmune disorders. We are using mouse models to investigate the role of E2A and other related transcription factors in lymphocyte development and immune function. We have shown that E2A plays an essential role in regulating both B and T cell development. Mice deficient for E2A cannot produce any B cell and exhibit high incidence of T cell leukemia. Separate studies also indicated that E2A is involved in the development of autoimmune disorders. Our current and future studies are to combine genetic, molecular biology, and immunology means to determine gene expression programs during lymphocyte development.

The mechanistic studies of gene function in animal models provide important clues in understanding relevant human diseases. It has been shown that about 20-30% of pediatric acute lymphocytic leukemias (ALL) are linked to chromosomal rearrangements at the E2A gene locus. Most of these genetic defects produce oncogenic forms of E2A proteins, which are the possible cause of leukemia. The use of animal models allows us to further define the molecular events underlying the disease development. Our long term goal is to provide molecular basis for early diagnosis and treatment of relevant lymphoid system diseases.

Laboratory website: Http://sites.duke.edu/zhuanglab .

Current Appointments & Affiliations

Professor of Integrative Immunobiology, Integrative Immunobiology, Basic Science Departments 2011
Professor of Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2011
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1995

Contact Information

328 Jones Building, 207 Resear, Box 3010 DUMC, Durham, NC 27710
Box 3010 DUMC, 328 Jones Building, Durham, NC 27710
yzhuang@duke.edu (919) 613-7824
Lab Webpage

Background
Education, Training, & Certifications
- Ph.D., Yale University 1989
Previous Appointments & Affiliations
- Director of Graduate Studies in the Department of Immunology, Integrative Immunobiology, Basic Science Departments 2009 - 2018
- Director of Undergraduate Studies in the Department of Immunology, Integrative Immunobiology, Basic Science Departments 2008 - 2011
- Associate Professor of Immunology, Integrative Immunobiology, Basic Science Departments 2002 - 2011
- Assistant Professor in Molecular Genetics and Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 2002 - 2011
- Assistant Professor of Genetics, School of Medicine, Duke University 1998 - 2002
- Assistant Professor of Immunology, Integrative Immunobiology, Basic Science Departments 1995 - 2002
Recognition
Awards & Honors
Expertise
Global Scholarship
- Research
  - China (Country)
Research
Selected Grants
- E2A/HEB MEDIATED TRANSCRIPTIONAL REGULATION IN T CELL DEVELOPMENT awarded by National Institutes of Health 1999 - 2022
- Regulation of the type 1 program during ILC3 plasticity awarded by National Institutes of Health 2020 - 2022
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- A New Method for Mosaic Analysis of Clonal Mutations in Mice awarded by National Institutes of Health 2018 - 2020
- Training Program in Inflammatory and Immunological Diseases awarded by National Institutes of Health 1980 - 2017
- A new approach to homeostatic maintenance of dendritic epidermal T cells awarded by National Institutes of Health 2014 - 2017
- Cancer Biology Training Grant awarded by National Cancer Institute 1993 - 2016
- A New Genetic Tool for Lineage Tracing of Mitotic Cells in Mice awarded by National Institutes of Health 2011 - 2014
- An episomal marking system for tracking cell proliferation in development, tissue homeostasis, and ageing awarded by National Institutes of Health 2009 - 2012
- Functions of E2A in B Lymphocyte Development awarded by National Institutes of Health 1997 - 2011
- Modeling Sjogrens Syndrome with Id3 Conditional Knockout Mice awarded by National Institutes of Health 2008 - 2010
- Orphan Nuclear Receptor in Thymocyte Differentiation awarded by National Institutes of Health 2002 - 2007
- The Functions Of E2a In B-Lymphocyte Development awarded by National Institutes of Health 1997 - 1999
- Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
- Comprehensive Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
External Relationships
- Fudan University
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Ratiu, Jeremy J., William E. Barclay, Elliot Lin, Qun Wang, Sebastian Wellford, Naren Mehta, Melissa J. Harnois, et al. “Loss of Zfp335 triggers cGAS/STING-dependent apoptosis of post-β selection thymocytes.” Nat Commun 13, no. 1 (October 6, 2022): 5901. https://doi.org/10.1038/s41467-022-33610-4.
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  - Dauphars, Danielle J., Ariana Mihai, Liuyang Wang, Yuan Zhuang, and Michael S. Krangel. “Trav15-dv6 family Tcrd rearrangements diversify the Tcra repertoire.” J Exp Med 219, no. 2 (February 7, 2022). https://doi.org/10.1084/jem.20211581.
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  - Wojnarowicz, Paulina M., Marta Garcia Escolano, Yun-Han Huang, Bina Desai, Yvette Chin, Riddhi Shah, Sijia Xu, et al. “Anti-tumor effects of an ID antagonist with no observed acquired resistance.” Npj Breast Cancer 7, no. 1 (May 24, 2021): 58. https://doi.org/10.1038/s41523-021-00266-0.
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  - Robins, Elizabeth, Ming Zheng, Qingshan Ni, Siqi Liu, Chen Liang, Baojun Zhang, Jian Guo, et al. “Conversion of effector CD4+ T cells to a CD8+ MHC II-recognizing lineage.” Cell Mol Immunol 18, no. 1 (January 2021): 150–61. https://doi.org/10.1038/s41423-019-0347-5.
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  - Wang, Qun, Yen-Yu Lin, Baojun Zhang, Jianxuan Wu, Sumedha Roy, Jeremy J. Ratiu, Yanping Xu, et al. “A mosaic analysis system with Cre or Tomato expression in the mouse.” Proc Natl Acad Sci U S A 117, no. 45 (November 10, 2020): 28212–20. https://doi.org/10.1073/pnas.2014308117.
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  - Chen, Yuhan, Baoying Yuan, Genwen Chen, Li Zhang, Yuan Zhuang, Hao Niu, and Zhaochong Zeng. “Circular RNA RSF1 promotes inflammatory and fibrotic phenotypes of irradiated hepatic stellate cell by modulating miR-146a-5p.” J Cell Physiol 235, no. 11 (November 2020): 8270–82. https://doi.org/10.1002/jcp.29483.
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  - Ko, Annette, Masashi Watanabe, Thomas Nguyen, Alvin Shi, Achouak Achour, Baojun Zhang, Xiaoping Sun, et al. “TCR Repertoires of Thymic Conventional and Regulatory T Cells: Identification and Characterization of Both Unique and Shared TCR Sequences.” J Immunol 204, no. 4 (February 15, 2020): 858–67. https://doi.org/10.4049/jimmunol.1901006.
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  - Chen, Yi-Xing, Yuan Zhuang, Ping Yang, Jia Fan, Jian Zhou, Yong Hu, Wen-Chao Zhu, Jing Sun, and Zhao-Chong Zeng. “Helical IMRT-Based Stereotactic Body Radiation Therapy Using an Abdominal Compression Technique and Modified Fractionation Regimen for Small Hepatocellular Carcinoma.” Technol Cancer Res Treat 19 (2020): 1533033820937002. https://doi.org/10.1177/1533033820937002.
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  - Ni, Qingshan, Jianyang Zhang, Zihan Zheng, Gang Chen, Laura Christian, Juha Grönholm, Haili Yu, et al. “VisTCR: An Interactive Software for T Cell Repertoire Sequencing Data Analysis.” Front Genet 11 (2020): 771. https://doi.org/10.3389/fgene.2020.00771.
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  - Li, Yuanyuan, David M. Umbach, Adrienna Bingham, Qi-Jing Li, Yuan Zhuang, and Leping Li. “Putative biomarkers for predicting tumor sample purity based on gene expression data.” Bmc Genomics 20, no. 1 (December 27, 2019): 1021. https://doi.org/10.1186/s12864-019-6412-8.
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  - Yuan, Bao-Ying, Yu-Han Chen, Zhi-Feng Wu, Yuan Zhuang, Gen-Wen Chen, Li Zhang, Hai-Ge Zhang, Jason Chia-Hsien Cheng, Qin Lin, and Zhao-Chong Zeng. “MicroRNA-146a-5p Attenuates Fibrosis-related Molecules in Irradiated and TGF-beta1-Treated Human Hepatic Stellate Cells by Regulating PTPRA-SRC Signaling.” Radiat Res 192, no. 6 (December 2019): 621–29. https://doi.org/10.1667/RR15401.1.
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  - Panea, Razvan I., Cassandra L. Love, Jennifer R. Shingleton, Anupama Reddy, Jeffrey A. Bailey, Ann M. Moormann, Juliana A. Otieno, et al. “The whole-genome landscape of Burkitt lymphoma subtypes.” Blood 134, no. 19 (November 7, 2019): 1598–1607. https://doi.org/10.1182/blood.2019001880.
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  - Kadakia, Tejas, Xuguang Tai, Michael Kruhlak, Jan Wisniewski, Il-Young Hwang, Sumedha Roy, Terry I. Guinter, et al. “E-protein-regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex.” J Exp Med 216, no. 8 (August 5, 2019): 1749–61. https://doi.org/10.1084/jem.20182285.
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  - Zhang, Li, Hao Niu, Jie Ma, Bao-Ying Yuan, Yu-Han Chen, Yuan Zhuang, Gen-Wen Chen, Zhao-Chong Zeng, and Zuo-Lin Xiang. “The molecular mechanism of LncRNA34a-mediated regulation of bone metastasis in hepatocellular carcinoma.” Mol Cancer 18, no. 1 (July 26, 2019): 120. https://doi.org/10.1186/s12943-019-1044-9.
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  - Yuan, Baoying, Yuhan Chen, Zhifeng Wu, Li Zhang, Yuan Zhuang, Xiaomei Zhao, Hao Niu, Jason Chia-Hsien Cheng, and Zhaochong Zeng. “Proteomic Profiling of Human Hepatic Stellate Cell Line LX2 Responses to Irradiation and TGF-β1.” J Proteome Res 18, no. 1 (January 4, 2019): 508–21. https://doi.org/10.1021/acs.jproteome.8b00814.
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  - Zhang, Li, Li Yan, Hao Niu, Jie Ma, Bao-Ying Yuan, Yu-Han Chen, Yuan Zhuang, Yong Hu, Zhao-Chong Zeng, and Zuo-Lin Xiang. “A nomogram to predict prognosis of patients with unresected hepatocellular carcinoma undergoing radiotherapy: a population-based study.” J Cancer 10, no. 19 (2019): 4564–73. https://doi.org/10.7150/jca.30365.
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  - Zhuang, Yuan, Bao-Ying Yuan, Gen-Wen Chen, Xiao-Mei Zhao, Yong Hu, Wen-Chao Zhu, Zhao-Chong Zeng, and Yi-Xing Chen. “Association Between Circulating Lymphocyte Populations and Outcome After Stereotactic Body Radiation Therapy in Patients With Hepatocellular Carcinoma.” Front Oncol 9 (2019): 896. https://doi.org/10.3389/fonc.2019.00896.
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  - Zhuang, Yuan, Bao-Ying Yuan, Yong Hu, Gen-Wen Chen, Li Zhang, Xiao-Mei Zhao, Yi-Xing Chen, and Zhao-Chong Zeng. “Pre/Post-Treatment Dynamic of Inflammatory Markers Has Prognostic Value in Patients with Small Hepatocellular Carcinoma Managed by Stereotactic Body Radiation Therapy.” Cancer Manag Res 11 (2019): 10929–37. https://doi.org/10.2147/CMAR.S231901.
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  - Sandrock, Inga, Annika Reinhardt, Sarina Ravens, Christoph Binz, Anneke Wilharm, Joana Martins, Linda Oberdörfer, et al. “Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells.” J Exp Med 215, no. 12 (December 3, 2018): 3006–18. https://doi.org/10.1084/jem.20181439.
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  - Zhang, Baojun, Anjun Jiao, Meifang Dai, David L. Wiest, and Yuan Zhuang. “Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity.” J Immunol 201, no. 5 (September 1, 2018): 1452–59. https://doi.org/10.4049/jimmunol.1800106.
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  - Roy, Sumedha, and Yuan Zhuang. “Paradoxical role of Id proteins in regulating tumorigenic potential of lymphoid cells.” Front Med 12, no. 4 (August 2018): 374–86. https://doi.org/10.1007/s11684-018-0652-x.
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  - Roy, Sumedha, Amanda J. Moore, Cassandra Love, Anupama Reddy, Deepthi Rajagopalan, Sandeep S. Dave, Leping Li, Cornelis Murre, and Yuan Zhuang. “Id Proteins Suppress E2A-Driven Invariant Natural Killer T Cell Development prior to TCR Selection.” Front Immunol 9 (2018): 42. https://doi.org/10.3389/fimmu.2018.00042.
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  - Wang, Herui, Chi Zhang, Xiaowen Wang, Yaru Lian, Bin Guo, Miao Han, Xiaoe Zhang, et al. “Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice.” Int J Biol Sci 14, no. 1 (2018): 10–20. https://doi.org/10.7150/ijbs.22768.
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  - Jin, Yan, Yaohui Chen, Shimin Zhao, Kun-Liang Guan, Yuan Zhuang, Wenhao Zhou, Xiaohui Wu, and Tian Xu. “DNA-PK facilitates piggyBac transposition by promoting paired-end complex formation.” Proc Natl Acad Sci U S A 114, no. 28 (July 11, 2017): 7408–13. https://doi.org/10.1073/pnas.1612980114.
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  - Carico, Zachary M., Kingshuk Roy Choudhury, Baojun Zhang, Yuan Zhuang, and Michael S. Krangel. “Tcrd Rearrangement Redirects a Processive Tcra Recombination Program to Expand the Tcra Repertoire.” Cell Rep 19, no. 10 (June 6, 2017): 2157–73. https://doi.org/10.1016/j.celrep.2017.05.045.
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  - Moffitt, Andrea B., Sarah L. Ondrejka, Matthew McKinney, Rachel E. Rempel, John R. Goodlad, Chun Huat Teh, Sirpa Leppa, et al. “Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2.” J Exp Med 214, no. 5 (May 1, 2017): 1371–86. https://doi.org/10.1084/jem.20160894.
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  - Li, Jia, Sumedha Roy, Young-Mi Kim, Shibo Li, Baojun Zhang, Cassandra Love, Anupama Reddy, et al. “Id2 Collaborates with Id3 To Suppress Invariant NKT and Innate-like Tumors.” J Immunol 198, no. 8 (April 15, 2017): 3136–48. https://doi.org/10.4049/jimmunol.1601935.
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  - Li, Gang, Zhisheng Ye, Cheng Shi, Ling Sun, Min Han, Yuan Zhuang, Tian Xu, Shimin Zhao, and Xiaohui Wu. “The Histone Methyltransferase Ash1l is Required for Epidermal Homeostasis in Mice.” Sci Rep 7 (April 4, 2017): 45401. https://doi.org/10.1038/srep45401.
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  - McKinney, Matthew, Andrea B. Moffitt, Philippe Gaulard, Marion Travert, Laurence De Leval, Alina Nicolae, Mark Raffeld, et al. “The Genetic Basis of Hepatosplenic T-cell Lymphoma.” Cancer Discov 7, no. 4 (April 2017): 369–79. https://doi.org/10.1158/2159-8290.CD-16-0330.
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  - Cui, Jing, Yi Ding, Shu Chen, Xiaoqiang Zhu, Yichen Wu, Mingliang Zhang, Yaxin Zhao, et al. “Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity.” J Clin Invest 126, no. 9 (September 1, 2016): 3192–3206. https://doi.org/10.1172/JCI85676.
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  - Zhang, Baojun, Qingzhu Jia, Cheryl Bock, Gang Chen, Haili Yu, Qingshan Ni, Ying Wan, Qijing Li, and Yuan Zhuang. “Glimpse of natural selection of long-lived T-cell clones in healthy life.” Proc Natl Acad Sci U S A 113, no. 35 (August 30, 2016): 9858–63. https://doi.org/10.1073/pnas.1601634113.
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  - Ye, Zhisheng, Lei Sun, Rongbo Li, Min Han, Yuan Zhuang, Xiaohui Wu, and Tian Xu. “Generation of a Mouse Full-length Balancer with Versatile Cassette-shuttling Selection Strategy.” Int J Biol Sci 12, no. 8 (2016): 911–16. https://doi.org/10.7150/ijbs.15172.
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  - Zhang, Baojun, Jianxuan Wu, Yiqun Jiao, Cheryl Bock, Meifang Dai, Benny Chen, Nelson Chao, Weiguo Zhang, and Yuan Zhuang. “Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells.” J Immunol 195, no. 9 (November 1, 2015): 4282–91. https://doi.org/10.4049/jimmunol.1501220.
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  - Ye, Jian, Hao Shi, Ye Shen, Chao Peng, Yan Liu, Chenyu Li, Kejing Deng, et al. “PP6 controls T cell development and homeostasis by negatively regulating distal TCR signaling.” J Immunol 194, no. 4 (February 15, 2015): 1654–64. https://doi.org/10.4049/jimmunol.1401692.
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  - Roy, Sumedha, and Yuan Zhuang. “Orchestration of invariant natural killer T cell development by E and Id proteins.” Crit Rev Immunol 35, no. 1 (2015): 33–48. https://doi.org/10.1615/critrevimmunol.2015012207.
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  - Belle, Ian, Josh Mahlios, Andrew McKenzie, and Yuan Zhuang. “Aberrant production of IL-13 by T cells promotes exocrinopathy in Id3 knockout mice.” Cytokine 69, no. 2 (October 2014): 226–33. https://doi.org/10.1016/j.cyto.2014.06.009.
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  - Niola, F., X. Zhao, D. Singh, R. Sullivan, A. Castano, A. Verrico, P. Zoppoli, et al. “Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis.” J Clin Invest 124, no. 9 (September 2, 2014): 4134. https://doi.org/10.1172/JCI77927.
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  - Shi, Fubiao, Sheng Ding, Shimin Zhao, Min Han, Yuan Zhuang, Tian Xu, and Xiaohui Wu. “A piggyBac insertion disrupts Foxl2 expression that mimics BPES syndrome in mice.” Hum Mol Genet 23, no. 14 (July 15, 2014): 3792–3800. https://doi.org/10.1093/hmg/ddu092.
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  - Liu, Juan, Chaofeng Han, Bin Xie, Yue Wu, Shuxun Liu, Kun Chen, Meng Xia, et al. “Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO.” Nat Immunol 15, no. 7 (July 2014): 612–22. https://doi.org/10.1038/ni.2898.
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  - Du, Xingrong, Hao Shi, Jiang Li, Yongli Dong, JieLiang Liang, Jian Ye, Shanshan Kong, et al. “Mst1/Mst2 regulate development and function of regulatory T cells through modulation of Foxo1/Foxo3 stability in autoimmune disease.” J Immunol 192, no. 4 (February 15, 2014): 1525–35. https://doi.org/10.4049/jimmunol.1301060.
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  - Zhang, Baojun, Yen-Yu Lin, Meifang Dai, and Yuan Zhuang. “Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like γδ T cells.” J Immunol 192, no. 3 (February 1, 2014): 1055–63. https://doi.org/10.4049/jimmunol.1302694.
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  - Belle, Ian, and Yuan Zhuang. “E proteins in lymphocyte development and lymphoid diseases.” Curr Top Dev Biol 110 (2014): 153–87. https://doi.org/10.1016/B978-0-12-405943-6.00004-X.
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  - Li, Jia, Di Wu, Ning Jiang, and Yuan Zhuang. “Combined deletion of Id2 and Id3 genes reveals multiple roles for E proteins in invariant NKT cell development and expansion.” J Immunol 191, no. 10 (November 15, 2013): 5052–64. https://doi.org/10.4049/jimmunol.1301252.
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  - Zhang, Baojun, Meifang Dai, Qi-Jing Li, and Yuan Zhuang. “Tracking proliferative history in lymphocyte development with cre-mediated sister chromatid recombination.” Plos Genet 9, no. 10 (October 2013): e1003887. https://doi.org/10.1371/journal.pgen.1003887.
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  - Li, Rongbo, Yuan Zhuang, Min Han, Tian Xu, and Xiaohui Wu. “piggyBac as a high-capacity transgenesis and gene-therapy vector in human cells and mice.” Dis Model Mech 6, no. 3 (May 2013): 828–33. https://doi.org/10.1242/dmm.010827.
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  - Sun, Ling V., Ke Jin, Yiming Liu, Wenwei Yang, Xing Xie, Lin Ye, Li Wang, et al. “PiggyBac Mutagenesis and Information Center.” Transgenic Research 22, no. 1 (February 1, 2013): 215–215.
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  - Niola, Francesco, Xudong Zhao, Devendra Singh, Ryan Sullivan, Angelica Castano, Antonio Verrico, Pietro Zoppoli, et al. “Mesenchymal high-grade glioma is maintained by the ID-RAP1 axis.” J Clin Invest 123, no. 1 (January 2013): 405–17. https://doi.org/10.1172/JCI63811.
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  - Lei, Kai, Xiaoqiang Zhu, Rener Xu, Chunlin Shao, Tian Xu, Yuan Zhuang, and Min Han. “Inner nuclear envelope proteins SUN1 and SUN2 play a prominent role in the DNA damage response.” Curr Biol 22, no. 17 (September 11, 2012): 1609–15. https://doi.org/10.1016/j.cub.2012.06.043.
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  - Lin, Yen-Yu, Mary E. Jones-Mason, Makoto Inoue, Anna Lasorella, Antonio Iavarone, Qi-Jing Li, Mari L. Shinohara, and Yuan Zhuang. “Transcriptional regulator Id2 is required for the CD4 T cell immune response in the development of experimental autoimmune encephalomyelitis.” J Immunol 189, no. 3 (August 1, 2012): 1400–1405. https://doi.org/10.4049/jimmunol.1200491.
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  - Zhu, Yi, Shiwei Liu, Qili Yin, Tian Xu, Xiaohui Wu, and Yuan Zhuang. “Generation of Dhx9-deficient clones in T-cell development with a mitotic recombination technique.” Genesis 50, no. 7 (July 2012): 543–51. https://doi.org/10.1002/dvg.22005.
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  - Niola, Francesco, Xudong Zhao, Devendra Singh, Angelica Castano, Ryan Sullivan, Mario Lauria, Hyung-song Nam, et al. “Id proteins synchronize stemness and anchorage to the niche of neural stem cells.” Nat Cell Biol 14, no. 5 (April 22, 2012): 477–87. https://doi.org/10.1038/ncb2490.
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  - Jones-Mason, Mary Elizabeth, Xudong Zhao, Dietmar Kappes, Anna Lasorella, Antonio Iavarone, and Yuan Zhuang. “E protein transcription factors are required for the development of CD4(+) lineage T cells.” Immunity 36, no. 3 (March 23, 2012): 348–61. https://doi.org/10.1016/j.immuni.2012.02.010.
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  - Mahlios, Josh, and Yuan Zhuang. “Contribution of IL-13 to early exocrinopathy in Id3-/- mice.” Mol Immunol 49, no. 1–2 (October 2011): 227–33. https://doi.org/10.1016/j.molimm.2011.08.012.
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  - Jones, Mary Elizabeth, and Yuan Zhuang. “Stage-specific functions of E-proteins at the β-selection and T-cell receptor checkpoints during thymocyte development.” Immunol Res 49, no. 1–3 (April 2011): 202–15. https://doi.org/10.1007/s12026-010-8182-x.
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  - Guo, Zengli, Hongmei Li, Min Han, Tian Xu, Xiaohui Wu, and Yuan Zhuang. “Modeling Sjögren's syndrome with Id3 conditional knockout mice.” Immunol Lett 135, no. 1–2 (March 30, 2011): 34–42. https://doi.org/10.1016/j.imlet.2010.09.009.
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  - Yu, Juehua, Kai Lei, Min Zhou, Cheryl M. Craft, Gezhi Xu, Tian Xu, Yuan Zhuang, Rener Xu, and Min Han. “KASH protein Syne-2/Nesprin-2 and SUN proteins SUN1/2 mediate nuclear migration during mammalian retinal development.” Hum Mol Genet 20, no. 6 (March 15, 2011): 1061–73. https://doi.org/10.1093/hmg/ddq549.
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  - Maruyama, Takashi, Jun Li, Jose P. Vaque, Joanne E. Konkel, Weifeng Wang, Baojun Zhang, Pin Zhang, et al. “Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3.” Nat Immunol 12, no. 1 (January 2011): 86–95. https://doi.org/10.1038/ni.1965.
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  - Zhang, Chi, Lei Tian, Congwu Chi, Xiaohui Wu, Xiao Yang, Min Han, Tian Xu, Yuan Zhuang, and Kejing Deng. “Adam10 is essential for early embryonic cardiovascular development.” Dev Dyn 239, no. 10 (October 2010): 2594–2602. https://doi.org/10.1002/dvdy.22391.
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  - Zhu, Yi, Young-Mi Kim, Shibo Li, and Yuan Zhuang. “Generation and analysis of partially haploid cells with Cre-mediated chromosome deletion in the lymphoid system.” J Biol Chem 285, no. 34 (August 20, 2010): 26005–12. https://doi.org/10.1074/jbc.M110.139196.
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  - Chi, Congwu, Huanhu Zhu, Min Han, Yuan Zhuang, Xiaohui Wu, and Tian Xu. “Disruption of lysosome function promotes tumor growth and metastasis in Drosophila.” J Biol Chem 285, no. 28 (July 9, 2010): 21817–23. https://doi.org/10.1074/jbc.M110.131714.
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  - Yi, Jing, Muyun Chen, Xiaohui Wu, Xiao Yang, Tian Xu, Yuan Zhuang, Min Han, and Rener Xu. “Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development.” Dev Dyn 239, no. 7 (July 2010): 2005–13. https://doi.org/10.1002/dvdy.22343.
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  - Zhang, Xiaochang, Kai Lei, Xiaobing Yuan, Xiaohui Wu, Yuan Zhuang, Tian Xu, Rener Xu, and Min Han. “SUN1/2 and Syne/Nesprin-1/2 complexes connect centrosome to the nucleus during neurogenesis and neuronal migration in mice.” Neuron 64, no. 2 (October 29, 2009): 173–87. https://doi.org/10.1016/j.neuron.2009.08.018.
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  - Wu, Yue, Yuan Zhuang, Min Han, Tian Xu, and Kejing Deng. “Ras promotes cell survival by antagonizing both JNK and Hid signals in the Drosophila eye.” Bmc Dev Biol 9 (October 20, 2009): 53. https://doi.org/10.1186/1471-213X-9-53.
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  - Jones, Mary E., Motonari Kondo, and Yuan Zhuang. “A tamoxifen inducible knock-in allele for investigation of E2A function.” Bmc Dev Biol 9 (October 12, 2009): 51. https://doi.org/10.1186/1471-213X-9-51.
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  - Yu, Juehua, Mingyao Ying, Yuan Zhuang, Tian Xu, Min Han, Xiaohui Wu, and Rener Xu. “C-terminal deletion of the atrophin-1 protein results in growth retardation but not neurodegeneration in mice.” Dev Dyn 238, no. 10 (October 2009): 2471–78. https://doi.org/10.1002/dvdy.22063.
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  - Dong, Yongli, Xingrong Du, Jian Ye, Min Han, Tian Xu, Yuan Zhuang, and Wufan Tao. “A cell-intrinsic role for Mst1 in regulating thymocyte egress.” J Immunol 183, no. 6 (September 15, 2009): 3865–72. https://doi.org/10.4049/jimmunol.0900678.
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  - Yashiro-Ohtani, Yumi, Yiping He, Takuya Ohtani, Mary E. Jones, Olga Shestova, Lanwei Xu, Terry C. Fang, et al. “Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.” Genes Dev 23, no. 14 (July 15, 2009): 1665–76. https://doi.org/10.1101/gad.1793709.
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  - Lei, Kai, Xiaochang Zhang, Xu Ding, Xue Guo, Muyun Chen, Binggen Zhu, Tian Xu, Yuan Zhuang, Rener Xu, and Min Han. “SUN1 and SUN2 play critical but partially redundant roles in anchoring nuclei in skeletal muscle cells in mice.” Proc Natl Acad Sci U S A 106, no. 25 (June 23, 2009): 10207–12. https://doi.org/10.1073/pnas.0812037106.
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  - Ueda-Hayakawa, Ikuko, Josh Mahlios, and Yuan Zhuang. “Id3 restricts the developmental potential of gamma delta lineage during thymopoiesis.” J Immunol 182, no. 9 (May 1, 2009): 5306–16. https://doi.org/10.4049/jimmunol.0804249.
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  - Wang, Xiaofang, Xing Chang, Valeria Facchinetti, Yuan Zhuang, and Bing Su. “MEKK3 is essential for lymphopenia-induced T cell proliferation and survival.” J Immunol 182, no. 6 (March 15, 2009): 3597–3608. https://doi.org/10.4049/jimmunol.0803738.
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  - Jones, Mary Elizabeth, and Yuan Zhuang. “Regulation of V(D)J recombination by E-protein transcription factors.” Adv Exp Med Biol 650 (2009): 148–56. https://doi.org/10.1007/978-1-4419-0296-2_12.
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  - Xu, Rong, Kejing Deng, Yi Zhu, Yue Wu, Jing Ren, Min Wan, Shouyuan Zhao, et al. “A large-scale functional approach to uncover human genes and pathways in Drosophila.” Cell Res 18, no. 11 (November 2008): 1114–27. https://doi.org/10.1038/cr.2008.295.
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  - Cisse, Babacar, Michele L. Caton, Manfred Lehner, Takahiro Maeda, Stefanie Scheu, Richard Locksley, Dan Holmberg, et al. “Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.” Cell 135, no. 1 (October 3, 2008): 37–48. https://doi.org/10.1016/j.cell.2008.09.016.
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  - Jia, Jingquan, Meifang Dai, and Yuan Zhuang. “E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene.” Eur J Immunol 38, no. 10 (October 2008): 2806–20. https://doi.org/10.1002/eji.200838144.
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  - Tian, Lei, Xiaohui Wu, Congwu Chi, Min Han, Tian Xu, and Yuan Zhuang. “ADAM10 is essential for proteolytic activation of Notch during thymocyte development.” Int Immunol 20, no. 9 (September 2008): 1181–87. https://doi.org/10.1093/intimm/dxn076.
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  - Zhuang, Yuan, and Mary Elizaberth Jones. “HEB and E2A enforce TCR checkpoint in T lymphocyte development.” Faseb Journal 22 (April 1, 2008).
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  - Sun, Lei, Xiaohui Wu, Min Han, Tian Xu, and Yuan Zhuang. “A mitotic recombination system for mouse chromosome 17.” Proc Natl Acad Sci U S A 105, no. 11 (March 18, 2008): 4237–41. https://doi.org/10.1073/pnas.0800798105.
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  - Sun, Ling V., Ke Jin, Yiming Liu, Wenwei Yang, Xing Xie, Lin Ye, Li Wang, et al. “PBmice: an integrated database system of piggyBac (PB) insertional mutations and their characterizations in mice.” Nucleic Acids Res 36, no. Database issue (January 2008): D729–34. https://doi.org/10.1093/nar/gkm790.
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  - Hayakawa, Ikuko, and Yuan Zhuang. “Id3 controls the developmental window of gamma delta T cells.” Faseb Journal 22 (2008).
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  - Jones, Mary Elizabeth, and Yuan Zhuang. “Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors.” Immunity 27, no. 6 (December 2007): 860–70. https://doi.org/10.1016/j.immuni.2007.10.014.
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  - Hayakawa, Ikuko, Thomas F. Tedder, and Yuan Zhuang. “B-lymphocyte depletion ameliorates Sjögren's syndrome in Id3 knockout mice.” Immunology 122, no. 1 (September 2007): 73–79. https://doi.org/10.1111/j.1365-2567.2007.02614.x.
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  - Ding, Xu, Rener Xu, Juehua Yu, Tian Xu, Yuan Zhuang, and Min Han. “SUN1 is required for telomere attachment to nuclear envelope and gametogenesis in mice.” Dev Cell 12, no. 6 (June 2007): 863–72. https://doi.org/10.1016/j.devcel.2007.03.018.
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  - Jia, Jingquan, Motonari Kondo, and Yuan Zhuang. “Germline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion.” Embo J 26, no. 9 (May 2, 2007): 2387–99. https://doi.org/10.1038/sj.emboj.7601671.
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  - Wojciechowski, Jason, Anne Lai, Motonari Kondo, and Yuan Zhuang. “E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression.” J Immunol 178, no. 9 (May 1, 2007): 5717–26. https://doi.org/10.4049/jimmunol.178.9.5717.
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  - Zhang, Xiaochang, Rener Xu, Binggen Zhu, Xiujuan Yang, Xu Ding, Shumin Duan, Tian Xu, Yuan Zhuang, and Min Han. “Syne-1 and Syne-2 play crucial roles in myonuclear anchorage and motor neuron innervation.” Development 134, no. 5 (March 2007): 901–8. https://doi.org/10.1242/dev.02783.
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  - Wan, Min, Xiaohui Wu, Kun-Liang Guan, Min Han, Yuan Zhuang, and Tian Xu. “Muscle atrophy in transgenic mice expressing a human TSC1 transgene.” Febs Lett 580, no. 24 (October 16, 2006): 5621–27. https://doi.org/10.1016/j.febslet.2006.09.008.
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  - Lazorchak, Adam S., Jason Wojciechowski, Meifang Dai, and Yuan Zhuang. “E2A promotes the survival of precursor and mature B lymphocytes.” J Immunol 177, no. 4 (August 15, 2006): 2495–2504. https://doi.org/10.4049/jimmunol.177.4.2495.
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  - Ying, Mingyao, Rener Xu, Xiaohui Wu, Huaxing Zhu, Yuan Zhuang, Min Han, and Tian Xu. “Sodium butyrate ameliorates histone hypoacetylation and neurodegenerative phenotypes in a mouse model for DRPLA.” J Biol Chem 281, no. 18 (May 5, 2006): 12580–86. https://doi.org/10.1074/jbc.M511677200.
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  - Lazorchak, Adam S., Mark S. Schlissel, and Yuan Zhuang. “E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells.” Mol Cell Biol 26, no. 3 (February 2006): 810–21. https://doi.org/10.1128/MCB.26.3.810-821.2006.
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  - Yu, Juehua, Daniel A. Starr, Xiaohui Wu, Susan M. Parkhurst, Yuan Zhuang, Tian Xu, Rener Xu, and Min Han. “The KASH domain protein MSP-300 plays an essential role in nuclear anchoring during Drosophila oogenesis.” Dev Biol 289, no. 2 (January 15, 2006): 336–45. https://doi.org/10.1016/j.ydbio.2005.10.027.
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  - Ding, Sheng, Xiaohui Wu, Gang Li, Min Han, Yuan Zhuang, and Tian Xu. “Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice.” Cell 122, no. 3 (August 12, 2005): 473–83. https://doi.org/10.1016/j.cell.2005.07.013.
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  - Lazorchak, Adam, Mary Elizabeth Jones, and Yuan Zhuang. “New insights into E-protein function in lymphocyte development.” Trends Immunol 26, no. 6 (June 2005): 334–38. https://doi.org/10.1016/j.it.2005.03.011.
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  - Zhu, Huaxing, Guangxue Wang, Gang Li, Min Han, Tian Xu, Yuan Zhuang, and Xiaohui Wu. “Ubiquitous expression of mRFP1 in transgenic mice.” Genesis 42, no. 2 (June 2005): 86–90. https://doi.org/10.1002/gene.20129.
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  - Greenbaum, S., A. S. Lazorchak, and Y. Zhuang. “Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes. (vol 279, pg 45028, 2004).” Journal of Biological Chemistry 280, no. 16 (April 22, 2005): 16528–16528.
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  - Greenbaum, S., A. S. Lazorchak, and Y. Zhuang. “Erratum: Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes (The Journal of Biological Chemistry (2004) 279 (45028-45035)).” Journal of Biological Chemistry 280, no. 16 (April 22, 2005): 16528.
  - Greenbaum, Stephen, Adam S. Lazorchak, and Yuan Zhuang. “Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes.” J Biol Chem 279, no. 43 (October 22, 2004): 45028–35. https://doi.org/10.1074/jbc.M400061200.
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  - Li, Hongmei, Meifang Dai, and Yuan Zhuang. “A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome.” Immunity 21, no. 4 (October 2004): 551–60. https://doi.org/10.1016/j.immuni.2004.08.013.
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  - Zhuang, Yuan, Annette Jackson, Lihua Pan, Kang Shen, and Meifang Dai. “Regulation of E2A gene expression in B-lymphocyte development.” Mol Immunol 40, no. 16 (March 2004): 1165–77. https://doi.org/10.1016/j.molimm.2003.11.031.
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  - Pan, Lihua, Curtis Bradney, Biao Zheng, and Yuan Zhuang. “Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes.” Immunology 111, no. 2 (February 2004): 147–54. https://doi.org/10.1111/j.0019-2805.2003.01802.x.
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  - Hsu, Lih-Yun, Josh Lauring, Hong-Erh Liang, Stephen Greenbaum, Dragana Cado, Yuan Zhuang, and Mark S. Schlissel. “A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.” Immunity 19, no. 1 (July 2003): 105–17. https://doi.org/10.1016/s1074-7613(03)00181-x.
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  - Bradney, Curtis, Mark Hjelmeland, Yasuhiko Komatsu, Minoru Yoshida, Tso-Pang Yao, and Yuan Zhuang. “Regulation of E2A activities by histone acetyltransferases in B lymphocyte development.” J Biol Chem 278, no. 4 (January 24, 2003): 2370–76. https://doi.org/10.1074/jbc.M211464200.
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  - Greenbaum, Stephen, and Yuan Zhuang. “Regulation of early lymphocyte development by E2A family proteins.” Semin Immunol 14, no. 6 (December 2002): 405–14. https://doi.org/10.1016/s1044532302000751.
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  - Greenbaum, Stephen, and Yuan Zhuang. “Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system.” Proc Natl Acad Sci U S A 99, no. 23 (November 12, 2002): 15030–35. https://doi.org/10.1073/pnas.232299999.
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  - Guo, Zijian, Gavin Clydesdale, Jinke Cheng, Kihwan Kim, Lin Gan, David J. McConkey, Stephen E. Ullrich, Yuan Zhuang, and Bing Su. “Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction.” Mol Cell Biol 22, no. 16 (August 2002): 5761–68. https://doi.org/10.1128/MCB.22.16.5761-5768.2002.
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  - Xu, Xuehong, Bing Su, Robert J. Barndt, Hanying Chen, Hongbo Xin, Guifan Yan, Linyuan Chen, et al. “FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506.” Transplantation 73, no. 11 (June 15, 2002): 1835–38. https://doi.org/10.1097/00007890-200206150-00023.
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  - Pan, Lihua, Jenifer Hanrahan, Jie Li, Laura P. Hale, and Yuan Zhuang. “An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus.” J Immunol 168, no. 8 (April 15, 2002): 3923–32. https://doi.org/10.4049/jimmunol.168.8.3923.
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  - Zhuang, Y., L. H. Pan, J. Hanrahan, J. Li, L. P. Hale, and B. Zheng. “E2A plays both T-lineage intrinsic and extrinsic roles in T cell development.” Faseb Journal 15, no. 5 (March 8, 2001): A1194–A1194.
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  - Barndt, R. J., M. Dai, and Y. Zhuang. “Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB.” Mol Cell Biol 20, no. 18 (September 2000): 6677–85. https://doi.org/10.1128/MCB.20.18.6677-6685.2000.
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  - Zhuang, Y. “Developmental regulation of the E2A gene in lymphopoiesis revealed by an E2AGFP allele.” Faseb Journal 14, no. 6 (April 20, 2000): A1034–A1034.
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  - Yang, J., M. Boerm, M. McCarty, C. Bucana, I. J. Fidler, Y. Zhuang, and B. Su. “Mekk3 is essential for early embryonic cardiovascular development.” Nat Genet 24, no. 3 (March 2000): 309–13. https://doi.org/10.1038/73550.
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  - Hanrahan, J., L. Pan, S. Greenbaum, C. Bradney, M. Hjelmeland, M. Dai, and Y. Zhuang. “A genetic investigation of E2A function in lymphocyte development.” Immunol Res 22, no. 2–3 (2000): 211–22. https://doi.org/10.1385/ir:22:2-3:211.
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  - Lyden, D., A. Z. Young, D. Zagzag, W. Yan, W. Gerald, R. O’Reilly, B. L. Bader, et al. “Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts.” Nature 401, no. 6754 (October 14, 1999): 670–77. https://doi.org/10.1038/44334.
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  - Barndt, R., M. F. Dai, and Y. Zhuang. “A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis.” J Immunol 163, no. 6 (September 15, 1999): 3331–43.
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  - Pan, L., S. Sato, J. P. Frederick, X. H. Sun, and Y. Zhuang. “Impaired immune responses and B-cell proliferation in mice lacking the Id3 gene.” Mol Cell Biol 19, no. 9 (September 1999): 5969–80. https://doi.org/10.1128/MCB.19.9.5969.
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  - Datto, M. B., J. P. Frederick, L. Pan, A. J. Borton, Y. Zhuang, and X. F. Wang. “Targeted disruption of Smad3 reveals an essential role in transforming growth factor beta-mediated signal transduction.” Mol Cell Biol 19, no. 4 (April 1999): 2495–2504. https://doi.org/10.1128/MCB.19.4.2495.
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  - Barndt, R. J., and Y. Zhuang. “A dominant-negative approach to study the redundant function of bHLH genes.” Faseb Journal 13, no. 4 (March 12, 1999): A619–A619.
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  - Pan, L. H., and Y. Zhuang. “Impaired immune responses and B cell proliferation in mice lack of the Id3 gene.” Faseb Journal 13, no. 4 (March 12, 1999): A327–A327.
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  - Barndt, R. J., and Y. Zhuang. “Controlling lymphopoiesis with a combinatorial E-protein code.” Cold Spring Harb Symp Quant Biol 64 (1999): 45–50. https://doi.org/10.1101/sqb.1999.64.45.
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  - Zhuang, Y., R. J. Barndt, L. Pan, R. Kelley, and M. Dai. “Functional replacement of the mouse E2A gene with a human HEB cDNA.” Mol Cell Biol 18, no. 6 (June 1998): 3340–49. https://doi.org/10.1128/MCB.18.6.3340.
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  - Yan, W., A. Z. Young, V. C. Soares, R. Kelley, R. Benezra, and Y. Zhuang. “High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice.” Mol Cell Biol 17, no. 12 (December 1997): 7317–27. https://doi.org/10.1128/MCB.17.12.7317.
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  - Sharma, A., E. Henderson, L. Gamer, Y. Zhuang, and R. Stein. “Analysis of the role of E2A-encoded proteins in insulin gene transcription.” Mol Endocrinol 11, no. 11 (October 1997): 1608–17. https://doi.org/10.1210/mend.11.11.0004.
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  - Zhuang, Y., P. Cheng, and H. Weintraub. “B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.” Mol Cell Biol 16, no. 6 (June 1996): 2898–2905. https://doi.org/10.1128/MCB.16.6.2898.
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  - Fiering, S., E. Epner, K. Robinson, Y. Zhuang, A. Telling, M. Hu, D. I. Martin, T. Enver, T. J. Ley, and M. Groudine. “Targeted deletion of 5'HS2 of the murine beta-globin LCR reveals that it is not essential for proper regulation of the beta-globin locus.” Genes Dev 9, no. 18 (September 15, 1995): 2203–13. https://doi.org/10.1101/gad.9.18.2203.
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  - Zhuang, Y., P. Soriano, and H. Weintraub. “The helix-loop-helix gene E2A is required for B cell formation.” Cell 79, no. 5 (December 2, 1994): 875–84. https://doi.org/10.1016/0092-8674(94)90076-0.
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  - Zhuang, Y., C. G. Kim, S. Bartelmez, P. Cheng, M. Groudine, and H. Weintraub. “Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis, or neurogenesis.” Proc Natl Acad Sci U S A 89, no. 24 (December 15, 1992): 12132–36. https://doi.org/10.1073/pnas.89.24.12132.
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  - Weintraub, H., R. Davis, S. Tapscott, M. Thayer, M. Krause, R. Benezra, T. K. Blackwell, D. Turner, R. Rupp, and S. Hollenberg. “The myoD gene family: nodal point during specification of the muscle cell lineage.” Science 251, no. 4995 (February 15, 1991): 761–66. https://doi.org/10.1126/science.1846704.
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  - Zhuang, Y., and A. M. Weiner. “The conserved dinucleotide AG of the 3' splice site may be recognized twice during in vitro splicing of mammalian mRNA precursors.” Gene 90, no. 2 (June 15, 1990): 263–69. https://doi.org/10.1016/0378-1119(90)90189-x.
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  - Zhuang, Y., and A. M. Weiner. “A compensatory base change in human U2 snRNA can suppress a branch site mutation.” Genes Dev 3, no. 10 (October 1989): 1545–52. https://doi.org/10.1101/gad.3.10.1545.
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  - Zhuang, Y. A., A. M. Goldstein, and A. M. Weiner. “UACUAAC is the preferred branch site for mammalian mRNA splicing.” Proc Natl Acad Sci U S A 86, no. 8 (April 1989): 2752–56. https://doi.org/10.1073/pnas.86.8.2752.
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  - Zhuang, Y., H. Leung, and A. M. Weiner. “The natural 5' splice site of simian virus 40 large T antigen can be improved by increasing the base complementarity to U1 RNA.” Mol Cell Biol 7, no. 8 (August 1987): 3018–20. https://doi.org/10.1128/mcb.7.8.3018-3020.1987.
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  - Zhuang, Yuan, Helios Leung, and Alan M. Weiner. “The Natural 5′ Splice Site of Simian Virus 40 Large T Antigen can be improved by increasing the base Complementarity to U1 RNA.” Molecular and Cellular Biology 7, no. 8 (August 1, 1987): 3018–20. https://doi.org/10.1128/mcb.7.8.3018-3020.1987.
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  - Zhuang, Y., and A. M. Weiner. “A compensatory base change in U1 snRNA suppresses a 5' splice site mutation.” Cell 46, no. 6 (September 12, 1986): 827–35. https://doi.org/10.1016/0092-8674(86)90064-4.
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- Conference Papers
  - Carico, Zachary Mark, BaoJun Zhang, Kingshuk Choudhury, Yuan Zhuang, and Michael S. Krangel. “Mechanisms that diversify an otherwise intrinsically processive Trav-Trqj recombination program.” In Journal of Immunology, Vol. 198. AMER ASSOC IMMUNOLOGISTS, 2017.
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  - Belle, Ian, Joshua Mahlios, and Yuan Zhuang. “Aberrant production of IL-13 by T cells promotes exocrinopathy in Id3 knockout mice.” In Journal of Immunology, Vol. 192. AMER ASSOC IMMUNOLOGISTS, 2014.
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  - Li, Jia, Dereje Jima, Sandeep Dave, and Yuan Zhuang. “Deletion of both Id2 and Id3 in developing T cell promotes NKT lymphoma formation in mice.” In Journal of Immunology, Vol. 192. AMER ASSOC IMMUNOLOGISTS, 2014.
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  - Zhang, Baojun, Yenyu Lin, Meifang Dai, and Yuan Zhuang. “Id3 and Id2 collaboratively regulate innate-like gamma delta T cell development.” In Journal of Immunology, Vol. 192. AMER ASSOC IMMUNOLOGISTS, 2014.
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  - Li, Jia, and Yuan Zhuang. “Double knockout of Id2 & Id3 in developing T cells promotes the development of CD4-CD8-alpha beta T cell.” In Journal of Immunology, Vol. 188. AMER ASSOC IMMUNOLOGISTS, 2012.
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  - Lin, Yen-Yu, Mary Jones-Mason, Makoto Inoue, Antonio Iavarone, Anna Lasorella, Mari Shinohara, and Yuan Zhuang. “Transcriptional regulator Id2 is required for the CD4 T cell immune response in the development of experimental autoimmune encephalomyelitis.” In Journal of Immunology, Vol. 188. AMER ASSOC IMMUNOLOGISTS, 2012.
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  - Mahlios, Josh M., and Yuan Zhuang. “Roles for Id3 in T Cell Development and Autoimmunity.” In Journal of Immunology, Vol. 182. AMER ASSOC IMMUNOLOGISTS, 2009.
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  - Hayakawa, I., and Y. Zhuang. “Id3 controls the developmental window of gamma delta T Cells.” In Journal of Investigative Dermatology, 128:S163–S163. NATURE PUBLISHING GROUP, 2008.
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  - Jia, J. Q., and Y. Zhuang. “Examining TCRVbeta germline transcription at single cell level during normal T cell development.” In Faseb Journal, 19:A15–A15. FEDERATION AMER SOC EXP BIOL, 2005.
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Teaching & Mentoring
Recent Courses
- BIOLOGY 515: Principles of Immunology 2021
- IMMUNOL 544: Principles of Immunology 2021
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- IMM544 Principles of Immunology

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