WildCARDs: inflammatory caspases directly detect LPS.

Journal Article (Journal Article)

Inflammasomes are sensors that serve as activation platforms for caspase-1 - a mechanism that set the prevailing paradigm for inflammatory caspase activation. A recent Nature paper by Shi et al. upends this paradigm by describing an unprecedented model for caspase activation whereby caspase-4, -5, and -11 directly bind their agonist, cytosolic LPS, triggering auto-activation and subsequent pyroptotic cell death.

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Published version (via Digital Object Identifier)
Pubmed Central version

Duke Authors

Miao, Edward A.

Cited Authors

Hagar, JA; Aachoui, Y; Miao, EA

Published Date

February 2015

Published In

Cell Research

Volume / Issue

25 / 2

Start / End Page

149 - 150

PubMed ID

25267404

Pubmed Central ID

PMC4650564

Electronic International Standard Serial Number (EISSN)

1748-7838

International Standard Serial Number (ISSN)

1001-0602

Digital Object Identifier (DOI)

10.1038/cr.2014.128

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