WildCARDs: inflammatory caspases directly detect LPS.

Journal Article (Journal Article)

Inflammasomes are sensors that serve as activation platforms for caspase-1 - a mechanism that set the prevailing paradigm for inflammatory caspase activation. A recent Nature paper by Shi et al. upends this paradigm by describing an unprecedented model for caspase activation whereby caspase-4, -5, and -11 directly bind their agonist, cytosolic LPS, triggering auto-activation and subsequent pyroptotic cell death.

Full Text

Duke Authors

Cited Authors

  • Hagar, JA; Aachoui, Y; Miao, EA

Published Date

  • February 2015

Published In

Volume / Issue

  • 25 / 2

Start / End Page

  • 149 - 150

PubMed ID

  • 25267404

Pubmed Central ID

  • PMC4650564

Electronic International Standard Serial Number (EISSN)

  • 1748-7838

International Standard Serial Number (ISSN)

  • 1001-0602

Digital Object Identifier (DOI)

  • 10.1038/cr.2014.128

Language

  • eng