WildCARDs: inflammatory caspases directly detect LPS.
Publication
, Journal Article
Hagar, JA; Aachoui, Y; Miao, EA
Published in: Cell Res
February 2015
Inflammasomes are sensors that serve as activation platforms for caspase-1 - a mechanism that set the prevailing paradigm for inflammatory caspase activation. A recent Nature paper by Shi et al. upends this paradigm by describing an unprecedented model for caspase activation whereby caspase-4, -5, and -11 directly bind their agonist, cytosolic LPS, triggering auto-activation and subsequent pyroptotic cell death.
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Published In
Cell Res
DOI
EISSN
1748-7838
Publication Date
February 2015
Volume
25
Issue
2
Start / End Page
149 / 150
Location
England
Related Subject Headings
- Lipopolysaccharides
- Immunity, Innate
- Humans
- Developmental Biology
- Caspases, Initiator
- Caspases
- Animals
- 3101 Biochemistry and cell biology
- 1103 Clinical Sciences
- 0601 Biochemistry and Cell Biology
Citation
APA
Chicago
ICMJE
MLA
NLM
Hagar, J. A., Aachoui, Y., & Miao, E. A. (2015). WildCARDs: inflammatory caspases directly detect LPS. Cell Res, 25(2), 149–150. https://doi.org/10.1038/cr.2014.128
Hagar, Jon Alan, Youssef Aachoui, and Edward Axel Miao. “WildCARDs: inflammatory caspases directly detect LPS.” Cell Res 25, no. 2 (February 2015): 149–50. https://doi.org/10.1038/cr.2014.128.
Hagar JA, Aachoui Y, Miao EA. WildCARDs: inflammatory caspases directly detect LPS. Cell Res. 2015 Feb;25(2):149–50.
Hagar, Jon Alan, et al. “WildCARDs: inflammatory caspases directly detect LPS.” Cell Res, vol. 25, no. 2, Feb. 2015, pp. 149–50. Pubmed, doi:10.1038/cr.2014.128.
Hagar JA, Aachoui Y, Miao EA. WildCARDs: inflammatory caspases directly detect LPS. Cell Res. 2015 Feb;25(2):149–150.
Published In
Cell Res
DOI
EISSN
1748-7838
Publication Date
February 2015
Volume
25
Issue
2
Start / End Page
149 / 150
Location
England
Related Subject Headings
- Lipopolysaccharides
- Immunity, Innate
- Humans
- Developmental Biology
- Caspases, Initiator
- Caspases
- Animals
- 3101 Biochemistry and cell biology
- 1103 Clinical Sciences
- 0601 Biochemistry and Cell Biology