WildCARDs: inflammatory caspases directly detect LPS.
Journal Article
Inflammasomes are sensors that serve as activation platforms for caspase-1 - a mechanism that set the prevailing paradigm for inflammatory caspase activation. A recent Nature paper by Shi et al. upends this paradigm by describing an unprecedented model for caspase activation whereby caspase-4, -5, and -11 directly bind their agonist, cytosolic LPS, triggering auto-activation and subsequent pyroptotic cell death.
Full Text
Duke Authors
Cited Authors
- Hagar, JA; Aachoui, Y; Miao, EA
Published Date
- February 2015
Published In
Volume / Issue
- 25 / 2
Start / End Page
- 149 - 150
PubMed ID
- 25267404
Pubmed Central ID
- 25267404
Electronic International Standard Serial Number (EISSN)
- 1748-7838
International Standard Serial Number (ISSN)
- 1001-0602
Digital Object Identifier (DOI)
- 10.1038/cr.2014.128
Language
- eng