The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3.

Journal Article

Vesicular stomatitis virus, a single-stranded RNA virus, triggers activation of the serine-threonine kinases RIP1 and RIP3, which damages mitochondria by activating the GTPase DRP1. This results in excessive production of reactive oxygen species and subsequent activation of the NLRP3 inflammasome.

Full Text

Duke Authors

Cited Authors

  • Rayamajhi, M; Miao, EA

Published Date

  • December 2014

Published In

Volume / Issue

  • 15 / 12

Start / End Page

  • 1100 - 1102

PubMed ID

  • 25396345

Pubmed Central ID

  • PMC5115691

Electronic International Standard Serial Number (EISSN)

  • 1529-2916

Digital Object Identifier (DOI)

  • 10.1038/ni.3030


  • eng

Conference Location

  • United States