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The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3.

Publication ,  Journal Article
Rayamajhi, M; Miao, EA
Published in: Nat Immunol
December 2014
Published version (DOI) Link to item

Vesicular stomatitis virus, a single-stranded RNA virus, triggers activation of the serine-threonine kinases RIP1 and RIP3, which damages mitochondria by activating the GTPase DRP1. This results in excessive production of reactive oxygen species and subsequent activation of the NLRP3 inflammasome.

Duke Scholars

Edward A. Miao
Author Edward A. Miao Integrative Immunobiology
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Published In

Nat Immunol

DOI

10.1038/ni.3030

EISSN

1529-2916

Publication Date

December 2014

Volume

15

Issue

12

Start / End Page

1100 / 1102

Location

United States

Related Subject Headings

  • Signal Transduction
  • Receptor-Interacting Protein Serine-Threonine Kinases
  • RNA Virus Infections
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Inflammasomes
  • Immunology
  • Humans
  • Carrier Proteins
  • Animals
  • 3204 Immunology
 

Citation

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Rayamajhi, M., & Miao, E. A. (2014). The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3. Nat Immunol, 15(12), 1100–1102. https://doi.org/10.1038/ni.3030
Rayamajhi, Manira, and Edward A. Miao. “The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3.” Nat Immunol 15, no. 12 (December 2014): 1100–1102. https://doi.org/10.1038/ni.3030.
Rayamajhi M, Miao EA. The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3. Nat Immunol. 2014 Dec;15(12):1100–2.
Rayamajhi, Manira, and Edward A. Miao. “The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3.” Nat Immunol, vol. 15, no. 12, Dec. 2014, pp. 1100–02. Pubmed, doi:10.1038/ni.3030.
Rayamajhi M, Miao EA. The RIP1-RIP3 complex initiates mitochondrial fission to fuel NLRP3. Nat Immunol. 2014 Dec;15(12):1100–1102.

Published In

Nat Immunol

DOI

10.1038/ni.3030

EISSN

1529-2916

Publication Date

December 2014

Volume

15

Issue

12

Start / End Page

1100 / 1102

Location

United States

Related Subject Headings

  • Signal Transduction
  • Receptor-Interacting Protein Serine-Threonine Kinases
  • RNA Virus Infections
  • NLR Family, Pyrin Domain-Containing 3 Protein
  • Inflammasomes
  • Immunology
  • Humans
  • Carrier Proteins
  • Animals
  • 3204 Immunology