Caspase-11 protects against bacteria that escape the vacuole.
Journal Article
Caspases are either apoptotic or inflammatory. Among inflammatory caspases, caspase-1 and -11 trigger pyroptosis, a form of programmed cell death. Whereas both can be detrimental in inflammatory disease, only caspase-1 has an established protective role during infection. Here, we report that caspase-11 is required for innate immunity to cytosolic, but not vacuolar, bacteria. Although Salmonella typhimurium and Legionella pneumophila normally reside in the vacuole, specific mutants (sifA and sdhA, respectively) aberrantly enter the cytosol. These mutants triggered caspase-11, which enhanced clearance of S. typhimurium sifA in vivo. This response did not require NLRP3, NLRC4, or ASC inflammasome pathways. Burkholderia species that naturally invade the cytosol also triggered caspase-11, which protected mice from lethal challenge with B. thailandensis and B. pseudomallei. Thus, caspase-11 is critical for surviving exposure to ubiquitous environmental pathogens.
Full Text
Duke Authors
Cited Authors
- Aachoui, Y; Leaf, IA; Hagar, JA; Fontana, MF; Campos, CG; Zak, DE; Tan, MH; Cotter, PA; Vance, RE; Aderem, A; Miao, EA
Published Date
- February 2013
Published In
Volume / Issue
- 339 / 6122
Start / End Page
- 975 - 978
PubMed ID
- 23348507
Pubmed Central ID
- 23348507
Electronic International Standard Serial Number (EISSN)
- 1095-9203
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.1230751
Language
- eng