Activation of the NLRP3 inflammasome by intracellular poly I:C.
Published
Journal Article
Several RNA viruses can be detected by the inflammasome, which promotes IL-1β and IL-18 secretion, but the underlying mechanisms of detection remain unclear. Cytosolic dsRNA is a replication intermediate of many RNA viruses. We show here that transfection of the dsRNA analogue poly I:C activates the NLRP3 inflammasome via a pathway requiring endosomal acidification. This detection is independent of the other poly I:C sensors: TLR3 and MDA5. These results suggest a mechanism by which cytosolic dsRNA produced during viral infection could activate the NLRP3 inflammasome.
Full Text
Duke Authors
Cited Authors
- Rajan, JV; Warren, SE; Miao, EA; Aderem, A
Published Date
- November 2010
Published In
Volume / Issue
- 584 / 22
Start / End Page
- 4627 - 4632
PubMed ID
- 20971108
Pubmed Central ID
- 20971108
Electronic International Standard Serial Number (EISSN)
- 1873-3468
International Standard Serial Number (ISSN)
- 0014-5793
Digital Object Identifier (DOI)
- 10.1016/j.febslet.2010.10.036
Language
- eng