Activation of the NLRP3 inflammasome by intracellular poly I:C.
Publication
, Journal Article
Rajan, JV; Warren, SE; Miao, EA; Aderem, A
Published in: FEBS Lett
November 19, 2010
Several RNA viruses can be detected by the inflammasome, which promotes IL-1β and IL-18 secretion, but the underlying mechanisms of detection remain unclear. Cytosolic dsRNA is a replication intermediate of many RNA viruses. We show here that transfection of the dsRNA analogue poly I:C activates the NLRP3 inflammasome via a pathway requiring endosomal acidification. This detection is independent of the other poly I:C sensors: TLR3 and MDA5. These results suggest a mechanism by which cytosolic dsRNA produced during viral infection could activate the NLRP3 inflammasome.
Duke Scholars
Published In
FEBS Lett
DOI
EISSN
1873-3468
Publication Date
November 19, 2010
Volume
584
Issue
22
Start / End Page
4627 / 4632
Location
England
Related Subject Headings
- Transfection
- Poly I-C
- NLR Family, Pyrin Domain-Containing 3 Protein
- Mice
- Macrophages
- Ligands
- Intracellular Space
- Interleukin-1beta
- Inflammasomes
- Hydrogen-Ion Concentration
Citation
APA
Chicago
ICMJE
MLA
NLM
Rajan, J. V., Warren, S. E., Miao, E. A., & Aderem, A. (2010). Activation of the NLRP3 inflammasome by intracellular poly I:C. FEBS Lett, 584(22), 4627–4632. https://doi.org/10.1016/j.febslet.2010.10.036
Rajan, Jayant V., Sarah E. Warren, Edward A. Miao, and Alan Aderem. “Activation of the NLRP3 inflammasome by intracellular poly I:C.” FEBS Lett 584, no. 22 (November 19, 2010): 4627–32. https://doi.org/10.1016/j.febslet.2010.10.036.
Rajan JV, Warren SE, Miao EA, Aderem A. Activation of the NLRP3 inflammasome by intracellular poly I:C. FEBS Lett. 2010 Nov 19;584(22):4627–32.
Rajan, Jayant V., et al. “Activation of the NLRP3 inflammasome by intracellular poly I:C.” FEBS Lett, vol. 584, no. 22, Nov. 2010, pp. 4627–32. Pubmed, doi:10.1016/j.febslet.2010.10.036.
Rajan JV, Warren SE, Miao EA, Aderem A. Activation of the NLRP3 inflammasome by intracellular poly I:C. FEBS Lett. 2010 Nov 19;584(22):4627–4632.
Published In
FEBS Lett
DOI
EISSN
1873-3468
Publication Date
November 19, 2010
Volume
584
Issue
22
Start / End Page
4627 / 4632
Location
England
Related Subject Headings
- Transfection
- Poly I-C
- NLR Family, Pyrin Domain-Containing 3 Protein
- Mice
- Macrophages
- Ligands
- Intracellular Space
- Interleukin-1beta
- Inflammasomes
- Hydrogen-Ion Concentration