Activation of the NLRP3 inflammasome by intracellular poly I:C.

Journal Article (Journal Article)

Several RNA viruses can be detected by the inflammasome, which promotes IL-1β and IL-18 secretion, but the underlying mechanisms of detection remain unclear. Cytosolic dsRNA is a replication intermediate of many RNA viruses. We show here that transfection of the dsRNA analogue poly I:C activates the NLRP3 inflammasome via a pathway requiring endosomal acidification. This detection is independent of the other poly I:C sensors: TLR3 and MDA5. These results suggest a mechanism by which cytosolic dsRNA produced during viral infection could activate the NLRP3 inflammasome.

Full Text

Duke Authors

Cited Authors

  • Rajan, JV; Warren, SE; Miao, EA; Aderem, A

Published Date

  • November 2010

Published In

Volume / Issue

  • 584 / 22

Start / End Page

  • 4627 - 4632

PubMed ID

  • 20971108

Pubmed Central ID

  • PMC3005299

Electronic International Standard Serial Number (EISSN)

  • 1873-3468

International Standard Serial Number (ISSN)

  • 0014-5793

Digital Object Identifier (DOI)

  • 10.1016/j.febslet.2010.10.036


  • eng