Activation of the NLRP3 inflammasome by intracellular poly I:C.

Journal Article (Journal Article)

Several RNA viruses can be detected by the inflammasome, which promotes IL-1β and IL-18 secretion, but the underlying mechanisms of detection remain unclear. Cytosolic dsRNA is a replication intermediate of many RNA viruses. We show here that transfection of the dsRNA analogue poly I:C activates the NLRP3 inflammasome via a pathway requiring endosomal acidification. This detection is independent of the other poly I:C sensors: TLR3 and MDA5. These results suggest a mechanism by which cytosolic dsRNA produced during viral infection could activate the NLRP3 inflammasome.

Full Text

Duke Authors

Miao, Edward A.

Cited Authors

Rajan, JV; Warren, SE; Miao, EA; Aderem, A

Published Date

November 2010

Published In

Febs Letters

Volume / Issue

584 / 22

Start / End Page

4627 - 4632

PubMed ID

20971108

Pubmed Central ID

PMC3005299

Electronic International Standard Serial Number (EISSN)

1873-3468

International Standard Serial Number (ISSN)

0014-5793

Digital Object Identifier (DOI)

10.1016/j.febslet.2010.10.036

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