Gasdermins: Effectors of Pyroptosis.

Journal Article (Journal Article;Review)

Pyroptosis is a form of lytic programmed cell death initiated by inflammasomes, which detect cytosolic contamination or perturbation. This drives activation of caspase-1 or caspase-11/4/5, which cleave gasdermin D, separating its N-terminal pore-forming domain (PFD) from the C-terminal repressor domain (RD). The PFD oligomerizes to form large pores in the membrane that drive swelling and membrane rupture. Gasdermin D is one of six (in humans) gasdermin family members; several other gasdermins have also been shown to form pores that cause pyroptosis after cleavage to activate their PFDs. One of these, gasdermin E, is activated by caspase-3 cleavage. We review our current understanding of pyroptosis as well as current knowledge of the gasdermin family.

Full Text

Duke Authors

Cited Authors

  • Kovacs, SB; Miao, EA

Published Date

  • September 2017

Published In

Volume / Issue

  • 27 / 9

Start / End Page

  • 673 - 684

PubMed ID

  • 28619472

Pubmed Central ID

  • PMC5565696

Electronic International Standard Serial Number (EISSN)

  • 1879-3088

Digital Object Identifier (DOI)

  • 10.1016/j.tcb.2017.05.005

Language

  • eng

Conference Location

  • England