Programmed cell death as a defence against infection.

Journal Article (Journal Article;Review)

Eukaryotic cells can die from physical trauma, which results in necrosis. Alternatively, they can die through programmed cell death upon the stimulation of specific signalling pathways. In this Review, we discuss the role of different cell death pathways in innate immune defence against bacterial and viral infection: apoptosis, necroptosis, pyroptosis and NETosis. We describe the interactions that interweave different programmed cell death pathways, which create complex signalling networks that cross-guard each other in the evolutionary 'arms race' with pathogens. Finally, we describe how the resulting cell corpses - apoptotic bodies, pore-induced intracellular traps (PITs) and neutrophil extracellular traps (NETs) - promote the clearance of infection.

Full Text

Duke Authors

Cited Authors

  • Jorgensen, I; Rayamajhi, M; Miao, EA

Published Date

  • March 2017

Published In

Volume / Issue

  • 17 / 3

Start / End Page

  • 151 - 164

PubMed ID

  • 28138137

Pubmed Central ID

  • PMC5328506

Electronic International Standard Serial Number (EISSN)

  • 1474-1741

Digital Object Identifier (DOI)

  • 10.1038/nri.2016.147


  • eng

Conference Location

  • England