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Programmed cell death as a defence against infection.

Publication ,  Journal Article
Jorgensen, I; Rayamajhi, M; Miao, EA
Published in: Nat Rev Immunol
March 2017

Eukaryotic cells can die from physical trauma, which results in necrosis. Alternatively, they can die through programmed cell death upon the stimulation of specific signalling pathways. In this Review, we discuss the role of different cell death pathways in innate immune defence against bacterial and viral infection: apoptosis, necroptosis, pyroptosis and NETosis. We describe the interactions that interweave different programmed cell death pathways, which create complex signalling networks that cross-guard each other in the evolutionary 'arms race' with pathogens. Finally, we describe how the resulting cell corpses - apoptotic bodies, pore-induced intracellular traps (PITs) and neutrophil extracellular traps (NETs) - promote the clearance of infection.

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Published In

Nat Rev Immunol

DOI

EISSN

1474-1741

Publication Date

March 2017

Volume

17

Issue

3

Start / End Page

151 / 164

Location

England

Related Subject Headings

  • Infections
  • Immunology
  • Immunity, Innate
  • Humans
  • Cell Death
  • Animals
  • 3204 Immunology
  • 1107 Immunology
 

Citation

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Jorgensen, I., Rayamajhi, M., & Miao, E. A. (2017). Programmed cell death as a defence against infection. Nat Rev Immunol, 17(3), 151–164. https://doi.org/10.1038/nri.2016.147
Jorgensen, Ine, Manira Rayamajhi, and Edward A. Miao. “Programmed cell death as a defence against infection.Nat Rev Immunol 17, no. 3 (March 2017): 151–64. https://doi.org/10.1038/nri.2016.147.
Jorgensen I, Rayamajhi M, Miao EA. Programmed cell death as a defence against infection. Nat Rev Immunol. 2017 Mar;17(3):151–64.
Jorgensen, Ine, et al. “Programmed cell death as a defence against infection.Nat Rev Immunol, vol. 17, no. 3, Mar. 2017, pp. 151–64. Pubmed, doi:10.1038/nri.2016.147.
Jorgensen I, Rayamajhi M, Miao EA. Programmed cell death as a defence against infection. Nat Rev Immunol. 2017 Mar;17(3):151–164.

Published In

Nat Rev Immunol

DOI

EISSN

1474-1741

Publication Date

March 2017

Volume

17

Issue

3

Start / End Page

151 / 164

Location

England

Related Subject Headings

  • Infections
  • Immunology
  • Immunity, Innate
  • Humans
  • Cell Death
  • Animals
  • 3204 Immunology
  • 1107 Immunology