Photoreceptor Discs: Built Like Ectosomes.

Journal Article (Journal Article;Review)

The light-sensitive outer segment organelle of the vertebrate photoreceptor cell is a modified cilium filled with hundreds of flattened 'disc' membranes that provide vast light-absorbing surfaces. The outer segment is constantly renewed with new discs added at its base every day. This continuous process is essential for photoreceptor viability. In this review, we describe recent breakthroughs in the understanding of disc morphogenesis, with a focus on the molecular mechanisms responsible for initiating disc formation from the ciliary membrane. We highlight the discoveries that this mechanism evolved from an innate ciliary process of releasing small extracellular vesicles, or ectosomes, and that both disc formation and ectosome release rely on the actin cytoskeleton.

Full Text

Duke Authors

Cited Authors

  • Spencer, WJ; Lewis, TR; Pearring, JN; Arshavsky, VY

Published Date

  • November 2020

Published In

Volume / Issue

  • 30 / 11

Start / End Page

  • 904 - 915

PubMed ID

  • 32900570

Pubmed Central ID

  • PMC7584774

Electronic International Standard Serial Number (EISSN)

  • 1879-3088

Digital Object Identifier (DOI)

  • 10.1016/j.tcb.2020.08.005

Language

  • eng

Conference Location

  • England