Vadim Y Arshavsky
Helena Rubinstein Foundation Distinguished Professor of Ophthalmology
Research conducted in our laboratory is dedicated to understanding how vision is performed on the molecular level. Our most mature direction addresses the function of rod and cone photoreceptors, which are sensory neurons responsible for the detection and primary processing of information entering the eye in the form of photons. Photoreceptors respond to capturing photons by generating electrical signals transmitted to the secondary neurons in the retina and, ultimately, to the brain. Our work is dedicated to uncovering the molecular mechanisms underlying three essential photoreceptor functions: their uniquely high light-sensitivity, their ability to rapidly recover from light excitation, and their capacity to modulate light-responses upon broad variations in the intensity of ambient illumination.
Our second direction is to elucidate the cellular processes responsible for building the light-sensitive organelle of photoreceptor cells, called the outer segment, and for populating this organelle with proteins conducting visual signaling. Of particular interest is the mechanism by which outer segments form their “disc” membrane stacks providing vast membrane surfaces for effective photon capture.
Finally, we are seeking connections between understanding the basic function of rods and cones and practical, translational approaches to ameliorate the retinal degeneration caused by mutations in critical photoreceptor-specific proteins. Most importantly, we explore the link between the balance of protein synthesis and degradation in photoreceptor cells (the “proteostasis”) and the status of their health.
Current Appointments & Affiliations
- Helena Rubinstein Foundation Distinguished Professor of Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery, Ophthalmology 2010
- Professor in Ophthalmology, Ophthalmology, Vitreoretinal Diseases & Surgery, Ophthalmology 2005
- Scientific Director, Ophthalmology, Ophthalmology, Clinical Science Departments 2007
- Co Vice-Chair of Basic Science Research, Ophthalmology, Clinical Science Departments 2021
- Professor in Pharmacology & Cancer Biology, Pharmacology & Cancer Biology, Basic Science Departments 2007
- Professor of Cell Biology, Cell Biology, Basic Science Departments 2022
- Faculty Network Member of the Duke Institute for Brain Sciences, Duke Institute for Brain Sciences, University Institutes and Centers 2008
Contact Information
- Box 3802 Med Ctr, Durham, NC 27710
- Duke Eye Center, 2351 Erwin Rd. Box 3802, 5012 Aeri, Durham, NC 27710
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vadim.arshavsky@duke.edu
(919) 668-5391
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Arshavsky Lab
- Background
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Education, Training, & Certifications
- Ph.D., Lomonosov Moscow State Universty (Russia) 1987
- B.S., Lomonosov Moscow State Universty (Russia) 1981
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Previous Appointments & Affiliations
- Professor of Neurobiology, Neurobiology, Basic Science Departments 2005 - 2007
- Instructor, Temporary of Ophthalmology, Ophthalmology, Clinical Science Departments 2005
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Academic Positions Outside Duke
- Associate Professor, Harvard Medical School. 2000 - 2005
- Assistant Professor, Harvard Medical School. 1995 - 2000
- Assistant Scientist, University of Wisconsin - Madison. 1989 - 1995
- Postdoctoral Researcher, A.N. Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Moscow State University, Russia. 1987 - 1989
- Recognition
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In the News
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MAY 2, 2018 Duke Health News
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- Research
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Selected Grants
- Role of Proteasome Overload in Pathogenesis of Retinitis Pigmentosa awarded by National Institutes of Health 2022 - 2027
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
- Activation of Cellular Proteostasis as an Approach to Treat Inherited Retinal Degenerations awarded by Foundation Fighting Blindness, Inc 2022 - 2025
- Mechanisms of photoreceptor disc maturation awarded by National Institutes of Health 2020 - 2025
- The role of ADAM9 in retinal health and disease awarded by National Institutes of Health 2022 - 2024
- Center Core Grant for Vision Research awarded by National Institutes of Health 2001 - 2023
- Molecular mechanisms of photoreceptor outer segment morphogenesis awarded by National Institutes of Health 2005 - 2023
- In Vivo Modeling of Mitochondrial Complex I Deficiency in Retinal Ganglion Cells awarded by National Institutes of Health 2018 - 2023
- Mechanisms of photoreceptor protein transport and compartmentalization awarded by SUNY Upstate Medical University 2021 - 2022
- Gene therapy treatment of neurodegeneration using proteasome activators awarded by Sio Gene Therapies 2021 - 2022
- Understanding the roles of ectosomes and the associated microglial response in photoreceptor degeneration awarded by Knights Templar Eye Foundation, Inc. 2021 - 2022
- Pathological and functional consequences of dimerization-deficient rhodopsin mutations awarded by National Institutes of Health 2019 - 2022
- Rhodopsin dimerization: mechanistic basis and functional consequences awarded by Weill Medical College of Cornell University 2017 - 2021
- Repulsive mechanisms for spatial segregation of developing neural circuits awarded by National Institutes of Health 2017 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- The Role of Basal Bodies in Wnt Signaling awarded by National Institutes of Health 2007 - 2020
- Coherent light scattering for early detection of Alzheimer's disease awarded by National Institutes of Health 2017 - 2020
- How Do Muller Glia Control Circuit-Specific Retinal Synaptogenesis? awarded by National Institutes of Health 2017 - 2019
- Understanding the function of PRCD, a small protein whose mutations cause blindness awarded by National Institutes of Health 2016 - 2019
- Molecular & cellular cues for circuit assembly in mouse retina awarded by National Institutes of Health 2016 - 2019
- RPB: 2014 Nelson Trust Award awarded by Research To Prevent Blindness, Inc. 2014 - 2019
- Developing a new therapeutic agent for retinal ciliopathies awarded by Rescindo Therapeutics Inc 2017 - 2019
- Identification of unique rod outer segment plasma membrane proteins awarded by National Institutes of Health 2017 - 2019
- Role of impaired protein degradation in photoreceptor degeneration awarded by National Institutes of Health 2013 - 2018
- Understanding the function of PRCD, a small protein whose mutations cause blindness awarded by National Institutes of Health 2015 - 2018
- Understanding Photoreceptor Trafficking Pathways to the Outer Segment awarded by National Institutes of Health 2015 - 2017
- Modifiers of Retinal Phenotypes in Ciliopathies awarded by National Institutes of Health 2011 - 2017
- P30 - Center Core Grant for Vision Research: Administrative Supplement awarded by National Institutes of Health 1997 - 2016
- Coherent light scattering for early detection of retinal disease awarded by National Institutes of Health 2013 - 2016
- Cellular mechanism of targeting peripherin to the sensory cilium awarded by National Institutes of Health 2012 - 2015
- Protein Translocation and Photoreceptor Light Adaptation awarded by National Institutes of Health 1994 - 2012
- Ankyrin G in protein sorting between rod plasma membrane and photoreceptor discs awarded by National Institutes of Health 2010 - 2012
- Proteome Map of the Photoreceptor Cell awarded by National Institutes of Health 2006 - 2009
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External Relationships
- Institute de la Vision
- Progress in Retinal and Eye Research journal
- Research to Prevent Blindness
- Sio Gene Therapies
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Pan, Christopher C., Raquel Maeso-Díaz, Tylor R. Lewis, Kun Xiang, Lianmei Tan, Yaosi Liang, Liuyang Wang, et al. “Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing.” Cell Res, May 11, 2023. https://doi.org/10.1038/s41422-023-00820-4.Full Text Link to Item
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Lewis, Tylor R., Sebastien Phan, Carson M. Castillo, Keun-Young Kim, Kelsey Coppenrath, William Thomas, Ying Hao, et al. “Photoreceptor disc incisures form as an adaptive mechanism ensuring the completion of disc enclosure.” Biorxiv, April 7, 2023. https://doi.org/10.1101/2023.04.06.535932.Full Text Link to Item
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Spencer, William J., Nicholas F. Schneider, Tylor R. Lewis, Carson M. Castillo, Nikolai P. Skiba, and Vadim Y. Arshavsky. “The WAVE complex drives the morphogenesis of the photoreceptor outer segment cilium.” Proc Natl Acad Sci U S A 120, no. 12 (March 21, 2023): e2215011120. https://doi.org/10.1073/pnas.2215011120.Full Text Link to Item
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Skiba, Nikolai P., Tylor R. Lewis, William J. Spencer, Carson M. Castillo, Andrej Shevchenko, and Vadim Y. Arshavsky. “Absolute quantification of photoreceptor outer segment proteins.” Biorxiv, January 20, 2023. https://doi.org/10.1101/2023.01.19.524794.Full Text Link to Item
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Thorson, Molly T., Stephanie E. Wei, Craig Johnson, Christopher J. Gabriel, Vadim Y. Arshavsky, and Jillian N. Pearring. “Nrl:CreERT2 mouse model to induce mosaic gene expression in rod photoreceptors.” Front Mol Neurosci 16 (2023): 1161127. https://doi.org/10.3389/fnmol.2023.1161127.Full Text Link to Item
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Lewis, Tylor R., Sebastien Phan, Keun-Young Kim, Isha Jha, Carson M. Castillo, Jin-Dong Ding, Benjamin S. Sajdak, Dana K. Merriman, Mark H. Ellisman, and Vadim Y. Arshavsky. “Microvesicle release from inner segments of healthy photoreceptors is a conserved phenomenon in mammalian species.” Dis Model Mech 15, no. 12 (November 1, 2022). https://doi.org/10.1242/dmm.049871.Full Text Link to Item
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Hanke-Gogokhia, Christin, Guillermo L. Lehmann, Ignacio Benedicto, Erwin de la Fuente-Ortega, Vadim Y. Arshavsky, Ryan Schreiner, and Enrique Rodriguez-Boulan. “Apical CLC-2 in retinal pigment epithelium is crucial for survival of the outer retina.” Faseb J 35, no. 7 (July 2021): e21689. https://doi.org/10.1096/fj.202100349R.Full Text Link to Item
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Khelashvili, George, Anoop Narayana Pillai, Joon Lee, Kalpana Pandey, Alexander M. Payne, Zarek Siegel, Michel A. Cuendet, et al. “Unusual mode of dimerization of retinitis pigmentosa-associated F220C rhodopsin.” Sci Rep 11, no. 1 (May 18, 2021): 10536. https://doi.org/10.1038/s41598-021-90039-3.Full Text Link to Item
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Lewis, Tylor R., Mustafa S. Makia, Carson M. Castillo, Muayyad R. Al-Ubaidi, Muna I. Naash, and Vadim Y. Arshavsky. “Photoreceptor Disc Enclosure Is Tightly Controlled by Peripherin-2 Oligomerization.” J Neurosci 41, no. 16 (April 21, 2021): 3588–96. https://doi.org/10.1523/JNEUROSCI.0041-21.2021.Full Text Link to Item
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Pearring, Jillian N., Jorge Martínez-Márquez, Jason R. Willer, Eric C. Lieu, Raquel Y. Salinas, and Vadim Y. Arshavsky. “The GARP Domain of the Rod CNG Channel's β1-Subunit Contains Distinct Sites for Outer Segment Targeting and Connecting to the Photoreceptor Disk Rim.” J Neurosci 41, no. 14 (April 7, 2021): 3094–3104. https://doi.org/10.1523/JNEUROSCI.2609-20.2021.Full Text Link to Item
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Maddala, Rupalatha, Junyuan Gao, Richard T. Mathias, Tylor R. Lewis, Vadim Y. Arshavsky, Adriana Levine, Jonathan M. Backer, Anne R. Bresnick, and Ponugoti V. Rao. “Absence of S100A4 in the mouse lens induces an aberrant retina-specific differentiation program and cataract.” Sci Rep 11, no. 1 (January 26, 2021): 2203. https://doi.org/10.1038/s41598-021-81611-y.Full Text Open Access Copy Link to Item
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Sharif, Ali S., Cecilia D. Gerstner, Martha A. Cady, Vadim Y. Arshavsky, Christina Mitchell, Guoxin Ying, Jeanne M. Frederick, and Wolfgang Baehr. “Deletion of the phosphatase INPP5E in the murine retina impairs photoreceptor axoneme formation and prevents disc morphogenesis.” J Biol Chem 296 (2021): 100529. https://doi.org/10.1016/j.jbc.2021.100529.Full Text Link to Item
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Skiba, Nikolai P., Martha A. Cady, Laurie Molday, John Y. S. Han, Tylor R. Lewis, William J. Spencer, Will J. Thompson, et al. “TMEM67, TMEM237, and Embigin in Complex With Monocarboxylate Transporter MCT1 Are Unique Components of the Photoreceptor Outer Segment Plasma Membrane.” Mol Cell Proteomics 20 (2021): 100088. https://doi.org/10.1016/j.mcpro.2021.100088.Full Text Link to Item
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Perfilov, Maxim M., Nadya G. Gurskaya, Ekaterina O. Serebrovskaya, Pavel A. Melnikov, Sergey L. Kharitonov, Tylor R. Lewis, Vadim Y. Arshavsky, Vladimir P. Baklaushev, Alexander S. Mishin, and Konstantin A. Lukyanov. “Highly photostable fluorescent labeling of proteins in live cells using exchangeable coiled coils heterodimerization.” Cell Mol Life Sci 77, no. 21 (November 2020): 4429–40. https://doi.org/10.1007/s00018-019-03426-5.Full Text Link to Item
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Spencer, William J., Tylor R. Lewis, Jillian N. Pearring, and Vadim Y. Arshavsky. “Photoreceptor Discs: Built Like Ectosomes.” Trends Cell Biol 30, no. 11 (November 2020): 904–15. https://doi.org/10.1016/j.tcb.2020.08.005.Full Text Link to Item
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Wang, Luyu, Mikael Klingeborn, Amanda M. Travis, Ying Hao, Vadim Y. Arshavsky, and Sidney M. Gospe. “Progressive optic atrophy in a retinal ganglion cell-specific mouse model of complex I deficiency.” Sci Rep 10, no. 1 (October 1, 2020): 16326. https://doi.org/10.1038/s41598-020-73353-0.Full Text Link to Item
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Ray, Thomas A., Kelly Cochran, Chris Kozlowski, Jingjing Wang, Graham Alexander, Martha A. Cady, William J. Spencer, et al. “Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease.” Nat Commun 11, no. 1 (July 3, 2020): 3328. https://doi.org/10.1038/s41467-020-17009-7.Full Text Link to Item
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Finkelstein, Stella, Sidney M. Gospe, Kai Schuhmann, Andrej Shevchenko, Vadim Y. Arshavsky, and Ekaterina S. Lobanova. “Phosphoinositide Profile of the Mouse Retina.” Cells 9, no. 6 (June 7, 2020). https://doi.org/10.3390/cells9061417.Full Text Link to Item
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Thompson, Debra A., Alessandro Iannaccone, Robin R. Ali, Vadim Y. Arshavsky, Isabelle Audo, James W. B. Bainbridge, Cagri G. Besirli, et al. “Advancing Clinical Trials for Inherited Retinal Diseases: Recommendations from the Second Monaciano Symposium.” Transl Vis Sci Technol 9, no. 7 (June 2020): 2. https://doi.org/10.1167/tvst.9.7.2.Full Text Open Access Copy Link to Item
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Song, Ge, Zachary A. Steelman, Stella Finkelstein, Ziyun Yang, Ludovic Martin, Kengyeh K. Chu, Sina Farsiu, Vadim Y. Arshavsky, and Adam Wax. “Multimodal Coherent Imaging of Retinal Biomarkers of Alzheimer's Disease in a Mouse Model.” Sci Rep 10, no. 1 (May 13, 2020): 7912. https://doi.org/10.1038/s41598-020-64827-2.Full Text Link to Item
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Lewis, Tylor R., Camilla R. Shores, Martha A. Cady, Ying Hao, Vadim Y. Arshavsky, and Marie E. Burns. “The F220C and F45L rhodopsin mutations identified in retinitis pigmentosa patients do not cause pathology in mice.” Sci Rep 10, no. 1 (May 5, 2020): 7538. https://doi.org/10.1038/s41598-020-64437-y.Full Text Link to Item
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Lewis, Tylor R., Mustafa S. Makia, Mashal Kakakhel, Muayyad R. Al-Ubaidi, Vadim Y. Arshavsky, and Muna I. Naash. “Photoreceptor Disc Enclosure Occurs in the Absence of Normal Peripherin-2/rds Oligomerization.” Front Cell Neurosci 14 (2020): 92. https://doi.org/10.3389/fncel.2020.00092.Full Text Link to Item
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Dexter, Paige M., Ekaterina S. Lobanova, Stella Finkelstein, and Vadim Y. Arshavsky. “Probing Proteostatic Stress in Degenerating Photoreceptors Using Two Complementary In Vivo Reporters of Proteasomal Activity.” Eneuro 7, no. 1 (2020). https://doi.org/10.1523/ENEURO.0428-19.2019.Full Text Link to Item
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Spencer, William J., Tylor R. Lewis, Sebastien Phan, Martha A. Cady, Ekaterina O. Serebrovskaya, Nicholas F. Schneider, Keun-Young Kim, et al. “Photoreceptor disc membranes are formed through an Arp2/3-dependent lamellipodium-like mechanism.” Proc Natl Acad Sci U S A 116, no. 52 (December 26, 2019): 27043–52. https://doi.org/10.1073/pnas.1913518117.Full Text Link to Item
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Lobanova, Ekaterina S., Kai Schuhmann, Stella Finkelstein, Tylor R. Lewis, Martha A. Cady, Ying Hao, Casey Keuthan, et al. “Disrupted Blood-Retina Lysophosphatidylcholine Transport Impairs Photoreceptor Health But Not Visual Signal Transduction.” J Neurosci 39, no. 49 (December 4, 2019): 9689–9701. https://doi.org/10.1523/JNEUROSCI.1142-19.2019.Full Text Link to Item
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Gospe, Sidney M., Amanda M. Travis, Alexander V. Kolesnikov, Mikael Klingeborn, Luyu Wang, Vladimir J. Kefalov, and Vadim Y. Arshavsky. “Photoreceptors in a mouse model of Leigh syndrome are capable of normal light-evoked signaling.” J Biol Chem 294, no. 33 (August 16, 2019): 12432–43. https://doi.org/10.1074/jbc.RA119.007945.Full Text Open Access Copy Link to Item
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Spencer, William J., Jin-Dong Ding, Tylor R. Lewis, Chen Yu, Sebastien Phan, Jillian N. Pearring, Keun-Young Kim, et al. “PRCD is essential for high-fidelity photoreceptor disc formation.” Proc Natl Acad Sci U S A 116, no. 26 (June 25, 2019): 13087–96. https://doi.org/10.1073/pnas.1906421116.Full Text Link to Item
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O’Koren, Emily G., Chen Yu, Mikael Klingeborn, Alicia Y. W. Wong, Cameron L. Prigge, Rose Mathew, Joan Kalnitsky, et al. “Microglial Function Is Distinct in Different Anatomical Locations during Retinal Homeostasis and Degeneration.” Immunity 50, no. 3 (March 19, 2019): 723-737.e7. https://doi.org/10.1016/j.immuni.2019.02.007.Full Text Link to Item
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Spencer, William J., and Vadim Y. Arshavsky. “PRCD Is a Small Disc-Specific Rhodopsin-Binding Protein of Unknown Function.” Adv Exp Med Biol 1185 (2019): 531–35. https://doi.org/10.1007/978-3-030-27378-1_87.Full Text Link to Item
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Lobanova, Ekaterina S., Stella Finkelstein, Jing Li, Amanda M. Travis, Ying Hao, Mikael Klingeborn, Nikolai P. Skiba, Raymond J. Deshaies, and Vadim Y. Arshavsky. “Increased proteasomal activity supports photoreceptor survival in inherited retinal degeneration.” Nat Commun 9, no. 1 (April 30, 2018): 1738. https://doi.org/10.1038/s41467-018-04117-8.Full Text Open Access Copy Link to Item
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Sharif, Ali S., Dongmei Yu, Stuart Loertscher, Richard Austin, Kevin Nguyen, Pranav D. Mathur, Anna M. Clark, et al. “C8ORF37 Is Required for Photoreceptor Outer Segment Disc Morphogenesis by Maintaining Outer Segment Membrane Protein Homeostasis.” J Neurosci 38, no. 13 (March 28, 2018): 3160–76. https://doi.org/10.1523/JNEUROSCI.2964-17.2018.Full Text Link to Item
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Travis, Amanda M., Stephanie J. Heflin, Arlene A. Hirano, Nicholas C. Brecha, and Vadim Y. Arshavsky. “Dopamine-Dependent Sensitization of Rod Bipolar Cells by GABA Is Conveyed through Wide-Field Amacrine Cells.” J Neurosci 38, no. 3 (January 17, 2018): 723–32. https://doi.org/10.1523/JNEUROSCI.1994-17.2017.Full Text Link to Item
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Dexter, Paige M., Ekaterina S. Lobanova, Stella Finkelstein, William J. Spencer, Nikolai P. Skiba, and Vadim Y. Arshavsky. “Transducin β-Subunit Can Interact with Multiple G-Protein γ-Subunits to Enable Light Detection by Rod Photoreceptors.” Eneuro 5, no. 3 (2018). https://doi.org/10.1523/ENEURO.0144-18.2018.Full Text Open Access Copy Link to Item
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Salinas, Raquel Y., Jillian N. Pearring, Jin-Dong Ding, William J. Spencer, Ying Hao, and Vadim Y. Arshavsky. “Photoreceptor discs form through peripherin-dependent suppression of ciliary ectosome release.” J Cell Biol 216, no. 5 (May 1, 2017): 1489–99. https://doi.org/10.1083/jcb.201608081.Full Text Link to Item
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Pearring, Jillian N., Jovenal T. San Agustin, Ekaterina S. Lobanova, Christopher J. Gabriel, Eric C. Lieu, William J. Monis, Michael W. Stuck, et al. “Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration.” Plos Genet 13, no. 4 (April 2017): e1006740. https://doi.org/10.1371/journal.pgen.1006740.Full Text Link to Item
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Ploier, Birgit, Lydia N. Caro, Takefumi Morizumi, Kalpana Pandey, Jillian N. Pearring, Michael A. Goren, Silvia C. Finnemann, et al. “Dimerization deficiency of enigmatic retinitis pigmentosa-linked rhodopsin mutants.” Nat Commun 7 (October 3, 2016): 12832. https://doi.org/10.1038/ncomms12832.Full Text Link to Item
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Spencer, William J., Jillian N. Pearring, Raquel Y. Salinas, David R. Loiselle, Nikolai P. Skiba, and Vadim Y. Arshavsky. “Progressive Rod-Cone Degeneration (PRCD) Protein Requires N-Terminal S-Acylation and Rhodopsin Binding for Photoreceptor Outer Segment Localization and Maintaining Intracellular Stability.” Biochemistry 55, no. 36 (September 13, 2016): 5028–37. https://doi.org/10.1021/acs.biochem.6b00489.Full Text Link to Item
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Kim, Sanghoon, Stephanie Heflin, Laura A. Kresty, Meredith Halling, Laura N. Perez, Derek Ho, Michael Crose, et al. “Analyzing spatial correlations in tissue using angle-resolved low coherence interferometry measurements guided by co-located optical coherence tomography.” Biomed Opt Express 7, no. 4 (April 1, 2016): 1400–1414. https://doi.org/10.1364/BOE.7.001400.Full Text Link to Item
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Pearring, Jillian N., William J. Spencer, Eric C. Lieu, and Vadim Y. Arshavsky. “Guanylate cyclase 1 relies on rhodopsin for intracellular stability and ciliary trafficking.” Elife 4 (November 21, 2015). https://doi.org/10.7554/eLife.12058.Full Text Link to Item
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Ding, Jin-Dong, Raquel Y. Salinas, and Vadim Y. Arshavsky. “Discs of mammalian rod photoreceptors form through the membrane evagination mechanism.” J Cell Biol 211, no. 3 (November 9, 2015): 495–502. https://doi.org/10.1083/jcb.201508093.Full Text Link to Item
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Arshavsky, Vadim Y. “Introducing Kirill A. Martemyanov, the 2014 recipient of the Cogan Award.” Invest Ophthalmol Vis Sci 55, no. 12 (December 15, 2014): 8200. https://doi.org/10.1167/iovs.14-14819.Full Text Link to Item
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Pearring, Jillian N., Eric C. Lieu, Joan R. Winter, Sheila A. Baker, and Vadim Y. Arshavsky. “R9AP targeting to rod outer segments is independent of rhodopsin and is guided by the SNARE homology domain.” Mol Biol Cell 25, no. 17 (September 1, 2014): 2644–49. https://doi.org/10.1091/mbc.E14-02-0747.Full Text Link to Item
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Kefalov, Vladimir J., and Vadim Y. Arshavsky. “FASEB Science Research Conference on Biology and Chemistry of Vision.” Faseb J 28, no. 6 (June 2014): 2395–97. https://doi.org/10.1096/fj.14-0602ufm.Full Text Link to Item
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Srinivasan, Pratul P., Stephanie J. Heflin, Joseph A. Izatt, Vadim Y. Arshavsky, and Sina Farsiu. “Automatic segmentation of up to ten layer boundaries in SD-OCT images of the mouse retina with and without missing layers due to pathology.” Biomed Opt Express 5, no. 2 (February 1, 2014): 348–65. https://doi.org/10.1364/BOE.5.000348.Full Text Link to Item
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Arshavsky, Vadim Y., and Marie E. Burns. “Current understanding of signal amplification in phototransduction.” Cell Logist 4 (2014): e29390. https://doi.org/10.4161/cl.29390.Full Text Link to Item
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Arshavsky, Vadim Y., and Theodore G. Wensel. “Timing is everything: GTPase regulation in phototransduction.” Invest Ophthalmol Vis Sci 54, no. 12 (November 21, 2013): 7725–33. https://doi.org/10.1167/iovs.13-13281.Full Text Link to Item
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Lobanova, Ekaterina S., Stella Finkelstein, Nikolai P. Skiba, and Vadim Y. Arshavsky. “Proteasome overload is a common stress factor in multiple forms of inherited retinal degeneration.” Proc Natl Acad Sci U S A 110, no. 24 (June 11, 2013): 9986–91. https://doi.org/10.1073/pnas.1305521110.Full Text Link to Item
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Skiba, Nikolai P., William J. Spencer, Raquel Y. Salinas, Eric C. Lieu, J Will Thompson, and Vadim Y. Arshavsky. “Proteomic identification of unique photoreceptor disc components reveals the presence of PRCD, a protein linked to retinal degeneration.” J Proteome Res 12, no. 6 (June 7, 2013): 3010–18. https://doi.org/10.1021/pr4003678.Full Text Link to Item
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Long, James H., Vadim Y. Arshavsky, and Marie E. Burns. “Absence of synaptic regulation by phosducin in retinal slices.” Plos One 8, no. 12 (2013): e83970. https://doi.org/10.1371/journal.pone.0083970.Full Text Link to Item
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Salinas, Raquel Y., Sheila A. Baker, Sidney M. Gospe, and Vadim Y. Arshavsky. “A single valine residue plays an essential role in peripherin/rds targeting to photoreceptor outer segments.” Plos One 8, no. 1 (2013): e54292. https://doi.org/10.1371/journal.pone.0054292.Full Text Link to Item
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Cohen, Staci P., Brian K. Buckley, Mickey Kosloff, Alaina L. Garland, Dustin E. Bosch, Gang Cheng, Harish Radhakrishna, et al. “Regulator of G-protein signaling-21 (RGS21) is an inhibitor of bitter gustatory signaling found in lingual and airway epithelia.” J Biol Chem 287, no. 50 (December 7, 2012): 41706–19. https://doi.org/10.1074/jbc.M112.423806.Full Text Link to Item
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Umino, Yumiko, Rolf Herrmann, Ching-Kang Chen, Robert B. Barlow, Vadim Y. Arshavsky, and Eduardo Solessio. “The relationship between slow photoresponse recovery rate and temporal resolution of vision.” J Neurosci 32, no. 41 (October 10, 2012): 14364–73. https://doi.org/10.1523/JNEUROSCI.1296-12.2012.Full Text Link to Item
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Rebrik, Tatiana I., Inna Botchkina, Vadim Y. Arshavsky, Cheryl M. Craft, and Juan I. Korenbrot. “CNG-modulin: a novel Ca-dependent modulator of ligand sensitivity in cone photoreceptor cGMP-gated ion channels.” J Neurosci 32, no. 9 (February 29, 2012): 3142–53. https://doi.org/10.1523/JNEUROSCI.5518-11.2012.Full Text Link to Item
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Arshavsky, Vadim Y., and Marie E. Burns. “Photoreceptor signaling: supporting vision across a wide range of light intensities.” J Biol Chem 287, no. 3 (January 13, 2012): 1620–26. https://doi.org/10.1074/jbc.R111.305243.Full Text Link to Item
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Gospe, Sidney M., Sheila A. Baker, Christopher Kessler, Martha F. Brucato, Joan R. Winter, Marie E. Burns, and Vadim Y. Arshavsky. “Membrane attachment is key to protecting transducin GTPase-activating complex from intracellular proteolysis in photoreceptors.” J Neurosci 31, no. 41 (October 12, 2011): 14660–68. https://doi.org/10.1523/JNEUROSCI.3516-11.2011.Full Text Link to Item
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Herrmann, Rolf, Stephanie J. Heflin, Timothy Hammond, Bowa Lee, Jing Wang, Raul R. Gainetdinov, Marc G. Caron, et al. “Rod vision is controlled by dopamine-dependent sensitization of rod bipolar cells by GABA.” Neuron 72, no. 1 (October 6, 2011): 101–10. https://doi.org/10.1016/j.neuron.2011.07.030.Full Text Link to Item
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Kosloff, Mickey, Amanda M. Travis, Dustin E. Bosch, David P. Siderovski, and Vadim Y. Arshavsky. “Integrating energy calculations with functional assays to decipher the specificity of G protein-RGS protein interactions.” Nat Struct Mol Biol 18, no. 7 (June 19, 2011): 846–53. https://doi.org/10.1038/nsmb.2068.Full Text Link to Item
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Osawa, Shoji, Rebecca Jo, Yubin Xiong, Boris Reidel, Nomingerel Tserentsoodol, Vadim Y. Arshavsky, P Michael Iuvone, and Ellen R. Weiss. “Phosphorylation of G protein-coupled receptor kinase 1 (GRK1) is regulated by light but independent of phototransduction in rod photoreceptors.” J Biol Chem 286, no. 23 (June 10, 2011): 20923–29. https://doi.org/10.1074/jbc.M111.230904.Full Text Link to Item
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Reidel, Boris, J Will Thompson, Sina Farsiu, M Arthur Moseley, Nikolai P. Skiba, and Vadim Y. Arshavsky. “Proteomic profiling of a layered tissue reveals unique glycolytic specializations of photoreceptor cells.” Mol Cell Proteomics 10, no. 3 (March 2011): M110.002469. https://doi.org/10.1074/mcp.M110.002469.Full Text Link to Item
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Herrmann, Rolf, Bowa Lee, and Vadim Y. Arshavsky. “RGS9 knockout causes a short delay in light responses of ON-bipolar cells.” Plos One 6, no. 11 (2011): e27573. https://doi.org/10.1371/journal.pone.0027573.Full Text Link to Item
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Gospe, Sidney M., Sheila A. Baker, and Vadim Y. Arshavsky. “Facilitative glucose transporter Glut1 is actively excluded from rod outer segments.” J Cell Sci 123, no. Pt 21 (November 1, 2010): 3639–44. https://doi.org/10.1242/jcs.072389.Full Text Open Access Copy Link to Item
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Kelly, Una, Ling Yu, Pallavi Kumar, Jin-Dong Ding, Haixiang Jiang, Gregory S. Hageman, Vadim Y. Arshavsky, Michael M. Frank, Michael A. Hauser, and Catherine Bowes Rickman. “Heparan sulfate, including that in Bruch's membrane, inhibits the complement alternative pathway: implications for age-related macular degeneration.” J Immunol 185, no. 9 (November 1, 2010): 5486–94. https://doi.org/10.4049/jimmunol.0903596.Full Text Link to Item
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Lobanova, Ekaterina S., Rolf Herrmann, Stella Finkelstein, Boris Reidel, Nikolai P. Skiba, Wen-Tao Deng, Rebecca Jo, Ellen R. Weiss, William W. Hauswirth, and Vadim Y. Arshavsky. “Mechanistic basis for the failure of cone transducin to translocate: why cones are never blinded by light.” J Neurosci 30, no. 20 (May 19, 2010): 6815–24. https://doi.org/10.1523/JNEUROSCI.0613-10.2010.Full Text Link to Item
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Herrmann, Rolf, Ekaterina S. Lobanova, Timothy Hammond, Christopher Kessler, Marie E. Burns, Laura J. Frishman, and Vadim Y. Arshavsky. “Phosducin regulates transmission at the photoreceptor-to-ON-bipolar cell synapse.” J Neurosci 30, no. 9 (March 3, 2010): 3239–53. https://doi.org/10.1523/JNEUROSCI.4775-09.2010.Full Text Link to Item
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Arshavsky, Vadim Y. “Vision: the retinoid cycle in Drosophila.” Curr Biol 20, no. 3 (February 9, 2010): R96–98. https://doi.org/10.1016/j.cub.2009.12.039.Full Text Link to Item
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Rajala, Ammaji, Roger J. Daly, Masaki Tanito, Dustin T. Allen, Lowenna J. Holt, Ekaterina S. Lobanova, Vadim Y. Arshavsky, and Raju V. S. Rajala. “Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation.” Biochemistry 48, no. 24 (June 23, 2009): 5563–72. https://doi.org/10.1021/bi9000062.Full Text Link to Item
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Kelly, Una, Catherine Bowes Rickman, Eric A. Postel, Michael A. Hauser, Gregory S. Hageman, Vadim Y. Arshavsky, and Nikolai P. Skiba. “Rapid and sensitive method for detection of Y402, H402, I62, and V62 variants of complement factor H in human plasma samples using mass spectrometry.” Invest Ophthalmol Vis Sci 50, no. 4 (April 2009): 1540–45. https://doi.org/10.1167/iovs.08-2782.Full Text Link to Item
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Kizhatil, Krishnakumar, Sheila A. Baker, Vadim Y. Arshavsky, and Vann Bennett. “Ankyrin-G promotes cyclic nucleotide-gated channel transport to rod photoreceptor sensory cilia.” Science 323, no. 5921 (March 20, 2009): 1614–17. https://doi.org/10.1126/science.1169789.Full Text Link to Item
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Martemyanov, Kirill A., Claudia M. Krispel, Polina V. Lishko, Marie E. Burns, and Vadim Y. Arshavsky. “Functional comparison of RGS9 splice isoforms in a living cell.” Proc Natl Acad Sci U S A 105, no. 52 (December 30, 2008): 20988–93. https://doi.org/10.1073/pnas.0808941106.Full Text Link to Item
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Kosloff, Mickey, Emil Alexov, Vadim Y. Arshavsky, and Barry Honig. “Electrostatic and lipid anchor contributions to the interaction of transducin with membranes: mechanistic implications for activation and translocation.” J Biol Chem 283, no. 45 (November 7, 2008): 31197–207. https://doi.org/10.1074/jbc.M803799200.Full Text Link to Item
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Baker, Sheila A., Mohammad Haeri, Peter Yoo, Sidney M. Gospe, Nikolai P. Skiba, Barry E. Knox, and Vadim Y. Arshavsky. “The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors.” J Cell Biol 183, no. 3 (November 3, 2008): 485–98. https://doi.org/10.1083/jcb.200806009.Full Text Link to Item
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Zhang, Xiu-Jun, Karyn B. Cahill, Arye Elfenbein, Vadim Y. Arshavsky, and Rick H. Cote. “Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.” J Biol Chem 283, no. 44 (October 31, 2008): 29699–705. https://doi.org/10.1074/jbc.M803948200.Full Text Link to Item
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Lobanova, Ekaterina S., Stella Finkelstein, Rolf Herrmann, Yen-Ming Chen, Christopher Kessler, Norman A. Michaud, Lynn H. Trieu, Katherine J. Strissel, Marie E. Burns, and Vadim Y. Arshavsky. “Transducin gamma-subunit sets expression levels of alpha- and beta-subunits and is crucial for rod viability.” J Neurosci 28, no. 13 (March 26, 2008): 3510–20. https://doi.org/10.1523/JNEUROSCI.0338-08.2008.Full Text Link to Item
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Krispel, Claudia M., Maxim Sokolov, Yen-Ming Chen, Hongman Song, Rolf Herrmann, Vadim Y. Arshavsky, and Marie E. Burns. “Phosducin regulates the expression of transducin betagamma subunits in rod photoreceptors and does not contribute to phototransduction adaptation.” J Gen Physiol 130, no. 3 (September 2007): 303–12. https://doi.org/10.1085/jgp.200709812.Full Text Link to Item
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Yu, Ling, Una Kelly, Jessica N. Ebright, Goldis Malek, Peter Saloupis, Dennis W. Rickman, Brian S. McKay, Vadim Y. Arshavsky, and Catherine Bowes Rickman. “Oxidative stress-induced expression and modulation of Phosphatase of Regenerating Liver-1 (PRL-1) in mammalian retina.” Biochim Biophys Acta 1773, no. 9 (September 2007): 1473–82. https://doi.org/10.1016/j.bbamcr.2007.06.005.Full Text Link to Item
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Hanson, Susan M., Ned Van Eps, Derek J. Francis, Christian Altenbach, Sergey A. Vishnivetskiy, Vadim Y. Arshavsky, Candice S. Klug, Wayne L. Hubbell, and Vsevolod V. Gurevich. “Structure and function of the visual arrestin oligomer.” Embo J 26, no. 6 (March 21, 2007): 1726–36. https://doi.org/10.1038/sj.emboj.7601614.Full Text Link to Item
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Lobanova, Ekaterina S., Stella Finkelstein, Hongman Song, Stephen H. Tsang, Ching-Kang Chen, Maxim Sokolov, Nikolai P. Skiba, and Vadim Y. Arshavsky. “Transducin translocation in rods is triggered by saturation of the GTPase-activating complex.” J Neurosci 27, no. 5 (January 31, 2007): 1151–60. https://doi.org/10.1523/JNEUROSCI.5010-06.2007.Full Text Link to Item
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Calvert, Peter D., Katherine J. Strissel, William E. Schiesser, Edward N. Pugh, and Vadim Y. Arshavsky. “Light-driven translocation of signaling proteins in vertebrate photoreceptors.” Trends Cell Biol 16, no. 11 (November 2006): 560–68. https://doi.org/10.1016/j.tcb.2006.09.001.Full Text Link to Item
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Johnston, Christopher A., Ekaterina S. Lobanova, Alexander S. Shavkunov, Justin Low, J Kevin Ramer, Rainer Blaesius, Zoey Fredericks, et al. “Minimal determinants for binding activated G alpha from the structure of a G alpha(i1)-peptide dimer.” Biochemistry 45, no. 38 (September 26, 2006): 11390–400. https://doi.org/10.1021/bi0613832.Full Text Link to Item
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Baker, Sheila A., Kirill A. Martemyanov, Alexander S. Shavkunov, and Vadim Y. Arshavsky. “Kinetic mechanism of RGS9-1 potentiation by R9AP.” Biochemistry 45, no. 35 (September 5, 2006): 10690–97. https://doi.org/10.1021/bi060376a.Full Text Link to Item
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Krispel, Claudia M., Desheng Chen, Nathan Melling, Yu-Jiun Chen, Kirill A. Martemyanov, Nidia Quillinan, Vadim Y. Arshavsky, Theodore G. Wensel, Ching-Kang Chen, and Marie E. Burns. “RGS expression rate-limits recovery of rod photoresponses.” Neuron 51, no. 4 (August 17, 2006): 409–16. https://doi.org/10.1016/j.neuron.2006.07.010.Full Text Link to Item
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Grant, Jennifer E., Lian-Wang Guo, Martha M. Vestling, Kirill A. Martemyanov, Vadim Y. Arshavsky, and Arnold E. Ruoho. “The N terminus of GTP gamma S-activated transducin alpha-subunit interacts with the C terminus of the cGMP phosphodiesterase gamma-subunit.” J Biol Chem 281, no. 10 (March 10, 2006): 6194–6202. https://doi.org/10.1074/jbc.M509511200.Full Text Link to Item
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Strissel, Katherine J., Maxim Sokolov, Lynn H. Trieu, and Vadim Y. Arshavsky. “Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin.” J Neurosci 26, no. 4 (January 25, 2006): 1146–53. https://doi.org/10.1523/JNEUROSCI.4289-05.2006.Full Text Link to Item
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Burns, Marie E., and Vadim Y. Arshavsky. “Beyond counting photons: trials and trends in vertebrate visual transduction.” Neuron 48, no. 3 (November 3, 2005): 387–401. https://doi.org/10.1016/j.neuron.2005.10.014.Full Text Link to Item
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Strissel, Katherine J., Polina V. Lishko, Lynn H. Trieu, Matthew J. Kennedy, James B. Hurley, and Vadim Y. Arshavsky. “Recoverin undergoes light-dependent intracellular translocation in rod photoreceptors.” J Biol Chem 280, no. 32 (August 12, 2005): 29250–55. https://doi.org/10.1074/jbc.M501789200.Full Text Link to Item
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Sampath, Alapakkam P., Katherine J. Strissel, Rajesh Elias, Vadim Y. Arshavsky, James F. McGinnis, Jeannie Chen, Satoru Kawamura, Fred Rieke, and James B. Hurley. “Recoverin improves rod-mediated vision by enhancing signal transmission in the mouse retina.” Neuron 46, no. 3 (May 5, 2005): 413–20. https://doi.org/10.1016/j.neuron.2005.04.006.Full Text Link to Item
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Martemyanov, Kirill A., Peter J. Yoo, Nikolai P. Skiba, and Vadim Y. Arshavsky. “R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family.” J Biol Chem 280, no. 7 (February 18, 2005): 5133–36. https://doi.org/10.1074/jbc.C400596200.Full Text Link to Item
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Guo, Lian-Wang, Abdol R. Hajipour, Monica L. Gavala, Marty Arbabian, Kirill A. Martemyanov, Vadim Y. Arshavsky, and Arnold E. Ruoho. “Sulfhydryl-reactive, cleavable, and radioiodinatable benzophenone photoprobes for study of protein-protein interaction.” Bioconjug Chem 16, no. 3 (2005): 685–93. https://doi.org/10.1021/bc050016k.Full Text Link to Item
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Strissel, Katherine J., and Vadim Y. Arshavsky. “Myosin III illuminates the mechanism of arrestin translocation.” Neuron 43, no. 1 (July 8, 2004): 2–4. https://doi.org/10.1016/j.neuron.2004.06.026.Full Text Link to Item
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Sokolov, Maxim, Katherine J. Strissel, Ilya B. Leskov, Norman A. Michaud, Viktor I. Govardovskii, and Vadim Y. Arshavsky. “Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse.” J Biol Chem 279, no. 18 (April 30, 2004): 19149–56. https://doi.org/10.1074/jbc.M311058200.Full Text Link to Item
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Keresztes, Gabor, Kirill A. Martemyanov, Claudia M. Krispel, Hideki Mutai, Peter J. Yoo, Stephane F. Maison, Marie E. Burns, Vadim Y. Arshavsky, and Stefan Heller. “Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse.” J Biol Chem 279, no. 3 (January 16, 2004): 1581–84. https://doi.org/10.1074/jbc.C300456200.Full Text Link to Item
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Martemyanov, Kirill A., and Vadim Y. Arshavsky. “Kinetic approaches to study the function of RGS9 isoforms.” Methods Enzymol 390 (2004): 196–209. https://doi.org/10.1016/S0076-6879(04)90013-4.Full Text Link to Item
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Nishiguchi, Koji M., Michael A. Sandberg, Aart C. Kooijman, Kirill A. Martemyanov, Jan W. R. Pott, Stephanie A. Hagstrom, Vadim Y. Arshavsky, Eliot L. Berson, and Thaddeus P. Dryja. “Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation.” Nature 427, no. 6969 (January 1, 2004): 75–78. https://doi.org/10.1038/nature02170.Full Text Link to Item
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Martemyanov, Kirill A., Polina V. Lishko, Nidia Calero, Gabor Keresztes, Maxim Sokolov, Katherine J. Strissel, Ilya B. Leskov, et al. “The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo.” J Neurosci 23, no. 32 (November 12, 2003): 10175–81. https://doi.org/10.1523/JNEUROSCI.23-32-10175.2003.Full Text Link to Item
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Arshavsky, Vadim Y. “Protein translocation in photoreceptor light adaptation: a common theme in vertebrate and invertebrate vision.” Sci Stke 2003, no. 204 (October 14, 2003): PE43. https://doi.org/10.1126/stke.2003.204.pe43.Full Text Link to Item
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Martemyanov, Kirill A., Johnathan A. Hopp, and Vadim Y. Arshavsky. “Specificity of G protein-RGS protein recognition is regulated by affinity adapters.” Neuron 38, no. 6 (June 19, 2003): 857–62. https://doi.org/10.1016/s0896-6273(03)00320-9.Full Text Link to Item
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Hong, Dong-Hyun, Basil Pawlyk, Maxim Sokolov, Katherine J. Strissel, Jun Yang, Brian Tulloch, Alan F. Wright, Vadim Y. Arshavsky, and Tiansen Li. “RPGR isoforms in photoreceptor connecting cilia and the transitional zone of motile cilia.” Invest Ophthalmol Vis Sci 44, no. 6 (June 2003): 2413–21. https://doi.org/10.1167/iovs.02-1206.Full Text Link to Item
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Obin, Martin, Bruce Y. Lee, Gretchen Meinke, Andrew Bohm, Rehwa H. Lee, Rachelle Gaudet, Johnathan A. Hopp, Vadim Y. Arshavsky, Barry M. Willardson, and Allen Taylor. “Ubiquitylation of the transducin betagamma subunit complex. Regulation by phosducin.” J Biol Chem 277, no. 46 (November 15, 2002): 44566–75. https://doi.org/10.1074/jbc.M205308200.Full Text Link to Item
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Arshavsky, Vadim. “Like night and day: rods and cones have different pigment regeneration pathways.” Neuron 36, no. 1 (September 26, 2002): 1–3. https://doi.org/10.1016/s0896-6273(02)00937-6.Full Text Link to Item
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Martemyanov, Kirill A., and Vadim Y. Arshavsky. “Noncatalytic domains of RGS9-1.Gbeta 5L play a decisive role in establishing its substrate specificity.” J Biol Chem 277, no. 36 (September 6, 2002): 32843–48. https://doi.org/10.1074/jbc.M205170200.Full Text Link to Item
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Lishko, Polina V., Kirill A. Martemyanov, Johnathan A. Hopp, and Vadim Y. Arshavsky. “Specific binding of RGS9-Gbeta 5L to protein anchor in photoreceptor membranes greatly enhances its catalytic activity.” J Biol Chem 277, no. 27 (July 5, 2002): 24376–81. https://doi.org/10.1074/jbc.M203237200.Full Text Link to Item
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Tate, Rothwelle J., Vadim Y. Arshavsky, and Nigel J. Pyne. “The identification of the inhibitory gamma-subunits of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase in non-retinal tissues: differential processing of mRNA transcripts.” Genomics 79, no. 4 (April 2002): 582–86. https://doi.org/10.1006/geno.2002.6740.Full Text Link to Item
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Sokolov, Maxim, Arkady L. Lyubarsky, Katherine J. Strissel, Andrey B. Savchenko, Viktor I. Govardovskii, Edward N. Pugh, and Vadim Y. Arshavsky. “Massive light-driven translocation of transducin between the two major compartments of rod cells: a novel mechanism of light adaptation.” Neuron 34, no. 1 (March 28, 2002): 95–106. https://doi.org/10.1016/s0896-6273(02)00636-0.Full Text Link to Item
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Arshavsky, Vadim Y. “Rhodopsin phosphorylation: from terminating single photon responses to photoreceptor dark adaptation.” Trends Neurosci 25, no. 3 (March 2002): 124–26. https://doi.org/10.1016/s0166-2236(00)02094-4.Full Text Link to Item
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Calvert, Peter D., Victor I. Govardovskii, Vadim Y. Arshavsky, and Clint L. Makino. “Two temporal phases of light adaptation in retinal rods.” J Gen Physiol 119, no. 2 (February 2002): 129–45. https://doi.org/10.1085/jgp.119.2.129.Full Text Link to Item
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Arshavsky, Vadim Y., Trevor D. Lamb, and Edward N. Pugh. “G proteins and phototransduction.” Annu Rev Physiol 64 (2002): 153–87. https://doi.org/10.1146/annurev.physiol.64.082701.102229.Full Text Link to Item
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Skiba, N. P., K. A. Martemyanov, A. Elfenbein, J. A. Hopp, A. Bohm, W. F. Simonds, and V. Y. Arshavsky. “RGS9-G beta 5 substrate selectivity in photoreceptors. Opposing effects of constituent domains yield high affinity of RGS interaction with the G protein-effector complex.” J Biol Chem 276, no. 40 (October 5, 2001): 37365–72. https://doi.org/10.1074/jbc.M106431200.Full Text Link to Item
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Govardovskii, V. I., P. D. Calvert, and V. Y. Arshavsky. “Photoreceptor light adaptation. Untangling desensitization and sensitization.” J Gen Physiol 116, no. 6 (December 2000): 791–94. https://doi.org/10.1085/jgp.116.6.791.Full Text Link to Item
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Skiba, N. P., J. A. Hopp, and V. Y. Arshavsky. “The effector enzyme regulates the duration of G protein signaling in vertebrate photoreceptors by increasing the affinity between transducin and RGS protein.” J Biol Chem 275, no. 42 (October 20, 2000): 32716–20. https://doi.org/10.1074/jbc.C000413200.Full Text Link to Item
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Leskov, I. B., V. A. Klenchin, J. W. Handy, G. G. Whitlock, V. I. Govardovskii, M. D. Bownds, T. D. Lamb, E. N. Pugh, and V. Y. Arshavsky. “The gain of rod phototransduction: reconciliation of biochemical and electrophysiological measurements.” Neuron 27, no. 3 (September 2000): 525–37. https://doi.org/10.1016/s0896-6273(00)00063-5.Full Text Link to Item
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Cowan, C. W., T. G. Wensel, and V. Y. Arshavsky. “Enzymology of GTPase acceleration in phototransduction.” Methods Enzymol 315 (2000): 524–38. https://doi.org/10.1016/s0076-6879(00)15865-3.Full Text Link to Item
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Makino, E. R., J. W. Handy, T. Li, and V. Y. Arshavsky. “The GTPase activating factor for transducin in rod photoreceptors is the complex between RGS9 and type 5 G protein beta subunit.” Proc Natl Acad Sci U S A 96, no. 5 (March 2, 1999): 1947–52. https://doi.org/10.1073/pnas.96.5.1947.Full Text Link to Item
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Liu, Y., V. Y. Arshavsky, and A. E. Ruoho. “Interaction sites of the C-terminal region of the cGMP phosphodiesterase inhibitory subunit with the GDP-bound transducin alpha-subunit.” Biochem J 337 ( Pt 2), no. Pt 2 (January 15, 1999): 281–88.Link to Item
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Tsang, S. H., M. E. Burns, P. D. Calvert, P. Gouras, D. A. Baylor, S. P. Goff, and V. Y. Arshavsky. “Role for the target enzyme in deactivation of photoreceptor G protein in vivo.” Science 282, no. 5386 (October 2, 1998): 117–21. https://doi.org/10.1126/science.282.5386.117.Full Text Link to Item
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Arshavsky, V. Y., and E. N. Pugh. “Lifetime regulation of G protein-effector complex: emerging importance of RGS proteins.” Neuron 20, no. 1 (January 1998): 11–14. https://doi.org/10.1016/s0896-6273(00)80430-4.Full Text Link to Item
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Artemyev, N. O., V. Y. Arshavsky, and R. H. Cote. “Photoreceptor phosphodiesterase: interaction of inhibitory gamma subunit and cyclic GMP with specific binding sites on catalytic subunits.” Methods 14, no. 1 (January 1998): 93–104. https://doi.org/10.1006/meth.1997.0568.Full Text Link to Item
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Calvert, P. D., T. W. Ho, Y. M. LeFebvre, and V. Y. Arshavsky. “Onset of feedback reactions underlying vertebrate rod photoreceptor light adaptation.” J Gen Physiol 111, no. 1 (January 1998): 39–51. https://doi.org/10.1085/jgp.111.1.39.Full Text Link to Item
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Tate, R. J., A. Lochhead, H. Brzeski, V. Arshavsky, and N. J. Pyne. “The gamma-subunit of the rod photoreceptor cGMP-binding cGMP-specific PDE is expressed in mouse lung.” Cell Biochem Biophys 29, no. 1–2 (1998): 133–44. https://doi.org/10.1007/BF02737832.Full Text Link to Item
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Lochhead, A., E. Nekrasova, V. Y. Arshavsky, and N. J. Pyne. “The regulation of the cGMP-binding cGMP phosphodiesterase by proteins that are immunologically related to gamma subunit of the photoreceptor cGMP phosphodiesterase.” J Biol Chem 272, no. 29 (July 18, 1997): 18397–403. https://doi.org/10.1074/jbc.272.29.18397.Full Text Link to Item
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Nekrasova, E. R., D. M. Berman, R. R. Rustandi, H. E. Hamm, A. G. Gilman, and V. Y. Arshavsky. “Activation of transducin guanosine triphosphatase by two proteins of the RGS family.” Biochemistry 36, no. 25 (June 24, 1997): 7638–43. https://doi.org/10.1021/bi970427r.Full Text Link to Item
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Pyne, N. J., V. Arshavsky, and A. Lochhead. “cGMP signal termination.” Biochem Soc Trans 24, no. 4 (November 1996): 1019–22. https://doi.org/10.1042/bst0241019.Full Text Link to Item
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Liu, Y., V. Y. Arshavsky, and A. E. Ruoho. “Interaction sites of the COOH-terminal region of the gamma subunit of cGMP phosphodiesterase with the GTP-bound alpha subunit of transducin.” J Biol Chem 271, no. 43 (October 25, 1996): 26900–907. https://doi.org/10.1074/jbc.271.43.26900.Full Text Link to Item
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Binder, B. M., T. M. O’Connor, M. D. Bownds, and V. Y. Arshavsky. “Phosphorylation of non-bleached rhodopsin in intact retinas and living frogs.” J Biol Chem 271, no. 33 (August 16, 1996): 19826–30. https://doi.org/10.1074/jbc.271.33.19826.Full Text Link to Item
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Slepak, V. Z., N. O. Artemyev, Y. Zhu, C. L. Dumke, L. Sabacan, J. Sondek, H. E. Hamm, M. D. Bownds, and V. Y. Arshavsky. “An effector site that stimulates G-protein GTPase in photoreceptors.” J Biol Chem 270, no. 24 (June 16, 1995): 14319–24. https://doi.org/10.1074/jbc.270.24.14319.Full Text Link to Item
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Bownds, M. D., and V. Y. Arshavsky. “What are the mechanisms of photoreceptor adaptation?” Behavioral and Brain Sciences 18, no. 3 (January 1, 1995): 415–24. https://doi.org/10.1017/s0140525x00039170.Full Text
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Arshavsky, V. Y., C. L. Dumke, Y. Zhu, N. O. Artemyev, N. P. Skiba, H. E. Hamm, and M. D. Bownds. “Regulation of transducin GTPase activity in bovine rod outer segments.” J Biol Chem 269, no. 31 (August 5, 1994): 19882–87.Link to Item
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Dumke, C. L., V. Y. Arshavsky, P. D. Calvert, M. D. Bownds, and E. N. Pugh. “Rod outer segment structure influences the apparent kinetic parameters of cyclic GMP phosphodiesterase.” J Gen Physiol 103, no. 6 (June 1994): 1071–98. https://doi.org/10.1085/jgp.103.6.1071.Full Text Link to Item
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Cote, R. H., M. D. Bownds, and V. Y. Arshavsky. “cGMP binding sites on photoreceptor phosphodiesterase: role in feedback regulation of visual transduction.” Proc Natl Acad Sci U S A 91, no. 11 (May 24, 1994): 4845–49. https://doi.org/10.1073/pnas.91.11.4845.Full Text Link to Item
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Sukharev, S. I., B. Martinac, V. Y. Arshavsky, and C. Kung. “Two types of mechanosensitive channels in the Escherichia coli cell envelope: solubilization and functional reconstitution.” Biophys J 65, no. 1 (July 1993): 177–83. https://doi.org/10.1016/S0006-3495(93)81044-0.Full Text Link to Item
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Arshavsky, V. Y., C. L. Dumke, and M. D. Bownds. “Noncatalytic cGMP-binding sites of amphibian rod cGMP phosphodiesterase control interaction with its inhibitory gamma-subunits. A putative regulatory mechanism of the rod photoresponse.” J Biol Chem 267, no. 34 (December 5, 1992): 24501–7.Link to Item
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Arshavsky VYu, M. D., and M. D. Bownds. “Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP.” Nature 357, no. 6377 (June 4, 1992): 416–17. https://doi.org/10.1038/357416a0.Full Text Link to Item
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Arshavsky VYu, M. D., M. P. Gray-Keller, and M. D. Bownds. “cGMP suppresses GTPase activity of a portion of transducin equimolar to phosphodiesterase in frog rod outer segments. Light-induced cGMP decreases as a putative feedback mechanism of the photoresponse.” J Biol Chem 266, no. 28 (October 5, 1991): 18530–37.Link to Item
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Arshavsky VYu, P. P., M. P. Antoch, K. A. Lukjanov, and P. P. Philippov. “Transducin GTPase provides for rapid quenching of the cGMP cascade in rod outer segments.” Febs Lett 250, no. 2 (July 3, 1989): 353–56. https://doi.org/10.1016/0014-5793(89)80754-9.Full Text Link to Item
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Arshavsky VYu, P. P., M. P. Antoch, and P. P. Philippov. “On the role of transducin GTPase in the quenching of a phosphodiesterase cascade of vision.” Febs Lett 224, no. 1 (November 16, 1987): 19–22. https://doi.org/10.1016/0014-5793(87)80414-3.Full Text Link to Item
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ARSHAVSKY, V. Y., M. P. ANTOCH, and P. P. PHILIPPOV. “ON THE ROLE OF TRANSDUCIN GTPASE IN PHOSPHODIESTERASE CASCADE QUENCHING.” Biologicheskie Membrany 4, no. 9 (1987): 900–905.Link to Item
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ARSHAVSKY, V. Y., M. P. ANTOCH, and P. P. PHILIPPOV. “TRANSDUCIN ACTIVATION BY INDIVIDUAL PHOSPHORYLATED FORMS OF RHODOPSIN IN A DETERGENT SOLUTION.” Biologicheskie Membrany 3, no. 12 (December 1, 1986): 1197–1203.Link to Item
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ARSHAVSKY, V. Y., A. M. DIZHOOR, M. P. ANTOCH, S. V. RAKHILIN, and P. P. PHILIPPOV. “TRANSDUCIN AND PHOSPHODIESTERASE ACTIVATION BY DELIPIDATED RHODOPSIN IN DETERGENT SOLUTION.” Biologicheskie Membrany 3, no. 11 (November 1, 1986): 1172–74.Link to Item
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DIZHOOR, A. M., V. Y. ARSHAVSKY, A. D. KAULEN, and P. P. FILIPPOV. “THE MECHANISM OF TRANSDUCIN LIGHT-DEPENDENT ACTIVATION BY RHODOPSIN - GDP GTP EXCHANGE OR PHOSPHORYLATION OF TRANSDUCIN-BOUND GDP.” Biologicheskie Membrany 3, no. 7 (July 1, 1986): 691–96.Link to Item
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Arshavsky, V. Y., A. M. Dizhoor, I. K. Shestakova, and P. Philippov. “The effect of rhodopsin phosphorylation on the light-dependent activation of phosphodiesterase from bovine rod outer segments.” Febs Lett 181, no. 2 (February 25, 1985): 264–66. https://doi.org/10.1016/0014-5793(85)80272-6.Full Text Link to Item
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ARSHAVSKY, V. Y., A. M. DIZHOOR, A. D. KAULEN, I. K. SHESTAKOVA, and P. P. PHILIPPOV. “A LIGHT-SCATTERING STUDY OF THE EFFECTS OF RHODOPSIN PHOSPHORYLATION ON ITS INTERACTION WITH TRANSDUCIN.” Biologicheskie Membrany 2, no. 1 (January 1, 1985): 5–10.Link to Item
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DIZHOOR, A. M., V. Y. ARSHAVSKY, V. O. RYBIN, and P. P. PHILIPPOV. “THE EFFECT OF MEMBRANES ON TRANSDUCIN-DEPENDENT ACTIVATION OF CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE FROM BOVINE ROD OUTER SEGMENTS.” Biologicheskie Membrany 2, no. 3 (January 1, 1985): 272–76.Link to Item
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DIZHOOR, A. M., V. Y. ARSHAVSKY, I. K. SHESTAKOVA, and P. P. PHILIPPOV. “THE EFFECT OF RHODOPSIN PHOSPHORYLATION ON THE LIGHT-DEPENDENT ACTIVATION OF CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE FROM BOVINE ROD OUTER SEGMENTS.” Biologicheskie Membrany 1, no. 10 (January 1, 1984): 1051–56.Link to Item
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Arshavsky, V. Y., V. A. Baryshev, I. I. Brown, A. N. Glagolev, and V. P. Skulachev. “Transmembrane gradient of K+ and Na+ ions as an energy buffer in Halobacterium halobium cells.” Febs Letters 133, no. 1 (October 12, 1981): 22–26. https://doi.org/10.1016/0014-5793(81)80462-0.Full Text
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Book Sections
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Herrmann, R., and V. Y. Arshavsky. “The role of dopamine in fine-tuning cone- and rod-driven vision.” In G Protein Signaling Mechanisms in the Retina, 121–41, 2014. https://doi.org/10.1007/978-1-4939-1218-6_8.Full Text
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Calvert, P. D., and V. Y. Arshavsky. “Light-driven translocation of signaling proteins in vertebrate photoreceptors.” In Encyclopedia of the Eye, Four-Volume Set, 577–80, 2010. https://doi.org/10.1016/B978-0-12-374203-2.00176-7.Full Text
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Calvert, P. D., and V. Y. Arshavsky. “Light-driven translocation of signaling proteins in vertebrate photoreceptors.” In Encyclopedia of the Eye, 577–80, 2010. https://doi.org/10.1016/B978-0-12-374203-2.00176-7.Full Text
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Martemyanov, Kirill A., and Vadim Y. Arshavsky. “Biology and functions of the RGS9 isoforms.,” 86:205–27, 2009. https://doi.org/10.1016/S1877-1173(09)86007-9.Full Text Link to Item
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Other Articles
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Tate, R. J., V. Y. Arshavsky, and N. J. Pyne. “Erratum: The identification of the inhibitory γ-subunits of the type 6 retinal cyclic guanosine monophosphate phosphodiesterase in non-retinal tissues: Differential processing of mRNA transcripts (Genomics (2002) 79 (582-586)).” Genomics, January 1, 2004. https://doi.org/10.1016/j.ygeno.2003.08.001.Full Text
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Conference Papers
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Gospe, Sidney M. I. I. I., Luyu Wang, Mikael Klingeborn, Amanda Travis, Ying Hao, and Vadim Y. Arshavsky. “Progressive Optic Atrophy in a Retinal Ganglion Cell-Specific Mouse Model of Complex I Deficiency.” In Investigative Ophthalmology & Visual Science, Vol. 61, 2020.Link to Item
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Arshavsky, Vadim Y. “How to build a photoreceptor disc?” In Investigative Ophthalmology & Visual Science, Vol. 60. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2019.Link to Item
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Lobanova, Katya, Kai Schuhman, Marie E. Burns, Andrej Shevchenko, and Vadim Y. Arshavsky. “Reduced docosahexaenoic acid content impairs photoreceptor health without affecting visual signal transduction.” In Investigative Ophthalmology & Visual Science, Vol. 60. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2019.Link to Item
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Pearring, Jillian Nydam, Jason Reed Willer, and Vadim Y. Arshavsky. “Ciliary Delivery of the CNG-gated Channel in Rod Photoreceptors.” In Investigative Ophthalmology & Visual Science, Vol. 60. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2019.Link to Item
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Ray, Thomas, Kelly Cochran, William Spencer, Martha Cady, Vadim Y. Arshavsky, and Jeremy Kay. “CRB1 expresses multiple isoforms in multiple retinal cell types - reevaluating CRB1 retinopathies.” In Investigative Ophthalmology & Visual Science, Vol. 60. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2019.Link to Item
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Spencer, William, Jillian Nydam Pearring, Jindong Ding, Nikolai P. Skiba, Marie E. Burns, and Vadim Y. Arshavsky. “PRCD supports the organized structure of the photoreceptor outer segment.” In Investigative Ophthalmology & Visual Science, Vol. 60. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2019.Link to Item
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Maddala, Rupalatha, Kelly Buddin, Vadim Y. Arshavsky, Anne R. Bresnick, and Vasantha Rao Ponugoti. “Deficiency of S100A4, a Ca2+-binding protein, Induces Expression of Neuronal S100A5 and the Retinal Specific Transcriptome in mouse lens.” In Investigative Ophthalmology & Visual Science, Vol. 59. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2018.Link to Item
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Skiba, Nikolai P., Laurie Molday, Robert S. Molday, and Vadim Y. Arshavsky. “Identification of protein components of the rod outer segment plasma membrane by label-free protein correlation profiling.” In Investigative Ophthalmology & Visual Science, Vol. 59. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2018.Link to Item
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Lobanova, Ekaterina, Stella Finkelstein, Nikolai Skiba, and Vadim Y. Arshavsky. “An increase in proteolytic capacity delays photoreceptor loss in retinal degeneration.” In Investigative Ophthalmology & Visual Science, Vol. 58. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2017.Link to Item
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Pearring, J. N., J. T. San Agustin, E. S. Lobanova, C. J. Gabriel, W. J. Monis, E. C. Lieu, M. W. Stuck, V. Y. Arshavsky, and G. J. Pazour. “Loss of Arf4 causes severe degeneration of the exocrine pancreas but not cystic kidney disease or retinal degeneration.” In Molecular Biology of the Cell, Vol. 28, 2017.Link to Item
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Baker, Sheila A., Martha F. Brucato, Vadim Y. Arshavsky, Sarah R. Hengel, Yuan Pan, and Joseph G. Laird. “Investigating Synaptophysin Targeting to the Photoreceptor Synapse.” In Faseb Journal, Vol. 26. FEDERATION AMER SOC EXP BIOL, 2012.Link to Item
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Baker, Sheila A., Martha F. Brucato, Vadim Y. Arshavsky, Sarah R. Hengel, Yuan Pan, and Joseph G. Laird. “Investigating Synaptophysin Targeting to the Photoreceptor Synapse.” In Faseb Journal, Vol. 26, 2012.Link to Item
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Sokolov, M., Y. M. Chen, C. M. Krispel, V. I. Govardovskii, J. Lem, M. E. Burns, and V. Y. Arshavsky. “Phosducin regulates the level of transducin expression in rod photoreceptors.” In Investigative Ophthalmology & Visual Science, Vol. 46. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2005.Link to Item
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Nishiguchi, K., M. A. Sandberg, A. C. Kooijman, K. A. Martemyanov, J. W. R. Pott, S. A. Hagstrom, V. Y. Arshavsky, E. L. Berson, and T. P. Dryja. “Defects in RGS9 or its anchor protein R9AP in patients with bradyopsia, a novel form of retinal dysfunction.” In Investigative Ophthalmology & Visual Science, Vol. 46, 2005.Link to Item
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Martemyanov, K. A., G. Keresztes, C. M. Krispel, P. Lishko, N. Calero, J. Lem, C. K. J. Chen, M. Burns, S. Heller, and V. Y. Arshavsky. “The interaction between the DEP domain of RGS9 and R9AP determines subcellular localization and stability of the RGS9-G beta 5 GTPase activating complex in photoreceptors.” In Investigative Ophthalmology & Visual Science, 45:U798–U798. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2004.Link to Item
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Nishiguchi, K., M. A. Sandberg, A. C. Kooijman, K. A. Martemyanov, J. W. R. Pott, S. A. Hagstrom, V. Y. Arshavsky, E. L. Berson, and T. P. Dryja. “Defects in RGS9 or its anchor protein R9AP in patients with bradyopsia, a novel form of retinal dysfunction.” In Investigative Ophthalmology & Visual Science, 45:U382–U382. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2004.Link to Item
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Sokolov, M., K. J. Strissel, I. B. Leskov, V. I. Govardovskii, and V. Y. Arshavsky. “Analysis of the phosducin knockout mouse reveals roles for phosducin in regulation of transducin beta y subunits level and in the light-dependent transducin translocation.” In Investigative Ophthalmology & Visual Science, 45:U140–U140. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2004.Link to Item
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Strissel, K., M. Sokolov, S. M. Hanson, and V. Y. Arshavsky. “Quantification of light-dependent arrestin translocation in mouse rod photoreceptors.” In Investigative Ophthalmology & Visual Science, 45:U140–U140. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2004.Link to Item
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Grant, J. E., L. W. Guo, M. M. Vestling, K. A. Martemyanov, V. Y. Arshavsky, and A. E. Ruoho. “Crosslinking of full-length intein-derived PDE gamma photoprobes to the G alpha t-GTP gamma S N-terminus.” In Faseb Journal, 18:A972–A972. FEDERATION AMER SOC EXP BIOL, 2004.Link to Item
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Martemyanov, K. A., P. V. Lishko, I. B. Leskov, N. Calero, A. V. Kolesnikov, M. E. Burns, C. J. Chen, and V. Y. Arshavsky. “R9AP regulates the activity of RGS9-GB5 and targets its localization in vivo.” In Investigative Ophthalmology & Visual Science, 44:U135–U135. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2003.Link to Item
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Strissel, K. J., A. Savchenko, A. L. Lyubarsky, M. Sokolov, I. B. Leskov, V. Y. Arshavsky, and E. N. Pugh. “Decrease in amplification of phototransduction correlated with light-dependent transducin translocation in mouse rod photoreceptors.” In Investigative Ophthalmology & Visual Science, 44:U455–U455. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2003.Link to Item
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Guo, L. W., J. E. Grant, A. R. Hajipour, M. Arbabian, A. Granovsky, K. Martemyanov, N. Artemyev, V. Y. Arshavsky, and A. E. Ruoho. “Photoactivable PDE gamma subunits: probes for identifying interactions in visual signal transduction.” In Faseb Journal, 17:A1041–A1041. FEDERATION AMER SOC EXP BIOL, 2003.Link to Item
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Lishko, P. V., K. A. Martemyanov, J. A. Hopp, and V. Y. Arshavsky. “Specific binding of RGS9-G beta 5 to photoreceptor membranes enhances its GAP activity. Requires a protein anchor and occurs via the DEP domain.” In Investigative Ophthalmology & Visual Science, 43:U817–U817. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2002.Link to Item
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Martemyanov, K. A., and V. Y. Arshavsky. “Noncatalytic domains of RGS9-G beta 5 are critical for its selective interaction with the transducin-phosphodiesterase complex in photoreceptors.” In Investigative Ophthalmology & Visual Science, 43:U317–U317. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2002.Link to Item
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Sokolov, M., K. J. Strissel, V. I. Govardovskii, and V. Y. Arshavsky. “Transducin-phosducin interactions in rod inner segments of the light-adapted rat.” In Investigative Ophthalmology & Visual Science, 43:U451–U451. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2002.Link to Item
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Strissel, K. J., M. Sokolov, I. B. Leskov, V. I. Govardovskii, and V. Y. Arshavsky. “An in situ model for investigating mechanisms of light-dependent transducin movement in rod photoreceptors of the rodent retina.” In Investigative Ophthalmology & Visual Science, 43:U311–U311. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2002.Link to Item
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Sokolov, M., K. J. Strissel, V. I. Govardovskii, and V. Y. Arshavsky. “Massive light-dependent movement of transducin from the outer segments of vertebrate rods.” In Investigative Ophthalmology & Visual Science, 42:S186–S186. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2001.Link to Item
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Arshavsky, V. Y., I. B. Leskov, V. A. Klenchin, J. W. Handy, J. L. Berlin, V. I. Govardovskii, E. N. Pugh, T. D. Lamb, and M. D. Bownds. “Signal amplification in the phototransduction cascade: New insights.” In Investigative Ophthalmology & Visual Science, 41:S605–S605. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2000.Link to Item
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Skiba, N. P., J. A. Hopp, E. R. Makino, A. Bohm, W. F. Simonds, and V. Y. Arshavsky. “The role of G protein beta 5 subunit in regulating transducin GTPase.” In Investigative Ophthalmology & Visual Science, 41:S322–S322. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 2000.Link to Item
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Makino, E. R., J. W. Handy, T. Li, and V. Y. Arshavsky. “The GTPase activating factor for transducin in rod outer segments is a tight complex between RGS9 and type 5 G-protein beta-subunit.” In Investigative Ophthalmology & Visual Science, 40:S379–S379. ASSOC RESEARCH VISION OPHTHALMOLOGY INC, 1999.Link to Item
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Calvert, P., and V. Arshavsky. “Onset rates of three feedback reactions that are considered to underlie light adaptation in frog rods.” In Investigative Ophthalmology and Visual Science, Vol. 38, 1997.
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Nekrasova, E. R., D. M. Berman, R. R. Rustandi, H. E. Hamm, A. G. Gilman, and V. Y. Arshavsky. “Activation of transducin GTPase by two proteins from the RGS family.” In Investigative Ophthalmology & Visual Science, 38:2209–2209. LIPPINCOTT-RAVEN PUBL, 1997.Link to Item
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Liu, Y., V. Arshavsky, and A. Ruoho. “Interaction sites of the C-terminal region of the 7 subunit of cgmp phosphodiesterase(P7) with the Q subunit of transducin (AT).” In Faseb Journal, 10:A1374, 1996.
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ARSHAVSKY, V. Y., T. W. HO, C. L. DUMKE, and M. D. BOWNDS. “THE INHIBITION OF TRANSDUCIN GTPASE BY CGMP REQUIRES THE OCCUPATION OF BOTH NONCATALYTIC CGMP-BINDING SITES ON FROG ROD CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE.” In Investigative Ophthalmology & Visual Science, 36:S381–S381. LIPPINCOTT-RAVEN PUBL, 1995.Link to Item
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ARSHAVSKY, V. Y., V. Z. SLEPAK, Y. ZHU, M. I. SIMON, and M. D. BOWNDS. “MECHANISM OF TRANSDUCIN GTPASE REGULATION BY THE GAMMA-SUBUNIT OF CGMP PHOSPHODIESTERASE FROM BOVINE ROD OUTER SEGMENTS.” In Biophysical Journal, 66:A355–A355. BIOPHYSICAL SOCIETY, 1994.Link to Item
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ARSHAVSKY, V. Y., C. L. DUMKE, N. O. ARTEMYEV, H. E. HAMM, and M. D. BOWNDS. “TRANSDUCTION GTPASE ACTIVITY IN BOVINE ROD OUTER SEGMENTS IS ACCELERATED BY THE GAMMA-SUBUNIT OF CGMP PHOSPHODIESTERASE.” In Investigative Ophthalmology & Visual Science, 34:1068–1068. LIPPINCOTT-RAVEN PUBL, 1993.Link to Item
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ARSHAVSKY, V. Y., M. P. GRAYKELLER, and M. D. BOWNDS. “CYCLIC-GMP REGULATION OF TRANSDUCIN GTPASE ACTIVITY IN AMPHIBIAN RODS RESIDES IN CGMP PHOSPHODIESTERASE.” In Investigative Ophthalmology & Visual Science, 33:1103–1103. LIPPINCOTT-RAVEN PUBL, 1992.Link to Item
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BOWNDS, M. D., V. Y. ARSHAVSKY, P. D. CALVERT, and C. L. DUMKE. “ROD OUTER SEGMENT CONCENTRATION AND STRUCTURE INFLUENCE THE APPARENT KINETICS OF CGMP PHOSPHODIESTERASE.” In Investigative Ophthalmology & Visual Science, 33:873–873. LIPPINCOTT-RAVEN PUBL, 1992.Link to Item
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GRAYKELLER, M. P., V. Y. ARSHAVSKY, and M. D. BOWNDS. “CGMP REGULATES SEVERAL SITES IN THE TRANSDUCTION CASCADE OF FROG RETINAL RODS BY MEANS OF A NEGATIVE FEEDBACK LOOP.” In Investigative Ophthalmology & Visual Science, 32:1053–1053. LIPPINCOTT-RAVEN PUBL, 1991.Link to Item
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