Recent trends in protein and peptide-based biomaterials for advanced drug delivery.

Journal Article (Review;Journal Article)

Engineering protein and peptide-based materials for drug delivery applications has gained momentum due to their biochemical and biophysical properties over synthetic materials, including biocompatibility, ease of synthesis and purification, tunability, scalability, and lack of toxicity. These biomolecules have been used to develop a host of drug delivery platforms, such as peptide- and protein-drug conjugates, injectable particles, and drug depots to deliver small molecule drugs, therapeutic proteins, and nucleic acids. In this review, we discuss progress in engineering the architecture and biological functions of peptide-based biomaterials -naturally derived, chemically synthesized and recombinant- with a focus on the molecular features that modulate their structure-function relationships for drug delivery.

Full Text

Duke Authors

Cited Authors

  • Varanko, A; Saha, S; Chilkoti, A

Published Date

  • January 2020

Published In

Volume / Issue

  • 156 /

Start / End Page

  • 133 - 187

PubMed ID

  • 32871201

Pubmed Central ID

  • PMC7456198

Electronic International Standard Serial Number (EISSN)

  • 1872-8294

International Standard Serial Number (ISSN)

  • 0169-409X

Digital Object Identifier (DOI)

  • 10.1016/j.addr.2020.08.008

Language

  • eng