Ashutosh Chilkoti
Alan L. Kaganov Distinguished Professor of Biomedical Engineering
Ashutosh Chilkoti is the Alan L. Kaganov Professor of Biomedical Engineering and Chair of the Department of Biomedical Engineering at Duke University.
My research in biomolecular engineering and biointerface science focuses on the development of new molecular tools and technologies that borrow from molecular biology, protein engineering, polymer chemistry and surface science that we then exploit for the development of applications that span the range from bioseparations, plasmonic biosensors, low-cost clinical diagnostics, and drug delivery.
Current Research Interests
Focused on biomolecular materials and biointerface science and emphasizes the development of applications that span the range from bioseparations, biosensors, biomaterials, and targeted drug delivery.
Current Appointments & Affiliations
- Alan L. Kaganov Distinguished Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2016
- Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2006
- Professor in the Department of Chemistry, Chemistry, Trinity College of Arts & Sciences 2009
- Research Professor of Global Health, Duke Global Health Institute, University Institutes and Centers 2020
- Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 1996
- Core Faculty in Innovation & Entrepreneurship, Duke Innovation & Entrepreneurship, Initiatives 2018
Contact Information
- 1427 CIEMAS, Durham, NC 27708
- Box 90281, Durham, NC 27708-0281
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(919) 660-5373
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Google Scholar
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http://chilkotilab.pratt.duke.edu
- Background
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Education, Training, & Certifications
- Ph.D., University of Washington 1991
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Previous Appointments & Affiliations
- Professor in the Department of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2016 - 2021
- Chair of the Department of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2014 - 2021
- Theo Pilkington Distinguished Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2008 - 2016
- Professor in the Department of Mechanical Engineering and Materials Science, Thomas Lord Department of Mechanical Engineering and Materials Science, Pratt School of Engineering 2012 - 2015
- Director of the Center for Biologically Inspired Materials and Material Systems, Biomedical Engineering, Pratt School of Engineering 2007 - 2010
- Professor of Chemistry, Chemistry, Trinity College of Arts & Sciences 2006 - 2009
- Associate Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 2002 - 2006
- Assistant Professor of Biomedical Engineering, Biomedical Engineering, Pratt School of Engineering 1996 - 2002
- Recognition
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In the News
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DEC 6, 2021 Pratt School of Engineering -
AUG 26, 2020 Pratt School of Engineering -
APR 28, 2020 Pratt School of Engineering -
MAR 12, 2020 Pratt School of Engineering -
NOV 26, 2019 -
OCT 29, 2019 Pratt School of Engineering -
SEP 16, 2019 Pratt School of Engineering -
OCT 30, 2018 Pratt School of Engineering -
OCT 15, 2018 Pratt School of Engineering -
SEP 7, 2017 Pratt School of Engineering -
AUG 8, 2017 Pratt School of Engineering -
AUG 8, 2017 The Engineer -
JUN 5, 2017 Pratt School of Engineering -
JAN 30, 2017 Pratt School of Engineering -
NOV 30, 2016 Pratt School of Engineering -
MAR 29, 2016 WRAL Tech Wire -
JAN 5, 2016 Pratt School of Engineering -
SEP 21, 2015 Pratt School of Engineering -
AUG 5, 2015 AZoNano -
AUG 4, 2015 Pratt School of Engineering -
DEC 16, 2014 Pratt School of Engineering -
OCT 9, 2014 Pratt School of Engineering -
AUG 8, 2014 Pratt School of Engineering
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Awards & Honors
- Distinguished Alumnus Award. Indian Institute of Technology Delhi, India. 2015
- Fellow. National Academy of Inventors. 2014
- Pritzker Distinguished Lecture Award. Biomedical Engineering Society. 2013
- Clemson Award for Contributions to the Literature. Society for Biomaterials. 2011
- Clemson Award for Contributions to the Literature. Society for Biomaterials. 2011
- Humboldt Senior Researcher Award. Alexander Von Humboldt Foundation. 2010
- Stansell Family Distinguished Research Award. Duke University, Pratt School of Engineering. 2008
- Fellow. American Institute for Medical and Biological Engineering. 1996
- Expertise
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Global Scholarship
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Research
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Teaching
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- Research
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Selected Grants
- Medical Scientist Training Program awarded by National Institutes of Health 2022 - 2027
- University Training Program in Biomolecular and Tissue Engineering awarded by National Institutes of Health 1994 - 2027
- Duke Program of Training in Pulmonary ReSearch to Promote, Engage and Retain Academic Researchers (PROSPER) awarded by National Institutes of Health 2022 - 2026
- A Fully Integrated Point-of-Care Test for Ebola awarded by National Institutes of Health 2020 - 2025
- Uncovering and applying the design principles of multiphasic natural and synthetic organelles awarded by Princeton University 2020 - 2025
- Pharmacological Sciences Training Grant awarded by National Institutes of Health 2020 - 2025
- Investigating the role of RNP granules during heart regeneration in the zebrafish awarded by American Heart Association 2022 - 2025
- Point-of-care cellular and molecular pathology of breast tumors on a cell phone awarded by National Institutes of Health 2020 - 2025
- Injectable PEG-like Conjugate for Sustained Delivery of a Peptide Drug for Type 2 Diabetes Treatment awarded by National Institutes of Health 2020 - 2024
- The mechanical role of the glycocalyx in cancer cell adhesion awarded by National Institutes of Health 2020 - 2024
- Detection of Operationally Relevant Biomarkers - preproposal awarded by Advanced Technology International 2020 - 2024
- Multiplex point-of-care test for diagnosis, prognosis and serology of COVID19 awarded by National Institutes of Health 2021 - 2024
- Printed Electronic Biosensors for Point-of-Care Testing of Cardiovascular Biomarkers awarded by National Institutes of Health 2019 - 2024
- Plasmonically Enhanced Point-of-care Detection of Cardiac Biomarkers by a Smart Phone awarded by National Institutes of Health 2019 - 2024
- Genetically Encoded Smart Biohybrid Materials awarded by National Institutes of Health 2018 - 2023
- Smartphone Enabled Point-of-Care Detection of Serum Markers of Liver Cancer awarded by National Institutes of Health 2017 - 2023
- Duke CTSA (TL1) Year 5 awarded by National Institutes of Health 2018 - 2023
- Multidisciplinary Heart and Vascular Diseases awarded by National Institutes of Health 1975 - 2023
- Generation of antibodies specific for optimal non-HRP2 malaria diagnostic antigens awarded by National Institutes of Health 2020 - 2023
- Rapid diagnosis and quantification of HIV by direct capture, labelling and detection of individual virions awarded by National Institutes of Health 2019 - 2022
- CA191146: Long-acting PEG-like conjugates of an immune checkpoint inhibitor and a selective cytokine for combination immunotherapy awarded by United States Army Medical Research Acquisition Activity 2020 - 2022
- Image-Guided Radiation Therapy System for Small Animals awarded by National Institutes of Health 2021 - 2022
- Medical Scientist Training Program awarded by National Institutes of Health 1997 - 2022
- Tissue-Specific Biomarkers for the Diagnosis of Human Kidney Disease awarded by Regents of the University of Michigan 2021 - 2022
- DMREF: Collaborative Research: High throughput Exploration of Sequence Space of Peptide Polymers that Exhibit Aqueous Demixing Phase Behavior awarded by National Science Foundation 2017 - 2021
- A Point-of-Injury Screening Assay for Tactical Damage Control Resuscitation awarded by United States Army Medical Research and Materiel Command 2017 - 2021
- Development of a Novel Point-of Care Prognostic Test of Neural Injury for Dogs awarded by North Carolina State University 2019 - 2021
- Center for Environmental Implications of Nanotechnology awarded by National Science Foundation 2008 - 2021
- Image-guided Dosimetry for Injectable Brachytherapy based on Elastin-like Polypeptide Nanoparticles awarded by National Institutes of Health 2017 - 2021
- Non-Immunogenic PEG-like conjugates of Uricase awarded by Gateway Bio, Inc. 2020 - 2021
- Multivalent Immunomodulatory Proteins for Targeted Cancer Therapy awarded by North Carolina Biotechnology Center 2020 - 2021
- In situ Enzymatic Synthesis of Aptamer Targeted Polynucleotide Drug Nanoparticles for Cancer Therapy (Year 2) awarded by National Institutes of Health 2018 - 2021
- Exploration and Development of Glycoconjugation "Click" Cycloaddition of Azide Polysaccharide and Alkyne CRM197 awarded by Pfizer, Inc. 2017 - 2021
- RAPID: Combined Antigen and Serology Rapid Test for COVID-19 awarded by National Science Foundation 2020 - 2021
- A novel sustained-release immunotoxin for treatment of glioblastoma multiforme awarded by National Institutes of Health 2019 - 2021
- Pharmacological Sciences Training Program awarded by National Institutes of Health 1975 - 2020
- A point-of-care, biomarker-based test to predict non-healing in chronic wounds awarded by The Plastic Surgery Foundation 2018 - 2020
- Point of Care Testing to Improve Monitoring of LVAD Patients awarded by National Institutes of Health 2018 - 2020
- Printable immunoassays using nanomaterial transistors for biological detection of severe acute malnutrition awarded by National Institutes of Health 2018 - 2019
- Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer awarded by National Institutes of Health 2018 - 2019
- Engineering Biology for Medicine awarded by North Carolina Biotechnology Center 2019
- Collaborative Research: Supramolecular Materials by Nucleic Acid Block Copolymer Selfassembly awarded by National Science Foundation 2014 - 2019
- Delivery of Paclitaxel by Recombinant Polypeptide Nanoparticles awarded by Dr. Reddy's Laboratories Ltd. 2017 - 2019
- SO150005: Smartphone Enabled Point-of-care Diagnostics for Operationally Significant Pathogens awarded by United States Army Medical Research Acquisition Activity 2016 - 2019
- Self-assembled microporous networks for cell culture awarded by EMD Millipore 2017 - 2019
- OptiDiag: Optimizing diagnosis and management of acute malnutrition awarded by Action Contre La Faim 2015 - 2018
- Non-immunogenic PEG conjugates of Biologics awarded by North Carolina Biotechnology Center 2016 - 2018
- MRI: Acquisition of a Triple Quadrupole LC/MS System awarded by National Science Foundation 2015 - 2018
- Treating Melanoma with a Molecularly Engineered, Long Circulating Immunotoxin awarded by National Institutes of Health 2015 - 2018
- Elastin Fusion Proteins awarded by National Institutes of Health 2000 - 2018
- Delivery of Cis-Platinate by Recombinant Polypeptide Nanoparticles awarded by Dr. Reddy's Laboratories Ltd. 2017 - 2018
- Acquisition of a MALDI-TOF Mass Spectrometer System at Duke University awarded by North Carolina Biotechnology Center 2017 - 2018
- Assessing the Manufacturability of a "Next-Gen" Non-Immunogenic PEG-like Conjugate awarded by North Carolina Biotechnology Center 2016 - 2017
- One-Pot Synthesis of Multicomponent Protein-Carbohydrate Antigens awarded by Pfizer, Inc. 2016 - 2017
- Texas State University PREM: Center on Interfaces in Materials awarded by Texas State University 2012 - 2017
- Thermally Triggered Multivalent Targeting of Tumors awarded by National Institutes of Health 2007 - 2016
- Thermally Targeted Drug Delivery by Elastin Biopolymers awarded by National Institutes of Health 2002 - 2016
- Protease Operated Depot for Delivery of GLP-1 awarded by National Institutes of Health 2012 - 2016
- A general, enzyme-based method of producing site-specific antibody-toxin conjugates for the treatment of cancer awarded by National Institutes of Health 2015 - 2016
- Local Radionuclide Delivery to Solid Tumors by Injectible Biopolymer awarded by National Institutes of Health 2009 - 2016
- Site-Specific Growth of Stealth Polymer from Peptide Therapeutics awarded by National Institutes of Health 2011 - 2015
- Surface Initiated Enzymatic Polymerization of DNA Nanostructures for Highly Amplified Sensing awarded by National Science Foundation 2010 - 2015
- 2-D Diffusion Assay on Polymer Brush for POC Cardiac Infarction Diagnosis awarded by National Institutes of Health 2012 - 2015
- Live-Animal Micro-CT System awarded by National Institutes of Health 2012 - 2014
- NSF MRI Research Triangle X-Ray Scattering Instrumentation: SAXS/WAXS/GISAXS awarded by National Science Foundation 2012 - 2013
- Inhibition of metastasis-initiating cells by chimeric polypeptide nanoparticles awarded by National Institutes of Health 2010 - 2012
- Delivery of Peptide Therapeutics by Molecular Release Depots awarded by National Institutes of Health 2010 - 2012
- Detection of Biomolecules by Nanoscale Plasmon Ruler awarded by National Institutes of Health 2009 - 2012
- Genetically Designed Materials for Cartilage Repair awarded by National Institutes of Health 2003 - 2012
- Small Animal PET / CT Molecular Imaging awarded by National Institutes of Health 2011 - 2012
- Plasmonic assay for detection of biomarkers at the single-molecule level awarded by National Institutes of Health 2009 - 2011
- Intravital point-scanning confocal microscope awarded by National Institutes of Health 2010 - 2011
- Molecular Imaging Using Hyperspectral Darkfield Microscope of Nanoparticles awarded by National Science Foundation 2007 - 2011
- NIRT: Hierarchical Bionanomanufacturing awarded by National Science Foundation 2006 - 2010
- Thermally-Induced Intra-Articular Drug Delivery System awarded by National Institutes of Health 2006 - 2009
- Training in Biomolecular and Tissue Engineering awarded by National Institutes of Health 2003 - 2009
- Elastin Fusion Proteins awarded by National Institutes of Health 2000 - 2009
- Nanophotonics for Select Agent Detection awarded by Centers for Disease Control and Prevention 2003 - 2008
- Nanophotonics for Select Agent Detection awarded by Centers for Disease Control and Prevention 2003 - 2008
- Nanophotonics for Select Agent Detection awarded by Centers for Disease Control and Prevention 2003 - 2008
- NER: Integrated Magnetic and Chemical Assembly Techniques for Building Nanoparticle Arrays awarded by National Science Foundation 2006 - 2008
- pH Sensitive Elastic-Like-Peptides for Tumor Targeting awarded by National Institutes of Health 2006 - 2008
- Biointerface Science GRC awarded by Army Research Office 2006 - 2007
- Thermally Targeted Drug Delivery by Elastin Biopolymers awarded by National Institutes of Health 2002 - 2007
- Nanofabrication of Polymer-Functionalized Surfaces Using Scanning Probe Lithography awarded by National Science Foundation 2002 - 2006
- Upgrade of a Shared Instrumentation Resource in the PSOE: The Laser Scanning Confocal Microscope awarded by Lord Foundation of North Carolina 2002 - 2005
- Elastin Fusion Proteins awarded by National Institutes of Health 2000 - 2005
- The AVS2004 Biomaterials Interfaces Symposium awarded by National Institutes of Health 2004 - 2005
- Acquisition of an Imaging XPS for Materials Research and Training awarded by National Science Foundation 2002 - 2004
- Elastin Bioelastomers for Microactuation awarded by Office of Naval Research 2000 - 2002
- CAREER: Smart Protein-Polymer Conjugates for Biotechnology awarded by National Science Foundation 1998 - 2002
- CAREER: Smart Protein - Polymer Conjugates for Biotechnology awarded by National Science Foundation 1998 - 2002
- Engineered Protein-Polymer Conjugates for Biotechnology awarded by National Science Foundation 1998 - 2002
- Elastin Nanobiosensors awarded by National Science Foundation 2000 - 2002
- Extrinsic Modulation of Protein-Ligand Recognition awarded by National Institutes of Health 1998 - 2000
- Extrinsic Modulation of Protein/Ligand Recognition awarded by National Institutes of Health 1998 - 2000
- An Engineering Outreach Program for High School Students at Duke University awarded by Lord Foundation of North Carolina 1998 - 1999
- Laboratories in Biomedical and Cellular Engineering awarded by Lord Foundation of North Carolina 1998 - 1999
- Isothermal Titration Calorimetry for Biological Research awarded by Division of Undergraduate Education 1998 - 1999
- Combined Atomic Force and Total Internal Reflection Fluorescence Microscopy for Biological Research awarded by National Science Foundation 1997 - 1999
- Matching Funds for Combined Atomic Force & Optical... awarded by Lord Foundation of North Carolina 1997 - 1998
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External Relationships
- BioStealth
- GatewayBio
- Isolere Bio, Inc
- PhaseBio Pharmaceuticals Inc.
- inSoma Bio, Inc
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Lin, Kevin H., Justine C. Rutter, Abigail Xie, Shane T. Killarney, Camille Vaganay, Chaima Benaksas, Frank Ling, et al. “P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia.” Nat Cancer, June 6, 2022. https://doi.org/10.1038/s43018-022-00394-x.Full Text Link to Item
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Kinnamon, David S., Jacob T. Heggestad, Jason Liu, and Ashutosh Chilkoti. “Technologies for Frugal and Sensitive Point-of-Care Immunoassays.” Annual Review of Analytical Chemistry (Palo Alto, Calif.) 15, no. 1 (June 2022): 123–49. https://doi.org/10.1146/annurev-anchem-061020-123817.Full Text
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Milligan, Joshua J., Soumen Saha, Irene C. Jenkins, and Ashutosh Chilkoti. “Genetically encoded elastin-like polypeptide nanoparticles for drug delivery.” Current Opinion in Biotechnology 74 (April 2022): 146–53. https://doi.org/10.1016/j.copbio.2021.11.006.Full Text
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Ozer, Imran, Garrett Kelly, Renpeng Gu, Xinghai Li, Nikita Zakharov, Parul Sirohi, Smita K. Nair, et al. “Polyethylene Glycol-Like Brush Polymer Conjugate of a Protein Drug Does Not Induce an Antipolymer Immune Response and Has Enhanced Pharmacokinetics than Its Polyethylene Glycol Counterpart.” Adv Sci (Weinh) 9, no. 11 (April 2022): e2103672. https://doi.org/10.1002/advs.202103672.Full Text Link to Item
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Semeniak, Daria, Daniela F. Cruz, Ashutosh Chilkoti, and Maiken H. Mikkelsen. “Plasmonic Fluorescence Enhancement in Diagnostics for Clinical Tests at Point-of-Care: A Review of Recent Technologies.” Advanced Materials (Deerfield Beach, Fla.), March 25, 2022, e2107986. https://doi.org/10.1002/adma.202107986.Full Text
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Kelly, Garrett, Joshua J. Milligan, Eric M. Mastria, Sarah Kim, Stephanie R. Zelenetz, Jarrett Dobbins, Leon Y. Cai, Xinghai Li, Smita K. Nair, and Ashutosh Chilkoti. “Intratumoral delivery of brachytherapy and immunotherapy by a thermally triggered polypeptide depot.” J Control Release 343 (March 2022): 267–76. https://doi.org/10.1016/j.jconrel.2022.01.024.Full Text Link to Item
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Ozer, Imran, George A. Pitoc, Juliana M. Layzer, Angelo Moreno, Lyra B. Olson, Kyle D. Layzer, Angus M. Hucknall, Bruce A. Sullenger, and Ashutosh Chilkoti. “PEG-Like Brush Polymer Conjugate of RNA Aptamer That Shows Reversible Anticoagulant Activity and Minimal Immune Response.” Adv Mater 34, no. 10 (March 2022): e2107852. https://doi.org/10.1002/adma.202107852.Full Text Link to Item
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Heggestad, Jacob T., David S. Kinnamon, Jason Liu, Daniel Y. Joh, Cassio M. Fontes, Qingshan Wei, Aydogan Ozcan, Angus M. Hucknall, and Ashutosh Chilkoti. “Smartphone Enabled Point-of-Care Detection of Serum Biomarkers.” Methods in Molecular Biology (Clifton, N.J.) 2393 (January 2022): 343–65. https://doi.org/10.1007/978-1-0716-1803-5_19.Full Text
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Heggestad, Jacob T., Rhett J. Britton, David S. Kinnamon, Simone A. Wall, Daniel Y. Joh, Angus M. Hucknall, Lyra B. Olson, et al. “Rapid test to assess the escape of SARS-CoV-2 variants of concern.” Sci Adv 7, no. 49 (December 3, 2021): eabl7682. https://doi.org/10.1126/sciadv.abl7682.Full Text Link to Item
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Weber, Patrick, Michael Dzuricky, Junseon Min, Irene Jenkins, and Ashutosh Chilkoti. “Concentration-Independent Multivalent Targeting of Cancer Cells by Genetically Encoded Core-Crosslinked Elastin/Resilin-like Polypeptide Micelles.” Biomacromolecules 22, no. 10 (October 2021): 4347–56. https://doi.org/10.1021/acs.biomac.1c00897.Full Text
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Joh, Daniel Y., Jacob T. Heggestad, Shengwei Zhang, Gray R. Anderson, Jayanta Bhattacharyya, Suzanne E. Wardell, Simone A. Wall, et al. “Author Correction: Cellphone enabled point-of-care assessment of breast tumor cytology and molecular HER2 expression from fine-needle aspirates.” Npj Breast Cancer 7, no. 1 (September 17, 2021): 126. https://doi.org/10.1038/s41523-021-00335-4.Full Text Link to Item
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Navarro, Luis A., Justin J. Ryan, Michael Dzuricky, Michael Gradzielski, Ashutosh Chilkoti, and Stefan Zauscher. “Microphase Separation of Resilin-like and Elastin-like Diblock Copolypeptides in Concentrated Solutions.” Biomacromolecules 22, no. 9 (September 2021): 3827–38. https://doi.org/10.1021/acs.biomac.1c00672.Full Text
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Joh, Daniel Y., Jacob T. Heggestad, Shengwei Zhang, Gray R. Anderson, Jayanta Bhattacharyya, Suzanne E. Wardell, Simone A. Wall, et al. “Cellphone enabled point-of-care assessment of breast tumor cytology and molecular HER2 expression from fine-needle aspirates.” Npj Breast Cancer 7, no. 1 (July 2, 2021): 85. https://doi.org/10.1038/s41523-021-00290-0.Full Text
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Jenkins, Irene C., Joshua J. Milligan, and Ashutosh Chilkoti. “Genetically Encoded Elastin-Like Polypeptides for Drug Delivery.” Advanced Healthcare Materials 10, no. 13 (July 2021): e2100209. https://doi.org/10.1002/adhm.202100209.Full Text
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Shapiro, Daniel Mark, Max Ney, Seyed Ali Eghtesadi, and Ashutosh Chilkoti. “Protein Phase Separation Arising from Intrinsic Disorder: First-Principles to Bespoke Applications.” The Journal of Physical Chemistry. B 125, no. 25 (July 2021): 6740–59. https://doi.org/10.1021/acs.jpcb.1c01146.Full Text
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Heggestad, Jacob T., David S. Kinnamon, Lyra B. Olson, Jason Liu, Garrett Kelly, Simone A. Wall, Solomon Oshabaheebwa, et al. “Multiplexed, quantitative serological profiling of COVID-19 from blood by a point-of-care test.” Science Advances 7, no. 26 (June 25, 2021): eabg4901. https://doi.org/10.1126/sciadv.abg4901.Full Text
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Fontes, Cassio M., Barbara D. Lipes, Jason Liu, Krystle N. Agans, Aiwei Yan, Patricia Shi, Daniela F. Cruz, et al. “Ultrasensitive point-of-care immunoassay for secreted glycoprotein detects Ebola infection earlier than PCR.” Sci Transl Med 13, no. 588 (April 7, 2021). https://doi.org/10.1126/scitranslmed.abd9696.Full Text Link to Item
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Hainline, Kelly M., Lucas S. Shores, Nicole L. Votaw, Zachary J. Bernstein, Sean H. Kelly, Chelsea N. Fries, Marisha S. Madhira, Caslin A. Gilroy, Ashutosh Chilkoti, and Joel H. Collier. “Modular complement assemblies for mitigating inflammatory conditions.” Proceedings of the National Academy of Sciences of the United States of America 118, no. 15 (April 2021): e2018627118. https://doi.org/10.1073/pnas.2018627118.Full Text
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Laaß, Katharina, Felipe García Quiroz, Johannes Hunold, Stefan Roberts, Ashutosh Chilkoti, and Dariush Hinderberger. “Nanoscopic Dynamics Dictate the Phase Separation Behavior of Intrinsically Disordered Proteins.” Biomacromolecules 22, no. 2 (February 2021): 1015–25. https://doi.org/10.1021/acs.biomac.0c01768.Full Text
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Zeng, X., C. Liu, M. J. Fossat, P. Ren, A. Chilkoti, and R. V. Pappu. “Design of intrinsically disordered proteins that undergo phase transitions with lower critical solution temperatures.” Apl Materials 9, no. 2 (February 1, 2021). https://doi.org/10.1063/5.0037438.Full Text
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Li, Linying, C Wyatt Shields, Jin Huang, Yiqun Zhang, Korine A. Ohiri, Benjamin B. Yellen, Ashutosh Chilkoti, and Gabriel P. López. “Rapid capture of biomolecules from blood via stimuli-responsive elastomeric particles for acoustofluidic separation.” The Analyst 145, no. 24 (January 2021): 8087–96. https://doi.org/10.1039/d0an01164a.Full Text
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Yousefpour, P., A. Varanko, R. Subrahmanyan, and A. Chilkoti. “Recombinant Fusion of Glucagon-Like Peptide-1 and an Albumin Binding Domain Provides Glycemic Control for a Week in Diabetic Mice.” Advanced Therapeutics 3, no. 10 (October 1, 2020). https://doi.org/10.1002/adtp.202000073.Full Text
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Dodd, Rebecca D., Amanda Scherer, Wesley Huang, Gavin R. McGivney, Wade R. Gutierrez, Emily A. Laverty, Kathleen A. Ashcraft, et al. “Tumor Subtype Determines Therapeutic Response to Chimeric Polypeptide Nanoparticle-based Chemotherapy in Pten-deleted Mouse Models of Sarcoma.” Clin Cancer Res 26, no. 18 (September 15, 2020): 5036–47. https://doi.org/10.1158/1078-0432.CCR-19-2597.Full Text Link to Item
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Dzuricky, Michael, Bradley A. Rogers, Abdulla Shahid, Paul S. Cremer, and Ashutosh Chilkoti. “De novo engineering of intracellular condensates using artificial disordered proteins.” Nature Chemistry 12, no. 9 (September 2020): 814–25. https://doi.org/10.1038/s41557-020-0511-7.Full Text
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Zeng, Xiangze, Alex S. Holehouse, Ashutosh Chilkoti, Tanja Mittag, and Rohit V. Pappu. “Connecting Coil-to-Globule Transitions to Full Phase Diagrams for Intrinsically Disordered Proteins.” Biophysical Journal 119, no. 2 (July 2020): 402–18. https://doi.org/10.1016/j.bpj.2020.06.014.Full Text
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Cruz, Daniela F., Cassio M. Fontes, Daria Semeniak, Jiani Huang, Angus Hucknall, Ashutosh Chilkoti, and Maiken H. Mikkelsen. “Ultrabright Fluorescence Readout of an Inkjet-Printed Immunoassay Using Plasmonic Nanogap Cavities.” Nano Letters 20, no. 6 (June 2020): 4330–36. https://doi.org/10.1021/acs.nanolett.0c01051.Full Text
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Varanko, Anastasia K., Jonathan C. Su, and Ashutosh Chilkoti. “Elastin-Like Polypeptides for Biomedical Applications.” Annual Review of Biomedical Engineering 22 (June 2020): 343–69. https://doi.org/10.1146/annurev-bioeng-092419-061127.Full Text
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Banskota, Samagya, Soumen Saha, Jayanta Bhattacharya, Nadia Kirmani, Parisa Yousefpour, Michael Dzuricky, Nikita Zakharov, et al. “Genetically Encoded Stealth Nanoparticles of a Zwitterionic Polypeptide-Paclitaxel Conjugate Have a Wider Therapeutic Window than Abraxane in Multiple Tumor Models.” Nano Letters 20, no. 4 (April 2020): 2396–2409. https://doi.org/10.1021/acs.nanolett.9b05094.Full Text
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Roberts, Stefan, Vincent Miao, Simone Costa, Joseph Simon, Garrett Kelly, Tejank Shah, Stefan Zauscher, and Ashutosh Chilkoti. “Complex microparticle architectures from stimuli-responsive intrinsically disordered proteins.” Nature Communications 11, no. 1 (March 12, 2020): 1342. https://doi.org/10.1038/s41467-020-15128-9.Full Text
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Heggestad, Jacob T., Cassio M. Fontes, Daniel Y. Joh, Angus M. Hucknall, and Ashutosh Chilkoti. “In Pursuit of Zero 2.0: Recent Developments in Nonfouling Polymer Brushes for Immunoassays.” Advanced Materials (Deerfield Beach, Fla.) 32, no. 2 (January 2020): e1903285. https://doi.org/10.1002/adma.201903285.Full Text
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Varanko, Anastasia, Soumen Saha, and Ashutosh Chilkoti. “Recent trends in protein and peptide-based biomaterials for advanced drug delivery.” Advanced Drug Delivery Reviews 156 (January 2020): 133–87. https://doi.org/10.1016/j.addr.2020.08.008.Full Text
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Wang, Jing, Soumen Saha, Jeffrey L. Schaal, Parisa Yousefpour, Xinghai Li, and Ashutosh Chilkoti. “Heuristics for the Optimal Presentation of Bioactive Peptides on Polypeptide Micelles.” Nano Letters 19, no. 11 (November 2019): 7977–87. https://doi.org/10.1021/acs.nanolett.9b03141.Full Text
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Garcia Quiroz, Felipe, Nan K. Li, Stefan Roberts, Patrick Weber, Michael Dzuricky, Isaac Weitzhandler, Yaroslava G. Yingling, and Ashutosh Chilkoti. “Intrinsically disordered proteins access a range of hysteretic phase separation behaviors.” Science Advances 5, no. 10 (October 18, 2019): eaax5177. https://doi.org/10.1126/sciadv.aax5177.Full Text
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Dai, Zhuojun, Anna J. Lee, Stefan Roberts, Tatyana A. Sysoeva, Shuqiang Huang, Michael Dzuricky, Xiaoyu Yang, et al. “Versatile biomanufacturing through stimulus-responsive cell-material feedback.” Nature Chemical Biology 15, no. 10 (October 2019): 1017–24. https://doi.org/10.1038/s41589-019-0357-8.Full Text
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Willems, Lione, Larissa van Westerveld, Stefan Roberts, Isaac Weitzhandler, Carlos Calcines Cruz, Armando Hernandez-Garcia, Ashutosh Chilkoti, Enrico Mastrobattista, John van der Oost, and Renko de Vries. “Nature of Amorphous Hydrophilic Block Affects Self-Assembly of an Artificial Viral Coat Polypeptide.” Biomacromolecules 20, no. 10 (October 2019): 3641–47. https://doi.org/10.1021/acs.biomac.9b00512.Full Text
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Dzuricky, Michael, Sinan Xiong, Patrick Weber, and Ashutosh Chilkoti. “Avidity and Cell Uptake of Integrin-Targeting Polypeptide Micelles is Strongly Shape-Dependent.” Nano Letters 19, no. 9 (September 2019): 6124–32. https://doi.org/10.1021/acs.nanolett.9b02095.Full Text
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Manzari, Mandana T., Gray R. Anderson, Kevin H. Lin, Ryan S. Soderquist, Merve Çakir, Mitchell Zhang, Chandler E. Moore, et al. “Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models.” Sci Adv 5, no. 9 (September 2019): eaaw9162. https://doi.org/10.1126/sciadv.aaw9162.Full Text Link to Item
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Simon, Joseph R., Seyed Ali Eghtesadi, Michael Dzuricky, Lingchong You, and Ashutosh Chilkoti. “Engineered Ribonucleoprotein Granules Inhibit Translation in Protocells.” Molecular Cell 75, no. 1 (July 2019): 66-75.e5. https://doi.org/10.1016/j.molcel.2019.05.010.Full Text
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Varanko, Anastasia K., and Ashutosh Chilkoti. “Molecular and Materials Engineering for Delivery of Peptide Drugs to Treat Type 2 Diabetes.” Advanced Healthcare Materials 8, no. 12 (June 2019): e1801509. https://doi.org/10.1002/adhm.201801509.Full Text
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Willems, Lione, Stefan Roberts, Isaac Weitzhandler, Ashutosh Chilkoti, Enrico Mastrobattista, John van der Oost, and Renko de Vries. “Inducible Fibril Formation of Silk-Elastin Diblocks.” Acs Omega 4, no. 5 (May 23, 2019): 9135–43. https://doi.org/10.1021/acsomega.9b01025.Full Text
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Koc, Julian, Tomer Simovich, Eric Schönemann, Ashutosh Chilkoti, Harrison Gardner, Geoffrey W. Swain, Kelli Hunsucker, André Laschewsky, and Axel Rosenhahn. “Sediment challenge to promising ultra-low fouling hydrophilic surfaces in the marine environment.” Biofouling 35, no. 4 (April 2019): 454–62. https://doi.org/10.1080/08927014.2019.1611790.Full Text
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Joh, Daniel Y., Zackary Zimmers, Manav Avlani, Jacob T. Heggestad, Hakan B. Aydin, Nancy Ganson, Shourya Kumar, et al. “Architectural Modification of Conformal PEG-Bottlebrush Coatings Minimizes Anti-PEG Antigenicity While Preserving Stealth Properties.” Adv Healthc Mater 8, no. 8 (April 2019): e1801177. https://doi.org/10.1002/adhm.201801177.Full Text Link to Item
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Yousefpour, Parisa, Lucie Ahn, Joel Tewksbury, Soumen Saha, Simone A. Costa, Joseph J. Bellucci, Xinghai Li, and Ashutosh Chilkoti. “Conjugate of Doxorubicin to Albumin-Binding Peptide Outperforms Aldoxorubicin.” Small (Weinheim an Der Bergstrasse, Germany) 15, no. 12 (March 2019): e1804452. https://doi.org/10.1002/smll.201804452.Full Text
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Banskota, Samagya, Parisa Yousefpour, Nadia Kirmani, Xinghai Li, and Ashutosh Chilkoti. “Long circulating genetically encoded intrinsically disordered zwitterionic polypeptides for drug delivery.” Biomaterials 192 (February 2019): 475–85. https://doi.org/10.1016/j.biomaterials.2018.11.012.Full Text
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Fontes, Cassio M., Rohan K. Achar, Daniel Y. Joh, Imran Ozer, Somnath Bhattacharjee, Angus Hucknall, and Ashutosh Chilkoti. “Engineering the Surface Properties of a Zwitterionic Polymer Brush to Enable the Simple Fabrication of Inkjet-Printed Point-of-Care Immunoassays.” Langmuir : The Acs Journal of Surfaces and Colloids 35, no. 5 (February 2019): 1379–90. https://doi.org/10.1021/acs.langmuir.8b01597.Full Text
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Mozhdehi, Davoud, Kelli M. Luginbuhl, Michael Dzuricky, Simone A. Costa, Sinan Xiong, Fred C. Huang, Mae M. Lewis, Stephanie R. Zelenetz, Christian D. Colby, and Ashutosh Chilkoti. “Genetically Encoded Cholesterol-Modified Polypeptides.” Journal of the American Chemical Society 141, no. 2 (January 4, 2019): 945–51. https://doi.org/10.1021/jacs.8b10687.Full Text
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Costa, Simone A., Davoud Mozhdehi, Michael J. Dzuricky, Farren J. Isaacs, Eric M. Brustad, and Ashutosh Chilkoti. “Active Targeting of Cancer Cells by Nanobody Decorated Polypeptide Micelle with Bio-orthogonally Conjugated Drug.” Nano Letters 19, no. 1 (January 2019): 247–54. https://doi.org/10.1021/acs.nanolett.8b03837.Full Text
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Roberts, Stefan, Tyler S. Harmon, Jeffrey L. Schaal, Vincent Miao, Kan Jonathan Li, Andrew Hunt, Yi Wen, et al. “Injectable tissue integrating networks from recombinant polypeptides with tunable order.” Nat Mater 17, no. 12 (December 2018): 1154–63. https://doi.org/10.1038/s41563-018-0182-6.Full Text Link to Item
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Roberts, Stefan, Tyler S. Harmon, Jeffrey L. Schaal, Vincent Miao, Kan Jonathan Li, Andrew Hunt, Yi Wen, et al. “Author Correction: Injectable tissue integrating networks from recombinant polypeptides with tunable order.” Nat Mater 17, no. 12 (December 2018): 1164. https://doi.org/10.1038/s41563-018-0233-z.Full Text Link to Item
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Yousefpour, Parisa, Jonathan R. McDaniel, Varun Prasad, Lucie Ahn, Xinghai Li, Rishi Subrahmanyan, Isaac Weitzhandler, Steven Suter, and Ashutosh Chilkoti. “Genetically Encoding Albumin Binding into Chemotherapeutic-loaded Polypeptide Nanoparticles Enhances Their Antitumor Efficacy.” Nano Letters 18, no. 12 (December 2018): 7784–93. https://doi.org/10.1021/acs.nanolett.8b03558.Full Text
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Ruff, Kiersten M., Stefan Roberts, Ashutosh Chilkoti, and Rohit V. Pappu. “Advances in Understanding Stimulus-Responsive Phase Behavior of Intrinsically Disordered Protein Polymers.” Journal of Molecular Biology 430, no. 23 (November 2018): 4619–35. https://doi.org/10.1016/j.jmb.2018.06.031.Full Text
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Gu, Renpeng, Thomas Oweida, Yaroslava G. Yingling, Ashutosh Chilkoti, and Stefan Zauscher. “Enzymatic Synthesis of Nucleobase-Modified Single-Stranded DNA Offers Tunable Resistance to Nuclease Degradation.” Biomacromolecules 19, no. 8 (August 2018): 3525–35. https://doi.org/10.1021/acs.biomac.8b00816.Full Text
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Li, Nan K., Stefan Roberts, Felipe Garcia Quiroz, Ashutosh Chilkoti, and Yaroslava G. Yingling. “Sequence Directionality Dramatically Affects LCST Behavior of Elastin-Like Polypeptides.” Biomacromolecules 19, no. 7 (July 2018): 2496–2505. https://doi.org/10.1021/acs.biomac.8b00099.Full Text
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Dzuricky, Michael, Stefan Roberts, and Ashutosh Chilkoti. “Convergence of Artificial Protein Polymers and Intrinsically Disordered Proteins.” Biochemistry 57, no. 17 (May 2018): 2405–14. https://doi.org/10.1021/acs.biochem.8b00056.Full Text
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Gilroy, Caslin A., Stefan Roberts, and Ashutosh Chilkoti. “Fusion of fibroblast growth factor 21 to a thermally responsive biopolymer forms an injectable depot with sustained anti-diabetic action.” Journal of Controlled Release : Official Journal of the Controlled Release Society 277 (May 2018): 154–64. https://doi.org/10.1016/j.jconrel.2018.03.015.Full Text
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Mozhdehi, Davoud, Kelli M. Luginbuhl, Joseph R. Simon, Michael Dzuricky, Rüdiger Berger, H Samet Varol, Fred C. Huang, et al. “Genetically encoded lipid-polypeptide hybrid biomaterials that exhibit temperature-triggered hierarchical self-assembly.” Nature Chemistry 10, no. 5 (May 2018): 496–505. https://doi.org/10.1038/s41557-018-0005-z.Full Text
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Costa, Simone A., Joseph R. Simon, Miriam Amiram, Lei Tang, Stefan Zauscher, Eric M. Brustad, Farren J. Isaacs, and Ashutosh Chilkoti. “Photo-Crosslinkable Unnatural Amino Acids Enable Facile Synthesis of Thermoresponsive Nano- to Microgels of Intrinsically Disordered Polypeptides.” Advanced Materials (Deerfield Beach, Fla.) 30, no. 5 (February 2018). https://doi.org/10.1002/adma.201704878.Full Text
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Li, Linying, Nan K. Li, Qing Tu, Owen Im, Chia-Kuei Mo, Wei Han, William H. Fuss, et al. “Functional Modification of Silica through Enhanced Adsorption of Elastin-Like Polypeptide Block Copolymers.” Biomacromolecules 19, no. 2 (February 2018): 298–306. https://doi.org/10.1021/acs.biomac.7b01307.Full Text
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Mastria, Eric M., Leon Y. Cai, Matthew J. Kan, Xinghai Li, Jeffrey L. Schaal, Steven Fiering, Michael D. Gunn, Mark W. Dewhirst, Smita K. Nair, and Ashutosh Chilkoti. “Nanoparticle formulation improves doxorubicin efficacy by enhancing host antitumor immunity.” J Control Release 269 (January 10, 2018): 364–73. https://doi.org/10.1016/j.jconrel.2017.11.021.Full Text Link to Item
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Luginbuhl, Kelli M., Davoud Mozhdehi, Michael Dzuricky, Parisa Yousefpour, Fred C. Huang, Nicholas R. Mayne, Kristen L. Buehne, and Ashutosh Chilkoti. “Recombinant Synthesis of Hybrid Lipid-Peptide Polymer Fusions that Self-Assemble and Encapsulate Hydrophobic Drugs.” Angewandte Chemie (International Ed. in English) 56, no. 45 (November 2017): 13979–84. https://doi.org/10.1002/anie.201704625.Full Text
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Wang, Jing, Michael Dzuricky, and Ashutosh Chilkoti. “The Weak Link: Optimization of the Ligand-Nanoparticle Interface To Enhance Cancer Cell Targeting by Polymer Micelles.” Nano Letters 17, no. 10 (October 2017): 5995–6005. https://doi.org/10.1021/acs.nanolett.7b02225.Full Text
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Bhattacharyya, Jayanta, Xiu-Rong Ren, Robert A. Mook, Jiangbo Wang, Ivan Spasojevic, Richard T. Premont, Xinghai Li, Ashutosh Chilkoti, and Wei Chen. “Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth.” Nanoscale 9, no. 34 (August 31, 2017): 12709–17. https://doi.org/10.1039/c7nr01973d.Full Text Link to Item
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Joh, Daniel Y., Angus M. Hucknall, Qingshan Wei, Kelly A. Mason, Margaret L. Lund, Cassio M. Fontes, Ryan T. Hill, et al. “Inkjet-printed point-of-care immunoassay on a nanoscale polymer brush enables subpicomolar detection of analytes in blood.” Proc Natl Acad Sci U S A 114, no. 34 (August 22, 2017): E7054–62. https://doi.org/10.1073/pnas.1703200114.Full Text Link to Item
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Wang, Jing, Jayanta Bhattacharyya, Eric Mastria, and Ashutosh Chilkoti. “A quantitative study of the intracellular fate of pH-responsive doxorubicin-polypeptide nanoparticles.” Journal of Controlled Release : Official Journal of the Controlled Release Society 260 (August 2017): 100–110. https://doi.org/10.1016/j.jconrel.2017.05.032.Full Text
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Weitzhandler, Isaac, Michael Dzuricky, Ingo Hoffmann, Felipe Garcia Quiroz, Michael Gradzielski, and Ashutosh Chilkoti. “Micellar Self-Assembly of Recombinant Resilin-/Elastin-Like Block Copolypeptides.” Biomacromolecules 18, no. 8 (August 2017): 2419–26. https://doi.org/10.1021/acs.biomac.7b00589.Full Text
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MacEwan, Sarah R., and Ashutosh Chilkoti. “From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carriers.” Angewandte Chemie (International Ed. in English) 56, no. 24 (June 2017): 6712–33. https://doi.org/10.1002/anie.201610819.Full Text
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Tang, Lei, Luis A. Navarro, Ashutosh Chilkoti, and Stefan Zauscher. “High-Molecular-Weight Polynucleotides by Transferase-Catalyzed Living Chain-Growth Polycondensation.” Angewandte Chemie (International Ed. in English) 56, no. 24 (June 2017): 6778–82. https://doi.org/10.1002/anie.201700991.Full Text
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Han, Wei, Ashutosh Chilkoti, and Gabriel P. López. “Self-assembled hybrid elastin-like polypeptide/silica nanoparticles enable triggered drug release.” Nanoscale 9, no. 18 (May 2017): 6178–86. https://doi.org/10.1039/c7nr00172j.Full Text
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Bhattacharyya, Jayanta, Isaac Weitzhandler, Shihan Bryan Ho, Jonathan R. McDaniel, Xinghai Li, Lei Tang, Jinyao Liu, Mark Dewhirst, and Ashutosh Chilkoti. “Encapsulating a Hydrophilic Chemotherapeutic into Rod-like Nanoparticles of a Genetically Encoded Asymmetric Triblock Polypeptide Improves its Efficacy.” Adv Funct Mater 27, no. 12 (March 24, 2017). https://doi.org/10.1002/adfm.201605421.Full Text Link to Item
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Weinberger, A., V. Walter, S. R. MacEwan, T. Schmatko, P. Muller, A. P. Schroder, A. Chilkoti, and C. M. Marques. “Cargo self-assembly rescues affinity of cell-penetrating peptides to lipid membranes.” Scientific Reports 7 (March 6, 2017). https://doi.org/10.1038/srep43963.Full Text
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Ozer, Imran, and Ashutosh Chilkoti. “Site-Specific and Stoichiometric Stealth Polymer Conjugates of Therapeutic Peptides and Proteins.” Bioconjugate Chemistry 28, no. 3 (March 2017): 713–23. https://doi.org/10.1021/acs.bioconjchem.6b00652.Full Text
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Widder, Katharina, Sarah R. MacEwan, Elisabeth Garanger, Vanesa Núñez, Sébastien Lecommandoux, Ashutosh Chilkoti, and Dariush Hinderberger. “Characterisation of hydration and nanophase separation during the temperature response in hydrophobic/hydrophilic elastin-like polypeptide (ELP) diblock copolymers.” Soft Matter 13, no. 9 (March 2017): 1816–22. https://doi.org/10.1039/c6sm02427k.Full Text
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Joh, Daniel Y., Felicia McGuire, Roozbeh Abedini-Nassab, Joseph B. Andrews, Rohan K. Achar, Zackary Zimmers, Darush Mozhdehi, et al. “Poly(oligo(ethylene glycol) methyl ether methacrylate) Brushes on High-κ Metal Oxide Dielectric Surfaces for Bioelectrical Environments.” Acs Applied Materials & Interfaces 9, no. 6 (February 2, 2017): 5522–29. https://doi.org/10.1021/acsami.6b15836.Full Text
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MacEwan, Sarah R., Isaac Weitzhandler, Ingo Hoffmann, Jan Genzer, Michael Gradzielski, and Ashutosh Chilkoti. “Phase Behavior and Self-Assembly of Perfectly Sequence-Defined and Monodisperse Multiblock Copolypeptides.” Biomacromolecules 18, no. 2 (February 2017): 599–609. https://doi.org/10.1021/acs.biomac.6b01759.Full Text
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Wang, Jing, Sarah R. MacEwan, and Ashutosh Chilkoti. “Quantitative Mapping of the Spatial Distribution of Nanoparticles in Endo-Lysosomes by Local pH.” Nano Letters 17, no. 2 (February 2017): 1226–32. https://doi.org/10.1021/acs.nanolett.6b05041.Full Text
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Banskota, Samagya, Parisa Yousefpour, and Ashutosh Chilkoti. “Cell-Based Biohybrid Drug Delivery Systems: The Best of the Synthetic and Natural Worlds.” Macromolecular Bioscience 17, no. 1 (January 2017). https://doi.org/10.1002/mabi.201600361.Full Text
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Gonzalez, Mark A., Joseph R. Simon, Ali Ghoorchian, Zachary Scholl, Shaoting Lin, Michael Rubinstein, Piotr Marszalek, Ashutosh Chilkoti, Gabriel P. López, and Xuanhe Zhao. “Strong, Tough, Stretchable, and Self-Adhesive Hydrogels from Intrinsically Unstructured Proteins.” Advanced Materials, 2017. https://doi.org/10.1002/adma.201604743.Full Text
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Luginbuhl, Kelli M., Jeffrey L. Schaal, Bret Umstead, Eric M. Mastria, Xinghai Li, Samagya Banskota, Susan Arnold, Mark Feinglos, David D’Alessio, and Ashutosh Chilkoti. “One-week glucose control via zero-order release kinetics from an injectable depot of glucagon-like peptide-1 fused to a thermosensitive biopolymer.” Nat Biomed Eng 1 (2017). https://doi.org/10.1038/s41551-017-0078.Full Text Link to Item
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Simon, Joseph R., Nick J. Carroll, Michael Rubinstein, Ashutosh Chilkoti, and Gabriel P. López. “Programming molecular self-assembly of intrinsically disordered proteins containing sequences of low complexity.” Nature Chemistry, 2017. https://doi.org/10.1038/nchem.2715.Full Text
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Kwok, Kevin W. H., Wu Dong, Stella M. Marinakos, Jie Liu, Ashutosh Chilkoti, Mark R. Wiesner, Melissa Chernick, and David E. Hinton. “Silver nanoparticle toxicity is related to coating materials and disruption of sodium concentration regulation.” Nanotoxicology 10, no. 9 (November 2016): 1306–17. https://doi.org/10.1080/17435390.2016.1206150.Full Text Open Access Copy
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Abedini-Nassab, Roozbeh, Daniel Y. Joh, Faris Albarghouthi, Ashutosh Chilkoti, David M. Murdoch, and Benjamin B. Yellen. “Magnetophoretic transistors in a tri-axial magnetic field.” Lab Chip 16, no. 21 (October 18, 2016): 4181–88. https://doi.org/10.1039/c6lc00878j.Full Text Link to Item
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Gilroy, Caslin A., Kelli M. Luginbuhl, and Ashutosh Chilkoti. “Controlled release of biologics for the treatment of type 2 diabetes.” Journal of Controlled Release : Official Journal of the Controlled Release Society 240 (October 2016): 151–64. https://doi.org/10.1016/j.jconrel.2015.12.002.Full Text
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Pham, An T., Ryohei Seto, Johannes Schönke, Daniel Y. Joh, Ashutosh Chilkoti, Eliot Fried, and Benjamin B. Yellen. “Crystallization kinetics of binary colloidal monolayers.” Soft Matter 12, no. 37 (October 2016): 7735–46. https://doi.org/10.1039/c6sm01072e.Full Text
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Liu, Jinyao, Yan Pang, Jayanta Bhattacharyya, Wenge Liu, Isaac Weitzhandler, Xinghai Li, and Ashutosh Chilkoti. “Developing Precisely Defined Drug-Loaded Nanoparticles by Ring-Opening Polymerization of a Paclitaxel Prodrug.” Advanced Healthcare Materials 5, no. 15 (August 2016): 1868–73. https://doi.org/10.1002/adhm.201600230.Full Text
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Pang, Yan, Jinyao Liu, Yizhi Qi, Xinghai Li, and Ashutosh Chilkoti. “A Modular Method for the High-Yield Synthesis of Site-Specific Protein-Polymer Therapeutics.” Angewandte Chemie (International Ed. in English) 55, no. 35 (August 2016): 10296–300. https://doi.org/10.1002/anie.201604661.Full Text
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Li, Linying, Chia-Kuei Mo, Ashutosh Chilkoti, Gabriel P. Lopez, and Nick J. Carroll. “Creating cellular patterns using genetically engineered, gold- and cell-binding polypeptides.” Biointerphases 11, no. 2 (June 27, 2016): 021009. https://doi.org/10.1116/1.4952452.Full Text
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Abedini-Nassab, Roozbeh, Daniel Y. Joh, Melissa Van Heest, Cody Baker, Ashutosh Chilkoti, David M. Murdoch, and Benjamin B. Yellen. “Magnetophoretic Conductors and Diodes in a 3D Magnetic Field.” Adv Funct Mater 26, no. 22 (June 14, 2016): 4026–34. https://doi.org/10.1002/adfm.201503898.Full Text Link to Item
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Schaal, Jeffrey L., Xinghai Li, Eric Mastria, Jayanta Bhattacharyya, Michael R. Zalutsky, Ashutosh Chilkoti, and Wenge Liu. “Injectable polypeptide micelles that form radiation crosslinked hydrogels in situ for intratumoral radiotherapy.” J Control Release 228 (April 28, 2016): 58–66. https://doi.org/10.1016/j.jconrel.2016.02.040.Full Text Link to Item
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Tang, Nicholas C., and Ashutosh Chilkoti. “Combinatorial codon scrambling enables scalable gene synthesis and amplification of repetitive proteins.” Nature Materials 15, no. 4 (April 2016): 419–24. https://doi.org/10.1038/nmat4521.Full Text
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Nawroth, Jonas F., Jonathan R. McDaniel, Ashutosh Chilkoti, Rainer Jordan, and Robert Luxenhofer. “Maleimide-Functionalized Poly(2-Oxazoline)s and Their Conjugation to Elastin-Like Polypeptides.” Macromolecular Bioscience 16, no. 3 (March 2016): 322–33. https://doi.org/10.1002/mabi.201500376.Full Text
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Mukerji, Ratul, Jeffrey Schaal, Xinghai Li, Jayanta Bhattacharyya, Daisuke Asai, Michael R. Zalutsky, Ashutosh Chilkoti, and Wenge Liu. “Spatiotemporally photoradiation-controlled intratumoral depot for combination of brachytherapy and photodynamic therapy for solid tumor.” Biomaterials 79 (February 2016): 79–87. https://doi.org/10.1016/j.biomaterials.2015.11.064.Full Text Link to Item
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Qi, Yizhi, Antonina Simakova, Nancy J. Ganson, Xinghai Li, Kelli M. Luginbuhl, Imran Özer, Wenge Liu, Michael S. Hershfield, Krzysztof Matyjaszewski, and Ashutosh Chilkoti. “A brush-polymer conjugate of exendin-4 reduces blood glucose for up to five days and eliminates poly(ethylene glycol) antigenicity.” Nat Biomed Eng 1 (2016). https://doi.org/10.1038/s41551-016-0002.Full Text Link to Item
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Bhattacharjee, Somnath, Wenge Liu, Wei-Han Wang, Isaac Weitzhandler, Xinghai Li, Yizhi Qi, Jinyao Liu, Yan Pang, Donald F. Hunt, and Ashutosh Chilkoti. “Site-Specific Zwitterionic Polymer Conjugates of a Protein Have Long Plasma Circulation.” Chembiochem : A European Journal of Chemical Biology 16, no. 17 (November 2015): 2451–55. https://doi.org/10.1002/cbic.201500439.Full Text
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Quiroz, Felipe García, and Ashutosh Chilkoti. “Sequence heuristics to encode phase behaviour in intrinsically disordered protein polymers.” Nature Materials 14, no. 11 (November 2015): 1164–71. https://doi.org/10.1038/nmat4418.Full Text
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Li, Nan K., William H. Fuss, Lei Tang, Renpeng Gu, Ashutosh Chilkoti, Stefan Zauscher, and Yaroslava G. Yingling. “Prediction of solvent-induced morphological changes of polyelectrolyte diblock copolymer micelles.” Soft Matter 11, no. 42 (November 2015): 8236–45. https://doi.org/10.1039/c5sm01742d.Full Text
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Abedini-Nassab, Roozbeh, Daniel Y. Joh, Melissa A. Van Heest, John S. Yi, Cody Baker, Zohreh Taherifard, David M. Margolis, et al. “Characterizing the Switching Thresholds of Magnetophoretic Transistors.” Adv Mater 27, no. 40 (October 28, 2015): 6176–80. https://doi.org/10.1002/adma.201502352.Full Text Open Access Copy Link to Item
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Qi, Yizhi, and Ashutosh Chilkoti. “Protein-polymer conjugation-moving beyond PEGylation.” Current Opinion in Chemical Biology 28 (October 2015): 181–93. https://doi.org/10.1016/j.cbpa.2015.08.009.Full Text
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Garanger, E., S. R. MacEwan, O. Sandre, A. Brûlet, L. Bataille, A. Chilkoti, and S. Lecommandoux. “Structural Evolution of a Stimulus-Responsive Diblock Polypeptide Micelle by Temperature Tunable Compaction of its Core.” Macromolecules 48, no. 18 (September 22, 2015): 6617–27. https://doi.org/10.1021/acs.macromol.5b01371.Full Text
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Roberts, Stefan, Michael Dzuricky, and Ashutosh Chilkoti. “Elastin-like polypeptides as models of intrinsically disordered proteins.” Febs Letters 589, no. 19 Pt A (September 2015): 2477–86. https://doi.org/10.1016/j.febslet.2015.08.029.Full Text
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Bhattacharyya, Jayanta, Joseph J. Bellucci, Isaac Weitzhandler, Jonathan R. McDaniel, Ivan Spasojevic, Xinghai Li, Chao-Chieh Lin, Jen-Tsan Ashley Chi, and Ashutosh Chilkoti. “A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models.” Nat Commun 6 (August 4, 2015): 7939. https://doi.org/10.1038/ncomms8939.Full Text Link to Item
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Han, Wei, Sarah R. MacEwan, Ashutosh Chilkoti, and Gabriel P. López. “Bio-inspired synthesis of hybrid silica nanoparticles templated from elastin-like polypeptide micelles.” Nanoscale 7, no. 28 (July 2015): 12038–44. https://doi.org/10.1039/c5nr01407g.Full Text
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Mastria, Eric M., Mingnan Chen, Jonathan R. McDaniel, Xinghai Li, Jinho Hyun, Mark W. Dewhirst, and Ashutosh Chilkoti. “Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma.” J Control Release 208 (June 28, 2015): 52–58. https://doi.org/10.1016/j.jconrel.2015.01.033.Full Text Link to Item
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Ghoorchian, A., J. R. Simon, B. Bharti, W. Han, X. Zhao, A. Chilkoti, and G. P. Lõpez. “Bioinspired reversibly cross-linked hydrogels comprising polypeptide micelles exhibit enhanced mechanical properties.” Advanced Functional Materials 25, no. 21 (June 1, 2015): 3122–30. https://doi.org/10.1002/adfm.201500699.Full Text
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Kimmerling, K. A., B. D. Furman, D. S. Mangiapani, M. A. Moverman, S. M. Sinclair, J. L. Huebner, A. Chilkoti, et al. “Sustained intra-articular delivery of IL-1RA from a thermally-responsive elastin-like polypeptide as a therapy for post-traumatic arthritis.” Eur Cell Mater 29 (January 31, 2015): 124–39. https://doi.org/10.22203/ecm.v029a10.Full Text Link to Item
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Bellucci, Joseph J., Jayanta Bhattacharyya, and Ashutosh Chilkoti. “A noncanonical function of sortase enables site-specific conjugation of small molecules to lysine residues in proteins.” Angewandte Chemie (International Ed. in English) 54, no. 2 (January 2015): 441–45. https://doi.org/10.1002/anie.201408126.Full Text
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Hassouneh, Wafa, Ekaterina B. Zhulina, Ashutosh Chilkoti, and Michael Rubinstein. “Elastin-like Polypeptide Diblock Copolymers Self-Assemble into Weak Micelles.” Macromolecules, 2015. https://doi.org/10.1021/acs.macromol.5b00431.Full Text
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Liu, Jinyao, Wenge Liu, Isaac Weitzhandler, Jayanta Bhattacharyya, Xinghai Li, Jing Wang, Yizhi Qi, Somnath Bhattacharjee, and Ashutosh Chilkoti. “Ring-opening polymerization of prodrugs: a versatile approach to prepare well-defined drug-loaded nanoparticles.” Angewandte Chemie (International Ed. in English) 54, no. 3 (January 2015): 1002–6. https://doi.org/10.1002/anie.201409293.Full Text
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McDaniel, Jonathan R., Isaac Weitzhandler, Sylvain Prevost, Kevin B. Vargo, Marie-Sousai Appavou, Daniel A. Hammer, Michael Gradzielski, and Ashutosh Chilkoti. “Noncanonical self-assembly of highly asymmetric genetically encoded polypeptide amphiphiles into cylindrical micelles.” Nano Letters 14, no. 11 (November 2014): 6590–98. https://doi.org/10.1021/nl503221p.Full Text
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Hill, Ryan T., Klaudia M. Kozek, Angus Hucknall, David R. Smith, and Ashutosh Chilkoti. “Nanoparticle-Film Plasmon Ruler Interrogated with Transmission Visible Spectroscopy.” Acs Photonics 1, no. 10 (October 2014): 974–84. https://doi.org/10.1021/ph500190q.Full Text
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Li, Nan K., Felipe García Quiroz, Carol K. Hall, Ashutosh Chilkoti, and Yaroslava G. Yingling. “Molecular description of the LCST behavior of an elastin-like polypeptide.” Biomacromolecules 15, no. 10 (October 2014): 3522–30. https://doi.org/10.1021/bm500658w.Full Text
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MacEwan, Sarah R., and Ashutosh Chilkoti. “Applications of elastin-like polypeptides in drug delivery.” Journal of Controlled Release : Official Journal of the Controlled Release Society 190 (September 2014): 314–30. https://doi.org/10.1016/j.jconrel.2014.06.028.Full Text
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Yousefpour, Parisa, and Ashutosh Chilkoti. “Co-opting biology to deliver drugs.” Biotechnology and Bioengineering 111, no. 9 (September 2014): 1699–1716. https://doi.org/10.1002/bit.25307.Full Text
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MacEwan, Sarah R., Wafa Hassouneh, and Ashutosh Chilkoti. “Non-chromatographic purification of recombinant elastin-like polypeptides and their fusions with peptides and proteins from Escherichia coli.” Journal of Visualized Experiments : Jove, no. 88 (June 9, 2014). https://doi.org/10.3791/51583.Full Text
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Ghoorchian, Ali, Ashutosh Chilkoti, and Gabriel P. López. “Simple assay for proteases based on aggregation of stimulus-responsive polypeptides.” Analytical Chemistry 86, no. 12 (June 2014): 6103–10. https://doi.org/10.1021/ac5012574.Full Text
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McDaniel, Jonathan R., Sarah R. MacEwan, Xinghai Li, D Christopher Radford, Chelsea D. Landon, Mark Dewhirst, and Ashutosh Chilkoti. “Rational design of "heat seeking" drug loaded polypeptide nanoparticles that thermally target solid tumors.” Nano Lett 14, no. 5 (May 14, 2014): 2890–95. https://doi.org/10.1021/nl5009376.Full Text Link to Item
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Tang, Lei, Vinalia Tjong, Nan Li, Yaroslava G. Yingling, Ashutosh Chilkoti, and Stefan Zauscher. “Enzymatic polymerization of high molecular weight DNA amphiphiles that self-assemble into star-like micelles.” Advanced Materials (Deerfield Beach, Fla.) 26, no. 19 (May 2014): 3050–54. https://doi.org/10.1002/adma.201306049.Full Text
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Tjong, Vinalia, Lei Tang, Stefan Zauscher, and Ashutosh Chilkoti. “"Smart" DNA interfaces.” Chemical Society Reviews 43, no. 5 (March 2014): 1612–26. https://doi.org/10.1039/c3cs60331h.Full Text
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Mastria, E., and A. Chilkoti. “Genetically encoded smart peptide polymers for biomedicine.” Mrs Bulletin 39, no. 1 (January 27, 2014): 35–43. https://doi.org/10.1557/mrs.2013.313.Full Text
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Qi, Y., and A. Chilkoti. “Growing polymers from peptides and proteins: A biomedical perspective.” Polymer Chemistry 5, no. 2 (January 21, 2014): 266–76. https://doi.org/10.1039/c3py01089a.Full Text
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MacEwan, S. R., W. Hassouneh, and A. Chilkoti. “Non-chromatographic purification of recombinant elastin-like polypeptides and their fusions with peptides and proteins from Escherichia coli.” Journal of Visualized Experiments : Jove, no. 88 (January 1, 2014).
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MacEwan, Sarah R., and Ashutosh Chilkoti. “Controlled apoptosis by a thermally toggled nanoscale amplifier of cellular uptake.” Nano Letters 14, no. 4 (January 2014): 2058–64. https://doi.org/10.1021/nl5002313.Full Text
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Li, L., O. Im, C. Ashutosh, and G. P. López. “Encapsulation of stimuli-responsive fusion proteins in silica: Thermally responsive metal ion-sensitive hybrid membranes.” Materials Research Society Symposium Proceedings 1498 (December 1, 2013): 169–75. https://doi.org/10.1557/opl.2013.332.Full Text
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Qi, Y., M. Amiram, W. Gao, and A. Chilkoti. “Sortase-mediated initiator attachment for in situ grafting of a PEG-based polymer brush from the C terminus of green fluorescent protein.” J Control Release 172, no. 1 (November 28, 2013): e121. https://doi.org/10.1016/j.jconrel.2013.08.288.Full Text Link to Item
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Amiram, M., K. M. Luginbuhl, X. Li, M. N. Feinglos, and A. Chilkoti. “A depot-forming glucagon-like peptide-1 fusion protein reduces blood glucose for five days with a single injection.” Journal of Controlled Release : Official Journal of the Controlled Release Society 172, no. 1 (November 2013): 144–51. https://doi.org/10.1016/j.jconrel.2013.07.021.Full Text
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Sinclair, S Michael, Jayanta Bhattacharyya, Jonathan R. McDaniel, David M. Gooden, Ramesh Gopalaswamy, Ashutosh Chilkoti, and Lori A. Setton. “A genetically engineered thermally responsive sustained release curcumin depot to treat neuroinflammation.” Journal of Controlled Release : Official Journal of the Controlled Release Society 171, no. 1 (October 2013): 38–47. https://doi.org/10.1016/j.jconrel.2013.06.032.Full Text Open Access Copy
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McDaniel, Jonathan R., Mark W. Dewhirst, and Ashutosh Chilkoti. “Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia.” Int J Hyperthermia 29, no. 6 (September 2013): 501–10. https://doi.org/10.3109/02656736.2013.819999.Full Text Link to Item
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Khan, M Nuruzzaman, Vinalia Tjong, Ashutosh Chilkoti, and Michael Zharnikov. “Spectroscopic study of a DNA brush synthesized in situ by surface initiated enzymatic polymerization.” The Journal of Physical Chemistry. B 117, no. 34 (August 15, 2013): 9929–38. https://doi.org/10.1021/jp404774x.Full Text
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Tjong, V., H. Yu, A. Hucknall, and A. Chilkoti. “Amplified fluorescence detection of DNA and RNA hybridization by surface initiated enzymatic polymerization (SIEP).” Technical Proceedings of the 2013 Nsti Nanotechnology Conference and Expo, Nsti Nanotech 2013 3 (August 9, 2013): 32–36.
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McDaniel, Jonathan R., D Christopher Radford, and Ashutosh Chilkoti. “A unified model for de novo design of elastin-like polypeptides with tunable inverse transition temperatures.” Biomacromolecules 14, no. 8 (August 2013): 2866–72. https://doi.org/10.1021/bm4007166.Full Text
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Qi, Yizhi, Miriam Amiram, Weiping Gao, Dewey G. McCafferty, and Ashutosh Chilkoti. “Sortase-catalyzed initiator attachment enables high yield growth of a stealth polymer from the C terminus of a protein.” Macromolecular Rapid Communications 34, no. 15 (August 2013): 1256–60. https://doi.org/10.1002/marc.201300460.Full Text
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Kurzbach, Dennis, Wafa Hassouneh, Jonathan R. McDaniel, Eva A. Jaumann, Ashutosh Chilkoti, and Dariush Hinderberger. “Hydration layer coupling and cooperativity in phase behavior of stimulus responsive peptide polymers.” Journal of the American Chemical Society 135, no. 30 (July 16, 2013): 11299–308. https://doi.org/10.1021/ja4047872.Full Text
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Hassouneh, Wafa, Michelle L. Nunalee, M Coleman Shelton, and Ashutosh Chilkoti. “Calcium binding peptide motifs from calmodulin confer divalent ion selectivity to elastin-like polypeptides.” Biomacromolecules 14, no. 7 (July 2013): 2347–53. https://doi.org/10.1021/bm400464s.Full Text
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Weller, D., J. R. McDaniel, K. Fischer, A. Chilkoti, and M. Schmidt. “Cylindrical polymer brushes with elastin-like polypeptide side chains.” Macromolecules 46, no. 12 (June 25, 2013): 4966–71. https://doi.org/10.1021/ma400917t.Full Text
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Christensen, Trine, Wafa Hassouneh, Kimberley Trabbic-Carlson, and Ashutosh Chilkoti. “Predicting transition temperatures of elastin-like polypeptide fusion proteins.” Biomacromolecules 14, no. 5 (May 2013): 1514–19. https://doi.org/10.1021/bm400167h.Full Text
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Bellucci, Joseph J., Miriam Amiram, Jayanta Bhattacharyya, Dewey McCafferty, and Ashutosh Chilkoti. “Three-in-one chromatography-free purification, tag removal, and site-specific modification of recombinant fusion proteins using sortase A and elastin-like polypeptides.” Angewandte Chemie (International Ed. in English) 52, no. 13 (March 2013): 3703–8. https://doi.org/10.1002/anie.201208292.Full Text
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Amiram, Miriam, Kelli M. Luginbuhl, Xinghai Li, Mark N. Feinglos, and Ashutosh Chilkoti. “Injectable protease-operated depots of glucagon-like peptide-1 provide extended and tunable glucose control.” Proceedings of the National Academy of Sciences of the United States of America 110, no. 8 (February 2013): 2792–97. https://doi.org/10.1073/pnas.1214518110.Full Text
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McDaniel, Jonathan R., Jayanta Bhattacharyya, Kevin B. Vargo, Wafa Hassouneh, Daniel A. Hammer, and Ashutosh Chilkoti. “Self-assembly of thermally responsive nanoparticles of a genetically encoded peptide polymer by drug conjugation.” Angewandte Chemie (International Ed. in English) 52, no. 6 (February 2013): 1683–87. https://doi.org/10.1002/anie.201200899.Full Text
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Lassiter, J Britt, Felicia McGuire, Jack J. Mock, Cristian Ciracì, Ryan T. Hill, Benjamin J. Wiley, Ashutosh Chilkoti, and David R. Smith. “Plasmonic waveguide modes of film-coupled metallic nanocubes.” Nano Letters 13, no. 12 (January 2013): 5866–72. https://doi.org/10.1021/nl402660s.Full Text
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MacEwan, Sarah R., and Ashutosh Chilkoti. “Harnessing the power of cell-penetrating peptides: activatable carriers for targeting systemic delivery of cancer therapeutics and imaging agents.” Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology 5, no. 1 (January 2013): 31–48. https://doi.org/10.1002/wnan.1197.Full Text
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Thapa, Arjun, Wei Han, Robin H. Simons, Ashutosh Chilkoti, Eva Y. Chi, and Gabriel P. López. “Effect of detergents on the thermal behavior of elastin-like polypeptides.” Biopolymers 99, no. 1 (January 2013): 55–62. https://doi.org/10.1002/bip.22137.Full Text
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Tjong, Vinalia, Hua Yu, Angus Hucknall, and Ashutosh Chilkoti. “Direct fluorescence detection of RNA on microarrays by surface-initiated enzymatic polymerization.” Analytical Chemistry 85, no. 1 (January 2013): 426–33. https://doi.org/10.1021/ac303132j.Full Text
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Christensen, T., W. Hassouneh, D. J. Callahan, and A. Chilkoti. “Protein switches” 3 (December 1, 2012): 238–66. https://doi.org/10.1016/B978-0-12-374920-8.00316-7.Full Text
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Moreau, Antoine, Cristian Ciracì, Jack J. Mock, Ryan T. Hill, Qiang Wang, Benjamin J. Wiley, Ashutosh Chilkoti, and David R. Smith. “Controlled-reflectance surfaces with film-coupled colloidal nanoantennas.” Nature 492, no. 7427 (December 2012): 86–89. https://doi.org/10.1038/nature11615.Full Text
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Liu, Wenge, Jonathan McDaniel, Xinghai Li, Daisuke Asai, Felipe Garcia Quiroz, Jeffery Schaal, Ji Sun Park, Michael Zalutsky, and Ashutosh Chilkoti. “Brachytherapy using injectable seeds that are self-assembled from genetically encoded polypeptides in situ.” Cancer Res 72, no. 22 (November 15, 2012): 5956–65. https://doi.org/10.1158/0008-5472.CAN-12-2127.Full Text Link to Item
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Manzoor, Ashley A., Lars H. Lindner, Chelsea D. Landon, Ji-Young Park, Andrew J. Simnick, Matthew R. Dreher, Shiva Das, et al. “Overcoming limitations in nanoparticle drug delivery: triggered, intravascular release to improve drug penetration into tumors.” Cancer Res 72, no. 21 (November 1, 2012): 5566–75. https://doi.org/10.1158/0008-5472.CAN-12-1683.Full Text Link to Item
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Hill, Ryan T., Jack J. Mock, Angus Hucknall, Scott D. Wolter, Nan M. Jokerst, David R. Smith, and Ashutosh Chilkoti. “Plasmon ruler with angstrom length resolution.” Acs Nano 6, no. 10 (October 2012): 9237–46. https://doi.org/10.1021/nn3035809.Full Text
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Khan, M Nuruzzaman, Vinalia Tjong, Ashutosh Chilkoti, and Michael Zharnikov. “Fabrication of ssDNA/oligo(ethylene glycol) monolayers and complex nanostructures by an irradiation-promoted exchange reaction.” Angewandte Chemie (International Ed. in English) 51, no. 41 (October 2012): 10303–6. https://doi.org/10.1002/anie.201204245.Full Text
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Kwok, Kevin W. H., Melanie Auffan, Appala R. Badireddy, Clay M. Nelson, Mark R. Wiesner, Ashutosh Chilkoti, Jie Liu, Stella M. Marinakos, and David E. Hinton. “Uptake of silver nanoparticles and toxicity to early life stages of Japanese medaka (Oryzias latipes): effect of coating materials.” Aquatic Toxicology (Amsterdam, Netherlands) 120–121 (September 2012): 59–66. https://doi.org/10.1016/j.aquatox.2012.04.012.Full Text
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Ciracì, C., R. T. Hill, J. J. Mock, Y. Urzhumov, A. I. Fernández-Domínguez, S. A. Maier, J. B. Pendry, A. Chilkoti, and D. R. Smith. “Probing the ultimate limits of plasmonic enhancement.” Science (New York, N.Y.) 337, no. 6098 (August 2012): 1072–74. https://doi.org/10.1126/science.1224823.Full Text Open Access Copy
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Xu, Donghua, Daisuke Asai, Ashutosh Chilkoti, and Stephen L. Craig. “Rheological properties of cysteine-containing elastin-like polypeptide solutions and hydrogels.” Biomacromolecules 13, no. 8 (August 2012): 2315–21. https://doi.org/10.1021/bm300760s.Full Text
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Hubbell, Jeffrey A., and Ashutosh Chilkoti. “Chemistry. Nanomaterials for drug delivery.” Science (New York, N.Y.) 337, no. 6092 (July 2012): 303–5. https://doi.org/10.1126/science.1219657.Full Text
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Asai, Daisuke, Donghua Xu, Wenge Liu, Felipe Garcia Quiroz, Daniel J. Callahan, Michael R. Zalutsky, Stephen L. Craig, and Ashutosh Chilkoti. “Protein polymer hydrogels by in situ, rapid and reversible self-gelation.” Biomaterials 33, no. 21 (July 2012): 5451–58. https://doi.org/10.1016/j.biomaterials.2012.03.083.Full Text Link to Item
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Macewan, Sarah R., and Ashutosh Chilkoti. “Digital switching of local arginine density in a genetically encoded self-assembled polypeptide nanoparticle controls cellular uptake.” Nano Letters 12, no. 6 (June 2012): 3322–28. https://doi.org/10.1021/nl301529p.Full Text
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McDaniel, Jonathan R., Sarah R. Macewan, Mark Dewhirst, and Ashutosh Chilkoti. “Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia.” J Control Release 159, no. 3 (May 10, 2012): 362–67. https://doi.org/10.1016/j.jconrel.2012.02.030.Full Text Link to Item
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Hassouneh, Wafa, Karl Fischer, Sarah R. MacEwan, Robert Branscheid, Chuan Lawrence Fu, Rihe Liu, Manfred Schmidt, and Ashutosh Chilkoti. “Unexpected multivalent display of proteins by temperature triggered self-assembly of elastin-like polypeptide block copolymers.” Biomacromolecules 13, no. 5 (May 2012): 1598–1605. https://doi.org/10.1021/bm300321n.Full Text
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Callahan, Daniel J., Wenge Liu, Xinghai Li, Matthew R. Dreher, Wafa Hassouneh, Minkyu Kim, Piotr Marszalek, and Ashutosh Chilkoti. “Triple stimulus-responsive polypeptide nanoparticles that enhance intratumoral spatial distribution.” Nano Letters 12, no. 4 (April 2012): 2165–70. https://doi.org/10.1021/nl300630c.Full Text
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Mock, Jack J., Ryan T. Hill, Yu-Ju Tsai, Ashutosh Chilkoti, and David R. Smith. “Probing dynamically tunable localized surface plasmon resonances of film-coupled nanoparticles by evanescent wave excitation.” Nano Letters 12, no. 4 (April 2012): 1757–64. https://doi.org/10.1021/nl204596h.Full Text
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Tjong, V., J. Zhang, A. Chilkoti, and S. Zauscher. “Stimulus-Responsive Polymers as Intelligent Coatings for Biosensors: Architectures, Response Mechanisms, and Applications,” February 3, 2012, 1–30. https://doi.org/10.1002/9781118181249.ch1.Full Text
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Hassouneh, Wafa, Sarah R. MacEwan, and Ashutosh Chilkoti. “Fusions of elastin-like polypeptides to pharmaceutical proteins.” Methods in Enzymology 502 (January 2012): 215–37. https://doi.org/10.1016/b978-0-12-416039-2.00024-0.Full Text
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Chen, S. Y., J. J. Mock, R. T. Hill, A. Chilkoti, D. R. Smith, and A. A. Lazarides. “Raman antenna formed by molecule/plasmonic nanostructure hybrid system.” Optics Infobase Conference Papers, December 1, 2011.
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Seekell, Kevin, Matthew J. Crow, Stella Marinakos, Julie Ostrander, Ashutosh Chilkoti, and Adam Wax. “Hyperspectral molecular imaging of multiple receptors using immunolabeled plasmonic nanoparticles.” Journal of Biomedical Optics 16, no. 11 (November 2011): 116003. https://doi.org/10.1117/1.3646529.Full Text
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Ferris, Robert, Angus Hucknall, Byung Seok Kwon, Tao Chen, Ashutosh Chilkoti, and Stefan Zauscher. “Field-induced nanolithography for patterning of non-fouling polymer brush surfaces.” Small (Weinheim an Der Bergstrasse, Germany) 7, no. 21 (November 2011): 3032–37. https://doi.org/10.1002/smll.201100923.Full Text
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Simnick, Andrew J., Miriam Amiram, Wenge Liu, Gabi Hanna, Mark W. Dewhirst, Christopher D. Kontos, and Ashutosh Chilkoti. “In vivo tumor targeting by a NGR-decorated micelle of a recombinant diblock copolypeptide.” J Control Release 155, no. 2 (October 30, 2011): 144–51. https://doi.org/10.1016/j.jconrel.2011.06.044.Full Text Link to Item
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Chen, S. Y., J. J. Mock, R. T. Hill, A. Chilkoti, D. R. Smith, and A. A. Lazarides. “Raman antenna formed by molecule/plasmonic nanostructure hybrid system.” 2011 Conference on Lasers and Electro Optics: Laser Science to Photonic Applications, Cleo 2011, September 1, 2011.
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Gao, W., D. Xu, D. W. Lim, S. L. Craig, and A. Chilkoti. “In situ growth of a thermoresponsive polymer from a genetically engineered elastin-like polypeptide.” Polymer Chemistry 2, no. 7 (July 1, 2011): 1561–66. https://doi.org/10.1039/c1py00074h.Full Text
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Nusz, Gregory J., Stella M. Marinakos, Srinath Rangarajan, and Ashutosh Chilkoti. “Dual-order snapshot spectral imaging of plasmonic nanoparticles.” Applied Optics 50, no. 21 (July 2011): 4198–4206. https://doi.org/10.1364/ao.50.004198.Full Text
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Tjong, Vinalia, Hua Yu, Angus Hucknall, Srinath Rangarajan, and Ashutosh Chilkoti. “Amplified on-chip fluorescence detection of DNA hybridization by surface-initiated enzymatic polymerization.” Analytical Chemistry 83, no. 13 (July 2011): 5153–59. https://doi.org/10.1021/ac200946t.Full Text
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Fluegel, Sabine, Jasmin Buehler, Karl Fischer, Jonathan R. McDaniel, Ashutosh Chilkoti, and Manfred Schmidt. “Self-assembly of monodisperse oligonucleotide-elastin block copolymers into stars and compound micelles.” Chemistry (Weinheim an Der Bergstrasse, Germany) 17, no. 20 (May 2011): 5503–6. https://doi.org/10.1002/chem.201100436.Full Text
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Crow, M. J., K. Seekell, S. Marinakos, J. Ostrander, A. Chilkoti, and A. P. Wax. “Hyperspectral molecular imaging of multiple receptors using immunolabeled plasmonic nanoparticles.” Progress in Biomedical Optics and Imaging Proceedings of Spie 7911 (April 29, 2011). https://doi.org/10.1117/12.874093.Full Text
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Ahmad, Shah Alang, Graham J. Leggett, Angus Hucknall, and Ashutosh Chilkoti. “Micro- and nanostructured poly[oligo(ethylene glycol)methacrylate] brushes grown from photopatterned halogen initiators by atom transfer radical polymerization.” Biointerphases 6, no. 1 (March 2011): 8–15. https://doi.org/10.1116/1.3553579.Full Text
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Amiram, Miriam, Felipe Garcia Quiroz, Daniel J. Callahan, and Ashutosh Chilkoti. “A highly parallel method for synthesizing DNA repeats enables the discovery of 'smart' protein polymers.” Nat Mater 10, no. 2 (February 2011): 141–48. https://doi.org/10.1038/nmat2942.Full Text Link to Item
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Yang, Peng, Stella M. Marinakos, and Ashutosh Chilkoti. “Spatially addressable chemoselective C-terminal ligation of an intein fusion protein from a complex mixture to a hydrazine-terminated surface.” Langmuir : The Acs Journal of Surfaces and Colloids 27, no. 4 (February 2011): 1463–71. https://doi.org/10.1021/la104186n.Full Text
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Chen, Mingnan, Jonathan R. McDaniel, J Andrew Mackay, and Ashutosh Chilkoti. “NANOSCALE SELF-ASSEMBLY FOR DELIVERY OF THERAPEUTICS AND IMAGING AGENTS.” Technology and Innovation 13, no. 1 (January 2011): 5–25. https://doi.org/10.3727/194982411x13003853539948.Full Text
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Crow, Matthew J., Stella M. Marinakos, J Michael Cook, Ashutosh Chilkoti, and Adam Wax. “Plasmonic flow cytometry by immunolabeled nanorods.” Cytometry A 79, no. 1 (January 2011): 57–65. https://doi.org/10.1002/cyto.a.20994.Full Text Link to Item
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Williams, Corin, Xin Q. Brown, Erzsebet Bartolak-Suki, Hongwei Ma, Ashutosh Chilkoti, and Joyce Y. Wong. “The use of micropatterning to control smooth muscle myosin heavy chain expression and limit the response to transforming growth factor β1 in vascular smooth muscle cells.” Biomaterials 32, no. 2 (January 2011): 410–18. https://doi.org/10.1016/j.biomaterials.2010.08.105.Full Text
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McDaniel, Jonathan R., Daniel J. Callahan, and Ashutosh Chilkoti. “Drug delivery to solid tumors by elastin-like polypeptides.” Advanced Drug Delivery Reviews 62, no. 15 (December 2010): 1456–67. https://doi.org/10.1016/j.addr.2010.05.004.Full Text
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Nettles, Dana L., Ashutosh Chilkoti, and Lori A. Setton. “Applications of elastin-like polypeptides in tissue engineering.” Advanced Drug Delivery Reviews 62, no. 15 (December 2010): 1479–85. https://doi.org/10.1016/j.addr.2010.04.002.Full Text
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Chen, Shiuan-Yeh, Jack J. Mock, Ryan T. Hill, Ashutosh Chilkoti, David R. Smith, and Anne A. Lazarides. “Gold nanoparticles on polarizable surfaces as Raman scattering antennas.” Acs Nano 4, no. 11 (November 2010): 6535–46. https://doi.org/10.1021/nn101644s.Full Text Open Access Copy
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Fluegel, Sabine, Karl Fischer, Jonathan R. McDaniel, Ashutosh Chilkoti, and Manfred Schmidt. “Chain stiffness of elastin-like polypeptides.” Biomacromolecules 11, no. 11 (November 2010): 3216–18. https://doi.org/10.1021/bm100965y.Full Text Open Access Copy
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Mackay, J Andrew, Daniel J. Callahan, Kelly N. Fitzgerald, and Ashutosh Chilkoti. “Quantitative model of the phase behavior of recombinant pH-responsive elastin-like polypeptides.” Biomacromolecules 11, no. 11 (November 2010): 2873–79. https://doi.org/10.1021/bm100571j.Full Text Open Access Copy
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Hill, Ryan T., Jack J. Mock, Yaroslav Urzhumov, David S. Sebba, Steven J. Oldenburg, Shiuan-Yeh Chen, Anne A. Lazarides, Ashutosh Chilkoti, and David R. Smith. “Leveraging nanoscale plasmonic modes to achieve reproducible enhancement of light.” Nano Letters 10, no. 10 (October 2010): 4150–54. https://doi.org/10.1021/nl102443p.Full Text Open Access Copy
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Gao, Weiping, Wenge Liu, Trine Christensen, Michael R. Zalutsky, and Ashutosh Chilkoti. “In situ growth of a PEG-like polymer from the C terminus of an intein fusion protein improves pharmacokinetics and tumor accumulation.” Proc Natl Acad Sci U S A 107, no. 38 (September 21, 2010): 16432–37. https://doi.org/10.1073/pnas.1006044107.Full Text Link to Item
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Hassouneh, Wafa, Trine Christensen, and Ashutosh Chilkoti. “Elastin-like polypeptides as a purification tag for recombinant proteins.” Current Protocols in Protein Science Chapter 6 (August 2010): Unit-6.11. https://doi.org/10.1002/0471140864.ps0611s61.Full Text
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MacEwan, Sarah R., Daniel J. Callahan, and Ashutosh Chilkoti. “Stimulus-responsive macromolecules and nanoparticles for cancer drug delivery.” Nanomedicine (London, England) 5, no. 5 (July 2010): 793–806. https://doi.org/10.2217/nnm.10.50.Full Text
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Alang Ahmad, Shahrul, Angus Hucknall, Ashutosh Chilkoti, and Graham J. Leggett. “Protein patterning by UV-induced photodegradation of poly(oligo(ethylene glycol) methacrylate) brushes.” Langmuir : The Acs Journal of Surfaces and Colloids 26, no. 12 (June 2010): 9937–42. https://doi.org/10.1021/la100438d.Full Text Open Access Copy
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Liu, Wenge, J Andrew MacKay, Matthew R. Dreher, Mingnan Chen, Jonathan R. McDaniel, Andrew J. Simnick, Daniel J. Callahan, Michael R. Zalutsky, and Ashutosh Chilkoti. “Injectable intratumoral depot of thermally responsive polypeptide-radionuclide conjugates delays tumor progression in a mouse model.” J Control Release 144, no. 1 (May 21, 2010): 2–9. https://doi.org/10.1016/j.jconrel.2010.01.032.Full Text Link to Item
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Jenness, Nathan J., Ryan T. Hill, Angus Hucknall, Ashutosh Chilkoti, and Robert L. Clark. “A versatile diffractive maskless lithography for single-shot and serial microfabrication.” Optics Express 18, no. 11 (May 2010): 11754–62. https://doi.org/10.1364/oe.18.011754.Full Text Open Access Copy
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McDaniel, Jonathan R., J Andrew Mackay, Felipe García Quiroz, and Ashutosh Chilkoti. “Recursive directional ligation by plasmid reconstruction allows rapid and seamless cloning of oligomeric genes.” Biomacromolecules 11, no. 4 (April 2010): 944–52. https://doi.org/10.1021/bm901387t.Full Text Open Access Copy
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Simnick, Andrew J., C Alexander Valencia, Rihe Liu, and Ashutosh Chilkoti. “Morphing low-affinity ligands into high-avidity nanoparticles by thermally triggered self-assembly of a genetically encoded polymer.” Acs Nano 4, no. 4 (April 2010): 2217–27. https://doi.org/10.1021/nn901732h.Full Text Open Access Copy
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MacEwan, Sarah R., and Ashutosh Chilkoti. “Elastin-like polypeptides: biomedical applications of tunable biopolymers.” Biopolymers 94, no. 1 (January 2010): 60–77. https://doi.org/10.1002/bip.21327.Full Text
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Meyer, J. N., C. A. Lord, X. Y. Yang, E. A. Turner, A. R. Badireddy, S. Marinakos, A. Chilkoti, M. R. Wiesner, and M. Auffan. “Intracellular uptake and associated toxicity of silver nanoparticles in Caenorhabditis elegans.” Aquatic Toxicol 100 (2010): 140–50.
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Nettles, Dana L., Mansoor A. Haider, Ashutosh Chilkoti, and Lori A. Setton. “Neural network analysis identifies scaffold properties necessary for in vitro chondrogenesis in elastin-like polypeptide biopolymer scaffolds.” Tissue Engineering. Part A 16, no. 1 (January 2010): 11–20. https://doi.org/10.1089/ten.tea.2009.0134.Full Text Open Access Copy
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MacKay, J Andrew, Mingnan Chen, Jonathan R. McDaniel, Wenge Liu, Andrew J. Simnick, and Ashutosh Chilkoti. “Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection.” Nature Materials 8, no. 12 (December 2009): 993–99. https://doi.org/10.1038/NMAT2569.Full Text Link to Item
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Cho, Younhee, Laura B. Sagle, Satoshi Iimura, Yanjie Zhang, Jaibir Kherb, Ashutosh Chilkoti, J Martin Scholtz, and Paul S. Cremer. “Hydrogen bonding of beta-turn structure is stabilized in D(2)O.” Journal of the American Chemical Society 131, no. 42 (October 2009): 15188–93. https://doi.org/10.1021/ja9040785.Full Text
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Gao, Weiping, Wenge Liu, J Andrew Mackay, Michael R. Zalutsky, Eric J. Toone, and Ashutosh Chilkoti. “In situ growth of a stoichiometric PEG-like conjugate at a protein's N-terminus with significantly improved pharmacokinetics.” Proc Natl Acad Sci U S A 106, no. 36 (September 8, 2009): 15231–36. https://doi.org/10.1073/pnas.0904378106.Full Text Link to Item
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Nettles, Dana L., Ashutosh Chilkoti, and Lori A. Setton. “Early metabolite levels predict long-term matrix accumulation for chondrocytes in elastin-like polypeptide biopolymer scaffolds.” Tissue Engineering. Part A 15, no. 8 (August 2009): 2113–21. https://doi.org/10.1089/ten.tea.2008.0448.Full Text
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Christensen, Trine, Miriam Amiram, Sue Dagher, Kimberly Trabbic-Carlson, Mohammed F. Shamji, Lori A. Setton, and Ashutosh Chilkoti. “Fusion order controls expression level and activity of elastin-like polypeptide fusion proteins.” Protein Science : A Publication of the Protein Society 18, no. 7 (July 2009): 1377–87. https://doi.org/10.1002/pro.157.Full Text
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Hucknall, A., S. Rangarajan, and A. Chilkoti. “In pursuit of zero: Polymer brushes that resist the adsorption of proteins.” Advanced Materials 21, no. 23 (June 19, 2009): 2441–46. https://doi.org/10.1002/adma.200900383.Full Text
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Crow, M., S. Marinakos, A. Chilkoti, and A. Wax. “Simultaneous molecular imaging of EGFR and HER2 using hyperspectral darkfield microscopy and immunotargeted nanoparticles.” Progress in Biomedical Optics and Imaging Proceedings of Spie 7192 (June 12, 2009). https://doi.org/10.1117/12.808968.Full Text
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Hucknall, Angus, Andrew J. Simnick, Ryan T. Hill, Ashutosh Chilkoti, Andres Garcia, Matthew S. Johannes, Robert L. Clark, Stefan Zauscher, and Buddy D. Ratner. “Versatile synthesis and micropatterning of nonfouling polymer brushes on the wafer scale.” Biointerphases 4, no. 2 (June 2009): FA50–57. https://doi.org/10.1116/1.3151968.Full Text
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Zauscher, Stefan, and Ashutosh Chilkoti. “Biological applications of polymer brushes. Preface.” Biointerphases 4, no. 2 (June 2009): FA1–2. https://doi.org/10.1116/1.3149787.Full Text
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Hucknall, Angus, Dong-Hwan Kim, Srinath Rangarajan, Ryan T. Hill, William M. Reichert, and Ashutosh Chilkoti. “Simple Fabrication of Antibody Microarrays on Nonfouling Polymer Brushes with Femtomolar Sensitivity for Protein Analytes in Serum and Blood.” Advanced Materials (Deerfield Beach, Fla.) 21, no. 19 (May 12, 2009): 1968–71. https://doi.org/10.1002/adma.200803125.Full Text
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Nusz, Greg J., Adam C. Curry, Stella M. Marinakos, Adam Wax, and Ashutosh Chilkoti. “Rational selection of gold nanorod geometry for label-free plasmonic biosensors.” Acs Nano 3, no. 4 (April 2009): 795–806. https://doi.org/10.1021/nn8006465.Full Text
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Chilkoti, Ashutosh. “Precision engineered control of biomolecules at interfaces by polymer brushes.” Abstracts of Papers of the American Chemical Society 237 (March 22, 2009).Link to Item
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Chilkoti, A. “Designing interfaces for optical biosensors.” Optics Infobase Conference Papers, January 1, 2009.
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MacKay, J Andrew, Mingnan Chen, Jonathan R. McDaniel, Wenge Liu, Andrew J. Simnick, and Ashutosh Chilkoti. “Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection.” Nature Materials 8 (2009): 993–99.
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Wu, Y. Q., J. A. Mackay, J. R. Mcdaniel, A. Chilkoti, and R. L. Clark. “Fabrication of Elastin-Like polypeptide Nanoparticles for Drug Delivery by Electrospraying.” Biomacromolecules 10, no. 1 (January 2009): 19–24.
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Chilkoti, A. “Patterning materials with biomolecules.” 8th World Biomaterials Congress 2008 4 (December 1, 2008): 2249–50.
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Kim, Bumjoon, and Ashutosh Chilkoti. “Allosteric actuation of inverse phase transition of a stimulus-responsive fusion polypeptide by ligand binding.” Journal of the American Chemical Society 130, no. 52 (December 2008): 17867–73. https://doi.org/10.1021/ja8059057.Full Text
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Cho, Y. H., Y. J. Zhang, T. Christensen, L. B. Sagle, A. Chilkoti, and P. S. Cremer. “Effects of Hofmeister Anions on the Phase Transition Temperature of Elastin-like Polypeptides.” Journal of Physical Chemistry B 112, no. 44 (November 2008): 13765–71.
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Mackay, J Andrew, and Ashutosh Chilkoti. “Temperature sensitive peptides: engineering hyperthermia-directed therapeutics.” International Journal of Hyperthermia : The Official Journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group 24, no. 6 (September 2008): 483–95. https://doi.org/10.1080/02656730802149570.Full Text
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Xu, Fei, Huang Min Joon, Kimberly Trabbic-Carlson, Ashutosh Chilkoti, and Wolfgang Knoll. “Surface plasmon optical study of the interfacial phase transition of elastinlike polypeptide grafted on gold.” Biointerphases 3, no. 3 (September 2008): 66–74. https://doi.org/10.1116/1.2965133.Full Text
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Shamji, Mohammed F., Jun Chen, Allan H. Friedman, William J. Richardson, Ashutosh Chilkoti, and Lori A. Setton. “Synthesis and characterization of a thermally-responsive tumor necrosis factor antagonist.” J Control Release 129, no. 3 (August 7, 2008): 179–86. https://doi.org/10.1016/j.jconrel.2008.04.021.Full Text Link to Item
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Mock, Jack J., Ryan T. Hill, Aloyse Degiron, Stefan Zauscher, Ashutosh Chilkoti, and David R. Smith. “Distance-dependent plasmon resonant coupling between a gold nanoparticle and gold film.” Nano Letters 8, no. 8 (August 2008): 2245–52. https://doi.org/10.1021/nl080872f.Full Text
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Valiaev, Alexei, Dong Woo Lim, Scott Schmidler, Robert L. Clark, Ashutosh Chilkoti, and Stefan Zauscher. “Hydration and conformational mechanics of single, end-tethered elastin-like polypeptides.” Journal of the American Chemical Society 130, no. 33 (August 2008): 10939–46. https://doi.org/10.1021/ja800502h.Full Text
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Nettles, Dana L., Kenichi Kitaoka, Neil A. Hanson, Charlene M. Flahiff, Brian A. Mata, Edward W. Hsu, Ashutosh Chilkoti, and Lori A. Setton. “In situ crosslinking elastin-like polypeptide gels for application to articular cartilage repair in a goat osteochondral defect model.” Tissue Engineering. Part A 14, no. 7 (July 2008): 1133–40. https://doi.org/10.1089/ten.tea.2007.0245.Full Text
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Shamji, Mohammed F., Lyman Whitlatch, Allan H. Friedman, William J. Richardson, Ashutosh Chilkoti, and Lori A. Setton. “An injectable and in situ-gelling biopolymer for sustained drug release following perineural administration.” Spine (Phila Pa 1976) 33, no. 7 (April 1, 2008): 748–54. https://doi.org/10.1097/BRS.0b013e3181695773.Full Text Link to Item
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Nusz, Greg J., Stella M. Marinakos, Adam C. Curry, Andreas Dahlin, Fredrik Höök, Adam Wax, and Ashutosh Chilkoti. “Label-free plasmonic detection of biomolecular binding by a single gold nanorod.” Analytical Chemistry 80, no. 4 (February 2008): 984–89. https://doi.org/10.1021/ac7017348.Full Text
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Chow, Dominic, Michelle L. Nunalee, Dong Woo Lim, Andrew J. Simnick, and Ashutosh Chilkoti. “Peptide-based Biopolymers in Biomedicine and Biotechnology.” Materials Science & Engineering. R, Reports : A Review Journal 62, no. 4 (January 2008): 125–55. https://doi.org/10.1016/j.mser.2008.04.004.Full Text
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Dreher, Matthew R., Andrew J. Simnick, Karl Fischer, Richard J. Smith, Anand Patel, Manfred Schmidt, and Ashutosh Chilkoti. “Temperature triggered self-assembly of polypeptides into multivalent spherical micelles.” Journal of the American Chemical Society 130, no. 2 (January 2008): 687–94. https://doi.org/10.1021/ja0764862.Full Text
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Lim, Dong Woo, Dana L. Nettles, Lori A. Setton, and Ashutosh Chilkoti. “In situ cross-linking of elastin-like polypeptide block copolymers for tissue repair.” Biomacromolecules 9, no. 1 (January 2008): 222–30. https://doi.org/10.1021/bm7007982.Full Text
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Skala, M. C., S. Marinakos, A. Chilkoti, and J. A. Izatt. “Photothermal optical coherence tomography for molecular contrast imaging.” Biomedical Optics, Biomed 2008, January 1, 2008. https://doi.org/10.1364/biomed.2008.bwf5.Full Text
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Lam, Y., A. Valiaev, D. W. Lim, A. Chilkoti, S. M. Alam, and S. Zauscher. “Single molecule nanomechanics of HIV-1 envelope glycoproteins and elastin-like polypeptides.” Proceedings of the Sem Annual Conference and Exposition on Experimental and Applied Mechanics 2007 1 (November 19, 2007): 624–25.
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Chow, Dominic C., and Ashutosh Chilkoti. “Surface-initiated enzymatic polymerization of DNA.” Langmuir : The Acs Journal of Surfaces and Colloids 23, no. 23 (November 2007): 11712–17. https://doi.org/10.1021/la701630g.Full Text
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Shamji, Mohammed F., Helawe Betre, Virginia B. Kraus, Jun Chen, Ashutosh Chilkoti, Rajeswari Pichika, Koichi Masuda, and Lori A. Setton. “Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic.” Arthritis Rheum 56, no. 11 (November 2007): 3650–61. https://doi.org/10.1002/art.22952.Full Text Link to Item
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Chilkoti, Ashutosh. “Elastin biopolymers for drug delivery.” Abstracts of Papers of the American Chemical Society 234 (August 19, 2007).Link to Item
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Garcia, Andres, Angus Hucknall, Matthew Johannes, Robert Clark, Ashutosh Chilkoti, and Stefan Zauscher. “POLY 627-Fabrication of bioconjugated and hybrid polymeric nanostructures by field-induced scanning probe lithography.” Abstracts of Papers of the American Chemical Society 234 (August 19, 2007).Link to Item
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Roberts, S Kenny, Ashutosh Chilkoti, and Lori A. Setton. “Multifunctional thermally transitioning oligopeptides prepared by ring-opening metathesis polymerization.” Biomacromolecules 8, no. 8 (August 2007): 2618–21. https://doi.org/10.1021/bm0702713.Full Text
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Dreher, Matthew R., and Ashutosh Chilkoti. “Toward a systems engineering approach to cancer drug delivery.” Journal of the National Cancer Institute 99, no. 13 (July 2007): 983–85. https://doi.org/10.1093/jnci/djm042.Full Text
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Marinakos, Stella M., Sihai Chen, and Ashutosh Chilkoti. “Plasmonic detection of a model analyte in serum by a gold nanorod sensor.” Analytical Chemistry 79, no. 14 (July 2007): 5278–83. https://doi.org/10.1021/ac0706527.Full Text
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Valiaev, Alexei, Dong Woo Lim, Terrence G. Oas, Ashutosh Chilkoti, and Stefan Zauscher. “Force-induced prolyl cis-trans isomerization in elastin-like polypeptides.” J Am Chem Soc 129, no. 20 (May 23, 2007): 6491–97. https://doi.org/10.1021/ja070147r.Full Text Link to Item
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Dreher, Matthew R., Wenge Liu, Charles R. Michelich, Mark W. Dewhirst, and Ashutosh Chilkoti. “Thermal cycling enhances the accumulation of a temperature-sensitive biopolymer in solid tumors.” Cancer Res 67, no. 9 (May 1, 2007): 4418–24. https://doi.org/10.1158/0008-5472.CAN-06-4444.Full Text Link to Item
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Lim, Dong Woo, Dana L. Nettles, Lori A. Setton, and Ashutosh Chilkoti. “Rapid cross-linking of elastin-like polypeptides with (hydroxymethyl)phosphines in aqueous solution.” Biomacromolecules 8, no. 5 (May 2007): 1463–70. https://doi.org/10.1021/bm061059m.Full Text
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Lim, Dong Woo, Kimberly Trabbic-Carlson, J Andrew Mackay, and Ashutosh Chilkoti. “Improved non-chromatographic purification of a recombinant protein by cationic elastin-like polypeptides.” Biomacromolecules 8, no. 5 (May 2007): 1417–24. https://doi.org/10.1021/bm060849t.Full Text
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Curry, Adam, Gregory Nusz, Ashutosh Chilkoti, and Adam Wax. “Analysis of total uncertainty in spectral peak measurements for plasmonic nanoparticle-based biosensors.” Applied Optics 46, no. 10 (April 2007): 1931–39. https://doi.org/10.1364/ao.46.001931.Full Text
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Lee, Woo-Kyung, Sihai Chen, Ashutosh Chilkoti, and Stefan Zauscher. “Fabrication of gold nanowires by electric-field-induced scanning probe lithography and in situ chemical development.” Small (Weinheim an Der Bergstrasse, Germany) 3, no. 2 (February 2007): 249–54. https://doi.org/10.1002/smll.200600396.Full Text
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Christensen1, Trine, Trine a, Kimberly Trabbic-Carlson1, Kimberly a, Wenge Liua, and Ashutosh Chilkoti. “Purification of recombinant proteins from Escherichia coli at low expression levels by inverse transition cycling.” Analytical Biochemistry Volume 360, Issue 1 (January 2007): 166–68.
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Dhawan, A., M. Gerhold, S. Marinakos, D. Leonard, H. N. Wang, A. Chilkoti, P. Russell, and T. Vo-Dinh. “Fabrication of fiber-optic sensors based on plasmon resonances of metallic nanostructures.” Ecs Transactions 11, no. 14 (January 1, 2007): 41–55. https://doi.org/10.1149/1.2902314.Full Text
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Simnick, A. J., D. W. Lim, D. Chow, and A. Chilkoti. “Biomedical and biotechnological applications of Elastin-like polypeptides.” Polymer Reviews 47, no. 1 (January 1, 2007): 121–54. https://doi.org/10.1080/15583720601109594.Full Text
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Kim, D. H., J. T. Smith, A. Chilkoti, and W. M. Reichert. “The effect of covalently immobilized rhIL-1ra-ELP fusion protein on the inflammatory profile of LPS-stimulated human monocytes.” Biomaterials 28, no. 23 (2007): 3369–77.
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Valiaev, Alexei, Nehal I. Abu-Lail, Dong Woo Lim, Ashutosh Chilkoti, and Stefan Zauscher. “Microcantilever sensing and actuation with end-grafted stimulus-responsive elastin-like polypeptides.” Langmuir : The Acs Journal of Surfaces and Colloids 23, no. 1 (January 2007): 339–44. https://doi.org/10.1021/la0616698.Full Text
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Chilkoti, Ashutosh, Trine Christensen, and J Andrew MacKay. “Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology.” Current Opinion in Chemical Biology 10, no. 6 (December 2006): 652–57. https://doi.org/10.1016/j.cbpa.2006.10.010.Full Text
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Liu, Wenge, Matthew R. Dreher, Darin Y. Furgeson, Katia V. Peixoto, Hong Yuan, Michael R. Zalutsky, and Ashutosh Chilkoti. “Tumor accumulation, degradation and pharmacokinetics of elastin-like polypeptides in nude mice.” J Control Release 116, no. 2 (November 28, 2006): 170–78. https://doi.org/10.1016/j.jconrel.2006.06.026.Full Text Link to Item
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Liu, W. E., M. R. Dreher, D. Y. Furgeson, K. V. Peixoto, H. Yuan, M. R. Zalutsky, and A. Chilkoti. “Tumor accumulation, degradation and pharmacokinetics of elastin-like polypeptides in nude mice.” Journal of Controlled Release 116, no. 2 (November 2006): 170–78.
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Betre, Helawe, Wenge Liu, Michael R. Zalutsky, Ashutosh Chilkoti, Virginia B. Kraus, and Lori A. Setton. “A thermally responsive biopolymer for intra-articular drug delivery.” J Control Release 115, no. 2 (October 10, 2006): 175–82. https://doi.org/10.1016/j.jconrel.2006.07.022.Full Text Link to Item
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Ge, Xin, Kimberly Trabbic-Carlson, Ashutosh Chilkoti, and Carlos D. M. Filipe. “Purification of an elastin-like fusion protein by microfiltration.” Biotechnology and Bioengineering 95, no. 3 (October 2006): 424–32. https://doi.org/10.1002/bit.21046.Full Text
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Liu, Wenge, Matthew R. Dreher, Dominic C. Chow, Michael R. Zalutsky, and Ashutosh Chilkoti. “Tracking the in vivo fate of recombinant polypeptides by isotopic labeling.” J Control Release 114, no. 2 (August 28, 2006): 184–92. https://doi.org/10.1016/j.jconrel.2006.06.001.Full Text Link to Item
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Chow, Dominic C., Matthew R. Dreher, Kimberly Trabbic-Carlson, and Ashutosh Chilkoti. “Ultra-high expression of a thermally responsive recombinant fusion protein in E. coli.” Biotechnology Progress 22, no. 3 (May 2006): 638–46. https://doi.org/10.1021/bp0503742.Full Text
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Pyhtila, John W., Hongwei Ma, Andrew J. Simnick, Ashutosh Chilkoti, and Adam Wax. “Analysis of long range correlations due to coherent light scattering from in-vitro cell arrays using angle-resolved low coherence interferometry.” Journal of Biomedical Optics 11, no. 3 (May 2006): 34022. https://doi.org/10.1117/1.2209561.Full Text
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Ma, Hongwei, Dejin Li, Xia Sheng, Bin Zhao, and Ashutosh Chilkoti. “Protein-resistant polymer coatings on silicon oxide by surface-initiated atom transfer radical polymerization.” Langmuir : The Acs Journal of Surfaces and Colloids 22, no. 8 (April 2006): 3751–56. https://doi.org/10.1021/la052796r.Full Text
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Chilkoti, Ashutosh. “Bionanofabrication with polymers and enzymes.” Abstracts of Papers of the American Chemical Society 231 (March 26, 2006).Link to Item
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Abu-Lail, Nehal, Marian Kaholek, Alexei Valiaev, Dong-Woo Lim, Ashutosh Chilkoti, Bruce LaMattina, Robert Clark, and Stefan Zauscher. “Micro-cantilevers decorated with tethered stimulus-responsive polymer brushes and polypeptides for actuation and sensing.” Abstracts of Papers of the American Chemical Society 231 (March 26, 2006).Link to Item
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Lee, Woo-Kyung, Sihai Chen, Ashutosh Chilkoti, and Stefan Zauscher. “Fabrication of bioconjugated polymeric nanostructures and metal nanowires by electric field-induced scanning probe lithography.” Abstracts of Papers of the American Chemical Society 231 (March 26, 2006).Link to Item
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Ma, H., M. Wells, T. P. Beebe, and A. Chilkoti. “Surface-initiated atom transfer radical polymerization of oligo(ethylene glycol) methyl methacrylate from a mixed self-assembled monolayer on gold.” Advanced Functional Materials 16, no. 5 (March 20, 2006): 640–48. https://doi.org/10.1002/adfm.200500426.Full Text
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Dreher, Matthew R., Wenge Liu, Charles R. Michelich, Mark W. Dewhirst, Fan Yuan, and Ashutosh Chilkoti. “Tumor vascular permeability, accumulation, and penetration of macromolecular drug carriers.” J Natl Cancer Inst 98, no. 5 (March 1, 2006): 335–44. https://doi.org/10.1093/jnci/djj070.Full Text Link to Item
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Hyun, Jinho, Jun Chen, Lori A. Setton, and Ashutosh Chilkoti. “Patterning cells in highly deformable microstructures: effect of plastic deformation of substrate on cellular phenotype and gene expression.” Biomaterials 27, no. 8 (March 2006): 1444–51. https://doi.org/10.1016/j.biomaterials.2005.08.018.Full Text
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Ma, Hongwei, Marcus Textor, Robert L. Clark, and Ashutosh Chilkoti. “Monitoring kinetics of surface initiated atom transfer radical polymerization by quartz crystal microbalance with dissipation.” Biointerphases 1, no. 1 (March 2006): 35. https://doi.org/10.1116/1.2190697.Full Text
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Ong, Shin R., Kimberly A. Trabbic-Carlson, Dana L. Nettles, Dong W. Lim, Ashutosh Chilkoti, and Lori A. Setton. “Epitope tagging for tracking elastin-like polypeptides.” Biomaterials 27, no. 9 (March 2006): 1930–35. https://doi.org/10.1016/j.biomaterials.2005.10.018.Full Text
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Betre, Helawe, Shin R. Ong, Farshid Guilak, Ashutosh Chilkoti, Beverley Fermor, and Lori A. Setton. “Chondrocytic differentiation of human adipose-derived adult stem cells in elastin-like polypeptide.” Biomaterials 27, no. 1 (January 2006): 91–99. https://doi.org/10.1016/j.biomaterials.2005.05.071.Full Text
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Curry, A., G. Nusz, A. Chilkoti, and A. Wax. “Measurement system for the high-throughput characterization of metal nanoparticles for biosensors.” Optics Infobase Conference Papers, January 1, 2006.
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Furgeson, Darin Y., Matthew R. Dreher, and Ashutosh Chilkoti. “Structural optimization of a "smart" doxorubicin-polypeptide conjugate for thermally targeted delivery to solid tumors.” Journal of Controlled Release : Official Journal of the Controlled Release Society 110, no. 2 (January 2006): 362–69. https://doi.org/10.1016/j.jconrel.2005.10.006.Full Text
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Zhang, Yanjie, Kimberly Trabbic-Carlson, Fernando Albertorio, Ashutosh Chilkoti, and Paul S. Cremer. “Aqueous two-phase system formation kinetics for elastin-like polypeptides of varying chain length.” Biomacromolecules 7, no. 7 (2006): 2192–99. https://doi.org/10.1021/bm060254y.Full Text Link to Item
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Buchheit, T. E., A. M. Minor, R. Spolenak, and K. Takashima. “Materials Research Society Symposium Proceedings: Preface.” Materials Research Society Symposium Proceedings 875 (December 1, 2005).
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Haider, M. A., D. L. Nettles, K. Trabbic-Carlson, A. Chilkoti, and L. A. Setton. “Predictive modeling of polypeptide hydrogel mechanical properties for cartilage repair using artificial neural networks.” Proceedings of the 2005 Summer Bioengineering Conference 2005 (December 1, 2005): 633–34.
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McHale, Melissa K., Lori A. Setton, and Ashutosh Chilkoti. “Synthesis and in vitro evaluation of enzymatically cross-linked elastin-like polypeptide gels for cartilaginous tissue repair.” Tissue Engineering 11, no. 11–12 (November 2005): 1768–79. https://doi.org/10.1089/ten.2005.11.1768.Full Text
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Chow, Dominic C., Woo-Kyung Lee, Stefan Zauscher, and Ashutosh Chilkoti. “Enzymatic fabrication of DNA nanostructures: extension of a self-assembled oligonucleotide monolayer on gold arrays.” Journal of the American Chemical Society 127, no. 41 (October 2005): 14122–23. https://doi.org/10.1021/ja052491z.Full Text
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Chilkoti, A. “Targeted drug delivery to solid tumors by thermally responsive polypeptides.” European Cells and Materials 10, no. SUPPL.5 (September 1, 2005): 11.
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Chilkoti, A. “Passive and active surfaces to control protein and cell interactions.” Abstracts of Papers of the American Chemical Society 230 (August 28, 2005): U4150–51.Link to Item
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Chow, D. C., A. Chilkoti, W. K. Lee, and S. Zauscher. “Rapid fabrication of DNA nanostructures by enzymatic reactions.” Abstracts of Papers of the American Chemical Society 230 (August 28, 2005): U1069–U1069.Link to Item
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Valiaev, Alexei, Nehal I. Abu-Lail, Dong Woo Lim, Ashutosh Chilkoti, and Stefan Zauscher. “Stimulus-responsive elastin-like polypetides as coatings for microcantilevers: Applications for sensing and actuation.” Abstracts of Papers of the American Chemical Society 230 (August 28, 2005): U4317–18.Link to Item
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Ge, Xin, Daniel S. C. Yang, Kimberly Trabbic-Carlson, Bumjoon Kim, Ashutosh Chilkoti, and Carlos D. M. Filipe. “Self-cleavable stimulus responsive tags for protein purification without chromatography.” Journal of the American Chemical Society 127, no. 32 (August 2005): 11228–29. https://doi.org/10.1021/ja0531125.Full Text
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Curry, A., G. Nusz, A. Chilkoti, and Adam Wax. “Substrate effect on refractive index dependence of plasmon resonance for individual silver nanoparticles observed using darkfield microspectroscopy.” Optics Express 13, no. 7 (April 2005): 2668–77. https://doi.org/10.1364/opex.13.002668.Full Text
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Chilkoti, A. “Nano- to micro-scale structures of polymers that repel and attract proteins.” Abstracts of Papers of the American Chemical Society 229 (March 13, 2005): U1158–U1158.Link to Item
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Chilkoti, Ashutosh, and Jeffrey A. Hubbell. “Biointerface Science.” Mrs Bulletin 30, no. 3 (March 2005): 175–79. https://doi.org/10.1557/mrs2005.48.Full Text
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Curry, A., G. Nusz, A. Chilkoti, and A. Wax. “Measurement system for the high-throughput characterization of metal nanoparticles for biosensors.” Optics Infobase Conference Papers, January 1, 2005.
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Curry, A., G. Nusz, A. Chilkoti, and A. Wax. “Measurement system for the high-throughput characterization of metal nanoparticles for biosensors.” 2005 Conference on Lasers and Electro Optics, Cleo 3 (January 1, 2005): 2160–62. https://doi.org/10.1109/cleo.2005.202402.Full Text
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Chow, D. C., M. S. Johannes, W. K. Lee, R. L. Clark, S. Zauscher, and A. Chilkoti. “Nanofabrication with biomolecules.” Materials Today 8, no. 12 SUPPL. 1 (January 1, 2005): 30–39. https://doi.org/10.1016/S1369-7021(05)71287-6.Full Text
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Ma, Hongwei, Jinho Hyun, Zhanping Zhang, Beebe T. P. Jr, and A. Chilkoti. “Fabrication of biofunctionalized quasi-three-dimensional microstructures of a nonfouling comb polymer using soft lithography.” Adv. Funct. Mater. (Germany) 15, no. 4 (2005): 529–40. https://doi.org/10.1002/adfm.200400088.Full Text Link to Item
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Valiaev, A., D. W. Lim, T. Oas, R. L. Clark, A. Chilkoti, and S. Zauscher. “Force-induced proline cis-trans isomerization in elastin-like polypeptides.” Biophysical Journal 88, no. 1 (January 1, 2005): 168A-168A.Link to Item
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Valiaev, A., W. L. Dong, A. Chilkoti, S. Schmidler, and S. Zauscher. “Polypeptide-solvent interactions measured by single molecule force spectroscopy.” Materials Research Society Symposium Proceedings 898 (January 1, 2005): 92–97. https://doi.org/10.1557/proc-0898-l06-06-nn04-06.Full Text
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Zhang, Zhanping, Hongwei Ma, Douglas B. Hausner, Ashutosh Chilkoti, and Thomas P. Beebe Jr. “Pretreatment of amphiphilic comb polymer surfaces dramatically affects protein adsorption.” Biomacromolecules 6, no. 6 (2005): 3388–96. https://doi.org/10.1021/bm050446d.Full Text Link to Item
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Trabbic-Carlson, Kimberly, Li Liu, Bumjoon Kim, and Ashutosh Chilkoti. “Expression and purification of recombinant proteins from Escherichia coli: Comparison of an elastin-like polypeptide fusion with an oligohistidine fusion.” Protein Science : A Publication of the Protein Society 13, no. 12 (December 2004): 3274–84. https://doi.org/10.1110/ps.04931604.Full Text
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Nath, N., J. Hyun, H. Ma, and A. Chilkoti. “Surface engineering strategies for control of protein and cell interactions.” Surface Science 570, no. 1–2 (October 10, 2004): 98–110. https://doi.org/10.1016/j.susc.2004.06.182.Full Text
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Dreher, Matthew R., Martyna Elas, Kazuhiro Ichikawa, Eugene D. Barth, Ashutosh Chilkoti, Gerald M. Rosen, Howard J. Halpern, and Mark Dewhirst. “Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry.” Med Phys 31, no. 10 (October 2004): 2755–62. https://doi.org/10.1118/1.1782677.Full Text Link to Item
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Nath, Nidhi, and Ashutosh Chilkoti. “Label-free biosensing by surface plasmon resonance of nanoparticles on glass: optimization of nanoparticle size.” Analytical Chemistry 76, no. 18 (September 2004): 5370–78. https://doi.org/10.1021/ac049741z.Full Text
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Nath, Nidhi, and Ashutosh Chilkoti. “Label free colorimetric biosensing using nanoparticles.” Journal of Fluorescence 14, no. 4 (July 2004): 377–89. https://doi.org/10.1023/b:jofl.0000031819.45448.dc.Full Text
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Hyun, Jinho, Woo-Kyung Lee, Nidhi Nath, Ashutosh Chilkoti, and Stefan Zauscher. “Capture and release of proteins on the nanoscale by stimuli-responsive elastin-like polypeptide "switches".” Journal of the American Chemical Society 126, no. 23 (June 2004): 7330–35. https://doi.org/10.1021/ja049721e.Full Text
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Meyer, Dan E., and Ashutosh Chilkoti. “Quantification of the effects of chain length and concentration on the thermal behavior of elastin-like polypeptides.” Biomacromolecules 5, no. 3 (May 2004): 846–51. https://doi.org/10.1021/bm034215n.Full Text
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Hyun, Jinho, Jeonghan Kim, Stephen L. Craig, and Ashutosh Chilkoti. “Enzymatic nanolithography of a self-assembled oligonucleotide monolayer on gold.” Journal of the American Chemical Society 126, no. 15 (April 2004): 4770–71. https://doi.org/10.1021/ja049956q.Full Text
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Ma, H., J. Hyun, P. Stiller, and A. Chilkoti. “"Non-Fouling" Oligo(ethylene glycol)-Functionalized Polymer Brushes Synthesized by Surface-Initiated Atom Transfer Radical Polymerization.” Advanced Materials 16, no. 4 (February 17, 2004): 338–41. https://doi.org/10.1002/adma.200305830.Full Text
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Piervincenzi, Ronald T., and Ashutosh Chilkoti. “Effect of genetic circular permutation near the active site on the activity and stability of an enzyme inhibitor.” Biomolecular Engineering 21, no. 1 (January 2004): 33–42. https://doi.org/10.1016/s1389-0344(03)00080-7.Full Text
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Trabbic-Carlson, K., D. E. Meyer, L. Liu, R. Piervincenzi, N. Nath, T. LaBean, and A. Chilkoti. “Effect of protein fusion on the transition temperature of an environmentally responsive elastin-like polypeptide: a role for surface hydrophobicity?” Protein Engineering, Design & Selection : Peds 17, no. 1 (January 2004): 57–66. https://doi.org/10.1093/protein/gzh006.Full Text
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Valiaev, A., R. L. Clark, A. Chilkoti, and S. Zauscher. “Conformational Mechanics of Stimulus-Responsive Polypeptides.” Proceedings of Spie the International Society for Optical Engineering 5053 (November 27, 2003): 31–40. https://doi.org/10.1117/12.484700.Full Text
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Blomfield, C. J., A. J. Roberts, S. J. Hutton, H. Ma, J. Hyun, and A. Chilkoti. “X-ray photoelectron spectroscopy as a tool for bio-surface analysis.” European Cells and Materials 6, no. SUPPL. 1 (September 1, 2003): 60.
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Ma, H., J. Hyun, N. Nath, and A. Chilkoti. “Surface engineering strategies for control of protein and cell interactions.” European Cells and Materials 6, no. SUPPL. 1 (September 1, 2003): 16–17.
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Dreher, Matthew R., Drazen Raucher, Narayanan Balu, O. Michael Colvin, Susan M. Ludeman, and Ashutosh Chilkoti. “Evaluation of an elastin-like polypeptide-doxorubicin conjugate for cancer therapy.” Journal of Controlled Release : Official Journal of the Controlled Release Society 91, no. 1–2 (August 2003): 31–43. https://doi.org/10.1016/s0168-3659(03)00216-5.Full Text
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Trabbic-Carlson, Kimberly, Lori A. Setton, and Ashutosh Chilkoti. “Swelling and mechanical behaviors of chemically cross-linked hydrogels of elastin-like polypeptides.” Biomacromolecules 4, no. 3 (May 2003): 572–80. https://doi.org/10.1021/bm025671z.Full Text
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Frey, W., D. E. Meyer, and A. Chilkoti. “Thermodynamically reversible addressing of a stimuli responsive fusion protein onto a patterned surface template.” Langmuir 19, no. 5 (March 4, 2003): 1641–53. https://doi.org/10.1021/la026359d.Full Text
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Frey, W., D. E. Meyer, and A. Chilkoti. “Dynamic addressing of a surface pattern by a stimuli-responsive fusion protein.” Advanced Materials 15, no. 3 (February 5, 2003): 248–51. https://doi.org/10.1002/adma.200390058.Full Text
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Chan, Bernard P., Ashutosh Chilkoti, William M. Reichert, and George A. Truskey. “Effect of streptavidin affinity mutants on the integrin-independent adhesion of biotinylated endothelial cells.” Biomaterials 24, no. 4 (February 2003): 559–70. https://doi.org/10.1016/s0142-9612(02)00367-8.Full Text
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Nath, Nidhi, and Ashutosh Chilkoti. “Fabrication of a reversible protein array directly from cell lysate using a stimuli-responsive polypeptide.” Analytical Chemistry 75, no. 4 (February 2003): 709–15. https://doi.org/10.1021/ac0261855.Full Text
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Hyun, Jinho, Hongwei Ma, Zhanping Zhang, Thomas P. Beebe Jr, and Ashutosh Chilkoti. “Universal route to cell micropatterning using an amphiphilic comb polymer.” Advanced Materials 15, no. 7–8 (2003): 576–79. https://doi.org/10.1002/adma.200304496.Full Text Link to Item
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Betre, H., A. Chilkoti, and L. A. Setton. “A two-step chondrocyte recovery system based on thermally sensitive elastin-like polypeptide scaffolds for cartilage tissue engineering.” Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings 1 (December 1, 2002): 829–30.
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Dreher, M., D. Raucher, N. Balu, M. Colvin, S. Ludeman, and A. Chilkoti. “Elastin-like polypeptide-doxorubicin conjugates for cancer therapy.” Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings 1 (December 1, 2002): 524–25.
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Nath, N., and A. Chilkoti. “A colorimetric gold nanoparticle biosensor: Effect of particle size on sensitivity.” Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings 1 (December 1, 2002): 574–75.
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Chilkoti, Ashutosh, Matthew R. Dreher, and Dan E. Meyer. “Design of thermally responsive, recombinant polypeptide carriers for targeted drug delivery.” Advanced Drug Delivery Reviews 54, no. 8 (October 2002): 1093–1111. https://doi.org/10.1016/s0169-409x(02)00060-1.Full Text
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Betre, Helawe, Lori A. Setton, Dan E. Meyer, and Ashutosh Chilkoti. “Characterization of a genetically engineered elastin-like polypeptide for cartilaginous tissue repair.” Biomacromolecules 3, no. 5 (September 2002): 910–16. https://doi.org/10.1021/bm0255037.Full Text
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Chilkoti, Ashutosh, Matthew R. Dreher, Dan E. Meyer, and Drazen Raucher. “Targeted drug delivery by thermally responsive polymers.” Advanced Drug Delivery Reviews 54, no. 5 (September 2002): 613–30. https://doi.org/10.1016/s0169-409x(02)00041-8.Full Text
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Chilkoti, A., and N. Nath. “A colorimetric gold nanoparticle sensor to interrogate biomolecular interactions in real-time on a surface.” Abstracts of Papers of the American Chemical Society 224 (August 18, 2002): U151–U151.Link to Item
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Hyun, J., H. Ma, P. Banerjee, J. Cole, K. Gonsalves, and A. Chilkoti. “Micropatterns of a cell-adhesive peptide on an amphiphilic comb polymer film.” Langmuir 18, no. 8 (April 16, 2002): 2975–79. https://doi.org/10.1021/la015712x.Full Text
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Rama Rao, G. V., S. Balamurugan, D. E. Meyer, A. Chilkoti, and G. P. López. “Hybrid bioinorganic smart membranes that incorporate protein-based molecular switches.” Langmuir 18, no. 5 (March 5, 2002): 1819–24. https://doi.org/10.1021/la011188i.Full Text
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Meyer, Dan E., and Ashutosh Chilkoti. “Genetically encoded synthesis of protein-based polymers with precisely specified molecular weight and sequence by recursive directional ligation: examples from the elastin-like polypeptide system.” Biomacromolecules 3, no. 2 (March 2002): 357–67. https://doi.org/10.1021/bm015630n.Full Text
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Nath, Nidhi, and Ashutosh Chilkoti. “A colorimetric gold nanoparticle sensor to interrogate biomolecular interactions in real time on a surface.” Analytical Chemistry 74, no. 3 (February 2002): 504–9. https://doi.org/10.1021/ac015657x.Full Text
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Nath, N., and A. Chilkoti. “An immobilized gold nanoparticle sensor for label free optical detection of biomolecular interactions.” Proceedings of Spie the International Society for Optical Engineering 4626 (January 1, 2002): 441–48. https://doi.org/10.1117/12.472110.Full Text
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Hyun, Jinho, Sang Jung Ahn, Woo Kyung Lee, A. Chilkoti, and S. Zauscher. “Molecular recognition-mediated fabrication of protein nanostructures by dip-pen lithography.” Nano Lett. (Usa) 2, no. 11 (2002): 1203–7. https://doi.org/10.1021/n10257364.Full Text Link to Item
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Nath, Nidhi, and Ashutosh Chilkoti. “Creating "smart" surfaces using stimuli responsive polymers.” Advanced Materials 14, no. 17 (2002): 1243–47. https://doi.org/10.1002/1521-4095(20020903)14:173.0.CO;2-M.Full Text Link to Item
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Hyun, J., Y. Zhu, A. Liebmann-Vinson, T. P. Beebe, and A. Chilkoti. “Microstamping on an activated polymer surface: Patterning biotin and streptavidin onto common polymeric biomaterials.” Langmuir 17, no. 20 (October 2, 2001): 6358–67. https://doi.org/10.1021/la010695x.Full Text
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Raucher, D., and A. Chilkoti. “Enhanced uptake of a thermally responsive polypeptide by tumor cells in response to its hyperthermia-mediated phase transition.” Cancer Research 61, no. 19 (October 2001): 7163–70.
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Chilkoti, A. “Biomedical applications of genetically encoded elastin biopolymers.” Abstracts of Papers of the American Chemical Society 222 (August 1, 2001): U421–U421.Link to Item
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Nath, N., and A. Chilkoti. “Interfacial phase transition of an environmentally responsive elastin biopolymer adsorbed on functionalized gold nanoparticles studied by colloidal surface plasmon resonance.” Journal of the American Chemical Society 123, no. 34 (August 2001): 8197–8202. https://doi.org/10.1021/ja015585r.Full Text
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Hyun, J., and A. Chilkoti. “Surface-initiated free radical polymerization of polystyrene micropatterns on a self-assembled monolayer on gold.” Macromolecules 34, no. 16 (July 31, 2001): 5644–52. https://doi.org/10.1021/ma002125u.Full Text
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Meyer, D. E., B. C. Shin, G. A. Kong, M. W. Dewhirst, and A. Chilkoti. “Drug targeting using thermally responsive polymers and local hyperthermia.” J Control Release 74, no. 1–3 (July 6, 2001): 213–24. https://doi.org/10.1016/s0168-3659(01)00319-4.Full Text Link to Item
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Hyun, J., and A. Chilkoti. “Micropatterning biological molecules on a polymer surface using elastomeric microwells.” Journal of the American Chemical Society 123, no. 28 (July 2001): 6943–44. https://doi.org/10.1021/ja015798g.Full Text
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Meyer, D. E., K. Trabbic-Carlson, and A. Chilkoti. “Protein purification by fusion with an environmentally responsive elastin-like polypeptide: effect of polypeptide length on the purification of thioredoxin.” Biotechnology Progress 17, no. 4 (July 2001): 720–28. https://doi.org/10.1021/bp010049o.Full Text
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Chilkoti, A., and N. Nath. “Phase transition of environmentally responsive elastin biopolymers adsorbed on gold nanoparticles studied by colloidal surface plasmon resonance.” Abstracts of Papers of the American Chemical Society 221 (April 1, 2001): U366–U366.Link to Item
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Meyer, D. E., G. A. Kong, M. W. Dewhirst, M. R. Zalutsky, and A. Chilkoti. “Targeting a genetically engineered elastin-like polypeptide to solid tumors by local hyperthermia.” Cancer Res 61, no. 4 (February 15, 2001): 1548–54.Link to Item
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Belu, A. M., Z. Yang, R. Aslami, and A. Chilkoti. “Enhanced TOF-SIMS imaging of a micropatterned protein by stable isotope protein labeling.” Analytical Chemistry 73, no. 2 (January 2001): 143–50. https://doi.org/10.1021/ac000771l.Full Text
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Chilkoti, A., J. Hyun, A. Belu, and Z. Yang. “Microstamping of biological ligands on activated polymer surfaces.” Annals of Biomedical Engineering 28, no. SUPPL. 1 (December 1, 2000).
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Frey, W., and A. Chilkoti. “Ultraflat nanosphere lithography: functionalized nanostructures for biomedical applications.” Annals of Biomedical Engineering 28, no. SUPPL. 1 (December 1, 2000).
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Hoffman, A. S., P. S. Stayton, V. Bulmus, G. Chen, J. Chen, C. Cheung, A. Chilkoti, et al. “Founder's Award, Society for Biomaterials. Sixth World Biomaterials Congress 2000, Kamuela, HI,May 15-20, 2000. Really smart bioconjugates of smart polymers and receptor proteins.” Journal of Biomedical Materials Research 52, no. 4 (December 2000): 577–86. https://doi.org/10.1002/1097-4636(20001215)52:4<577::aid-jbm1>3.0.co;2-5.Full Text
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Meyer, D., and A. Chilkoti. “Engineered fusion protein of an elastin-like polypeptide and autofluorescent proteins: a genetically encodable nanobiosensor.” Annals of Biomedical Engineering 28, no. SUPPL. 1 (December 1, 2000).
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Meyer, D., and A. Chilkoti. “Elastin-like polypeptides as thermally targeted drug carriers.” Annals of Biomedical Engineering 28, no. SUPPL. 1 (December 1, 2000).
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Yang, Z., A. M. Belu, A. Liebmann-Vinson, H. Sugg, and A. Chilkoti. “Molecular imaging of a micropatterned biological ligand on an activated polymer surface.” Langmuir 16, no. 19 (September 1, 2000): 7482–92. https://doi.org/10.1021/la0000623.Full Text
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Chilkoti, A., D. E. Meyer, G. H. Kong, M. W. Dewhirst, C. Foulon, and M. R. Zalutsky. “Genetically engineered biopolymer conjugate for thermal targeting of anticancer therapeutics.” Abstracts of Papers of the American Chemical Society 219 (March 26, 2000): U453–U453.Link to Item
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Chilkoti, A., Z. P. Yang, and A. M. Belu. “Microstamping of biological ligands on activated polymer surfaces.” Abstracts of Papers of the American Chemical Society 219 (March 26, 2000): U573–U573.Link to Item
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Meyer, D. E., G. A. Kong, M. W. Dewhirst, C. Foulon, M. R. Zalutsky, and A. Chilkoti. “Genetically engineered polypeptide carrier for thermal targeting of anticancer therapeutics.” American Chemical Society, Polymer Preprints, Division of Polymer Chemistry 41, no. 1 (March 1, 2000): 1020–21.
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Stayton, P. S., A. S. Hoffman, N. Murthy, C. Lackey, C. Cheung, P. Tan, L. A. Klumb, A. Chilkoti, F. S. Wilbur, and O. W. Press. “Molecular engineering of proteins and polymers for targeting and intracellular delivery of therapeutics.” Journal of Controlled Release : Official Journal of the Controlled Release Society 65, no. 1–2 (March 2000): 203–20. https://doi.org/10.1016/s0168-3659(99)00236-9.Full Text
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Yang, Z., and A. Chilkoti. “Microstamping of a Biological Ligand onto an Activated Polymer Surface.” Advanced Materials 12, no. 6 (March 2000): 413–17. https://doi.org/10.1002/(sici)1521-4095(200003)12:6<413::aid-adma413>3.3.co;2-r.Full Text
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Chilkoti, Ashutosh, Jinho Hyun, Anna Belu, and Zhongping Yang. “Microstamping of biological ligands on activated polymer surfaces.” Annals of Biomedical Engineering 28, no. SUPPL 1 (2000): 92.
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Frey, Wolfgang, and Ashutosh Chilkoti. “Ultraflat nanosphere lithography: functionalized nanostructures for biomedical applications.” Annals of Biomedical Engineering 28, no. SUPPL 1 (2000): 94.
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Meyer, Dan, and Ashutosh Chilkoti. “Engineered fusion protein of an elastin-like polypeptide and autofluorescent proteins: a genetically encodable nanobiosensor.” Annals of Biomedical Engineering 28, no. SUPPL 1 (2000): 95.
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Frey, W., C. K. Woods, and A. Chilkoti. “Ultraflat nanosphere lithography: a new method to fabricate flat nanostructures.” Adv. Mater. (Germany) 12, no. 20 (2000): 1515–19. https://doi.org/10.1002/1521-4095(200010)12:203.0.CO;2-J.Full Text Link to Item
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Hoffman, Allan S., Patrick S. Stayton, Volga Bulmus, Guohua Chen, Jingping Chen, Chuck Cheung, Ashutosh Chilkoti, et al. “Really smart bioconjugates of smart polymers and receptor proteins.” Journal of Biomedical Materials Research 52, no. 4 (2000): 577–86. https://doi.org/10.1002/1097-4636(20001215)52:43.0.CO;2-5.Full Text Link to Item
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Yang, Zhongping, W. Frey, T. Oliver, and A. Chilkoti. “Light-activated affinity micropatterning of proteins on self-assembled monolayers on gold.” Langmuir (Usa) 16, no. 4 (2000): 1751–58. https://doi.org/10.1021/la998079.Full Text Link to Item
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Yang, Zhongping, and Ashutosh Chilkoti. “Microstamping of a biological ligand onto an activated polymer surface.” Advanced Materials 12, no. 6 (2000): 413–17. https://doi.org/10.1002/(SICI)1521-4095(200003)12:63.0.CO;2.Full Text Link to Item
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Freitag, S., I. Le Trong, L. A. Klumb, V. Chu, A. Chilkoti, P. S. Stayton, and R. E. Stenkamp. “X-ray crystallographic studies of streptavidin mutants binding to biotin.” Biomolecular Engineering 16, no. 1–4 (December 1999): 13–19. https://doi.org/10.1016/s1050-3862(99)00048-0.Full Text
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Meyer, D. E., G. Kong, M. Dewhirst, and A. Chilkoti. “Genetically-engineered polypeptide carrier for thermal targeting of therapeutics.” Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings 2 (December 1, 1999): 1289.
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Piervincenzi, R. T., and A. Chilkoti. “Controlling the orientation of immobilized proteins by genetic circular permutation.” Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings 1 (December 1, 1999): 93.
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Stayton, P. S., S. Freitag, L. A. Klumb, A. Chilkoti, V. Chu, J. E. Penzotti, R. To, et al. “Streptavidin-biotin binding energetics.” Biomolecular Engineering 16, no. 1–4 (December 1999): 39–44. https://doi.org/10.1016/s1050-3862(99)00042-x.Full Text
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Wong, J., A. Chilkoti, and V. T. Moy. “Direct force measurements of the streptavidin-biotin interaction.” Biomolecular Engineering 16, no. 1–4 (December 1999): 45–55. https://doi.org/10.1016/s1050-3862(99)00035-2.Full Text
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Yang, Z. P., and A. Chilkoti. “Light-activated affinity micropatterning of proteins.” Annual International Conference of the Ieee Engineering in Medicine and Biology Proceedings 2 (December 1, 1999): 738.
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Meyer, D. E., and A. Chilkoti. “Purification of recombinant proteins by fusion with thermally-responsive polypeptides.” Nat Biotechnol 17, no. 11 (November 1999): 1112–15. https://doi.org/10.1038/15100.Full Text Link to Item
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Meyer, D. E., and A. Chilkoti. “Polypeptide fusion tag for thermal purification of recombinant proteins.” Abstracts of Papers of the American Chemical Society 217 (March 21, 1999): U177–U177.Link to Item
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Freitag, S., I. Le Trong, A. Chilkoti, L. A. Klumb, P. S. Stayton, and R. E. Stenkamp. “Structural studies of binding site tryptophan mutants in the high-affinity streptavidin-biotin complex.” Journal of Molecular Biology 279, no. 1 (May 1998): 211–21. https://doi.org/10.1006/jmbi.1998.1735.Full Text
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Hoffman, A. S., P. S. Stayton, T. Shimoboji, G. Chen, Z. Ding, A. Chilkoti, C. Long, et al. “Conjugates of Stimuli-Responsive Polymers and Biomolecules: Random and Site-Specific Conjugates of Temperature-Sensitive Polymers and Proteins.” Macromolecular Symposia 118 (January 1, 1997): 553–62. https://doi.org/10.1002/masy.19971180173.Full Text
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Shimoboji, T., P. S. Stayton, C. Long, A. Chilkoti, G. Chen, J. M. Harris, and A. S. Hoffman. “Site-specific conjugation of a temperature-sensitive polymer to a genetically-engineered protein.” Transactions of the Annual Meeting of the Society for Biomaterials in Conjunction With the International Biomaterials Symposium 1 (December 1, 1996): 897.
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Frey, W., W. R. Schief, D. W. Pack, C. T. Chen, A. Chilkoti, P. Stayton, V. Vogel, and F. H. Arnold. “Two-dimensional protein crystallization via metal-ion coordination by naturally occurring surface histidines.” Proceedings of the National Academy of Sciences of the United States of America 93, no. 10 (May 1996): 4937–41. https://doi.org/10.1073/pnas.93.10.4937.Full Text
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Chilkoti, A., B. L. Schwartz, R. D. Smith, C. J. Long, and P. S. Stayton. “Engineered chimeric streptavidin tetramers as novel tools for bioseparations and drug delivery.” Bio/Technology (Nature Publishing Company) 13, no. 11 (November 1995): 1198–1204. https://doi.org/10.1038/nbt1195-1198.Full Text
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Chilkoti, A., T. Boland, B. D. Ratner, and P. S. Stayton. “The relationship between ligand-binding thermodynamics and protein-ligand interaction forces measured by atomic force microscopy.” Biophysical Journal 69, no. 5 (November 1995): 2125–30. https://doi.org/10.1016/s0006-3495(95)80083-4.Full Text
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Stayton, P. S., T. Shimoboji, C. Long, A. Chilkoti, G. Chen, J. M. Harris, and A. S. Hoffman. “Control of protein-ligand recognition using a stimuli-responsive polymer.” Nature 378, no. 6556 (November 1995): 472–74. https://doi.org/10.1038/378472a0.Full Text
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Chilkoti, A., A. E. Schmierer, V. H. Pérez-Luna, and B. D. Ratner. “Investigating the relationship between surface chemistry and endothelial cell growth: partial least-squares regression of the static secondary ion mass spectra of oxygen-containing plasma-deposited films.” Analytical Chemistry 67, no. 17 (September 1995): 2883–91. https://doi.org/10.1021/ac00113a024.Full Text
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Schwartz, B. L., J. E. Bruce, G. A. Anderson, S. A. Hofstadler, A. L. Rockwood, R. D. Smith, A. Chilkoti, and P. S. Stayton. “Dissociation of tetrameric ions of noncovalent streptavidin complexes formed by electrospray ionization.” Journal of the American Society for Mass Spectrometry 6, no. 6 (June 1995): 459–65. https://doi.org/10.1016/1044-0305(95)00191-f.Full Text
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Chilkoti, A., P. H. Tan, and P. S. Stayton. “Site-directed mutagenesis studies of the high-affinity streptavidin-biotin complex: contributions of tryptophan residues 79, 108, and 120.” Proceedings of the National Academy of Sciences of the United States of America 92, no. 5 (February 1995): 1754–58. https://doi.org/10.1073/pnas.92.5.1754.Full Text
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Chilkoti, A., and P. S. Stayton. “Molecular Origins of the Slow Streptavidin—Biotin Dissociation Kinetics.” Journal of the American Chemical Society 117, no. 43 (January 1, 1995): 10622–28. https://doi.org/10.1021/ja00148a003.Full Text
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Schwartz, B. L., D. C. Gale, R. D. Smith, A. Chilkoti, and P. S. Stayton. “Investigation of non‐covalent ligand binding to the intact streptavidin tetramer by electrospray ionization mass spectrometry.” Journal of Mass Spectrometry 30, no. 8 (January 1, 1995): 1095–1102. https://doi.org/10.1002/jms.1190300806.Full Text
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Chilkoti, A., G. Chen, P. S. Stayton, and A. S. Hoffman. “Site-specific conjugation of a temperature-sensitive polymer to a genetically-engineered protein.” Bioconjugate Chemistry 5, no. 6 (November 1994): 504–7. https://doi.org/10.1021/bc00030a004.Full Text
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Chilkoti, A., B. D. Ratner, and D. Briggs. “Static secondary ion mass spectrometric investigation of the surface chemistry of organic plasma-deposited films created from oxygen-containing precursors. 3. Multivariate statistical modeling.” Analytical Chemistry 65, no. 13 (July 1993): 1736–45. https://doi.org/10.1021/ac00061a017.Full Text
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Chilkoti, A., G. P. Lopez, B. D. Ratner, M. J. Hearn, and D. Briggs. “Analysis of Polymer Surfaces by SIMS. 16. Investigation of Surface Cross-Linking in Polymer Gels of 2-Hydroxyethyl Methacrylate.” Macromolecules 26, no. 18 (January 1, 1993): 4825–32. https://doi.org/10.1021/ma00070a016.Full Text
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Chilkoti, A., and B. D. Ratner. “X-ray Photoelectron Spectroscopy of Iodine-Doped Nonconjugated Polymers.” Chemistry of Materials 5, no. 6 (January 1, 1993): 786–92. https://doi.org/10.1021/cm00030a012.Full Text
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Ratner, B. D., B. J. Tyler, and A. Chilkoti. “Analysis of biomedical polymer surfaces: polyurethanes and plasma-deposited thin films.” Clinical Materials 13, no. 1–4 (January 1993): 71–84. https://doi.org/10.1016/0267-6605(93)90093-m.Full Text
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Stayton, P. S., A. Chilkoti, C. J. Long, D. K. Pettit, P. H. S. Tan, G. Chen, and A. S. Hoffman. “Engineered proteins for biomaterials.” Materials Research Society Symposium Proceedings 292 (January 1, 1993): 77–82.
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Chilkoti, A., B. D. Ratner, D. Briggs, and F. Reich. “Static secondary ion mass spectrometry of organic plasma‐deposited films created from stable isotope‐labeled precursors. II. Mixtures of acetone and oxygen.” Journal of Polymer Science Part A: Polymer Chemistry 30, no. 7 (January 1, 1992): 1261–78. https://doi.org/10.1002/pola.1992.080300704.Full Text
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Chilkoti, A., B. D. Ratner, and D. Briggs. “Analysis of polymer surfaces by SIMS: Part 15. Oxygen‐functionalized aliphatic homopolymers.” Surface and Interface Analysis 18, no. 8 (January 1, 1992): 604–18. https://doi.org/10.1002/sia.740180807.Full Text
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Leggett, G. J., A. Chilkoti, B. D. Ratner, and J. C. Vickerman. “A tandem SIMS study of poly(vinyl methyl ether).” Surface and Interface Analysis 18, no. 3 (January 1, 1992): 210–16. https://doi.org/10.1002/sia.740180306.Full Text
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López, G. P., A. Chilkoti, D. Briggs, and B. D. Ratner. “Substrate temperature effects on film chemistry in plasma deposition of organics. III. Analysis by static secondary ion mass spectrometry.” Journal of Polymer Science Part A: Polymer Chemistry 30, no. 11 (January 1, 1992): 2427–41. https://doi.org/10.1002/pola.1992.080301117.Full Text
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Ratner, B. D., A. Chilkoti, and D. G. Castner. “Contemporary methods for characterizing complex biomaterial surfaces.” Clinical Materials 11, no. 1–4 (January 1, 1992): 25–36. https://doi.org/10.1016/0267-6605(92)90027-Q.Full Text
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Ertel, S. I., A. Chilkoti, T. A. Horbett, and B. D. Ratner. “Endothelial cell growth on oxygen-containing films deposited by radio-frequency plasmas: the role of surface carbonyl groups.” Journal of Biomaterials Science. Polymer Edition 3, no. 2 (December 1, 1991): 163–83.
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Leggett, G. J., A. Chilkoti, D. G. Castner, B. D. Ratner, and J. C. Vickerman. “Direct emission of molecular fragments during the sputtering of poly(4-hydroxystyrene) and determination of ion structures using tandem secondary ion mass spectrometry.” International Journal of Mass Spectrometry and Ion Processes 108, no. 1 (September 2, 1991): 29–39. https://doi.org/10.1016/0168-1176(91)87004-K.Full Text
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Chilkoti, A., B. D. Ratner, and D. Briggs. “Static secondary-ion mass spectrometric investigation of the surface structure of organic plasma-deposited films prepared from stable-isotope-labeled precursors. 1. Carbonyl precursors.” Analytical Chemistry 63, no. 15 (August 1991): 1612–20. https://doi.org/10.1021/ac00015a022.Full Text
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Chilkoti, Ashutosh, David G. Castner, and Buddy D. Ratner. “Static Secondary Ion Mass Spectrometry and X-Ray Photoelectron Spectroscopy of Deuterium- and Methyl-Substituted Polystyrene.” Applied Spectroscopy 45, no. 2 (February 1991): 209–17. https://doi.org/10.1366/0003702914337588.Full Text
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Chilkoti, A., B. D. Ratner, and D. Briggs. “Plasma-Deposited Polymeric Films Prepared from Carbonyl-Containing Volatile Precursors: XPS Chemical Derivatization and Static SIMS Surface Characterization.” Chemistry of Materials 3, no. 1 (January 1, 1991): 51–61. https://doi.org/10.1021/cm00013a016.Full Text
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Chilkoti, A., B. D. Ratner, and D. Briggs. “Structural elucidation of oxygen-containing plasma deposited films by static secondary ion mass spectrometry.” Transactions of the Annual Meeting of the Society for Biomaterials in Conjunction With the International Biomaterials Symposium 14 (January 1, 1991): 180.
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Chilkoti, A., and B. D. Ratner. “An X‐ray photoelectron spectroscopic investigation of the selectivity of hydroxyl derivatization reactions.” Surface and Interface Analysis 17, no. 8 (January 1, 1991): 567–74. https://doi.org/10.1002/sia.740170805.Full Text
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Ertel, S. I., A. Chilkoti, T. A. Horbett, and B. D. Ratner. “Endothelial cell growth on oxygen-containing films deposited by radio-frequency plasmas: the role of surface carbonyl groups.” Journal of Biomaterials Science. Polymer Edition 3, no. 2 (January 1991): 163–83. https://doi.org/10.1163/156856291x00269.Full Text
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Chilkoti, A., B. D. Ratner, and D. Briggs. “Static SIMS investigation of the surface structure of plasma deposited films prepared from stable isotope-labeled carbonyl precursors.” Polymeric Materials Science and Engineering, Proceedings of the Acs Division of Polymeric Materials Science and Engineering 62 (January 1, 1990): 135–39.
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Chilkoti, A., D. G. Castner, and D. Briggs. “Surface characterization of a poly(styrene/p-hydroxystyrene) copolymer series using x-ray photoelectron spectroscopy, static secondary ion mass spectrometry, and chemical derivatization techniques.” Journal of Vacuum Science and Technology A: Vacuum, Surfaces and Films 8, no. 3 (January 1, 1990): 2274–82. https://doi.org/10.1116/1.576750.Full Text
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Chilkoti, A., and B. D. Ratner. “Effect of monomer type on the surface chemistry of rf-plasma deposited surfaces prepared for cell culture.” Polymeric Materials Science and Engineering, Proceedings of the Acs Division of Polymeric Materials Science and Engineering 59 (December 1, 1988): 258–62.
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Book Sections
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Deshpande, Sonal, Yunqi Yang, Ashutosh Chilkoti, and Stefan Zauscher. “Enzymatic synthesis and modification of high molecular weight DNA using terminal deoxynucleotidyl transferase.,” 627:163–88, 2019. https://doi.org/10.1016/bs.mie.2019.07.044.Full Text
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Bhattacharyya, J., J. J. Bellucci, and A. Chilkoti. “Elastin-Like Polypeptides: Bio-Inspired Smart Polymers for Protein Purification, Drug Delivery and Tissue Engineering.” In Biomaterials from Nature for Advanced Devices and Therapies, 106–26, 2016. https://doi.org/10.1002/9781119126218.ch7.Full Text
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Hill, R. T., and A. Chilkoti. “Surface Patterning.” In Biomaterials Science: An Introduction to Materials: Third Edition, 276–301, 2013. https://doi.org/10.1016/B978-0-08-087780-8.00028-0.Full Text
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Nusz, G., and A. Chilkoti. “Individual plasmonic nanostructures as label free biosensors.” In Nanoplasmonic Sensors, 105–26, 2012. https://doi.org/10.1007/978-1-4614-3933-2_5.Full Text
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Conference Papers
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Bhattacharyya, Jayanta, and Ashutosh Chilkoti. “Abstract 4481: Genetically encoded chimeric polypeptide nanoparticles for gemcitabine delivery to solid tumors.” In Cancer Chemistry. American Association for Cancer Research, 2014. https://doi.org/10.1158/1538-7445.am2014-4481.Full Text
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Liu, Wenge, Ratul Mukerji, Xinghai Li, Jeff Schaal, Jayanta Bhattacharyya, Michael Zalutsky, and Ashutosh Chilkoti. “Abstract 4583: In situ photocontrolled intratumoral depot for combined photodynamic therapy and brachytherapy for solid tumor.” In Experimental and Molecular Therapeutics. American Association for Cancer Research, 2014. https://doi.org/10.1158/1538-7445.am2014-4583.Full Text
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Chilkoti, Ashutosh. “Surface initiated polymerization and its applications in medicine.” In Abstracts of Papers of the American Chemical Society, Vol. 248. AMER CHEMICAL SOC, 2014.Link to Item
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Chilkoti, Ashutosh. “Genetically encoded polypeptide nanoparticles for delivery of drugs.” In Abstracts of Papers of the American Chemical Society, Vol. 247. AMER CHEMICAL SOC, 2014.Link to Item
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Quiroz, F. G., and A. Chilkoti. “The language of protein polymers.” In Acs Symposium Series, 1170:15–33, 2014. https://doi.org/10.1021/bk-2014-1170.ch002.Full Text
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Chilkoti, Ashutosh. “Genetically engineered polypeptide conjugates and fusions for drug delivery.” In Abstracts of Papers of the American Chemical Society, Vol. 246. AMER CHEMICAL SOC, 2013.Link to Item
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Chilkoti, Ashutosh. “Syntax of "smart" peptide polymers governs their function.” In Abstracts of Papers of the American Chemical Society, Vol. 246. AMER CHEMICAL SOC, 2013.Link to Item
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Garanger, Elisabeth, Sarah Mac Ewan, Annie Brulet, Laure Bataille, Olivier Sandre, Ashutosh Chilkoti, and Sebastien Lecommandoux. “Elastin-based amphiphilic copolymers as precision building blocks for controlled self-assembly.” In Abstracts of Papers of the American Chemical Society, Vol. 246. AMER CHEMICAL SOC, 2013.Link to Item
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Tang, Lei, Vinalia Tjong, Renpeng Gu, Ashutosh Chilkoti, and Stefan Zauscher. “Enzyme catalyzed polymerization of DNA amphiphiles that self-assemble into star-like micelles.” In Abstracts of Papers of the American Chemical Society, Vol. 246. AMER CHEMICAL SOC, 2013.Link to Item
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Weinberger, A., S. Macewan, T. Schmatko, A. Schroder, A. Chilkoti, and C. M. Marques. “Interactions of elastin-like polypeptides with model membranes on GUVs.” In European Biophysics Journal With Biophysics Letters, 42:S158–S158. SPRINGER, 2013.Link to Item
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Bhattacharyya, Jayanta, Jonathan McDaniel, and Ashutosh Chilkoti. “Abstract 4509: Genetically encoded chimeric polypeptide nanoparticles for paclitaxel delivery to triple negative breast cancer.” In Cancer Chemistry. American Association for Cancer Research, 2013. https://doi.org/10.1158/1538-7445.am2013-4509.Full Text
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Liu, Wenge, Jonathan R. McDaniel, Xinghai Li, Jeffery Schaal, Jayanta Bhattacharyya, Michael R. Zalutsky, and Ashutosh Chilkoti. “Abstract 4341: A novel injectable polymer liquid that self-assembles into radioactive “seeds” for brachytherapy.” In Experimental and Molecular Therapeutics. American Association for Cancer Research, 2013. https://doi.org/10.1158/1538-7445.am2013-4341.Full Text
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Schaal, Jeffrey L., Wenge Liu, Xinghai Li, Michael Zalutsky, and Ashutosh Chilkoti. “Abstract 5615: Evaluation of the antitumoral efficacy and toxicity of injectable, polymeric radionuclide seeds in a noninvasive preclinical prostate tumor model.” In Experimental and Molecular Therapeutics. American Association for Cancer Research, 2013. https://doi.org/10.1158/1538-7445.am2013-5615.Full Text
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Caudill, Cassie, Jayanta Bhattacharyya, and Ashutosh Chilkoti. “Delivery of paclitaxel with elastin-like polypeptides.” In Abstracts of Papers of the American Chemical Society, Vol. 245. AMER CHEMICAL SOC, 2013.Link to Item
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Sinclair, S. M., J. Bhattacharyya, D. Little, R. D. Bowles, D. M. Gooden, E. J. Toone, A. Chilkoti, and L. A. Setton. “Pharmacokinetics of a thermally responsive curcumin conjugate for local antagonism of neuroinflammation in disc herniation.” In Osteoarthritis and Cartilage, 21:S292–93. Elsevier BV, 2013. https://doi.org/10.1016/j.joca.2013.02.613.Full Text
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Chilkoti, Ashutosh. “Biomolecular toolbox for the in situ synthesis of protein-polymer conjugates.” In Abstracts of Papers of the American Chemical Society, Vol. 244. AMER CHEMICAL SOC, 2012.Link to Item
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Chilkoti, Ashutosh. “Genetically encoded stimulus responsive elastin-like polypeptides: Applications in drug delivery.” In Abstracts of Papers of the American Chemical Society, Vol. 243. AMER CHEMICAL SOC, 2012.Link to Item
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Fluegel, Sabine, Tina Kiefer, Nils Heimann, Jasmin Buehler, Karl Fischer, Jonathan McDaniel, Ashutosh Chilkoti, and Manfred Schmidt. “Conjugates of polypeptides and synthetic polymers with oligonucleotides: Stars, micelles and multiblockcopolymers.” In Abstracts of Papers of the American Chemical Society, Vol. 243. AMER CHEMICAL SOC, 2012.Link to Item
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Ferris, Robert, Angus Hucknall, Byung Seok Kwon, Ashutosh Chilkoti, and Stefan Zauscher. “Field-induced nanolithography for the patterning of non-fouling polymer brushes.” In Abstracts of Papers of the American Chemical Society, Vol. 243, 2012.Link to Item
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Chilkoti, A. “Designing interfaces for optical biosensors.” In Optics Infobase Conference Papers, 2009. https://doi.org/10.1364/fio.2009.ftuy3.Full Text
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Chilkoti, Ashutosh. “PMSE 446-Architecture of polymer-drug conjugate controls in vivo fate and efficacy.” In Abstracts of Papers of the American Chemical Society, Vol. 236. AMER CHEMICAL SOC, 2008.Link to Item
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Chilkoti, Ashutosh. “PMSE 206-Architecture of polymer-drug conjugate controls in vivo fate and efficacy.” In Abstracts of Papers of the American Chemical Society, Vol. 235. AMER CHEMICAL SOC, 2008.Link to Item
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Chilkoti, Ashutosh. “POLY 351-Thermally responsive elastin biopolymers for drug delivery.” In Abstracts of Papers of the American Chemical Society, Vol. 235. AMER CHEMICAL SOC, 2008.Link to Item
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Dagher, S., D. Rose, and A. Chilkoti. “Novel technology for cost-effective expression and purification of recombinant proteins and peptides.” In Biopolymers, 80:530–31. JOHN WILEY & SONS INC, 2005.Link to Item
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Dagher, S., D. Rose, and A. Chilkoti. “Novel technology for cost-effective expression and purification of recombinant proteins and peptides.” In Biopolymers, 80:538–39. JOHN WILEY & SONS INC, 2005.Link to Item
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Wong, J. Y., A. L. Plant, C. E. Schmidt, L. Shea, A. J. Coury, C. S. Chen, A. E. Barron, et al. “Materials Research Society Symposium Proceedings: Preface.” In Materials Research Society Symposium Proceedings, Vol. EXS, 2004.
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Valiaev, A., D. W. Lim, R. Clark, A. Chilkoti, and S. Zauscher. “Mechanics of stimulus-responsive elastin-like polypeptides studied by force spectroscopy.” In Abstracts of Papers of the American Chemical Society, 228:U485–U485. AMER CHEMICAL SOC, 2004.Link to Item
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Kaholek, M., J. Hyun, W. K. Lee, A. Chilkoti, and S. Zauscher. “Fabrication of "smart" biomolecular and polymeric nanostructures using molecular recognition, surface-initiated nanopolymerization and scanning probe lithography.” In Abstracts of Papers of the American Chemical Society, 227:U861–U861. AMER CHEMICAL SOC, 2004.Link to Item
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Prohaska, S., M. Dreher, M. W. Dewhirst, A. Chilkoti, A. R. Pries, M. Westerhoff, and A. J. M. Cornelissen. “3-D reconstruction of tumor vascular networks.” In Journal of Vascular Research, 41:463–463. KARGER, 2004.Link to Item
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Nath, N., A. Chilkoti, S. Zauscher, J. H. Hyun, and W. K. Lee. “Non-covalent, environmentally modulated molecular recognition between ELP biopolymers: A convenient route to reversible protein arrays.” In Abstracts of Papers of the American Chemical Society, 226:U410–U410. AMER CHEMICAL SOC, 2003.Link to Item
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Zauscher, S., A. Chilkoti, J. Hyun, and W. K. Lee. “Fabrication of "smart" protein nanostructures using molecular recognition and dip-pen nano-lithography.” In Abstracts of Papers of the American Chemical Society, 226:U485–U485. AMER CHEMICAL SOC, 2003.Link to Item
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Chilkoti, A. “Nanoparticle biosensors.” In Abstracts of Papers of the American Chemical Society, 225:U964–U964. AMER CHEMICAL SOC, 2003.Link to Item
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Chilkoti, A., H. W. Ma, J. Hyun, and N. Nath. “Passive and active nonfouling polymer grafts.” In Abstracts of Papers of the American Chemical Society, 225:U654–55. AMER CHEMICAL SOC, 2003.Link to Item
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Zauscher, S., A. Chilkoti, S. J. Ahn, J. Hyun, and W. K. Lee. “Fabrication of surface confined, stimulus-responsive polymer nanostructures using dip-pen nanolithography.” In Abstracts of Papers of the American Chemical Society, 225:U655–U655. AMER CHEMICAL SOC, 2003.Link to Item
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- Teaching & Mentoring
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Recent Courses
- BME 394: Projects in Biomedical Engineering (GE) 2022
- BME 493: Projects in Biomedical Engineering (GE) 2022
- BME 494: Projects in Biomedical Engineering (GE) 2022
- BME 791: Graduate Independent Study 2022
- EGR 391: Projects in Engineering 2022
- EGR 393: Research Projects in Engineering 2022
- BME 394: Projects in Biomedical Engineering (GE) 2021
- BME 493: Projects in Biomedical Engineering (GE) 2021
- BME 570L: Introduction to Biomolecular Engineering (GE, BB, MC) 2021
- BME 792: Continuation of Graduate Independent Study 2021
- CHEM 394: Research Independent Study 2021
- CHEM 494: Research Independent Study 2021
- BME 493: Projects in Biomedical Engineering (GE) 2020
- BME 494: Projects in Biomedical Engineering (GE) 2020
- BME 791: Graduate Independent Study 2020
- CHEM 393: Research Independent Study 2020
- CHEM 394: Research Independent Study 2020
- CHEM 493: Research Independent Study 2020
- CHEM 494: Research Independent Study 2020
- Scholarly, Clinical, & Service Activities
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Outreach & Engaged Scholarship
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