Research Interests
Focused on biomolecular materials and biointerface science and emphasizes the development of applications that span the range from bioseparations, biosensors, biomaterials, and targeted drug delivery.
Selected Grants
Breast Cancer Diagnostic Kit to Improve Early Diagnosis in Uganda
ResearchPrincipal Investigator · Awarded by Vanderbilt University Medical Center · 2024 - 2029Development, Clinical Validation, and Readiness for Implementation of a Novel Mp1p D4 Point of Care Test for Rapid Diagnosis of Talaromycosis
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2023 - 2028Scale up and toxicity studies of POEGMA-Uricase
ResearchPrincipal Investigator · Awarded by Gateway Bio, Inc. · 2024 - 2027Development of point-of-care testing for Lassa and other hemorrhagic fever arenaviruses
ResearchCo Investigator · Awarded by National Institute of Allergy and Infectious Diseases · 2022 - 2027Medical Scientist Training Program
Inst. Training Prgm or CMEPreceptor · Awarded by National Institute of General Medical Sciences · 2022 - 2027University Training Program in Biomolecular and Tissue Engineering
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1994 - 2027Duke Program of Training in Pulmonary ReSearch to Promote, Engage and Retain Academic Researchers (PROSPER)
Inst. Training Prgm or CMEPreceptor · Awarded by National Heart, Lung, and Blood Institute · 2022 - 2026Development of Novel Rapid Immunoassays for Emerging Toxins--Full proposal
ResearchPrincipal Investigator · Awarded by Advanced Technology International · 2024 - 2026Point-of-care cellular and molecular pathology of breast tumors on a cell phone
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2026Plasmonically Enhanced Point-of-care Detection of Cardiac Biomarkers by a Smart Phone
ResearchCo Investigator · Awarded by National Institutes of Health · 2019 - 2026Enhancing Peripheral Nerve Repair with an Injectable Recombinant Polypeptide Scaffold
ResearchPrincipal Investigator · Awarded by inSoma Bio · 2025 - 2026Next-gen stealth polymer for biofilm-resistant orthopedic implant coatings
ResearchCo-Principal Investigator · Awarded by American Foundation for Surgery of the Hand · 2023 - 2025A Fully Integrated Point-of-Care Test for Ebola
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2025Uncovering and applying the design principles of multiphasic natural and synthetic organelles
ResearchPrincipal Investigator · Awarded by Princeton University · 2020 - 2025Regulation of oncogenesis and tumor response to radiation therapy by phase separation
ResearchPrincipal Investigator · Awarded by American Society for Radiation Oncology · 2024 - 2025Detection of Operationally Relevant Biomarkers - preproposal
ResearchPrincipal Investigator · Awarded by Advanced Technology International · 2020 - 2025Liquid Brachytherapy in a Porcine Model to Treat Pancreatic Cancer
ResearchPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2024 - 2025Pharmacological Sciences Training Grant
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2020 - 2025Multiplex point-of-care test for diagnosis, prognosis and serology of COVID19
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2021 - 2025Injectable PEG-like Conjugate for Sustained Delivery of a Peptide Drug for Type 2 Diabetes Treatment
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2025Acquisition of a Photoelectron Spectrometer (XPS) for Fundamental and Applied Biomedical Research, Education and Training
EquipmentMajor User · Awarded by North Carolina Biotechnology Center · 2024 - 2025Investigating the role of RNP granules during heart regeneration in the zebrafish
ResearchCollaborating Investigator · Awarded by American Heart Association · 2022 - 2025Printed Electronic Biosensors for Point-of-Care Testing of Cardiovascular Biomarkers
ResearchCo Investigator · Awarded by National Institutes of Health · 2019 - 2025The mechanical role of the glycocalyx in cancer cell adhesion
ResearchCo-Mentor · Awarded by National Institutes of Health · 2020 - 2024Duke CTSA (TL1) Year 5
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2018 - 2024CRISPR-based, rapid bedside bacteremia detection for ED sepsis management
ResearchMentor · Awarded by Society for Academic Emergency Medicine · 2023 - 2024Genetically Encoded Smart Biohybrid Materials
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2023Rapid diagnosis and quantification of HIV by direct capture, labelling and detection of individual virions
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2019 - 2023Smartphone Enabled Point-of-Care Detection of Serum Markers of Liver Cancer
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2017 - 2023Multidisciplinary Heart and Vascular Diseases
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1975 - 2023Acquisition of a Biacore T200 Surface Plasmon Resonance Instrument for Shared Use
EquipmentPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2022 - 2023Generation of antibodies specific for optimal non-HRP2 malaria diagnostic antigens
ResearchCo Investigator · Awarded by National Institutes of Health · 2020 - 2023Image-Guided Radiation Therapy System for Small Animals
EquipmentMinor User · Awarded by National Institutes of Health · 2021 - 2022Medical Scientist Training Program
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 1997 - 2022Tissue-Specific Biomarkers for the Diagnosis of Human Kidney Disease
ResearchCollaborator · Awarded by Regents of the University of Michigan · 2021 - 2022DMREF: Collaborative Research: High throughput Exploration of Sequence Space of Peptide Polymers that Exhibit Aqueous Demixing Phase Behavior
ResearchPrincipal Investigator · Awarded by National Science Foundation · 2017 - 2021A Point-of-Injury Screening Assay for Tactical Damage Control Resuscitation
ResearchPrincipal Investigator · Awarded by United States Army Medical Research and Materiel Command · 2017 - 2021Development of a Novel Point-of Care Prognostic Test of Neural Injury for Dogs
ResearchPrincipal Investigator · Awarded by North Carolina State University · 2019 - 2021CA191146: Long-acting PEG-like conjugates of an immune checkpoint inhibitor and a selective cytokine for combination immunotherapy
ResearchMentor · Awarded by United States Army Medical Research Acquisition Activity · 2020 - 2021Center for Environmental Implications of Nanotechnology
ResearchInvestigator · Awarded by National Science Foundation · 2008 - 2021Image-guided Dosimetry for Injectable Brachytherapy based on Elastin-like Polypeptide Nanoparticles
ResearchCo Investigator · Awarded by National Institutes of Health · 2017 - 2021Non-Immunogenic PEG-like conjugates of Uricase
ResearchPrincipal Investigator · Awarded by Gateway Bio, Inc. · 2020 - 2021Multivalent Immunomodulatory Proteins for Targeted Cancer Therapy
ResearchPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2020 - 2021In situ Enzymatic Synthesis of Aptamer Targeted Polynucleotide Drug Nanoparticles for Cancer Therapy (Year 2)
ResearchCo Investigator · Awarded by National Institutes of Health · 2018 - 2021Exploration and Development of Glycoconjugation "Click" Cycloaddition of Azide Polysaccharide and Alkyne CRM197
ResearchPrincipal Investigator · Awarded by Pfizer, Inc. · 2017 - 2021RAPID: Combined Antigen and Serology Rapid Test for COVID-19
ResearchPrincipal Investigator · Awarded by National Science Foundation · 2020 - 2021A novel sustained-release immunotoxin for treatment of glioblastoma multiforme
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2019 - 2021Pharmacological Sciences Training Program
Inst. Training Prgm or CMEParticipating Faculty Member · Awarded by National Institutes of Health · 1975 - 2020A point-of-care, biomarker-based test to predict non-healing in chronic wounds
ResearchCo-Principal Investigator · Awarded by The Plastic Surgery Foundation · 2018 - 2020Point of Care Testing to Improve Monitoring of LVAD Patients
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2018 - 2020Thermo Lumos Tribrid High-Resolution Accurate-Mass Tandem Mass Spectrometer
EquipmentMajor User · Awarded by National Institutes of Health · 2018 - 2019Engineering Biology for Medicine
ConferencePrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2019 - 2019Collaborative Research: Supramolecular Materials by Nucleic Acid Block Copolymer Selfassembly
ResearchCo-Principal Investigator · Awarded by National Science Foundation · 2014 - 2019Printable immunoassays using nanomaterial transistors for biological detection of severe acute malnutrition
FellowshipCo-Sponsor · Awarded by National Institutes of Health · 2018 - 2019Delivery of Paclitaxel by Recombinant Polypeptide Nanoparticles
ResearchPrincipal Investigator · Awarded by Dr. Reddy's Laboratories Ltd. · 2017 - 2019SO150005: Smartphone Enabled Point-of-care Diagnostics for Operationally Significant Pathogens
ResearchPrincipal Investigator · Awarded by United States Army Medical Research Acquisition Activity · 2016 - 2019Self-assembled microporous networks for cell culture
ResearchPrincipal Investigator · Awarded by EMD Millipore · 2017 - 2019OptiDiag: Optimizing diagnosis and management of acute malnutrition
ResearchConsultant · Awarded by Action Contre La Faim · 2015 - 2018Non-immunogenic PEG conjugates of Biologics
ResearchPrincipal Investigator · Awarded by North Carolina Biotechnology Center · 2016 - 2018MRI: Acquisition of a Triple Quadrupole LC/MS System
EquipmentMajor User · Awarded by National Science Foundation · 2015 - 2018Treating Melanoma with a Molecularly Engineered, Long Circulating Immunotoxin
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2018Elastin Fusion Proteins
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2000 - 2018Delivery of Cis-Platinate by Recombinant Polypeptide Nanoparticles
ResearchPrincipal Investigator · Awarded by Dr. Reddy's Laboratories Ltd. · 2017 - 2018Acquisition of a MALDI-TOF Mass Spectrometer System at Duke University
EquipmentMajor User · Awarded by North Carolina Biotechnology Center · 2017 - 2018Assessing the Manufacturability of a "Next-Gen" Non-Immunogenic PEG-like Conjugate
ResearchCo Investigator · Awarded by North Carolina Biotechnology Center · 2016 - 2017One-Pot Synthesis of Multicomponent Protein-Carbohydrate Antigens
ResearchPrincipal Investigator · Awarded by Pfizer, Inc. · 2016 - 2017Texas State University PREM: Center on Interfaces in Materials
ResearchCo Investigator · Awarded by Texas State University · 2012 - 2017Thermally Triggered Multivalent Targeting of Tumors
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2007 - 2016Thermally Targeted Drug Delivery by Elastin Biopolymers
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2016Protease Operated Depot for Delivery of GLP-1
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2012 - 2016A general, enzyme-based method of producing site-specific antibody-toxin conjugates for the treatment of cancer
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2015 - 2016Local Radionuclide Delivery to Solid Tumors by Injectible Biopolymer
ResearchCo Investigator · Awarded by National Institutes of Health · 2009 - 2016Site-Specific Growth of Stealth Polymer from Peptide Therapeutics
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2011 - 2015Surface Initiated Enzymatic Polymerization of DNA Nanostructures for Highly Amplified Sensing
ResearchPrincipal Investigator · Awarded by National Science Foundation · 2010 - 20152-D Diffusion Assay on Polymer Brush for POC Cardiac Infarction Diagnosis
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2012 - 2015Live-Animal Micro-CT System
EquipmentMajor User · Awarded by National Institutes of Health · 2012 - 2014NSF MRI Research Triangle X-Ray Scattering Instrumentation: SAXS/WAXS/GISAXS
EquipmentCo Investigator · Awarded by National Science Foundation · 2012 - 2013Inhibition of metastasis-initiating cells by chimeric polypeptide nanoparticles
ResearchMentor · Awarded by National Institutes of Health · 2010 - 2012Delivery of Peptide Therapeutics by Molecular Release Depots
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2010 - 2012Detection of Biomolecules by Nanoscale Plasmon Ruler
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2012Genetically Designed Materials for Cartilage Repair
ResearchInvestigator · Awarded by National Institutes of Health · 2003 - 2012Small Animal PET / CT Molecular Imaging
EquipmentMajor User · Awarded by National Institutes of Health · 2011 - 2012Plasmonic assay for detection of biomarkers at the single-molecule level
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2009 - 2011Intravital point-scanning confocal microscope
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2010 - 2011Molecular Imaging Using Hyperspectral Darkfield Microscope of Nanoparticles
ResearchCo-Principal Investigator · Awarded by National Science Foundation · 2007 - 2011NIRT: Hierarchical Bionanomanufacturing
ResearchCo-Principal Investigator · Awarded by National Science Foundation · 2006 - 2010Thermally-Induced Intra-Articular Drug Delivery System
ResearchCollaborator · Awarded by National Institutes of Health · 2006 - 2009Training in Biomolecular and Tissue Engineering
Inst. Training Prgm or CMEMentor · Awarded by National Institutes of Health · 2003 - 2009Elastin Fusion Proteins
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2000 - 2009Nanophotonics for Select Agent Detection
ResearchPrincipal Investigator · Awarded by Centers for Disease Control and Prevention · 2003 - 2008Nanophotonics for Select Agent Detection
ResearchPrincipal Investigator · Awarded by Centers for Disease Control and Prevention · 2003 - 2008Nanophotonics for Select Agent Detection
ResearchPrincipal Investigator · Awarded by Centers for Disease Control and Prevention · 2003 - 2008NER: Integrated Magnetic and Chemical Assembly Techniques for Building Nanoparticle Arrays
ResearchCo-Principal Investigator · Awarded by National Science Foundation · 2006 - 2008pH Sensitive Elastic-Like-Peptides for Tumor Targeting
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2006 - 2008Biointerface Science GRC
ConferencePrincipal Investigator · Awarded by Army Research Office · 2006 - 2007Thermally Targeted Drug Delivery by Elastin Biopolymers
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2002 - 2007Nanofabrication of Polymer-Functionalized Surfaces Using Scanning Probe Lithography
ResearchCo-Principal Investigator · Awarded by National Science Foundation · 2002 - 2006Upgrade of a Shared Instrumentation Resource in the PSOE: The Laser Scanning Confocal Microscope
EquipmentPrincipal Investigator · Awarded by Lord Foundation of North Carolina · 2002 - 2005Elastin Fusion Proteins
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2000 - 2005The AVS2004 Biomaterials Interfaces Symposium
ConferencePrincipal Investigator · Awarded by National Institutes of Health · 2004 - 2005Acquisition of an Imaging XPS for Materials Research and Training
EquipmentPrincipal Investigator · Awarded by National Science Foundation · 2002 - 2004Elastin Bioelastomers for Microactuation
ResearchPrincipal Investigator · Awarded by Office of Naval Research · 2000 - 2002CAREER: Smart Protein-Polymer Conjugates for Biotechnology
ResearchPrincipal Investigator · Awarded by National Science Foundation · 1998 - 2002Engineered Protein-Polymer Conjugates for Biotechnology
ResearchPrincipal Investigator · Awarded by National Science Foundation · 1998 - 2002CAREER: Smart Protein - Polymer Conjugates for Biotechnology
ResearchPrincipal Investigator · Awarded by National Science Foundation · 1998 - 2002Elastin Nanobiosensors
ResearchPrincipal Investigator · Awarded by National Science Foundation · 2000 - 2002Extrinsic Modulation of Protein-Ligand Recognition
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 2000Extrinsic Modulation of Protein/Ligand Recognition
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 1998 - 2000An Engineering Outreach Program for High School Students at Duke University
ResearchPrincipal Investigator · Awarded by Lord Foundation of North Carolina · 1998 - 1999Laboratories in Biomedical and Cellular Engineering
ResearchPrincipal Investigator · Awarded by Lord Foundation of North Carolina · 1998 - 1999Isothermal Titration Calorimetry for Biological Research
EquipmentPrincipal Investigator · Awarded by Division of Undergraduate Education · 1998 - 1999Combined Atomic Force and Total Internal Reflection Fluorescence Microscopy for Biological Research
EquipmentPrincipal Investigator · Awarded by National Science Foundation · 1997 - 1999Matching Funds for Combined Atomic Force & Optical...
Public ServicePrincipal Investigator · Awarded by Lord Foundation of North Carolina · 1997 - 1998External Relationships
- BioStealth
- GatewayBio
- SimplusDx
- inSoma Bio, Inc
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.