Practice patterns related to prostate cancer grading: results of a 2019 Genitourinary Pathology Society clinician survey.

Journal Article (Journal Article)

PURPOSE: To survey urologic clinicians regarding interpretation of and practice patterns in relation to emerging aspects of prostate cancer grading, including quantification of high-grade disease, cribriform/intraductal carcinoma, and impact of magnetic resonance imaging-targeted needle biopsy. MATERIALS AND METHODS: The Genitourinary Pathology Society distributed a survey to urology and urologic oncology-focused societies and hospital departments. Eight hundred and thirty four responses were collected and analyzed using descriptive statistics. RESULTS: Eighty percent of survey participants use quantity of Gleason pattern 4 on needle biopsy for clinical decisions, less frequently with higher Grade Groups. Fifty percent interpret "tertiary" grade as a minor/<5% component. Seventy percent of respondents would prefer per core grading as well as a global/overall score per set of biopsies, but 70% would consider highest Gleason score in any single core as the grade for management. Seventy five percent utilize Grade Group terminology in patient discussions. For 45%, cribriform pattern would affect management, while for 70% the presence of intraductal carcinoma would preclude active surveillance. CONCLUSION: This survey of practice patterns in relationship to prostate cancer grading highlights similarities and differences between contemporary pathology reporting and its clinical application. As utilization of Gleason pattern 4 quantification, minor tertiary pattern, cribriform/intraductal carcinoma, and the incorporation of magnetic resonance imaging-based strategies evolve, these findings may serve as a basis for more nuanced communication and guide research efforts involving pathologists and clinicians.

Full Text

Duke Authors

Cited Authors

  • Fine, SW; Trpkov, K; Amin, MB; Algaba, F; Aron, M; Baydar, DE; Beltran, AL; Brimo, F; Cheville, JC; Colecchia, M; Comperat, E; Costello, T; da Cunha, IW; Delprado, W; DeMarzo, AM; Giannico, GA; Gordetsky, JB; Guo, CC; Hansel, DE; Hirsch, MS; Huang, J; Humphrey, PA; Jimenez, RE; Khani, F; Kong, MX; Kryvenko, ON; Kunju, LP; Lal, P; Latour, M; Lotan, T; Maclean, F; Magi-Galluzzi, C; Mehra, R; Menon, S; Miyamoto, H; Montironi, R; Netto, GJ; Nguyen, JK; Osunkoya, AO; Parwani, A; Pavlovich, CP; Robinson, BD; Rubin, MA; Shah, RB; So, JS; Takahashi, H; Tavora, F; Tretiakova, MS; True, L; Wobker, SE; Yang, XJ; Zhou, M; Zynger, DL; Epstein, JI

Published Date

  • May 1, 2021

Published In

Volume / Issue

  • 39 / 5

Start / End Page

  • 295.e1 - 295.e8

PubMed ID

  • 32948433

Pubmed Central ID

  • PMC9399962

Electronic International Standard Serial Number (EISSN)

  • 1873-2496

Digital Object Identifier (DOI)

  • 10.1016/j.urolonc.2020.08.027

Language

  • eng

Conference Location

  • United States