Computational Framework to Evaluate the Hydrodynamics of Cell Scaffold Geometries

Published

Conference Paper

© 2020 IEEE. The fluid dynamics of microporous materials are important to many biomedical processes such as cell deposition in scaffold materials, tissue engineering, and bioreactors. Microporous scaffolds are frequently composed of suspensions of beads that have varying topology which, in turn, informs their hydrodynamic properties. Previous work has shown that shear stress distributions can affect the response of cells in microporous environments. Using computational fluid dynamics, we characterize localized differences in fluid flow attributes such wall shear stress and velocity to better understand the fluid dynamics underpinning microporous device function. We evaluated whether bead packings with similar void fractions had different fluid dynamics as characterized by the distribution of velocity magnitudes and wall shear stress and found that there are differences despite the similarities in void fraction. We show that another metric, the average distance to the nearest wall, can provide an additional variable to measure the porosity and susceptibility of microporous materials to high shear stress. By increasing our understanding of the impact of bead size on cell scaffold fluid dynamics we aim to increase the ability to predict important attributes such as loading efficiency in these devices.

Full Text

Duke Authors

Cited Authors

  • Puleri, DF; Roychowdhury, S; Ames, J; Randles, A

Published Date

  • July 1, 2020

Published In

Volume / Issue

  • 2020-July /

Start / End Page

  • 2299 - 2302

International Standard Serial Number (ISSN)

  • 1557-170X

International Standard Book Number 13 (ISBN-13)

  • 9781728119908

Digital Object Identifier (DOI)

  • 10.1109/EMBC44109.2020.9176313

Citation Source

  • Scopus