Perspective on Epithelial-Mesenchymal Transitions in Embryos.

Journal Article (Journal Article)

The epithelial-mesenchymal transition (EMT) is a key process required for building the early body plan of metazoa. It involves coordinated and precisely timed changes in multiple cell processes such as de-adhesion, motility, invasion, and cell polarity. While much has been learned about how embryos deploy epithelial-mesenchymal transitions since Betty Hay named the process decades ago, a number of things are still not well understood. Here I will discuss some of the big questions that remain, including how is all of this controlled, how does each of the cell biological events work, and how are they so nicely coordinated with one another?

Full Text

Duke Authors

Cited Authors

  • McClay, DR

Published Date

  • January 2021

Published In

Volume / Issue

  • 2179 /

Start / End Page

  • 7 - 12

PubMed ID

  • 32939708

Pubmed Central ID

  • PMC8294114

Electronic International Standard Serial Number (EISSN)

  • 1940-6029

International Standard Serial Number (ISSN)

  • 1064-3745

Digital Object Identifier (DOI)

  • 10.1007/978-1-0716-0779-4_2


  • eng