David R. McClay Jr.
Arthur S. Pearse Distinguished Professor of Biology
We ask how the embryo works. Prior to morphogenesis the
embryo specifies each cell through transcriptional regulation
and signaling. Our research builds gene regulatory networks to
understand how that early specification works. We then ask how
this specification programs cells for their morphogenetic
movements at gastrulation, and how the cells deploy patterning
information.
Current projects examine 1) novel signal transduction
mechanisms that establish and maintain embryonic boundaries
mold the embryo at gastrulation; 2) specification of primary
mesenchyme cells in such a way that they are prepared to
execute an epithelial-mesenchymal transition, and then study
mechanistically the regulation of that transition; 3) the
specification of endoderm necessary for invagination of the
archenteron; 4) formation of the oral/aboral ectoderm and the
means by which patterning information is distributed three
dimensionally around the embryo. That information is necessary
for patterning and inducing skeletogenesis.
Other projects examine neural tube folding with the goal of
identifying genes associated with neural tube defects. Finally, a
large current effort in systems biology is being expended with
the goal of enlarging our knowledge of early networks and how
they interact.
Current Appointments & Affiliations
- Arthur S. Pearse Distinguished Professor of Biology, Biology, Trinity College of Arts & Sciences 2004
- Professor of Biology, Biology, Trinity College of Arts & Sciences 2000
- Professor of Neurobiology, Neurobiology, Basic Science Departments 2000
- Professor of Cell BIology, Cell Biology, Basic Science Departments 2022
- Affiliate of the Duke Regeneration Center, Regeneration Next Initiative, Basic Science Departments 2021
Contact Information
- 4102 French Science Center, Science Dr., Durham, NC 27708
- Box 90338, Department of Biology, Durham, NC 27708-1000
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dmcclay@duke.edu
(919) 613-8188
- Background
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Education, Training, & Certifications
- Ph.D., University of North Carolina - Chapel Hill 1971
- M.S., University of Vermont 1965
- B.S., Pennsylvania State University 1963
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Previous Appointments & Affiliations
- Associate Chair of Biology, Biology, Trinity College of Arts & Sciences 2017 - 2019
- Director of Developmental Biology Training Program, Cell Biology, Basic Science Departments 2001 - 2013
- Professor in the Nicholas School Marine Science and Conservation Division, Marine Science and Conservation, Nicholas School of the Environment 2010 - 2013
- Professor of Immunology, Integrative Immunobiology, Basic Science Departments 2002 - 2012
- John Tate Lanning Professor of Biology, Biology, Trinity College of Arts & Sciences 2004
- Professor of Coastal Systems Science and Policy, Nicholas School of the Environment, Duke University 2001 - 2004
- Professor of Immunology, Integrative Immunobiology, Basic Science Departments 2000 - 2001
- Professor with Tenure, Biology, Trinity College of Arts & Sciences 1985 - 2000
- Director of Duke Cellular and Molecular Training Program, Cell Biology, Basic Science Departments 1990 - 2000
- Professor of Neurobiology, Neurobiology, Basic Science Departments 1989 - 1999
- Professor of Immunology in the Department of Immunology, Integrative Immunobiology, Basic Science Departments 1994 - 1999
- Professor of Immunology, Molecular Genetics and Microbiology, Basic Science Departments 1988 - 1994
- Professor of Immunology in the Department of Microbiology and Immunology, Molecular Genetics and Microbiology, Basic Science Departments 1991 - 1992
- Assistant Professor, Molecular Genetics and Microbiology, Basic Science Departments 1978 - 1988
- Assistant Professor of Immunology in the Department of Microbiology, Molecular Genetics and Microbiology, Basic Science Departments 1987 - 1988
- Associate Professor with Tenure, Biology, Trinity College of Arts & Sciences 1985
- Assistant Professor, Biology, Trinity College of Arts & Sciences 1973 - 1985
- Recognition
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In the News
- Research
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Selected Grants
- Embryonic Cell Recognition: Specificity Determinants awarded by National Institutes of Health 1980 - 2028
- Training Program in Developmental and Stem Cell Biology awarded by National Institutes of Health 2001 - 2027
- Cell and Molecular Biology Training Program awarded by National Institutes of Health 2021 - 2026
- Genetic and Genomics Training Grant awarded by National Institutes of Health 2020 - 2025
- Bioinformatics and Computational Biology Training Program awarded by National Institutes of Health 2005 - 2021
- How Gene Regulatory Networks Connect to Development awarded by California Institute of Technology 2009 - 2021
- Genetics Training Grant awarded by National Institutes of Health 1979 - 2020
- Organization and Function of Cellular Structure awarded by National Institutes of Health 1975 - 2020
- Lightsheet Imaging System awarded by National Institutes of Health 2016 - 2017
- Illumina Hi-Seq 2000 Sequencing System awarded by National Institutes of Health 2012 - 2013
- Mechanism of a novel cause of spina bifida awarded by National Institutes of Health 2009 - 2012
- Live cell widefield fluorescence microscope with activation and bleaching lasers awarded by National Institutes of Health 2010 - 2011
- Germ Layer Specification awarded by National Institutes of Health 1999 - 2008
- Neural Tube Defects awarded by National Institutes of Health 2001 - 2007
- BMP signaling in mammalian neural tube development awarded by National Institutes of Health 2001 - 2004
- Role of p38 in Patterning of Sea Urchin Embryos awarded by National Institutes of Health 2002 - 2004
- Sea Urchin Developmental Biology Conference XIV awarded by Public Health Service 2002 - 2003
- Embryonic Cell Recognition: Specificity Determinants awarded by National Institutes of Health 1980 - 2000
- Embryonic Cell Recognition: Specificity Determinants awarded by National Institutes of Health 1980 - 2000
- Organization And Function Of Cellular Structure awarded by National Institutes of Health 1996 - 1999
- Organization And Function Of Cellular Structures awarded by National Institutes of Health 1995 - 1999
- Organization And Function Of Cellular Structure Cmb awarded by National Institutes of Health 1975 - 1999
- Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
- Comprehensive Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
- Comprehensive Cancer Center Core Support Grant awarded by National Institutes of Health 1976 - 1998
- Confocal Microscope for the SRC awarded by National Science Foundation 1994 - 1996
- Embryonic Cell Recognition: Specificity Determinants awarded by National Institutes of Health 1980 - 1996
- Embryonic Cell Recognition: Specificity Determinants awarded by National Institutes of Health 1980 - 1996
- Embryonic Cell Recognition: Specificity Determinants awarded by National Institutes of Health 1980 - 1996
- Embryonic Cell Recognition: Specificity Determinants awarded by National Institutes of Health 1980 - 1996
- Teratocarcinoma Cells - Cell Adhesion and Differentiation awarded by National Institutes of Health 1990 - 1995
- Teratocarcinoma Cells--Cell Adhesion & Differentiation awarded by National Institutes of Health 1990 - 1995
- Teratocarcinoma Cells-Cell Adhesion and Differentiation awarded by National Institutes of Health 1990 - 1995
- Teratocarcinoma Cells: Cell Adhesion and Differentiation awarded by National Institutes of Health 1990 - 1995
- Tetratocarcinoma Cells: Cell Adhesion and Differentiation awarded by National Institutes of Health 1990 - 1995
- Extracellular Matrix Proteins and Differentiation awarded by National Institutes of Health 1988 - 1993
- Extracellular Matrix Proteins and Differentiation awarded by National Institutes of Health 1988 - 1993
- Embryonic Cell Recognition: Specificity Determinants awarded by National Institutes of Health 1987 - 1991
- Embryonic Cell Recognition: Specificity Determinants awarded by National Institutes of Health 1980 - 1991
- Embryonic Cell Recognition: Specificity Determinants awarded by National Institutes of Health 1980 - 1991
- Ontogeny of the Basal Lamina of the Sea Urchin awarded by National Institutes of Health 1988 - 1991
- Genetics Post Doctoral Fellowship awarded by National Institutes of Health 1987 - 1990
- The Role of Cell Contacts During Sea Urchin Gastrulation awarded by National Institutes of Health 1988 - 1989
- Modulation of Cell Contact Behavior in a Rearranging Epithelium during Gastrulation awarded by National Institutes of Health 1988 - 1989
- Cell Surface Molecules in Embryonic Cell Adhesion awarded by National Institutes of Health 1982 - 1988
- Modulation of Cell Contact Behavior in a Re-arranging Epithelium during Gastrulation.
- Publications & Artistic Works
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Selected Publications
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Academic Articles
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Allen, Raymond L., Andrew N. George, Esther Miranda, Taji M. Phillips, Janice M. Crawford, Daniel P. Kiehart, and David R. McClay. “Wound repair in sea urchin larvae involves pigment cells and blastocoelar cells.” Developmental Biology 491 (November 2022): 56–65. https://doi.org/10.1016/j.ydbio.2022.08.005.Full Text
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McClay, David R., Jenifer C. Croce, and Jacob F. Warner. “Reprint of: Conditional specification of endomesoderm.” Cells & Development 168 (December 2021): 203731. https://doi.org/10.1016/j.cdev.2021.203731.Full Text
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Yang, Jing, Parker Antin, Geert Berx, Cédric Blanpain, Thomas Brabletz, Marianne Bronner, Kyra Campbell, et al. “Author Correction: Guidelines and definitions for research on epithelial-mesenchymal transition.” Nature Reviews. Molecular Cell Biology 22, no. 12 (December 2021): 834. https://doi.org/10.1038/s41580-021-00428-9.Full Text
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Massri, Abdull J., Laura Greenstreet, Anton Afanassiev, Alejandro Berrio, Gregory A. Wray, Geoffrey Schiebinger, and David R. McClay. “Developmental single-cell transcriptomics in the Lytechinus variegatus sea urchin embryo.” Development (Cambridge, England) 148, no. 19 (October 2021): dev198614. https://doi.org/10.1242/dev.198614.Full Text Open Access Copy
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McClay, David R., Jenifer C. Croce, and Jacob F. Warner. “Conditional specification of endomesoderm.” Cells & Development 167 (September 2021): 203716. https://doi.org/10.1016/j.cdev.2021.203716.Full Text
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McClay, David R. “Perspective on Epithelial-Mesenchymal Transitions in Embryos.” Methods in Molecular Biology (Clifton, N.J.) 2179 (January 2021): 7–12. https://doi.org/10.1007/978-1-0716-0779-4_2.Full Text
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Massri, Abdull J., Geoffrey R. Schiebinger, Alejandro Berrio, Lingyu Wang, Gregory A. Wray, and David R. McClay. “Methodologies for Following EMT In Vivo at Single Cell Resolution.” Methods in Molecular Biology (Clifton, N.J.) 2179 (January 2021): 303–14. https://doi.org/10.1007/978-1-0716-0779-4_23.Full Text
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Davidson, Phillip L., Haobing Guo, Lingyu Wang, Alejandro Berrio, He Zhang, Yue Chang, Andrew L. Soborowski, David R. McClay, Guangyi Fan, and Gregory A. Wray. “Chromosomal-Level Genome Assembly of the Sea Urchin Lytechinus variegatus Substantially Improves Functional Genomic Analyses.” Genome Biology and Evolution 12, no. 7 (July 2020): 1080–86. https://doi.org/10.1093/gbe/evaa101.Full Text
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Yang, Jing, Parker Antin, Geert Berx, Cédric Blanpain, Thomas Brabletz, Marianne Bronner, Kyra Campbell, et al. “Guidelines and definitions for research on epithelial-mesenchymal transition.” Nature Reviews. Molecular Cell Biology 21, no. 6 (June 2020): 341–52. https://doi.org/10.1038/s41580-020-0237-9.Full Text
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Slota, Leslie A., Esther Miranda, Brianna Peskin, and David R. McClay. “Developmental origin of peripheral ciliary band neurons in the sea urchin embryo.” Developmental Biology 459, no. 2 (March 2020): 72–78. https://doi.org/10.1016/j.ydbio.2019.12.011.Full Text
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Massri, Abdull, Laura Greenstreet, Anton Afanassiev, Alejandro Berrio Escobar, Gregory Wray, Geoffrey Schiebinger, and David McClay. “Developmental Single-cell transcriptomics in theLytechinus variegatusSea Urchin Embryo,” 2020. https://doi.org/10.1101/2020.11.12.380675.Full Text Open Access Copy
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George, Andrew N., and David R. McClay. “Methods for transplantation of sea urchin blastomeres.” Methods in Cell Biology 150 (January 2019): 223–33. https://doi.org/10.1016/bs.mcb.2018.11.012.Full Text
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Slota, Leslie A., Esther M. Miranda, and David R. McClay. “Spatial and temporal patterns of gene expression during neurogenesis in the sea urchin Lytechinus variegatus.” Evodevo 10 (January 2019): 2. https://doi.org/10.1186/s13227-019-0115-8.Full Text
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McClay, David R., Esther Miranda, and Stacy L. Feinberg. “Neurogenesis in the sea urchin embryo is initiated uniquely in three domains.” Development (Cambridge, England) 145, no. 21 (November 2018): dev167742. https://doi.org/10.1242/dev.167742.Full Text
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Slota, Leslie A., and David R. McClay. “Identification of neural transcription factors required for the differentiation of three neuronal subtypes in the sea urchin embryo.” Developmental Biology 435, no. 2 (March 2018): 138–49. https://doi.org/10.1016/j.ydbio.2017.12.015.Full Text
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Martik, Megan L., and David R. McClay. “New insights from a high-resolution look at gastrulation in the sea urchin, Lytechinus variegatus.” Mechanisms of Development 148 (December 2017): 3–10. https://doi.org/10.1016/j.mod.2017.06.005.Full Text
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McClay, D. “Reprint of: In Memoriam - Eric H. Davidson (1937-2015).” Developmental Biology 412, no. 2 (April 15, 2016): S1–2. https://doi.org/10.1016/j.ydbio.2016.03.025.Full Text
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Israel, Jennifer W., Megan L. Martik, Maria Byrne, Elizabeth C. Raff, Rudolf A. Raff, David R. McClay, and Gregory A. Wray. “Comparative Developmental Transcriptomics Reveals Rewiring of a Highly Conserved Gene Regulatory Network during a Major Life History Switch in the Sea Urchin Genus Heliocidaris.” Plos Biology 14, no. 3 (March 2016): e1002391. https://doi.org/10.1371/journal.pbio.1002391.Full Text
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Warner, Jacob F., Esther L. Miranda, and David R. McClay. “Contribution of hedgehog signaling to the establishment of left-right asymmetry in the sea urchin.” Developmental Biology 411, no. 2 (March 2016): 314–24. https://doi.org/10.1016/j.ydbio.2016.02.008.Full Text
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Martik, Megan L., Deirdre C. Lyons, and David R. McClay. “Developmental gene regulatory networks in sea urchins and what we can learn from them.” F1000research 5 (January 2016): F1000FacultyRev-203. https://doi.org/10.12688/f1000research.7381.1.Full Text
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McClay, David R. “Sea Urchin Morphogenesis.” Current Topics in Developmental Biology 117 (January 2016): 15–29. https://doi.org/10.1016/bs.ctdb.2015.11.003.Full Text
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McClay, Dave. “Eric H. Davidson (1937–2015).” Developmental Biology 406, no. 2 (October 2015): 107–8. https://doi.org/10.1016/j.ydbio.2015.10.004.Full Text
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Martik, Megan L., and David R. McClay. “Deployment of a retinal determination gene network drives directed cell migration in the sea urchin embryo.” Elife 4 (September 2015): e08827. https://doi.org/10.7554/elife.08827.Full Text
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Lyons, Deirdre C., Megan L. Martik, Lindsay R. Saunders, and David R. McClay. “Specification to biomineralization: following a single cell type as it constructs a skeleton.” Integrative and Comparative Biology 54, no. 4 (October 2014): 723–33. https://doi.org/10.1093/icb/icu087.Full Text
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Cheng, Xianrui, Deirdre C. Lyons, Joshua E. S. Socolar, and David R. McClay. “Delayed transition to new cell fates during cellular reprogramming.” Developmental Biology 391, no. 2 (July 2014): 147–57. https://doi.org/10.1016/j.ydbio.2014.04.015.Full Text
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Saunders, Lindsay R., and David R. McClay. “Sub-circuits of a gene regulatory network control a developmental epithelial-mesenchymal transition.” Development (Cambridge, England) 141, no. 7 (April 2014): 1503–13. https://doi.org/10.1242/dev.101436.Full Text
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Angerer, Lynne M. “Editorial-sea urchin special issue.” Genesis (New York, N.Y. : 2000) 52, no. 3 (March 2014): 157. https://doi.org/10.1002/dvg.22486.Full Text
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McIntyre, Daniel C., Deirdre C. Lyons, Megan Martik, and David R. McClay. “Branching out: origins of the sea urchin larval skeleton in development and evolution.” Genesis (New York, N.Y. : 2000) 52, no. 3 (March 2014): 173–85. https://doi.org/10.1002/dvg.22756.Full Text
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Warner, J. F., and D. R. Mcclay. “Left-right asymmetry in the Sea Urchin.” Genesis 52, no. 6 (January 1, 2014): 481–87. https://doi.org/10.1002/dvg.22752.Full Text
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Warner, Jacob F., Ali M. McCarthy, Robert L. Morris, and David R. McClay. “Hedgehog signaling requires motile cilia in the sea urchin.” Molecular Biology and Evolution 31, no. 1 (January 2014): 18–22. https://doi.org/10.1093/molbev/mst176.Full Text
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Warner, Jacob F., and David R. McClay. “Perturbations to the hedgehog pathway in sea urchin embryos.” Methods in Molecular Biology (Clifton, N.J.) 1128 (January 2014): 211–21. https://doi.org/10.1007/978-1-62703-974-1_14.Full Text
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McIntyre, Daniel C., N Winn Seay, Jenifer C. Croce, and David R. McClay. “Short-range Wnt5 signaling initiates specification of sea urchin posterior ectoderm.” Development (Cambridge, England) 140, no. 24 (December 2013): 4881–89. https://doi.org/10.1242/dev.095844.Full Text
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Lhomond, G. D., R. McClay, C. Gache, and J. C. Croce. “Frizzled 1/2/7 signaling directs beta catenin nuclearization and initiates endoderm specification in macromeres during sea urchin morphogenesis.” Development 138 (2012): 2639–48.
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Warner, Jacob F., Deirdre C. Lyons, and David R. McClay. “Left-right asymmetry in the sea urchin embryo: BMP and the asymmetrical origins of the adult.” Plos Biology 10, no. 10 (January 2012): e1001404. https://doi.org/10.1371/journal.pbio.1001404.Full Text
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Lyons, D. C., S. L. Kaltenbach, and D. R. McClay. “Morphogenesis in sea urchin embryos: linking cellular events to gene regulatory states.” Wires Dev Biol 1 (2012): 231–52. https://doi.org/10.1002/wdev.18.Full Text
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McClay, David R. “Evolutionary crossroads in developmental biology: sea urchins.” Development (Cambridge, England) 138, no. 13 (July 2011): 2639–48. https://doi.org/10.1242/dev.048967.Full Text
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Rho, Ho Kyung, and David R. McClay. “The control of foxN2/3 expression in sea urchin embryos and its function in the skeletogenic gene regulatory network.” Development (Cambridge, England) 138, no. 5 (March 2011): 937–45. https://doi.org/10.1242/dev.058396.Full Text
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Croce, J., R. Range, S. Y. Wu, E. Miranda, G. Lhomond, C. F. Peng, T. Lepage, and D. R. McClay. “Wnt6 activates endoderm in the sea urchin gene regulatory network.” Development 138: (2011): 3297.-3306.
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McClay, D. R. “Cleavage and Gastrulation in the Sea Urchin.” Encyclopedia of Life Sciences., 2011.
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Croce, Jenifer C., and David R. McClay. “Dynamics of Delta/Notch signaling on endomesoderm segregation in the sea urchin embryo.” Development (Cambridge, England) 137, no. 1 (January 2010): 83–91. https://doi.org/10.1242/dev.044149.Full Text Open Access Copy
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Byrum, C. A., J. M. Bince, R. H. Xu, M. H. Illies, D. R. McClay, C. Ettensohn, and A. H. Wikramanayake. “Roles of Dsh in the regulation of sea urchin gastrulation.” Dev Dyn 238 (December 2009): 1649–65.
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Byrum, Christine A., Ronghui Xu, Joanna M. Bince, David R. McClay, and Athula H. Wikramanayake. “Blocking Dishevelled signaling in the noncanonical Wnt pathway in sea urchins disrupts endoderm formation and spiculogenesis, but not secondary mesoderm formation.” Developmental Dynamics : An Official Publication of the American Association of Anatomists 238, no. 7 (July 2009): 1649–65. https://doi.org/10.1002/dvdy.21978.Full Text
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Walton, Katherine D., Jacob Warner, Philip H. Hertzler, and David R. McClay. “Hedgehog signaling patterns mesoderm in the sea urchin.” Developmental Biology 331, no. 1 (July 2009): 26–37. https://doi.org/10.1016/j.ydbio.2009.04.018.Full Text
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McIntyre, Daniel C., and David R. McClay. “Sea urchin embryonic skeletogenesis is regulated by microRNA.” Developmental Biology 331, no. 2 (July 2009): 433–433. https://doi.org/10.1016/j.ydbio.2009.05.168.Full Text
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Rho, Ho Kyung, and David R. McClay. “The role and regulation of FoxN2/3 in the skeletogenic cells during sea urchin development.” Developmental Biology 331, no. 2 (July 2009): 432–33. https://doi.org/10.1016/j.ydbio.2009.05.167.Full Text
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Bradham, Cynthia A., Catherine Oikonomou, Alexander Kühn, Amanda B. Core, Joshua W. Modell, David R. McClay, and Albert J. Poustka. “Chordin is required for neural but not axial development in sea urchin embryos.” Developmental Biology 328, no. 2 (April 2009): 221–33. https://doi.org/10.1016/j.ydbio.2009.01.027.Full Text
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Range, R., T. Glenn, and D. R. McClay. “Lv-Numb promotes Notch-mediated specification of secondary mesenchyme cells in the sea urchin embryo.” Development 135 (December 2008): 2445–54.
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Range, Ryan C., Thomas D. Glenn, Esther Miranda, and David R. McClay. “LvNumb works synergistically with Notch signaling to specify non-skeletal mesoderm cells in the sea urchin embryo.” Development (Cambridge, England) 135, no. 14 (August 2008): 2445–54. https://doi.org/10.1242/dev.018101.Full Text
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Röttinger, E., A. Saudemont, V. Duboc, L. Besnardeau, D. McClay, and T. Lepage. “Erratum: FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis and regulate gastrulation during sea urchin development (Development vol. 135 (353-365)).” Development 135, no. 4 (February 1, 2008): 785. https://doi.org/10.1242/dev.020016.Full Text
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Croce, Jenifer C., and David R. McClay. “Evolution of the Wnt pathways.” Methods in Molecular Biology (Clifton, N.J.) 469 (January 2008): 3–18. https://doi.org/10.1007/978-1-60327-469-2_1.Full Text
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Röttinger, Eric, Alexandra Saudemont, Véronique Duboc, Lydia Besnardeau, David McClay, and Thierry Lepage. “FGF signals guide migration of mesenchymal cells, control skeletal morphogenesis [corrected] and regulate gastrulation during sea urchin development.” Development (Cambridge, England) 135, no. 2 (January 2008): 353–65. https://doi.org/10.1242/dev.014282.Full Text
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Voronina, E., M. Lopez, C. Juliano, E. Gustafson, J. Song, C. Extavour, S. George, P. Oliveri, D. R. McClay, and G. M. Wessel. “Vasa protein expression is restricted to the small micromeres of the sea urchin, but is inducible in other lineages early in development.” Dev Biol 314 (2008): 276–86.
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Wu, R. C., R. C. S-Y, Y. -. P. Yang, and D. R. McClay. “Twist is an essential regulator of the skeletogenic gene regulatory network in the sea urchin embryo.” Dev Biol 319 (2008): 406–15.
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Bradham, C. A., and D. R. McClay. “Secondary axis specification in sea urchin embryos.” Signal Transduction 7, no. 2 (May 14, 2007): 181–86. https://doi.org/10.1002/sita.200600121.Full Text
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Wu, S. Y., and D. R. McClay. “The Snail repressor is required for PMC ingression in the sea urchin embryo.” Development (Cambridge, England) 134, no. 6 (March 2007): 1061–70. https://doi.org/10.1242/dev.02805.Full Text
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Wu, S. Y., M. Ferkowicz, and D. R. McClay. “Ingression of primary mesenchyme cells of the sea urchin embryo: a precisely timed epithelial mesenchymal transition.” Embryology Today, Reviews 81 (2007): 241–52.
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Beane, Wendy S., Ekaterina Voronina, Gary M. Wessel, and David R. McClay. “Lineage-specific expansions provide genomic complexity among sea urchin GTPases.” Developmental Biology 300, no. 1 (December 2006): 165–79. https://doi.org/10.1016/j.ydbio.2006.08.046.Full Text
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Bradham, Cynthia A., Kathy R. Foltz, Wendy S. Beane, Maria I. Arnone, Francesca Rizzo, James A. Coffman, Arcady Mushegian, et al. “The sea urchin kinome: a first look.” Developmental Biology 300, no. 1 (December 2006): 180–93. https://doi.org/10.1016/j.ydbio.2006.08.074.Full Text
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Croce, J. C., S. Y. Wu, C. Byrum, R. Xu, L. Duloquin, A. H. Wikramanayake, C. Gache, and D. R. McClay. “A genome-wide survey of the evolutionarily conserved Wnt pathways in the sea urchin Strongylocentrotus purpuratus.” Developmental Biology 300, no. 1 (December 2006): 121–31. https://doi.org/10.1016/j.ydbio.2006.08.045.Full Text
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Lapraz, François, Eric Röttinger, Véronique Duboc, Ryan Range, Louise Duloquin, Katherine Walton, Shu-Yu Wu, et al. “RTK and TGF-beta signaling pathways genes in the sea urchin genome.” Developmental Biology 300, no. 1 (December 2006): 132–52. https://doi.org/10.1016/j.ydbio.2006.08.048.Full Text
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Robertson, Anthony J., Jenifer Croce, Seth Carbonneau, Ekaterina Voronina, Esther Miranda, David R. McClay, and James A. Coffman. “The genomic underpinnings of apoptosis in Strongylocentrotus purpuratus.” Developmental Biology 300, no. 1 (December 2006): 321–34. https://doi.org/10.1016/j.ydbio.2006.08.053.Full Text
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Walton, K. D., J. C. Croce, T. D. Glenn, S. Y. Wu, and D. R. McClay. “Genomics and expression profiles of the Hedgehog and Notch signaling pathways in sea urchin development.” Developmental Biology 300, no. 1 (December 2006): 153–64. https://doi.org/10.1016/j.ydbio.2006.08.064.Full Text
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Byrum, C. A., K. D. Walton, A. J. Robertson, S. Carbonneau, R. T. Thomason, J. A. Coffman, and D. R. McClay. “Protein tyrosine and serine-threonine phosphatases in the sea urchin, Strongylocentrotus purpuratus: identification and potential functions.” Developmental Biology 300, no. 1 (December 2006): 194–218. https://doi.org/10.1016/j.ydbio.2006.08.050.Full Text
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Oliveri, Paola, Katherine D. Walton, Eric H. Davidson, and David R. McClay. “Repression of mesodermal fate by foxa, a key endoderm regulator of the sea urchin embryo.” Development (Cambridge, England) 133, no. 21 (November 2006): 4173–81. https://doi.org/10.1242/dev.02577.Full Text
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Beane, Wendy S., Jeffrey M. Gross, and David R. McClay. “RhoA regulates initiation of invagination, but not convergent extension, during sea urchin gastrulation.” Developmental Biology 292, no. 1 (April 2006): 213–25. https://doi.org/10.1016/j.ydbio.2005.12.031.Full Text
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Bradham, Cynthia, and David R. McClay. “p38 MAPK in development and cancer.” Cell Cycle (Georgetown, Tex.) 5, no. 8 (April 2006): 824–28. https://doi.org/10.4161/cc.5.8.2685.Full Text
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Croce, Jenifer C., and David R. McClay. “The canonical Wnt pathway in embryonic axis polarity.” Seminars in Cell & Developmental Biology 17, no. 2 (April 2006): 168–74. https://doi.org/10.1016/j.semcdb.2006.04.004.Full Text
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Croce, Jenifer, Louise Duloquin, Guy Lhomond, David R. McClay, and Christian Gache. “Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development.” Development (Cambridge, England) 133, no. 3 (February 2006): 547–57. https://doi.org/10.1242/dev.02218.Full Text
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Bradham, Cynthia A., and David R. McClay. “p38 MAPK is essential for secondary axis specification and patterning in sea urchin embryos.” Development (Cambridge, England) 133, no. 1 (January 2006): 21–32. https://doi.org/10.1242/dev.02160.Full Text
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Sodergren, C. L., C. L. E, G. M. Weinstock, and The Sea Urchin Genome Sequencing Consortium. “The genome of the sea urchin Stongylocentrotus purpuratus.” Science 314 (2006): 941–52.
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Deak, Kristen L., Abee L. Boyles, Heather C. Etchevers, Elizabeth C. Melvin, Deborah G. Siegel, Felicia L. Graham, Susan H. Slifer, et al. “SNPs in the neural cell adhesion molecule 1 gene (NCAM1) may be associated with human neural tube defects.” Hum Genet 117, no. 2–3 (July 2005): 133–42. https://doi.org/10.1007/s00439-005-1299-7.Full Text Link to Item
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Peterson, Robert E., and David R. McClay. “A Fringe-modified Notch signal affects specification of mesoderm and endoderm in the sea urchin embryo.” Developmental Biology 282, no. 1 (June 2005): 126–37. https://doi.org/10.1016/j.ydbio.2005.02.033.Full Text
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Range, Ryan C., Judith M. Venuti, and David R. McClay. “LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo.” Developmental Biology 279, no. 1 (March 2005): 252–67. https://doi.org/10.1016/j.ydbio.2004.12.023.Full Text
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Otim, Ochan, Gabriele Amore, Takuya Minokawa, David R. McClay, and Eric H. Davidson. “SpHnf6, a transcription factor that executes multiple functions in sea urchin embryogenesis.” Developmental Biology 273, no. 2 (September 2004): 226–43. https://doi.org/10.1016/j.ydbio.2004.05.033.Full Text
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Wikramanayake, Athula H., Robert Peterson, Jing Chen, Ling Huang, Joanna M. Bince, David R. McClay, and William H. Klein. “Nuclear beta-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages.” Genesis (New York, N.Y. : 2000) 39, no. 3 (July 2004): 194–205. https://doi.org/10.1002/gene.20045.Full Text
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Bradham, C. A., E. L. Miranda, and D. R. McClay. “PI3K inhibitors block skeletogenesis but not patterning in sea urchin embryos.” Developmental Dynamics : An Official Publication of the American Association of Anatomists 229, no. 4 (April 2004): 713–21. https://doi.org/10.1002/dvdy.10470.Full Text
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Bradham, C. A., E. Miranda, and D. R. McClay. “PI3K Activity is Required for Skeletogenesis in Sea Urchin Embryos.” Dev Dyn 229 (2004): 713–21.
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McClay, D. R. “Methods for embryo dissociation and for studying cell associations using sea urchin material.” Methods of Cell Biology 74 (2004): 311–29.
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McClay, David R. “Methods for embryo dissociation and analysis of cell adhesion.” Methods in Cell Biology 74 (January 2004): 311–29. https://doi.org/10.1016/s0091-679x(04)74014-5.Full Text
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Sweet, Hyla, Shonan Amemiya, Andrew Ransick, Takuya Minokawa, David R. McClay, Athula Wikramanayake, Ritsu Kuraishi, Masato Kiyomoto, Hiroki Nishida, and Jonathan Henry. “Blastomere isolation and transplantation.” Methods in Cell Biology 74 (January 2004): 243–71. https://doi.org/10.1016/s0091-679x(04)74011-x.Full Text
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Wikramanayake, A. H., R. Peterson, J. Chen, L. Huang, D. R. McClay, and W. H. Klein. “Selective expression of Wnt8 in vegetal cells of the early sea urchin embryo mediates endomesoderm specification in a nuclear beta-catenin-dependent manner.” Genesis 39 (2004): 194–205.
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Amore, Gabriele, Robert G. Yavrouian, Kevin J. Peterson, Andrew Ransick, David R. McClay, and Eric H. Davidson. “Spdeadringer, a sea urchin embryo gene required separately in skeletogenic and oral ectoderm gene regulatory networks.” Developmental Biology 261, no. 1 (September 2003): 55–81. https://doi.org/10.1016/s0012-1606(03)00278-1.Full Text
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Oliveri, Paola, Eric H. Davidson, and David R. McClay. “Activation of pmar1 controls specification of micromeres in the sea urchin embryo.” Developmental Biology 258, no. 1 (June 2003): 32–43. https://doi.org/10.1016/s0012-1606(03)00108-8.Full Text
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Peterson, Robert E., and David R. McClay. “Primary mesenchyme cell patterning during the early stages following ingression.” Developmental Biology 254, no. 1 (February 2003): 68–78. https://doi.org/10.1016/s0012-1606(02)00025-8.Full Text
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Davidson, Eric H., David R. McClay, and Leroy Hood. “Regulatory gene networks and the properties of the developmental process.” Proceedings of the National Academy of Sciences of the United States of America 100, no. 4 (February 2003): 1475–80. https://doi.org/10.1073/pnas.0437746100.Full Text
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Oliveri, P. E., H. Davidson, and D. R. McClay. “Activation of pmar1 controls specification of micromeres in the sea urchin embryo.” Dev. Biol 258 (2003): 25–38.
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Gross, J. M., R. E. Peterson, and D. R. McClay. “LvTbx2/3, a T-box Family Transcription Factor Involved in Formation of the Oral/Aboral Axis of the Sea Urchin Embryo.” Development 130 (2003): 1989–99.
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Davidson, Eric H., Jonathan P. Rast, Paola Oliveri, Andrew Ransick, Cristina Calestani, Chiou-Hwa Yuh, Takuya Minokawa, et al. “A provisional regulatory gene network for specification of endomesoderm in the sea urchin embryo.” Developmental Biology 246, no. 1 (June 2002): 162–90. https://doi.org/10.1006/dbio.2002.0635.Full Text
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Davidson, Eric H., Jonathan P. Rast, Paola Oliveri, Andrew Ransick, Cristina Calestani, Chiou-Hwa Yuh, Takuya Minokawa, et al. “A genomic regulatory network for development.” Science (New York, N.Y.) 295, no. 5560 (March 2002): 1669–78. https://doi.org/10.1126/science.1069883.Full Text
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Sherwood, D. R., and D. R. McClay. “LvNotch signaling plays a dual role in regulating the position of the ectoderm-endoderm boundary in the sea urchin embryo.” Development (Cambridge, England) 128, no. 12 (June 2001): 2221–32. https://doi.org/10.1242/dev.128.12.2221.Full Text
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McClay, D. R., and P. L. Hertzler. “Quantitative measurement of cell adhesion using centrifugal force.” Current Protocols in Cell Biology Chapter 9 (May 2001): Unit-9.2. https://doi.org/10.1002/0471143030.cb0902s00.Full Text
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Gross, J. M., and D. R. McClay. “The Role of Brachyruy (T) During Gastrulations Movement in the Sea Urchin, Lytechinus variegatus.” Developmental Biology 239 (2001): 232–47.
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McClay, D. R., R. E. Peterson, R. C. Range, A. M. Winter-Vann, and M. J. Ferkowicz. “A micromere induction signal is activated by beta-catenin and acts through notch to initiate specification of secondary mesenchyme cells in the sea urchin embryo.” Development (Cambridge, England) 127, no. 23 (December 2000): 5113–22. https://doi.org/10.1242/dev.127.23.5113.Full Text
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Angerer, L. M., D. W. Oleksyn, C. Y. Logan, D. R. McClay, L. Dale, and R. C. Angerer. “A BMP pathway regulates cell fate allocation along the sea urchin animal-vegetal embryonic axis.” Development (Cambridge, England) 127, no. 5 (March 2000): 1105–14. https://doi.org/10.1242/dev.127.5.1105.Full Text
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McClay, D. R. “Specification of endoderm and mesoderm in the sea urchin.” Zygote (Cambridge, England) 8 Suppl 1 (January 2000): S41.
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McClay, D. R. “The role of thin filopodia in motility and morphogenesis.” Experimental Cell Research 253, no. 2 (December 1999): 296–301. https://doi.org/10.1006/excr.1999.4723.Full Text
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Sherwood, D. R., and D. R. McClay. “LvNotch signaling mediates secondary mesenchyme specification in the sea urchin embryo.” Development (Cambridge, England) 126, no. 8 (April 1999): 1703–13. https://doi.org/10.1242/dev.126.8.1703.Full Text
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Hertzler, P. L., and D. R. McClay. “alphaSU2, an epithelial integrin that binds laminin in the sea urchin embryo.” Developmental Biology 207, no. 1 (March 1999): 1–13. https://doi.org/10.1006/dbio.1998.9165.Full Text
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Logan, C. Y., J. R. Miller, M. J. Ferkowicz, and D. R. McClay. “Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo.” Development (Cambridge, England) 126, no. 2 (January 1999): 345–57. https://doi.org/10.1242/dev.126.2.345.Full Text
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Zito, F., V. Tesoro, D. R. McClay, E. Nakano, and V. Matranga. “Ectoderm cell--ECM interaction is essential for sea urchin embryo skeletogenesis.” Developmental Biology 196, no. 2 (April 1998): 184–92. https://doi.org/10.1006/dbio.1998.8866.Full Text
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Matese, J. C., and D. R. McClay. “Cortical granule exocytosis is triggered by different thresholds of calcium during fertilisation in sea urchin eggs.” Zygote (Cambridge, England) 6, no. 1 (February 1998): 55-65a. https://doi.org/10.1017/s0967199400005086.Full Text
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Wessel, G. M., L. Berg, D. L. Adelson, G. Cannon, and D. R. McClay. “A molecular analysis of hyalin--a substrate for cell adhesion in the hyaline layer of the sea urchin embryo.” Developmental Biology 193, no. 2 (January 1998): 115–26. https://doi.org/10.1006/dbio.1997.8793.Full Text
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Miller, J. R., and D. R. McClay. “Changes in the pattern of adherens junction-associated beta-catenin accompany morphogenesis in the sea urchin embryo.” Developmental Biology 192, no. 2 (December 1997): 310–22. https://doi.org/10.1006/dbio.1997.8739.Full Text
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Miller, J. R., and D. R. McClay. “Characterization of the role of cadherin in regulating cell adhesion during sea urchin development.” Developmental Biology 192, no. 2 (December 1997): 323–39. https://doi.org/10.1006/dbio.1997.8740.Full Text
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Sherwood, D. R., and D. R. McClay. “Identification and localization of a sea urchin Notch homologue: insights into vegetal plate regionalization and Notch receptor regulation.” Development (Cambridge, England) 124, no. 17 (September 1997): 3363–74. https://doi.org/10.1242/dev.124.17.3363.Full Text
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Matese, J. C., S. Black, and D. R. McClay. “Regulated exocytosis and sequential construction of the extracellular matrix surrounding the sea urchin zygote.” Developmental Biology 186, no. 1 (June 1997): 16–26. https://doi.org/10.1006/dbio.1997.8585.Full Text
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Logan, C. Y., and D. R. McClay. “The allocation of early blastomeres to the ectoderm and endoderm is variable in the sea urchin embryo.” Development (Cambridge, England) 124, no. 11 (June 1997): 2213–23. https://doi.org/10.1242/dev.124.11.2213.Full Text
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McClay, D. R., C. H. Damsky, M. Bronner-Fraser, C. Wylie, M. Bernfield, and R. R. Markwald. “NIEHS/EPA Workshops. Cellular migration.” Reproductive Toxicology (Elmsford, N.Y.) 11, no. 2–3 (March 1997): 321–29. https://doi.org/10.1016/s0890-6238(96)00215-8.Full Text
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Bachman, E. S., and D. R. McClay. “Molecular cloning of the first metazoan beta-1,3 glucanase from eggs of the sea urchin Strongylocentrotus purpuratus.” Proceedings of the National Academy of Sciences of the United States of America 93, no. 13 (June 1996): 6808–13. https://doi.org/10.1073/pnas.93.13.6808.Full Text
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McClay, D. R., and C. Y. Logan. “Regulative capacity of the archenteron during gastrulation in the sea urchin.” Development (Cambridge, England) 122, no. 2 (February 1996): 607–16. https://doi.org/10.1242/dev.122.2.607.Full Text
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Miller, J., S. E. Fraser, and D. McClay. “Dynamics of thin filopodia during sea urchin gastrulation.” Development (Cambridge, England) 121, no. 8 (August 1995): 2501–11. https://doi.org/10.1242/dev.121.8.2501.Full Text
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McClay, D. R., J. R. Miller, C. Y. Logan, P. L. Hertzler, E. S. Bachman, J. C. Matese, D. R. Sherwood, and N. A. Armstrong. “Cell adhesion and cell signaling at gastrulation in the sea urchin.” Theriogenology 44, no. 8 (January 1, 1995): 1145–65. https://doi.org/10.1016/0093-691X(95)00326-4.Full Text
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Bachman, E. S., and D. R. McClay. “Characterization of moesin in the sea urchin Lytechinus variegatus: redistribution to the plasma membrane following fertilization is inhibited by cytochalasin B.” Journal of Cell Science 108 ( Pt 1) (January 1995): 161–71. https://doi.org/10.1242/jcs.108.1.161.Full Text
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Burdsal, C. A., M. M. Lotz, J. Miller, and D. R. McClay. “Quantitative switch in integrin expression accompanies differentiation of F9 cells treated with retinoic acid.” Developmental Dynamics : An Official Publication of the American Association of Anatomists 201, no. 4 (December 1994): 344–53. https://doi.org/10.1002/aja.1002010406.Full Text
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Armstrong, N., and D. R. McClay. “Skeletal pattern is specified autonomously by the primary mesenchyme cells in sea urchin embryos.” Developmental Biology 162, no. 2 (April 1994): 329–38. https://doi.org/10.1006/dbio.1994.1090.Full Text
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McCain, E. R., and D. R. McClay. “The establishment of bilateral asymmetry in sea urchin embryos.” Development 120, no. 2 (February 1, 1994): 395–404.
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Armstrong, N., J. Hardin, and D. R. McClay. “Cell-cell interactions regulate skeleton formation in the sea urchin embryo.” Development (Cambridge, England) 119, no. 3 (November 1993): 833–40. https://doi.org/10.1242/dev.119.3.833.Full Text
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McClay, D. R., N. A. Armstrong, and J. Hardin. “Pattern formation during gastrulation in the sea urchin embryo.” Development, no. SUPPL. (December 1, 1992): 33–41.
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Hardin, J., J. A. Coffman, S. D. Black, and D. R. McClay. “Commitment along the dorsoventral axis of the sea urchin embryo is altered in response to NiCl2.” Development (Cambridge, England) 116, no. 3 (November 1992): 671–85. https://doi.org/10.1242/dev.116.3.671.Full Text
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Alliegro, M. C., S. D. Black, and D. R. McClay. “Deployment of extracellular matrix proteins in sea urchin embryogenesis.” Microscopy Research and Technique 22, no. 1 (June 1992): 2–10. https://doi.org/10.1002/jemt.1070220103.Full Text
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Adelson, D. L., M. C. Alliegro, and D. R. McClay. “On the ultrastructure of hyalin, a cell adhesion protein of the sea urchin embryo extracellular matrix.” The Journal of Cell Biology 116, no. 5 (March 1992): 1283–89. https://doi.org/10.1083/jcb.116.5.1283.Full Text
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McClay, D. R., N. A. Armstrong, and J. Hardin. “Pattern formation during gastrulation in the sea urchin embryo.” Development (Cambridge, England). Supplement, January 1992, 33–41.
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McClay, D. R. “Gastrulation.” Current Opinion in Genetics & Development 1, no. 2 (August 1991): 191–95. https://doi.org/10.1016/s0959-437x(05)80069-3.Full Text
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Burdsal, C. A., M. C. Alliegro, and D. R. McClay. “Tissue-specific, temporal changes in cell adhesion to echinonectin in the sea urchin embryo.” Developmental Biology 144, no. 2 (April 1991): 327–34. https://doi.org/10.1016/0012-1606(91)90425-3.Full Text
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Hardin, J., and D. R. McClay. “Target recognition by the archenteron during sea urchin gastrulation.” Developmental Biology 142, no. 1 (November 1990): 86–102. https://doi.org/10.1016/0012-1606(90)90153-a.Full Text
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Coffman, J. A., and D. R. McClay. “A hyaline layer protein that becomes localized to the oral ectoderm and foregut of sea urchin embryos.” Developmental Biology 140, no. 1 (July 1990): 93–104. https://doi.org/10.1016/0012-1606(90)90056-o.Full Text
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Alliegro, M. C., C. A. Burdsal, and D. R. McClay. “In vitro biological activities of echinonectin.” Biochemistry 29, no. 8 (February 1990): 2135–41. https://doi.org/10.1021/bi00460a025.Full Text
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Lieth, E., D. R. McClay, and J. M. Lauder. “Neuronal-glial interactions: complexity of neurite outgrowth correlates with substrate adhesivity of serotonergic neurons.” Glia 3, no. 3 (January 1990): 169–79. https://doi.org/10.1002/glia.440030304.Full Text
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Lotz, M. M., C. A. Burdsal, H. P. Erickson, and D. R. McClay. “Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response.” J Cell Biol 109, no. 4 Pt 1 (October 1989): 1795–1805. https://doi.org/10.1083/jcb.109.4.1795.Full Text Link to Item
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Lotz, M. M., C. A. Burdsal, H. P. Erickson, and D. R. McClay. “Cell adhesion to fibronectin and tenascin: quantitative measurements of initial binding and subsequent strengthening response.” The Journal of Cell Biology 109, no. 4 Pt 1 (October 1989): 1795–1805. https://doi.org/10.1083/jcb.109.4.1795.Full Text
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Bernacki, S. H., and D. R. McClay. “Embryonic cellular organization: differential restriction of fates as revealed by cell aggregates and lineage markers.” The Journal of Experimental Zoology 251, no. 2 (August 1989): 203–16. https://doi.org/10.1002/jez.1402510208.Full Text
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WRAY, G. A., and D. R. MCCLAY. “MOLECULAR HETEROCHRONIES AND HETEROTOPIES IN EARLY ECHINOID DEVELOPMENT.” Evolution 43, no. 4 (1989): 803–13. https://doi.org/10.2307/2409308.Full Text Link to Item
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Alliegro, M. C., C. A. Ettensohn, C. A. Burdsal, H. P. Erickson, and D. R. McClay. “Echinonectin: a new embryonic substrate adhesion protein.” J Cell Biol 107, no. 6 Pt 1 (December 1988): 2319–27. https://doi.org/10.1083/jcb.107.6.2319.Full Text Link to Item
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Nelson, S. H., and D. R. McClay. “Cell polarity in sea urchin embryos: reorientation of cells occurs quickly in aggregates.” Developmental Biology 127, no. 2 (June 1988): 235–47. https://doi.org/10.1016/0012-1606(88)90311-9.Full Text
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Wray, G. A., and D. R. McClay. “The origin of spicule-forming cells in a 'primitive' sea urchin (Eucidaris tribuloides) which appears to lack primary mesenchyme cells.” Development (Cambridge, England) 103, no. 2 (June 1988): 305–15. https://doi.org/10.1242/dev.103.2.305.Full Text
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Ettensohn, C. A., and D. R. McClay. “Cell lineage conversion in the sea urchin embryo.” Developmental Biology 125, no. 2 (February 1988): 396–409. https://doi.org/10.1016/0012-1606(88)90220-5.Full Text
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Alliegro, M. C., C. A. Ettensohn, C. A. Burdsal, H. P. Erickson, and D. R. McClay. “Echinonectin: A new embryonic substrate adhesion protein.” Journal of Cell Biology 107, no. 6 I (January 1, 1988): 2319–27. https://doi.org/10.1083/jcb.107.6.2319.Full Text
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Alliegro, M. C., and D. R. McClay. “Storage and mobilization of extracellular matrix proteins during sea urchin development.” Developmental Biology 125, no. 1 (January 1988): 208–16. https://doi.org/10.1016/0012-1606(88)90074-7.Full Text
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Wessel, G. M., M. R. Truschel, S. A. Chambers, and D. R. McClay. “A cortical granule-specific enzyme, B-1,3-glucanase, in sea urchin eggs.” Gamete Research 18, no. 4 (December 1987): 339–48. https://doi.org/10.1002/mrd.1120180408.Full Text
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Peeler, M. T., S. A. Chambers, C. Y. Wang, and D. R. McClay. “Stage-specific expression of beta-1, 3-glucanase in sea urchin embryos and hybrids.” The Journal of Experimental Zoology 244, no. 2 (November 1987): 215–22. https://doi.org/10.1002/jez.1402440205.Full Text
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Wessel, G. M., and D. R. McClay. “Gastrulation in the sea urchin embryo requires the deposition of crosslinked collagen within the extracellular matrix.” Developmental Biology 121, no. 1 (May 1987): 149–65. https://doi.org/10.1016/0012-1606(87)90148-5.Full Text
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Ettensohn, C. A., and D. R. McClay. “A new method for isolating primary mesenchyme cells of the sea urchin embryo. Panning on wheat germ agglutinin-coated dishes.” Experimental Cell Research 168, no. 2 (February 1987): 431–38. https://doi.org/10.1016/0014-4827(87)90015-2.Full Text
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McClay, D. R., and C. A. Ettensohn. “Cell adhesion in morphogenesis.” Annual Review of Cell Biology 3 (January 1987): 319–45. https://doi.org/10.1146/annurev.cb.03.110187.001535.Full Text
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Ettensohn, C. A., and D. R. McClay. “The regulation of primary mesenchyme cell migration in the sea urchin embryo: transplantations of cells and latex beads.” Developmental Biology 117, no. 2 (October 1986): 380–91. https://doi.org/10.1016/0012-1606(86)90307-6.Full Text
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McClay, D. R., and V. Matranga. “On the role of calcium in the adhesion of embryonic sea urchin cells.” Experimental Cell Research 165, no. 1 (July 1986): 152–64. https://doi.org/10.1016/0014-4827(86)90540-9.Full Text
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Wessel, G. M., and D. R. McClay. “Two embryonic, tissue-specific molecules identified by a double-label immunofluorescence technique for monoclonal antibodies.” The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society 34, no. 6 (June 1986): 703–6. https://doi.org/10.1177/34.6.3084626.Full Text
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McClay, D. R. “Embryo dissociation, cell isolation, and cell reassociation.” Methods in Cell Biology 27 (January 1986): 309–23. https://doi.org/10.1016/s0091-679x(08)60355-6.Full Text
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Truschel, M. R., S. A. Chambers, and D. R. McClay. “Two antigenically distinct forms of β-1,3-glucanase in sea urchin embryonic development.” Developmental Biology 117, no. 1 (January 1, 1986): 277–85. https://doi.org/10.1016/0012-1606(86)90370-2.Full Text
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Wessel, G. M., and D. R. McClay. “Sequential expression of germ-layer specific molecules in the sea urchin embryo.” Developmental Biology 111, no. 2 (October 1985): 451–63. https://doi.org/10.1016/0012-1606(85)90497-x.Full Text
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Fink, R. D., and D. R. McClay. “Three cell recognition changes accompany the ingression of sea urchin primary mesenchyme cells.” Developmental Biology 107, no. 1 (January 1985): 66–74. https://doi.org/10.1016/0012-1606(85)90376-8.Full Text
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McClay, D. R., and G. M. Wessel. “The surface of the sea urchin embryo at gastrulation: a molecular mosaic.” Trends in Genetics 1, no. C (January 1, 1985): 12–16. https://doi.org/10.1016/0168-9525(85)90008-3.Full Text
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Wessel, G. M., R. B. Marchase, and D. R. McClay. “Ontogeny of the basal lamina in the sea urchin embryo.” Developmental Biology 103, no. 1 (May 1984): 235–45. https://doi.org/10.1016/0012-1606(84)90025-3.Full Text
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Fink, R. D., and D. R. McClay. “Cell recognition processes in the differentiation of embryonic sea urchins.” Progress in Clinical and Biological Research 157 (January 1984): 143–48.
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Wessel, G. M., L. Berg, D. Adelson, G. Cannon, and D. R. McClay. “A molecularanalysis of hyalin, the major component of the cortical granules that is secreted at fertilization of the sea urchin egg.” Dev. Biol 193 (December 1983): 115–26.
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McClay, D. R., and R. D. Fink. “Sea urchin hyalin: appearance and function in development.” Developmental Biology 92, no. 2 (August 1982): 285–93. https://doi.org/10.1016/0012-1606(82)90175-0.Full Text
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Marchase, R. B., L. A. Koro, C. M. Kelly, and D. R. McClay. “Retinal ligatin recognizes glycoproteins bearing oligosaccharides terminating in phosphodiester-linked glucose.” Cell 28, no. 4 (April 1982): 813–20. https://doi.org/10.1016/0092-8674(82)90060-5.Full Text
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Marchase, R. B., L. A. Koro, C. M. Kelly, and D. R. McClay. “A possible role for ligatin and the phosphoglycoproteins it binds in calcium-dependent retinal cell adhesion.” Journal of Cellular Biochemistry 18, no. 4 (January 1982): 461–68. https://doi.org/10.1002/jcb.1982.240180407.Full Text
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McClay, D. R. “Cell recognition during gastrulation in the sea urchin.” Cell Differentiation 11, no. 5–6 (January 1, 1982): 341–44. https://doi.org/10.1016/0045-6039(82)90054-9.Full Text
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McClay, D. R., and R. B. Marchase. “Calcium-dependent and calcium-independent adhesive mechanisms are present during initial binding events of neural retina cells.” Journal of Cellular Biochemistry 18, no. 4 (January 1982): 469–78. https://doi.org/10.1002/jcb.1982.240180408.Full Text
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McClay, D. R., G. M. Wessel, and R. B. Marchase. “Intercellular recognition: quantitation of initial binding events.” Proceedings of the National Academy of Sciences of the United States of America 78, no. 8 (August 1981): 4975–79. https://doi.org/10.1073/pnas.78.8.4975.Full Text
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Banzhaf, W. C., R. H. Warren, and D. R. McClay. “Cortical reorganization following fertilization of sea urchin eggs: sensitivity to cytochalasin B.” Developmental Biology 80, no. 2 (December 1980): 506–15. https://doi.org/10.1016/0012-1606(80)90424-8.Full Text
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McClay, D. R., and R. B. Marchase. “Separation of ectoderm and endoderm from sea urchin pluteus larvae and demonstration of germ layer-specific antigens.” Developmental Biology 71, no. 2 (August 1979): 289–96. https://doi.org/10.1016/0012-1606(79)90170-2.Full Text
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McClay, D. R. “Surface antigens involved in interactions of embryonic sea urchin cells.” Current Topics in Developmental Biology 13 Pt 1 (January 1979): 199–214. https://doi.org/10.1016/s0070-2153(08)60695-x.Full Text
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McClay, D. R., and L. R. Gooding. “Involvement of histocompatibility antigens in embryonic cell recognition events.” Nature 274, no. 5669 (July 1978): 367–68. https://doi.org/10.1038/274367a0.Full Text
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McClay, D. R., and A. F. Chambers. “Identification of four classes of cell surface antigens appearing at gastrulation in sea urchin embryos.” Developmental Biology 63, no. 1 (March 1978): 179–86. https://doi.org/10.1016/0012-1606(78)90123-9.Full Text
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McCLAY, D. R., L. R. Gooding, and M. E. Fransen. “A requirement for trypsin-sensitive cell-surface components for cell-cell interactions of embryonic neural retina cells.” The Journal of Cell Biology 75, no. 1 (October 1977): 56–66. https://doi.org/10.1083/jcb.75.1.56.Full Text
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McClay, D. R., A. F. Chambers, and R. H. Warren. “Specificity of cell-cell interactions in sea urchin embryos. Appearance of new cell-surface determinants at gastrulation.” Developmental Biology 56, no. 2 (April 1977): 343–55. https://doi.org/10.1016/0012-1606(77)90275-5.Full Text
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McClay, D. R., and R. E. Hausman. “Specificity of cell adhesion: differences between normal and hybrid sea urchin cells.” Developmental Biology 47, no. 2 (December 1975): 454–60. https://doi.org/10.1016/0012-1606(75)90298-5.Full Text
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McClay, D. R., and S. R. Baker. “A kinetic study of embryonic cell adhesion.” Developmental Biology 43, no. 1 (March 1975): 109–22. https://doi.org/10.1016/0012-1606(75)90135-9.Full Text
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McClay, D. R., and A. A. Moscona. “Purification of the specific cell-aggregating factor from embryonic neural retina cells.” Experimental Cell Research 87, no. 2 (August 1974): 438–43. https://doi.org/10.1016/0014-4827(74)90514-x.Full Text
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McClay, D. R. “Cell aggregation: properties of cell surface factors from five species of sponge.” The Journal of Experimental Zoology 188, no. 1 (April 1974): 89–101. https://doi.org/10.1002/jez.1401880110.Full Text
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Book Sections
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McClay, David R. “Development of a larval nervous system in the sea urchin.,” 146:25–48, 2022. https://doi.org/10.1016/bs.ctdb.2021.10.002.Full Text
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McClay, David R., Jacob Warner, Megan Martik, Esther Miranda, and Leslie Slota. “Gastrulation in the sea urchin.,” 136:195–218, 2020. https://doi.org/10.1016/bs.ctdb.2019.08.004.Full Text
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McClay, David. “Unlocking mechanisms of development through advances in tools.,” 151:37–41, 2019. https://doi.org/10.1016/bs.mcb.2019.03.005.Full Text
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Conference Papers
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Lyons, Diedre, Dan McIntyre, and David R. McClay. “Ectodermal inputs into patterning skeletogenesis.” In Integrative and Comparative Biology, 54:E128–E128. OXFORD UNIV PRESS INC, 2014.Link to Item
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Lyons, Deirdre C., and David R. Mcclay. “Programmed cell fusion of PMCs during skeletal development in the sea urchin Lytechinus variegatus.” In Integrative and Comparative Biology, 52:E287–E287. OXFORD UNIV PRESS INC, 2012.Link to Item
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McIntyre, Daniel C., Winn Seay, and David R. McClay. “IrxA expression and function in establishing the sea urchin endoderm–ectoderm boundary.” In Developmental Biology, 344:469–469. Elsevier BV, 2010. https://doi.org/10.1016/j.ydbio.2010.05.226.Full Text
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McClay, David R., Jenifer C. Croce, Shu-Yu Wu, Wendy S. Beane, and Katherine D. Walton. “Gene regulatory networks governing morphogenesis.” In Developmental Biology, 319:477–477. Elsevier BV, 2008. https://doi.org/10.1016/j.ydbio.2008.05.043.Full Text
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Beane, Wendy S., and David R. McClay. “Patterning the sea urchin skeleton: A role for calcium signaling.” In Developmental Biology, 306:400–400. Elsevier BV, 2007. https://doi.org/10.1016/j.ydbio.2007.03.599.Full Text
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Croce, Jenifer C., and David R. McClay. “A new role for an old gene: Brachyury and the subdivision of the endomesoderm.” In Developmental Biology, 306:294–294. Elsevier BV, 2007. https://doi.org/10.1016/j.ydbio.2007.03.065.Full Text
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Wu, Shu-Yu, and David R. McClay. “Constructing the EMT regulatory network of PMCs in sea urchin embryos.” In Developmental Biology, 306:435–435. Elsevier BV, 2007. https://doi.org/10.1016/j.ydbio.2007.03.673.Full Text
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Beane, Wendy S., and David R. McClay. “Clearing the way: The small GTPase RhoA and endomesodermal specification.” In Developmental Biology, 295:411–12. Elsevier BV, 2006. https://doi.org/10.1016/j.ydbio.2006.04.264.Full Text
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Bradham, Cynthia A., Albert J. Poustka, and David R. McClay. “Chordin is required for neural but not axial specification in sea urchin embryos.” In Developmental Biology, 295:331–331. Elsevier BV, 2006. https://doi.org/10.1016/j.ydbio.2006.04.035.Full Text
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Wu, Shu-Yu, and David R. McClay. “Epithelial–mesenchymal transition regulators Snail and Twist are required for PMC ingression in the sea urchin embryo.” In Developmental Biology, 295:411–411. Elsevier BV, 2006. https://doi.org/10.1016/j.ydbio.2006.04.263.Full Text
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- Teaching & Mentoring
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Recent Courses
- BIOLOGY 221D: Developmental Biology: Development, Stem Cells, and Regeneration 2023
- BIOLOGY 493: Research Independent Study 2023
- CELLBIO 830: Developmental Biology Colloquium 2023
- NEUROSCI 494: Research Independent Study 2 2023
- BIOLOGY 293: Research Independent Study 2022
- BIOLOGY 493: Research Independent Study 2022
- CELLBIO 830: Developmental Biology Colloquium 2022
- CMB 710A: Cell & Molecular Biology Module I 2022
- NEUROSCI 493: Research Independent Study 1 2022
- UPGEN 778B: University Program in Genetics and Genomics Biological Solutions Module Il 2022
- BIOLOGY 221D: Developmental Biology: Development, Stem Cells, and Regeneration 2021
- BIOLOGY 293: Research Independent Study 2021
- CELLBIO 830: Developmental Biology Colloquium 2021
- Scholarly, Clinical, & Service Activities
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Presentations & Appearances
- Gene regulatory networks course. October 1, 2013 2013
- Aquatics model conference. July 1, 2013 2013
- Evolution conference,. July 1, 2013 2013
- International conference on right left asymmetry,. July 1, 2013 2013
- SDB society meeting. July 1, 2013 2013
- Woods Hole Embryology course. June 1, 2013 2013
- Oceanographique,. May 1, 2013 2013
- Academica Sinica,. February 1, 2013 2013
- Caltech,. January 1, 2013 2013
- EMT in embryogenesis of the sea urchin. November 13, 2012 2012
- Perturbations in analysis of systems. October 31, 2012 2012
- GRN regulation of morphogenesis. October 26, 2012 2012
- GRNs that drive morphogenesis. October 15, 2012 2012
- GRNs in early development. October 11, 2012 2012
- Sea urchin development. June 6, 2012 2012
- Advances in developmental biology. March 22, 2012 2012
- Early development and gene regulatory networks. February 28, 2012 2012
- Epithelial mesenchymal transition in the sea urchin. February 27, 2012 2012
- Gene regulatory networks and their control of morphogenesis. DCMB seminar. December 11, 2011 2011
- Gene regulatory networks and control of an epithelial mesenchymal transition. December 2, 2011 2011
- Gene regulatory networks and their control of morphogenesis. November 30, 2011 2011
- Gene regulatory networks and their control of morphogenesis. October 17, 2011 2011
- Gene regulatory networks and control of an epithelial mesenchymal transition. October 11, 2011 2011
- Gene regulatory networks and their control of morphogenesis. July 7, 2011 2011
- Gene regulatory networks and their control of morphogenesis. April 27, 2011 2011
- Gene regulatory networks and their control of morphogenesis. February 9, 2011 2011
- Gene regulatory networks and their control of morphogenesis. January 31, 2011 2011
- Transfating impact on gene regulatory networks. December 8, 2010 2010
- Gene regulatory networks and their control of morphogenesis. October 15, 2010 2010
- Gene regulatory networks in development. October 3, 2010 2010
- Morphogenesis and its control by gene regulatory networks. September 24, 2010 2010
- Morphogenesis and its control by gene regulatory networks. August 13, 2010 2010
- Sea urchin Development. July 13, 2010 2010
- Manipulation of gene regulatory networks in Development. February 26, 2010 2010
- Manipulation of gene regulatory networks in Development. January 28, 2010 2010
- Gene regulatory networks in development of the sea urchin. October 27, 2009 2009
- Gene regulatory networks in development of the sea urchin. October 26, 2009 2009
- Early development. October 16, 2009 2009
- Gene regulatory networks in development. July 15, 2009 2009
- Epithelial mesenchyme transition in sea urchin embryos. May 23, 2009 2009
- Gene regulatory networks in development of the sea urchin. February 24, 2009 2009
- Gene regulatory networks in development of the sea urchin. January 23, 2009 2009
- Gene regulatory networks in early development of sea urchins. October 14, 2008 2008
- Gene regulatory networks in early development of sea urchins. August 22, 2008 2008
- Gene regulatory networks in early development of sea urchins. July 27, 2008 2008
- Surviving the tenure clock. July 25, 2008 2008
- Gene regulatory networks in early development of sea urchins. July 1, 2008 2008
- gene regulatory networks in early development of sea urchins. June 27, 2008 2008
- Gene regulatory networks in early development of sea urchins. May 29, 2008 2008
- Gene regulatory networks in early development. April 29, 2008 2008
- Gene regulatory networks in morphogenesis. April 24, 2008 2008
- Gene regulatory networks in early development. February 27, 2008 2008
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Outreach & Engaged Scholarship
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Service to the Profession
- Organizer : Organizer of Sea urchin XXI. 2013 2013
- Co-Chair : NIH-NICHD Conference on future of developmental biological research. February 15, 2011 2011
- Gene Patterns and Expression. 2010 2010
- Genesis. 2010 2010
- Mechanisms of Development. 2010 2010
- Reviewer : Development, Developmental Biology, PNAS, Development, Science, Nature, Cell, and Evolution,. 2010 2010
- Consultant : National Institute for Child Health and Human Development. December 15, 2009 2009
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