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Association of mild cognitive impairment and characteristic of COPD and overall health status in a cohort study.

Publication ,  Journal Article
Yohannes, AM; N Eakin, M; Holbrook, JT; Sugar, EA; Henderson, R; Baker, AM; Casper, AS; Kaminsky, DA; Rea, AL; Mathews, AM; Que, LG; Wise, RA ...
Published in: Expert Rev Respir Med
January 2021

Introduction: We evaluated risk factors and demographic characteristics of associated with mild cognitive impairment (MCI) in patients with COPD. Methods: 220 individuals with COPD enrolled in a cohort study designed to evaluate anxiety conducted at 16 clinical centers. Cognitive impairment was assessed with the Montreal Cognitive Assessment (MoCA), a cutoff score of <26 defined as MCI. Data were collected including spirometry, 6-minute walk test, symptom burden by COPD Assessment Test and dyspnea by Modified Medical Research Council, anxiety measured by Anxiety Inventory of Respiratory Disease, Generalized Anxiety Disorder-7 and Hospital Anxiety Depression Scale, depression by Patient Health Questionnaire-9 and health status by Patient Reported Outcomes Measurement Information System and sleep quality by the Pittsburg Sleep Quality Index. Results: The median age was 65 years and 54% of participants were male. 119(54%) of participants had MCI as classified by MoCA. In multivariable logistic regression, higher odds ratios (OR) (95% confidence interval) for MCI (MoCA) <26 were associated with increased years of age, 1.06 (1.02 -1-09, p<0.003); African-American race, 3.68(1.67-8.11, p<0.001); persistent phlegm, 2 (1.12-3.57, p<0.01) and sleep disturbance, 1.04(1.01-1.08, p<0.01). Conclusions: COPD patients commonly screen positive for MCI. Characteristics associated with MCI included age, African-American race, sleep disturbance and persistent phlegm.

Duke Scholars

Published In

Expert Rev Respir Med

DOI

EISSN

1747-6356

Publication Date

January 2021

Volume

15

Issue

1

Start / End Page

153 / 159

Location

England

Related Subject Headings

  • Respiratory System
  • Pulmonary Disease, Chronic Obstructive
  • Mental Status and Dementia Tests
  • Male
  • Infant
  • Humans
  • Health Status
  • Cohort Studies
  • Cognitive Dysfunction
  • Aged
 

Citation

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Yohannes, A. M., N Eakin, M., Holbrook, J. T., Sugar, E. A., Henderson, R., Baker, A. M., … Hanania, N. A. (2021). Association of mild cognitive impairment and characteristic of COPD and overall health status in a cohort study. Expert Rev Respir Med, 15(1), 153–159. https://doi.org/10.1080/17476348.2021.1838278
Yohannes, Abebaw M., Michelle N Eakin, Janet T. Holbrook, Elizabeth A. Sugar, Robert Henderson, Anna M. Baker, Anne S. Casper, et al. “Association of mild cognitive impairment and characteristic of COPD and overall health status in a cohort study.Expert Rev Respir Med 15, no. 1 (January 2021): 153–59. https://doi.org/10.1080/17476348.2021.1838278.
Yohannes AM, N Eakin M, Holbrook JT, Sugar EA, Henderson R, Baker AM, et al. Association of mild cognitive impairment and characteristic of COPD and overall health status in a cohort study. Expert Rev Respir Med. 2021 Jan;15(1):153–9.
Yohannes, Abebaw M., et al. “Association of mild cognitive impairment and characteristic of COPD and overall health status in a cohort study.Expert Rev Respir Med, vol. 15, no. 1, Jan. 2021, pp. 153–59. Pubmed, doi:10.1080/17476348.2021.1838278.
Yohannes AM, N Eakin M, Holbrook JT, Sugar EA, Henderson R, Baker AM, Casper AS, Kaminsky DA, Rea AL, Mathews AM, Que LG, Ramsdell JW, Gerald LB, Wise RA, Hanania NA. Association of mild cognitive impairment and characteristic of COPD and overall health status in a cohort study. Expert Rev Respir Med. 2021 Jan;15(1):153–159.
Journal cover image

Published In

Expert Rev Respir Med

DOI

EISSN

1747-6356

Publication Date

January 2021

Volume

15

Issue

1

Start / End Page

153 / 159

Location

England

Related Subject Headings

  • Respiratory System
  • Pulmonary Disease, Chronic Obstructive
  • Mental Status and Dementia Tests
  • Male
  • Infant
  • Humans
  • Health Status
  • Cohort Studies
  • Cognitive Dysfunction
  • Aged