Overview
My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.
Key words: nitrosative defense, lung injury, nitric oxide
Key words: nitrosative defense, lung injury, nitric oxide
Current Appointments & Affiliations
Professor of Medicine
·
2019 - Present
Medicine, Pulmonary, Allergy, and Critical Care Medicine,
Medicine
Chief, Division of Pulmonary
·
2021 - Present
Medicine, Pulmonary, Allergy, and Critical Care Medicine,
Medicine
Recent Publications
Asthma in pregnancy: contemporary management.
Journal Article Am J Obstet Gynecol · March 13, 2026 Asthma affects 8% to 13% of pregnancies and is associated with adverse maternal and fetal outcomes. The evidence consistently demonstrates that uncontrolled asthma in pregnancy is the primary driver of this pregnancy risk rather than the diagnosis alone. C ... Full text Link to item CiteEffect of a self-directed lifestyle-based weight management program among patients with comorbid COPD and sleep apnea: a secondary analysis of the INSIGHT COPD trial.
Journal Article Ann Am Thorac Soc · March 1, 2026 RATIONALE: Excess weight contributes to impaired physical function among individuals with chronic obstructive pulmonary disease (COPD) and sleep apnea. Self-directed lifestyle-based weight management programs are an accessible option to promote weight loss ... Full text Link to item CiteUsing hyperpolarised xenon-129 magnetic resonance imaging to investigate longitudinal effects of long COVID on pulmonary function.
Journal Article ERJ Open Res · March 2026 Hyperpolarised 129Xe MRI shows significant improvements in VDP and select gas exchange metrics at ∼20 months compared to ∼14 months following initial COVID-19 infection https://bit.ly/3LoJry4. ... Full text Link to item CiteRecent Grants
Targeted Implementation of Pulmonary Rehabilitation for Post-Tuberculosis Lung Disease
ResearchMentor · Awarded by National Institutes of Health · 2025 - 2030GSK Cough Study. A prospective Cohort Study of Patients with Refractory or Unexplained Chronic Cough measuring Cough Variability and Burden on Patients' Lives.
Clinical TrialPrincipal Investigator · Awarded by GlaxoSmithKline · 2026 - 2030AMGEN AMG-451 Pro00115602 A Phase 2, Double-blind, Placebo-controlled, Dose Ranging Study Assessing Rocatinlimab in Moderate-to-severe Asthma
Clinical TrialPrincipal Investigator · Awarded by Amgen, Inc. · 2024 - 2029View All Grants
Education
The University of Chicago ·
1989
M.D.