Overview
My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.
Key words: nitrosative defense, lung injury, nitric oxide
Key words: nitrosative defense, lung injury, nitric oxide
Current Appointments & Affiliations
Professor of Medicine
·
2019 - Present
Medicine, Pulmonary, Allergy, and Critical Care Medicine,
Medicine
Chief, Division of Pulmonary
·
2021 - Present
Medicine, Pulmonary, Allergy, and Critical Care Medicine,
Medicine
Recent Publications
Obesity-driven airway eosinophilia and neutrophilia in asthma.
Journal Article J Asthma · September 2025 OBJECTIVE: Asthma patients with comorbid obesity tend to have more severe, difficult-to-control asthma than lean asthma patients. This increase in asthma severity may be due, in part, to obesity-related adipokines, such as leptin, which contribute to airwa ... Full text Open Access Link to item CiteFraction of Nitric Oxide in Exhaled Breath.
Journal Article Clin Chest Med · September 2025 Nitric oxide (NO) is an odorless gaseous molecule important for biological functions including regulation of vasodilation, smooth muscle relaxation, neurotransmission, platelet aggregation inhibition, and airway epithelial barrier function. It was first di ... Full text Link to item CiteDetermining an appropriate fosfomycin (ZTI-01) dosing regimen in pneumonia patients by utilizing minimal PBPK modeling and target attainment analysis.
Journal Article Antimicrob Agents Chemother · June 4, 2025 Fosfomycin, a broad-spectrum antibiotic used for uncomplicated cystitis, represents a potential promising candidate in combating resistant pneumonia. To facilitate the transition of fosfomycin to broader indications, including pneumonia, a minimal physiolo ... Full text Link to item CiteRecent Grants
Targeted Implementation of Pulmonary Rehabilitation for Post-Tuberculosis Lung Disease
ResearchMentor · Awarded by National Institutes of Health · 2025 - 2030AMGEN AMG-451 Pro00115602 A Phase 2, Double-blind, Placebo-controlled, Dose Ranging Study Assessing Rocatinlimab in Moderate-to-severe Asthma
Clinical TrialPrincipal Investigator · Awarded by Amgen, Inc. · 2024 - 2029PROSPERO AZ Pro00115490
Clinical TrialPrincipal Investigator · Awarded by AstraZeneca AB · 2024 - 2029View All Grants
Education, Training & Certifications
The University of Chicago ·
1989
M.D.