Overview
My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.
Key words: nitrosative defense, lung injury, nitric oxide
Key words: nitrosative defense, lung injury, nitric oxide
Current Appointments & Affiliations
Professor of Medicine
·
2019 - Present
Medicine, Pulmonary, Allergy, and Critical Care Medicine,
Medicine
Chief, Division of Pulmonary
·
2021 - Present
Medicine, Pulmonary, Allergy, and Critical Care Medicine,
Medicine
Recent Publications
Leptin augments IL-13-induced airway eotaxins and submucosal eosinophilia in obesity-associated asthma.
Journal Article J Allergy Clin Immunol · March 2025 BACKGROUND: Airway tissue eosinophilia can be an observed feature of obesity-associated type 2 (T2) asthma, but the processes mediating this inflammation are unknown. OBJECTIVE: To investigate a process whereby leptin, an adipokine elevated in obesity, pot ... Full text Link to item CiteEvaluation of the safety profile and intrapulmonary pharmacokinetics of intravenous fosfomycin in healthy adults.
Journal Article Antimicrob Agents Chemother · February 13, 2025 UNLABELLED: This Phase 1 trial described the intrapulmonary pharmacokinetics and safety profile of IV fosfomycin in healthy participants. Fosfomycin, a broad-spectrum antibiotic mainly used to treat urinary tract infections, is being considered for treatme ... Full text Link to item CiteRisk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults.
Journal Article J Am Heart Assoc · January 21, 2025 BACKGROUND: Meta-analyses have suggested that the risk of cardiovascular disease events is significantly higher after a chronic obstructive pulmonary disease (COPD) exacerbation, but the populations at highest risk have not been well characterized to date. ... Full text Link to item CiteRecent Grants
AMGEN AMG-451 Pro00115602 A Phase 2, Double-blind, Placebo-controlled, Dose Ranging Study Assessing Rocatinlimab in Moderate-to-severe Asthma
Clinical TrialPrincipal Investigator · Awarded by Amgen, Inc. · 2024 - 2029PROSPERO AZ Pro00115490
Clinical TrialPrincipal Investigator · Awarded by AstraZeneca AB · 2024 - 2029NICHD Pediatric and Maternal Resource Center: Bridging Pharmacology and the Real World
ResearchCo Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2024 - 2028View All Grants
Education, Training & Certifications
The University of Chicago ·
1989
M.D.