Loretta Georgina Que | Scholars@Duke

Loretta Georgina Que
Professor of Medicine

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Current Appointments & Affiliations

Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2019

Contact Information

279 Msrb1, Durham, NC 27710
Duke Box 2629, 203 Research Dr, Durham, NC 27710
loretta.que@duke.edu (919) 681-8551

Background
Education, Training, & Certifications
- Pulmonary Fellow, Medicine, Duke University 1993 - 1996
- Clinical Instructor, Medicine, Yale University 1992 - 1993
- Medical Resident, Medicine, Yale University 1989 - 1992
- M.D., The University of Chicago 1989
Duke Appointment History
- Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2011 - 2019
- Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2001 - 2010
- Associate in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1996 - 2001
Research
Selected Grants
- Oxidative Stress and Regional Airway Remodeling and Fibrosis in Obese Asthma awarded by National Institutes of Health 2020 - 2024
- A Longitudinal Prospective Observational Study of the Characteristics, Treatment Patterns and Health Outcomes of Individuals with Severe Asthma in the United States awarded by AstraZeneca Pharmaceuticals, LP 2018 - 2023
- RofLumilast or Azithromycin to preveNt COPD Exacerbations (RELIANCE) awarded by University of Illinois at Chicago 2017 - 2023
- CXCL10/CXCR3 regulation of ozone-induced epithelial permeability awarded by National Institutes of Health 2017 - 2022
- A double-blind, placebo-controlled, multi-centre, clinical trial to investigate the efficacy and safety of therapy with inhaled colistimethate sodium in the treatment of subjects with non-CF bronchiectasis chronically infected with P. aeruginosa awarded by Zambon SpA 2018 - 2021
- Research Training in Allergy and Clinical Immunology awarded by National Institutes of Health 2000 - 2021
- AZ D5180C00018 DESTINATION: A multicentre double blind randomized placebo controlled parallel group phase 3 safety extension study to evaluate safety & tolerability of Tezepelumab awarded by AstraZeneca Pharmaceuticals, LP 2019 - 2021
- EFC1580 BOREAS: A randomized double blind placebo controlled parallel group 52wk study to assess the efficacy, safety, and tolerability of Dupilumab in patients with moderate to severe COPD w/Type 2 awarded by Sanofi US 2019 - 2021
- Mechanisms that Direct Airway Remodeling in Obese Asthma awarded by National Institutes of Health 2017 - 2021
- Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 2009 - 2021
- D5180C00009 SOURCE A multicentre randomized double blind placebo controlled Phase 3 study to evaluate the efficacy and safety of Tezepelumab awarded by AstraZeneca AB 2018 - 2021
- Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRI awarded by National Institutes of Health 2011 - 2021
- Task Area B-D Task Order 16-0058.B1C1D1.0076 awarded by National Institutes of Health 2017 - 2021
- VACCINE AND TREATMENT EVALUATION UNITS (VTEU) PROTOCOL DEVELOPMENT, IMPLEMENTATION AND ASSAYS TASK AREA B-D PHASE 1 PK TRIAL TO EVALUATE FOSFOMYCIN TASK ORDER 16-0058.B1C1D1.0076 awarded by National Institutes of Health 2017 - 2020
- VTEU Task Order 16-0058.B1C1D1.0076 - Task D awarded by National Institutes of Health 2017 - 2020
- Mitochondrial Redox Perturbations in Obese Allergic Asthma awarded by University of Vermont 2019 - 2020
- A Randomized Phase II Clinical Trial of L-Citrulline to Improve Asthma Control in Obese Late Onset Asthma awarded by University of Colorado - Denver 2019 - 2020
- Improving Medication Adherence with Telehealthcare Medication Therapy Management to Change Health Outcomes in Adolescents and Young Adults with Asthma (MATCH) awarded by American Lung Association 2019 - 2020
- Asthma BMI Baseline Study (ABBS) awarded by American Lung Association 2018 - 2020
- Trial of Roflumilast in Asthma Management (TRIM) awarded by American Lung Association 2018 - 2020
- Pilot: Zinc Acetate to Treat Chronic Refractory Cough (ZICO) awarded by American Lung Association 2017 - 2020
- American Lung Association Airways Clinical Research Centers Network awarded by American Lung Association 2016 - 2020
- A multi-center, randomized, double-blind, placebo controlled, parallel group study to compare cessation versus continuation of long-term mepolizumab treatment in patients with severe eosinophilic asthma (201810) awarded by GlaxoSmithKline 2016 - 2020
- American Lung Association (ALA) Novel Digital Diary (ANDDI) Trial awarded by American Lung Association 2019 - 2020
- Modulation of Asthma by GSNO-based Therapies awarded by National Institutes of Health 2013 - 2018
- Diesel-induced Alterations of Influenza Infectivity awarded by University of North Carolina - Chapel Hill 2015 - 2017
- Surfactant Protein-A regulation of eosinophil apoptosis in asthma awarded by University of Arizona 2015 - 2017
- HIV and Asthma in the Post- ART Era awarded by National Institutes of Health 2014 - 2016
- The Duke Multidisciplinary Training Program in Pediatric Lung Disease awarded by National Institutes of Health 2010 - 2016
- Clinical Center Core awarded by University of Arizona 2009 - 2016
- Asthma Clinical Research Center of the American Lung Association awarded by American Lung Association 2009 - 2016
- I2PP2A and Asthma awarded by Cognosci, Inc. 2014 - 2015
- Diesel-induced Alterations of Influenza Infectivity awarded by University of North Carolina - Chapel Hill 2013 - 2014
- GSNO Reductase, S-Nitrosothiols, and Asthma awarded by National Institutes of Health 2007 - 2013
- Genetic regulation of O3-induced inflammation in humans awarded by National Institutes of Health 2000 - 2007
- Modulation of NO with Pulmonary Gene Transfer awarded by National Institutes of Health 2000 - 2006
External Relationships
- AstraZeneca
- LPN Research and Development Corporation
- Robling Medical
- Sanofi and Regeneron Pharmaceuticals
- Zambon SpA
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Holguin, Fernando, Hartmut Grasemann, Sunita Sharma, Daniel Winnica, Karen Wasil, Vong Smith, Margaret H. Cruse, et al. “L-Citrulline increases nitric oxide and improves control in obese asthmatics.” Jci Insight 4, no. 24 (December 19, 2019). https://doi.org/10.1172/jci.insight.131733.
    Full Text Link to Item
  - Winnica, Daniel, Catherine Corey, Steven Mullett, Michael Reynolds, Gabrielle Hill, Stacy Wendell, Loretta Que, Fernando Holguin, and Sruti Shiva. “Bioenergetic Differences in the Airway Epithelium of Lean Versus Obese Asthmatics Are Driven by Nitric Oxide and Reflected in Circulating Platelets.” Antioxid Redox Signal 31, no. 10 (October 1, 2019): 673–86. https://doi.org/10.1089/ars.2018.7627.
    Full Text Link to Item
  - Wechsler, Michael E., Stanley J. Szefler, Victor E. Ortega, Jacqueline A. Pongracic, Vernon Chinchilli, John J. Lima, Jerry A. Krishnan, et al. “Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma.” N Engl J Med 381, no. 13 (September 26, 2019): 1227–39. https://doi.org/10.1056/NEJMoa1905560.
    Full Text Link to Item
  - Dy, Alane Blythe C., Muhammad Z. Arif, Kenneth J. Addison, Loretta G. Que, Scott Boitano, Monica Kraft, and Julie G. Ledford. “Genetic Variation in Surfactant Protein-A2 Delays Resolution of Eosinophilia in Asthma.” J Immunol 203, no. 5 (September 1, 2019): 1122–30. https://doi.org/10.4049/jimmunol.1900546.
    Full Text Link to Item
  - Lazarus, Stephen C., Jerry A. Krishnan, Tonya S. King, Jason E. Lang, Kathryn V. Blake, Ronina Covar, Njira Lugogo, et al. “Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level.” N Engl J Med 380, no. 21 (May 23, 2019): 2009–19. https://doi.org/10.1056/NEJMoa1814917.
    Full Text Link to Item
  - Riley, Isaretta L., Beverly Murphy, Zayd Razouki, Jerry A. Krishnan, Andrea Apter, Sande Okelo, Monica Kraft, Cindy Feltner, Loretta G. Que, and L Ebony Boulware. “A Systematic Review of Patient- and Family-Level Inhaled Corticosteroid Adherence Interventions in Black/African Americans.” J Allergy Clin Immunol Pract 7, no. 4 (April 2019): 1184-1193.e3. https://doi.org/10.1016/j.jaip.2018.10.036.
    Full Text Link to Item
  - Riley, Isaretta L., L Ebony Boulware, Jie-Lena Sun, Karen Chiswell, Loretta G. Que, Monica Kraft, Jamie L. Todd, Scott M. Palmer, and Monique L. Anderson. “Factors associated with reporting results for pulmonary clinical trials in ClinicalTrials.gov.” Clin Trials 15, no. 1 (February 2018): 87–94. https://doi.org/10.1177/1740774517740352.
    Full Text Link to Item
  - Paul, D. W., D. K. Lagat, N. MacIntyre, J. R. Egger, D. M. Murdoch, L. G. Que, and P. S. Kussin. “Validation of spirometry prediction equations in western Kenya.” Int J Tuberc Lung Dis 22, no. 1 (January 1, 2018): 112–18. https://doi.org/10.5588/ijtld.17.0005.
    Full Text Link to Item
  - Foster, Matthew W., Zhonghui Yang, David M. Gooden, J Will Thompson, Carol H. Ball, Meredith E. Turner, Yongyong Hou, Jingbo Pi, M Arthur Moseley, and Loretta G. Que. “Correction to "Proteomic Characterization of the Cellular Response to Nitrosative Stress Mediated by S-Nitrosoglutathione Reductase Inhibition".” J Proteome Res 16, no. 7 (July 7, 2017): 2661. https://doi.org/10.1021/acs.jproteome.7b00368.
    Full Text Link to Item
  - Durack, Juliana, Susan V. Lynch, Snehal Nariya, Nirav R. Bhakta, Avraham Beigelman, Mario Castro, Anne-Marie Dyer, et al. “Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment.” J Allergy Clin Immunol 140, no. 1 (July 2017): 63–75. https://doi.org/10.1016/j.jaci.2016.08.055.
    Full Text Link to Item
  - Winnica, D., L. G. Que, C. Baffi, H. Grasemann, K. Fiedler, Z. Yang, E. Etling, et al. “l-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells.” Clin Exp Allergy 47, no. 2 (February 2017): 190–99. https://doi.org/10.1111/cea.12802.
    Full Text Link to Item
  - He, Mu, Bastiaan Driehuys, Loretta G. Que, and Yuh-Chin T. Huang. “Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution.” Acad Radiol 23, no. 12 (December 2016): 1521–31. https://doi.org/10.1016/j.acra.2016.07.014.
    Full Text Link to Item
  - Ray, Samriddha, Norika Chiba, Changfu Yao, Xiangrong Guan, Alicia M. McConnell, Brian Brockway, Loretta Que, Jonathan L. McQualter, and Barry R. Stripp. “Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection.” Stem Cell Reports 7, no. 5 (November 8, 2016): 817–25. https://doi.org/10.1016/j.stemcr.2016.09.010.
    Full Text Link to Item
  - Baffi, Cynthia W., Lisa Wood, Daniel Winnica, Patrick J. Strollo, Mark T. Gladwin, Loretta G. Que, and Fernando Holguin. “Metabolic Syndrome and the Lung.” Chest 149, no. 6 (June 2016): 1525–34. https://doi.org/10.1016/j.chest.2015.12.034.
    Full Text Link to Item
  - Ledford, Julie G., Kenneth J. Addison, Dave Francisco, Matthew W. Foster, Dennis R. Voelker, Loretta G. Que, and Monica Kraft. “Genetic Variation in Surfactant Protein-A2 Results in Altered Regulation of Eosinophil Activities and Enhanced Eosinophilia in Patients with Asthma.” Ann Am Thorac Soc 13 Suppl 1 (March 2016): S101. https://doi.org/10.1513/AnnalsATS.201508-520MG.
    Full Text Link to Item
  - Ingram, Jennifer L., David Slade, Tony D. Church, Dave Francisco, Karissa Heck, R Wesley Sigmon, Michael Ghio, et al. “Role of Matrix Metalloproteinases-1 and -2 in Interleukin-13-Suppressed Elastin in Airway Fibroblasts in Asthma.” Am J Respir Cell Mol Biol 54, no. 1 (January 2016): 41–50. https://doi.org/10.1165/rcmb.2014-0290OC.
    Full Text Link to Item
  - Yu, Yen-Rei A., Emily G. O’Koren, Danielle F. Hotten, Matthew J. Kan, David Kopin, Erik R. Nelson, Loretta Que, and Michael D. Gunn. “A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues.” Plos One 11, no. 3 (2016): e0150606. https://doi.org/10.1371/journal.pone.0150606.
    Full Text Link to Item
  - Schmalbeck, R., L. Faulk, S. Alaimo, K. Gronbjerg, J. Colombo, D. Mason, T. Dearing, et al. “Ask the Experts.” Wallethub, 2015.
  - Mehta, K., E. J. Soderblom, J. W. Thompson, L. G. Que, H. E. Marshall, M. A. Moseley, and M. W. Foster. “Targeted proteomics for unraveling the post-translational regulation of human nitric oxide synthase 2.” Nitric Oxide 42C (November 15, 2014): 132. https://doi.org/10.1016/j.niox.2014.09.100.
    Full Text Link to Item
  - Ledford, Julie G., Kenneth J. Addison, Matthew W. Foster, and Loretta G. Que. “Eosinophil-associated lung diseases. A cry for surfactant proteins A and D help?” Am J Respir Cell Mol Biol 51, no. 5 (November 2014): 604–14. https://doi.org/10.1165/rcmb.2014-0095TR.
    Full Text Link to Item
  - Castro, Mario, Tonya S. King, Susan J. Kunselman, Michael D. Cabana, Loren Denlinger, Fernando Holguin, Shamsah D. Kazani, et al. “Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial.” Jama 311, no. 20 (May 2014): 2083–91. https://doi.org/10.1001/jama.2014.5052.
    Full Text Link to Item
  - Catania, Jelena, Loretta G. Que, Joseph A. Govert, John W. Hollingsworth, and Cameron R. Wolfe. “High intensive care unit admission rate for 2013-2014 influenza is associated with a low rate of vaccination.” Am J Respir Crit Care Med 189, no. 4 (February 15, 2014): 485–87. https://doi.org/10.1164/rccm.201401-0066LE.
    Full Text Link to Item
  - Foster, Matthew W., J Will Thompson, Loretta G. Que, Ivana V. Yang, David A. Schwartz, M Arthur Moseley, and Harvey E. Marshall. “Proteomic analysis of human bronchoalveolar lavage fluid after subsgemental exposure.” J Proteome Res 12, no. 5 (May 3, 2013): 2194–2205. https://doi.org/10.1021/pr400066g.
    Full Text Link to Item
  - Foster, M. W., J. W. Thompson, L. G. Que, I. V. Yang, D. A. Schwartz, M. A. Moseley, and H. E. Marshall. “Proteomic Analysis Of Human Bronchoalveolar Lavage Fluid After Subsegmental Challenge.” American Journal of Respiratory and Critical Care Medicine 187 (2013).
    Link to Item
  - Foster, Matthew W., Zhonghui Yang, David M. Gooden, J Will Thompson, Carol H. Ball, Meredith E. Turner, Yongyong Hou, Jingbo Pi, M Arthur Moseley, and Loretta G. Que. “Proteomic characterization of the cellular response to nitrosative stress mediated by s-nitrosoglutathione reductase inhibition.” J Proteome Res 11, no. 4 (April 6, 2012): 2480–91. https://doi.org/10.1021/pr201180m.
    Full Text Link to Item
  - Wang, Ying, Zhou Zhu, Tony D. Church, Njira L. Lugogo, Loretta G. Que, Dave Francisco, Jennifer L. Ingram, et al. “SHP-1 as a critical regulator of Mycoplasma pneumoniae-induced inflammation in human asthmatic airway epithelial cells.” J Immunol 188, no. 7 (April 1, 2012): 3371–81. https://doi.org/10.4049/jimmunol.1100573.
    Full Text Link to Item
  - Yang, Ivana V., John Tomfohr, Jaspal Singh, Catherine M. Foss, Harvey E. Marshall, Loretta G. Que, Erin McElvania-Tekippe, Sarita Florence, John S. Sundy, and David A. Schwartz. “The clinical and environmental determinants of airway transcriptional profiles in allergic asthma.” Am J Respir Crit Care Med 185, no. 6 (March 15, 2012): 620–27. https://doi.org/10.1164/rccm.201108-1503OC.
    Full Text Link to Item
  - Que, Loretta G., and Yvonne Janssen-Heininger. “Biochemistry of asthma.” Biochim Biophys Acta 1810, no. 11 (November 2011): 1007. https://doi.org/10.1016/j.bbagen.2011.08.013.
    Full Text Link to Item
  - Que, Loretta G., Jane V. Stiles, John S. Sundy, and W Michael Foster. “Pulmonary function, bronchial reactivity, and epithelial permeability are response phenotypes to ozone and develop differentially in healthy humans.” J Appl Physiol (1985) 111, no. 3 (September 2011): 679–87. https://doi.org/10.1152/japplphysiol.00337.2011.
    Full Text Link to Item
  - Norfolk, Stephanie G., Caroline L. Hollingsworth, Cameron R. Wolfe, Joseph A. Govert, Loretta G. Que, Ira M. Cheifetz, and John W. Hollingsworth. “Rescue therapy in adult and pediatric patients with pH1N1 influenza infection: a tertiary center intensive care unit experience from April to October 2009.” Crit Care Med 38, no. 11 (November 2010): 2103–7. https://doi.org/10.1097/CCM.0b013e3181f268f1.
    Full Text Link to Item
  - Huang, Yuh-Chin T., Michael Schmitt, Zhonghui Yang, Loretta G. Que, Judith C. Stewart, Mark W. Frampton, and Robert B. Devlin. “Gene expression profile in circulating mononuclear cells after exposure to ultrafine carbon particles.” Inhal Toxicol 22, no. 10 (August 2010): 835–46. https://doi.org/10.3109/08958378.2010.486419.
    Full Text Link to Item
  - Choudhry, Shweta, Loretta G. Que, Zhonghui Yang, Limin Liu, Celeste Eng, Sung O. Kim, Gunjan Kumar, et al. “GSNO reductase and beta2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterol.” Pharmacogenet Genomics 20, no. 6 (June 2010): 351–58. https://doi.org/10.1097/FPC.0b013e328337f992.
    Full Text Link to Item
  - Wahidi, Momen M., Gerard A. Silvestri, Raymond D. Coakley, J Scott Ferguson, R Wesley Shepherd, Leonard Moses, John Conforti, et al. “A prospective multicenter study of competency metrics and educational interventions in the learning of bronchoscopy among new pulmonary fellows.” Chest 137, no. 5 (May 2010): 1040–49. https://doi.org/10.1378/chest.09-1234.
    Full Text Link to Item
  - Que, Loretta G., Zhonghui Yang, Jonathan S. Stamler, Njira L. Lugogo, and Monica Kraft. “S-nitrosoglutathione reductase: an important regulator in human asthma.” Am J Respir Crit Care Med 180, no. 3 (August 1, 2009): 226–31. https://doi.org/10.1164/rccm.200901-0158OC.
    Full Text Link to Item
  - Chudgar, Saumil M., Christopher E. Cox, Loretta G. Que, Kathryn Andolsek, Nancy W. Knudsen, and Alison S. Clay. “Current teaching and evaluation methods in critical care medicine: has the Accreditation Council for Graduate Medical Education affected how we practice and teach in the intensive care unit?” Crit Care Med 37, no. 1 (January 2009): 49–60. https://doi.org/10.1097/CCM.0b013e31819265c8.
    Full Text Link to Item
  - Que, L. G., Z. Yang, T. D. Church, D. M. Beaver, D. Jinwright, N. L. Lugogo, and M. Kraft. “GSNO Reductase Expression and Activity Are Increased in Asthmatic Airway Macrophages.” American Journal of Respiratory and Critical Care Medicine 179 (January 1, 2009).
    Link to Item
  - Lugogo, Njira L., Geoffrey S. Ginsburg, and Loretta G. Que. “Genetic profiling and tailored therapy in asthma: are we there yet?” Curr Opin Mol Ther 9, no. 6 (December 2007): 528–37.
    Link to Item
  - Clay, A. S., L. G. Que, J. A. Govert, and K. M. Andolsek. “"A rose by any other name"? Toward a common terminology in simulation education and assessment [6].” Critical Care Medicine 35, no. 9 (September 1, 2007): 2238. https://doi.org/10.1097/01.CCM.0000281641.66736.90.
    Full Text
  - Whalen, Erin J., Matthew W. Foster, Akio Matsumoto, Kentaro Ozawa, Jonathan D. Violin, Loretta G. Que, Chris D. Nelson, et al. “Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2.” Cell 129, no. 3 (May 4, 2007): 511–22. https://doi.org/10.1016/j.cell.2007.02.046.
    Full Text Link to Item
  - Clay, Alison S., Loretta Que, Emil R. Petrusa, Mark Sebastian, and Joseph Govert. “Debriefing in the intensive care unit: a feedback tool to facilitate bedside teaching.” Crit Care Med 35, no. 3 (March 2007): 738–54. https://doi.org/10.1097/01.CCM.0000257329.22025.18.
    Full Text Link to Item
  - Que, Loretta G., Limin Liu, Yun Yan, Gregory S. Whitehead, Stephen H. Gavett, David A. Schwartz, and Jonathan S. Stamler. “Protection from experimental asthma by an endogenous bronchodilator.” Science 308, no. 5728 (June 10, 2005): 1618–21. https://doi.org/10.1126/science.1108228.
    Full Text Link to Item
  - Liu, Limin, Yun Yan, Ming Zeng, Jian Zhang, Martha A. Hanes, Gregory Ahearn, Timothy J. McMahon, et al. “Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock.” Cell 116, no. 4 (February 20, 2004): 617–28. https://doi.org/10.1016/s0092-8674(04)00131-x.
    Full Text Link to Item
  - Yu, Qing, Loretta G. Que, and Don C. Rockey. “Adenovirus-mediated gene transfer to nonparenchymal cells in normal and injured liver.” Am J Physiol Gastrointest Liver Physiol 282, no. 3 (March 2002): G565–72. https://doi.org/10.1152/ajpgi.00512.2000.
    Full Text Link to Item
  - Que, Loretta G., Samuel E. George, Tomomi Gotoh, Masataka Mori, and Yuh-Chin T. Huang. “Effects of arginase isoforms on NO Production by nNOS.” Nitric Oxide 6, no. 1 (February 2002): 1–8. https://doi.org/10.1006/niox.2001.0355.
    Full Text Link to Item
  - Liu, L., A. Hausladen, M. Zeng, L. Que, J. Heitman, and J. S. Stamler. “A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans.” Nature 410, no. 6827 (March 22, 2001): 490–94. https://doi.org/10.1038/35068596.
    Full Text Link to Item
  - Liu, L., A. Hausladen, M. Zeng, L. Que, J. Heitman, J. S. Stamler, and D. Steverding. “Nitrosative stress: protection by glutathione-dependent formaldehyde dehydrogenase.” Redox Rep 6, no. 4 (2001): 209–10. https://doi.org/10.1179/135100001101536337.
    Full Text Link to Item
  - Que, L. G., and Y. C. Tony Huang. “Pharmacologic adjuncts during mechanical ventilation.” Semin Respir Crit Care Med 21, no. 3 (2000): 223–32. https://doi.org/10.1055/s-2000-9848.
    Full Text Link to Item
  - Lau, C. L., R. C. Bentley, J. P. Gockerman, L. G. Que, and T. A. D’Amico. “Malignant melanoma presenting as a mediastinal mass.” Ann Thorac Surg 67, no. 3 (March 1999): 851–52. https://doi.org/10.1016/s0003-4975(99)00075-2.
    Full Text Link to Item
  - Que, L. G., S. P. Kantrow, C. P. Jenkinson, C. A. Piantadosi, and Y. C. Huang. “Induction of arginase isoforms in the lung during hyperoxia.” Am J Physiol 275, no. 1 (July 1998): L96-102. https://doi.org/10.1152/ajplung.1998.275.1.L96.
    Full Text Link to Item
  - Que, L. G., S. P. Kantrow, C. P. Jenkinson, C. A. Piantadosi, and Y. C. T. Huang. “Induction of arginase isoforms in the lung during hyperoxia.” American Journal of Physiology Lung Cellular and Molecular Physiology 275, no. 1 (July 1, 1998): L96–102.
    Link to Item
  - Que, L. G., B. H. Kang, Y. C. Huang, C. A. Piantadosi, and L. Y. Chang. “Anti-intercellular adhesion molecule-1 antibody and intercellular adhesion molecule-1 gene deficiency do not prevent pulmonary neutrophil recruitment in polymicrobial sepsis.” Shock 9, no. 4 (April 1998): 304–9. https://doi.org/10.1097/00024382-199804000-00011.
    Full Text Link to Item
  - Carraway, M. S., K. E. Welty-Wolf, S. P. Kantrow, Y. C. Huang, S. G. Simonson, L. G. Que, T. K. Kishimoto, and C. A. Piantadosi. “Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons.” Am J Respir Crit Care Med 157, no. 3 Pt 1 (March 1998): 938–49. https://doi.org/10.1164/ajrccm.157.3.9707129.
    Full Text Link to Item
- Book Sections
  - Marshall, H. E., L. G. Que, J. S. Stamler, and B. Gaston. “S-nitrosothiols in lung inflammation.” In Therapeutic Targets in Airway Inflammation, 123–42, 2003.
- Journal Issues
  - Bose, Sonali, Robert J. Henderson, Linda Rogers, Thomas Casale, Gwen Skloot, Xavier Soler, Robert A. Wise, and Loretta G. Que. “Identifying an at-risk population for poor asthma outcomes: Data from the American Lung Association Asthma Clinical Trials Registry.” J Allergy Clin Immunol Pract, November 2019. https://doi.org/10.1016/j.jaip.2019.04.024.
    Full Text Link to Item
  - Birukova, Anastasiya, Jaime Cyphert-Daly, Robert Ian Cumming, Yen-Rei Yu, Kymberly M. Gowdy, Loretta G. Que, and Robert M. Tighe. “Sex Modifies Acute Ozone-Mediated Airway Physiologic Responses.” Toxicol Sci, June 1, 2019. https://doi.org/10.1093/toxsci/kfz056.
    Full Text Link to Item
  - Yang, Shigao, Alfred T. Harding, Catherine Sweeney, David Miao, Gregory Swan, Connie Zhou, Zhaozhao Jiang, et al. “Control of antiviral innate immune response by protein geranylgeranylation.” Sci Adv, May 2019. https://doi.org/10.1126/sciadv.aav7999.
    Full Text Open Access Copy Link to Item
  - Tang, Monica, Robert J. Henderson, Janet T. Holbrook, Loretta G. Que, Anne M. Mathews, Robert A. Wise, Anne E. Dixon, et al. “Does Obesity Increase Respiratory Tract Infections in Patients with Asthma?” J Allergy Clin Immunol Pract, March 2019. https://doi.org/10.1016/j.jaip.2018.09.033.
    Full Text Link to Item
  - Yang, Zhonghui, Yury A. Bochkov, Dennis R. Voelker, Matthew W. Foster, and Loretta G. Que. “Identification of a Novel Inhibitor of Human Rhinovirus Replication and Inflammation in Airway Epithelial Cells.” Am J Respir Cell Mol Biol, January 2019. https://doi.org/10.1165/rcmb.2018-0058OC.
    Full Text Link to Item
  - Baker, Anna M., Janet T. Holbrook, Abebaw M. Yohannes, Michelle N. Eakin, Elizabeth A. Sugar, Robert J. Henderson, Anne S. Casper, et al. “Test Performance Characteristics of the AIR, GAD-7, and HADS-Anxiety Screening Questionnaires for Anxiety in Chronic Obstructive Pulmonary Disease.” Ann Am Thorac Soc, August 2018. https://doi.org/10.1513/AnnalsATS.201708-631OC.
    Full Text Link to Item
  - Que, Loretta G., Zhonghui Yang, Njira L. Lugogo, Rohit K. Katial, Steven A. Shoemaker, Janice M. Troha, David M. Rodman, Robert M. Tighe, and Monica Kraft. “Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma.” Immun Inflamm Dis, June 2018. https://doi.org/10.1002/iid3.220.
    Full Text Link to Item
  - Paul, Devon W., Nigel B. Neely, Meredith Clement, Isaretta Riley, Mashael Al-Hegelan, Matthew Phelan, Monica Kraft, et al. “Development and validation of an electronic medical record (EMR)-based computed phenotype of HIV-1 infection.” J Am Med Inform Assoc, February 1, 2018. https://doi.org/10.1093/jamia/ocx061.
    Full Text Link to Item
  - Wu, Jinhong, Jialong Yang, Kai Yang, Hongxia Wang, Balachandra Gorentla, Jinwook Shin, Yurong Qiu, et al. “iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.” J Clin Invest, November 1, 2017. https://doi.org/10.1172/JCI98066.
    Full Text Link to Item
  - Suwanpradid, Jutamas, Michael Shih, Lauren Pontius, Bin Yang, Anastasiya Birukova, Emma Guttman-Yassky, David L. Corcoran, Loretta G. Que, Robert M. Tighe, and Amanda S. MacLeod. “Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity.” J Immunol, September 1, 2017. https://doi.org/10.4049/jimmunol.1700739.
    Full Text Link to Item
- Conference Papers
  - Cyphert-Daly, Jaime M., Zhonghui Yang, Jennifer L. Ingram, Robert M. Tighe, and Loretta G. Que. “Physiologic response to chronic house dust mite exposure in mice is dependent on lot characteristics.” In J Allergy Clin Immunol, 144:1428-1432.e8, 2019. https://doi.org/10.1016/j.jaci.2019.07.019.
    Full Text Link to Item
  - Ihrie, Mark, Victoria McQuade, Akhil Hegde, Jingjing Niu, Jenny Tong, David D’Alessio, Julia K. L. Walker, Loretta G. Que, and Jennifer L. Ingram. “Sleeve gastrectomy surgery reduces airway resistance and inflammation in chronically allergen-challenged obese mice.” In Journal of Allergy and Clinical Immunology, 143:AB307–AB307. Elsevier BV, 2019. https://doi.org/10.1016/j.jaci.2018.12.935.
    Full Text
  - Holguin, F., S. Sharma, D. E. Winnica, K. Wasil, V. L. Smith, M. H. Cruse, N. Perez, et al. “L-Citrulline as Add-On Therapy to Increase Exhaled Nitric Oxide and Improve Lung Function and Asthma Control in Obese Asthmatics.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.
    Link to Item
  - Riley, I., R. A. Pleasants, D. Crabtree, S. Riebel, L. Svetkey, L. G. Que, M. Handley, A. Cattamanchi, H. Bosworth, and L. E. Boulware. “AdheRence to Inhaled Corticosteroids in Asthma (ARICA): Intervention Development.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.
    Link to Item
  - Winnica, D. E., S. Sharma, L. G. Que, S. Ye, V. L. Smith, M. H. Cruse, N. Perez, and F. Holguin. “Up-Regulation of Paraoxonase 2 in Human Bronchial Epithelial Cells.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.
    Link to Item
  - Yu, Y. A., J. Daly, S. Phelan, R. I. Cumming, A. Birukova, Y. Malakhau, J. L. Ingram, M. D. Gunn, L. G. Que, and R. M. Tighe. “Replacement of Fetal-Derived with Bone Marrow-Derived Pulmonary Resident Macrophages Reduces House Dust Mite-Induced Airway Hyperresponsiveness.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.
    Link to Item
  - Holguin, F., C. Liu, S. A. A. Comhair, S. Hazen, E. R. Bleecker, W. W. Busse, W. J. Calhoun, et al. “Upregulation of Paraxonase 1 (PON1) in Severe Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
    Link to Item
  - Ingram, J. L., V. McQuade, B. Theriot, J. Niu, J. Daly, J. Wong, J. Tong, R. M. Tighe, L. G. Que, and D. D’Alessio. “Vertical Sleeve Gastrectomy in Allergen-Challenged Obese Mice Is Associated with Reduced Airway Resistance and Fibrosis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
    Link to Item
  - Mathews, A. M., A. M. Baker, J. T. Holbrook, A. M. Yohannes, M. Eakin, E. A. Sugar, R. Henderson, et al. “The Relationship Between Sleep Quality, Age, and Quality of Life in Patients with COPD and Clinical Depression and Anxiety.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
    Link to Item
  - Pederson, W., M. Prasetyo, J. M. Cyphert, R. M. Tighe, L. G. Que, and J. G. Ledford. “Genetic Variation in Surfactant Protein-A2 Differentially Mediates Responses to Ozone.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
    Link to Item
  - Winnica, D. E., C. Corey, L. G. Que, F. Holguin, and S. Shiva. “Platelet and Airway Epithelium Bioenergetics Are Different in Obese Versus Lean Asthmatics.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
    Link to Item
  - Yang, Z., J. Daly, D. E. Winnica, F. Holguin, V. McQuade, J. L. Ingram, R. M. Tighe, and L. G. Que. “Characterization of Paraoxonases in Mice with Obese Allergic Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
    Link to Item
  - Yang, Z., Y. A. Bochkov, D. R. Voelker, M. W. Foster, and L. G. Que. “S-Nitrosoglutathione Reductase Inhibitor Blockade of Rhinovirus A16 Replication by Targeting ICAM-1.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
    Link to Item
  - Yohannes, A. M., M. Eakin, J. T. Holbrook, E. M. Sugar, R. Henderson, A. M. Baker, D. A. Kaminsky, et al. “Chronic Obstructive Pulmonary Disease Related with Increased Risk of Mild Cognitive Impairment.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
    Link to Item
  - Giovacchini, Coral X., Lauren Pacek, F Joseph McClernon, and Loretta G. Que. “Use and Perceived Risk of Electronic Cigarettes Among North Carolina Middle and High School Students.” In N C Med J, 78:7–13, 2017. https://doi.org/10.18043/ncm.78.1.7.
    Full Text Link to Item
  - He, M., S. H. Robertson, J. M. Wang, L. G. Que, K. Mahmood, B. Driehuys, and Y. -. C. Huang. “Characterizing The Ventilation Distribution In Healthy Normal Subjects To Establish Robust Quantitative Analysis Of 129xe Mri.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
    Link to Item
  - Huang, Y. -. C., and L. G. Que. “Clinical Significance Of Isolated Decrease In Single Breath Lung Volume-Total Lung Capacity Ratio (va/tlc).” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
    Link to Item
  - Winnica, D. E., H. Grasemann, L. G. Que, B. Freeman, K. Wasil, S. E. Wenzel, and F. Holguin. “L-Citrulline Prevents Asymmetric Di-Methyl Arginine Uncoupling Of Nitric Oxide Synthase In Primary Human Airway Epithelial Cells.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
    Link to Item
  - Yang, Z., Y. Bochkov, D. R. Voelker, M. W. Foster, and L. G. Que. “A Gsnor Inhibitor Blocks Hrv Infection Of Primary Human Airway Epithelial Cells.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
    Link to Item
  - Ledford, J. G., K. J. Addison, D. C. Francisco, M. W. Foster, D. R. Voelker, L. G. Que, and M. Kraft. “Genetic Variation In Surfactant Protein-A2 Leads To Differential Regulation Of Eosinophil Activities And More Pronounced Eosinophilia In Asthmatics.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.
    Link to Item
  - Ledford, J. G., N. Lugogo, N. Agada, J. Weiss, D. C. Francisco, J. L. Ingram, M. E. Sunday, L. G. Que, and M. Kraft. “Increased Tissue Eosinophilia In Obese Asthma May Be Due To Decreased Surfactant Protein-A Levels.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.
    Link to Item
  - Que, L. G., M. Kraft, N. Lugogo, R. Katial, S. A. Shoemaker, and J. M. Troha. “A Novel Therapeutic Target In Asthma: Translational Evidence For Inhibition Of S-Nitrosoglutathione Reductase.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.
    Link to Item
  - Wang, Y., J. G. Ledford, M. Ghio, D. C. Francisco, K. Addison, L. G. Que, J. W. Hollingsworth, and M. Kraft. “Surfactant Protein A Inhibits Il-13-Induced Inflammatory Response And Mucin Production In Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.
    Link to Item
  - Wang, Y., D. C. Francisco, N. Lugogo, J. Thomas, D. M. Beaver, J. W. Hollingsworth, W. M. Foster, et al. “Genetic Variation In Surfactant Protein A2 Alters Airway Epithelial Response To Mycoplasma Pneumoniae Infection In Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 189. AMER THORACIC SOC, 2014.
    Link to Item
  - Wang, Y., D. Francisco, J. M. Thomas, N. Lugogo, L. G. Que, J. G. Ledford, S. Choudhury, D. Beaver, and M. Kraft. “Surfactant Protein A Inhibits Il-13-Induced Pro-Inflammatory Response In Asthmatic Airway Epithelial Cells.” In American Journal of Respiratory and Critical Care Medicine, Vol. 187. AMER THORACIC SOC, 2013.
    Link to Item
  - Huang, Y. C., M. Schmitt, Z. Yang, L. G. Que, J. Stewart, M. W. Frampton, and R. B. Devlin. “Gene Expression in Circulating Mononuclear Cells after Ultrafine Carbon Particle Exposure.” In American Journal of Respiratory and Critical Care Medicine, Vol. 179. AMER THORACIC SOC, 2009.
    Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.

Education, Training, & Certifications

Duke Appointment History

Selected Grants

External Relationships

Selected Publications

Academic Articles

Book Sections

Journal Issues

Conference Papers