Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Pulmonary Fellow, Medicine, Duke University 1993 - 1996
  • Clinical Instructor, Medicine, Yale University 1992 - 1993
  • Medical Resident, Medicine, Yale University 1989 - 1992
  • M.D., University of Chicago 1989
• 

  Duke Appointment History

  • Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2001 - 2010
  • Associate in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1996 - 2001
• Research
• 

  Selected Grants

  • A Longitudinal Prospective Observational Study of the Characteristics, Treatment Patterns and Health Outcomes of Individuals with Severe Asthma in the United States awarded by AstraZeneca Pharmaceuticals, LP 2018 - 2023
  • CXCL10/CXCR3 regulation of ozone-induced epithelial permeability awarded by National Institutes of Health 2017 - 2022
  • Research Training in Allergy and Clinical Immunology awarded by National Institutes of Health 2000 - 2021
  • Mechanisms that Direct Airway Remodeling in Obese Asthma awarded by National Institutes of Health 2017 - 2021
  • Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRI awarded by National Institutes of Health 2011 - 2021
  • Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 2009 - 2020
  • Mitochondrial Redox Perturbations in Obese Allergic Asthma awarded by University of Vermont 2018 - 2019
  • Trial of Roflumilast in Asthma Management (TRIM) awarded by American Lung Association 2018 - 2019
  • Pilot: Zinc Acetate to Treat Chronic Refractory Cough (ZICO) awarded by American Lung Association 2017 - 2019
  • ALA-ACRC Network awarded by American Lung Association 2016 - 2019
  • VTEU Task Order 16-0058 - Task B awarded by National Institutes of Health 2017 - 2019
  • VTEU Task Order 16-0058 - Task C awarded by National Institutes of Health 2017 - 2019
  • VTEU Task Order 16-0058.B1C1D1.0076 - Task D awarded by National Institutes of Health 2017 - 2019
  • Modulation of Asthma by GSNO-based Therapies awarded by National Institutes of Health 2013 - 2018
  • Diesel-induced Alterations of Influenza Infectivity awarded by University of North Carolina - Chapel Hill 2015 - 2017
  • Surfactant Protein-A regulation of eosinophil apoptosis in asthma awarded by University of Arizona 2015 - 2017
  • HIV and Asthma in the Post- ART Era awarded by National Institutes of Health 2014 - 2016
  • The Duke Multidisciplinary Training Program in Pediatric Lung Disease awarded by National Institutes of Health 2010 - 2016
  • Clinical Center Core awarded by University of Arizona 2009 - 2016
  • Asthma Clinical Research Center of the American Lung Association awarded by American Lung Association 2009 - 2016
  • I2PP2A and Asthma awarded by Cognosci, Inc. 2014 - 2015
  • Diesel-induced Alterations of Influenza Infectivity awarded by University of North Carolina - Chapel Hill 2013 - 2014
  • GSNO Reductase, S-Nitrosothiols, and Asthma awarded by National Institutes of Health 2007 - 2013
  • Genetic regulation of O3-induced inflammation in humans awarded by National Institutes of Health 2000 - 2007
  • Modulation of NO with Pulmonary Gene Transfer awarded by National Institutes of Health 2000 - 2006
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Yang, Z, Bochkov, YA, Voelker, DR, Foster, MW, and Que, LG. "Identification of a Novel Inhibitor of Human Rhinovirus Replication and Inflammation in Airway Epithelial Cells." American Journal of Respiratory Cell and Molecular Biology 60, no. 1 (January 2019): 58-67.  Full Text
    • Tang, M, Henderson, RJ, Holbrook, JT, Que, LG, Mathews, AM, Wise, RA, Dixon, AE, Peters, SP, Rogers, L, Smith, LJ, Teague, WG, and Lang, JE. "Does Obesity Increase Respiratory Tract Infections in Patients with Asthma?." The Journal of Allergy and Clinical Immunology. in Practice (October 9, 2018).  Full Text
    • Que, LG, Yang, Z, Lugogo, NL, Katial, RK, Shoemaker, SA, Troha, JM, Rodman, DM, Tighe, RM, and Kraft, M. "Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma." Immunity, Inflammation and Disease 6, no. 2 (June 2018): 322-331.  Full Text
    • Paul, DW, Neely, NB, Clement, M, Riley, I, Al-Hegelan, M, Phelan, M, Kraft, M, Murdoch, DM, Lucas, J, Bartlett, J, McKellar, M, and Que, LG. "Development and validation of an electronic medical record (EMR)-based computed phenotype of HIV-1 infection." Journal of the American Medical Informatics Association : Jamia 25, no. 2 (February 2018): 150-157.  Full Text
    • Riley, IL, Boulware, LE, Sun, J-L, Chiswell, K, Que, LG, Kraft, M, Todd, JL, Palmer, SM, and Anderson, ML. "Factors associated with reporting results for pulmonary clinical trials in ClinicalTrials.gov." Clinical Trials (London, England) 15, no. 1 (February 2018): 87-94.  Full Text
    • Paul, DW, Lagat, DK, MacIntyre, N, Egger, JR, Murdoch, DM, Que, LG, and Kussin, PS. "Validation of spirometry prediction equations in western Kenya." The International Journal of Tuberculosis and Lung Disease 22, no. 1 (January 2018): 112-118.  Full Text
    • Suwanpradid, J, Shih, M, Pontius, L, Yang, B, Birukova, A, Guttman-Yassky, E, Corcoran, DL, Que, LG, Tighe, RM, and MacLeod, AS. "Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity." Journal of Immunology (Baltimore, Md. : 1950) 199, no. 5 (September 2017): 1827-1834.  Full Text
    • Durack, J, Lynch, SV, Nariya, S, Bhakta, NR, Beigelman, A, Castro, M, Dyer, A-M, Israel, E, Kraft, M, Martin, RJ, Mauger, DT, Rosenberg, SR, Sharp-King, T, White, SR, Woodruff, PG, Avila, PC, Denlinger, LC, Holguin, F, Lazarus, SC, Lugogo, N, Moore, WC, Peters, SP, Que, L, Smith, LJ, Sorkness, CA, Wechsler, ME, Wenzel, SE, Boushey, HA, Huang, YJ, National Heart, and Lung and Blood Institute's “AsthmaNet”, . "Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment." The Journal of Allergy and Clinical Immunology 140, no. 1 (July 2017): 63-75.  Full Text
    • Winnica, D, Que, LG, Baffi, C, Grasemann, H, Fiedler, K, Yang, Z, Etling, E, Wasil, K, Wenzel, SE, Freeman, B, and Holguin, F. "l-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells." Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology 47, no. 2 (February 2017): 190-199.  Full Text
    • He, M, Driehuys, B, Que, LG, and Huang, Y-CT. "Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution." Academic Radiology 23, no. 12 (December 2016): 1521-1531.  Full Text
    • Ray, S, Chiba, N, Yao, C, Guan, X, McConnell, AM, Brockway, B, Que, L, McQualter, JL, and Stripp, BR. "Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection." Stem Cell Reports 7, no. 5 (November 2016): 817-825.  Full Text
    • Baffi, CW, Wood, L, Winnica, D, Strollo, PJ, Gladwin, MT, Que, LG, and Holguin, F. "Metabolic Syndrome and the Lung." Chest 149, no. 6 (June 2016): 1525-1534. (Review)  Full Text
    • Ingram, JL, Slade, D, Church, TD, Francisco, D, Heck, K, Sigmon, RW, Ghio, M, Murillo, A, Firszt, R, Lugogo, NL, Que, L, Sunday, ME, and Kraft, M. "Role of Matrix Metalloproteinases-1 and -2 in Interleukin-13-Suppressed Elastin in Airway Fibroblasts in Asthma." American Journal of Respiratory Cell and Molecular Biology 54, no. 1 (January 2016): 41-50.  Full Text
    • Yu, Y-RA, O'Koren, EG, Hotten, DF, Kan, MJ, Kopin, D, Nelson, ER, Que, L, and Gunn, MD. "A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues." Plos One 11, no. 3 (January 2016): e0150606-null.  Full Text
    • Mehta, K, Soderblom, EJ, Thompson, JW, Que, LG, Marshall, HE, Moseley, MA, and Foster, MW. "Targeted proteomics for unraveling the post-translational regulation of human nitric oxide synthase 2." Nitric Oxide 42C (November 15, 2014): 132-.  Full Text  Link to Item
    • Ledford, JG, Addison, KJ, Foster, MW, and Que, LG. "Eosinophil-associated lung diseases. A cry for surfactant proteins A and D help?." American Journal of Respiratory Cell and Molecular Biology 51, no. 5 (November 2014): 604-614. (Review)  Full Text
    • Castro, M, King, TS, Kunselman, SJ, Cabana, MD, Denlinger, L, Holguin, F, Kazani, SD, Moore, WC, Moy, J, Sorkness, CA, Avila, P, Bacharier, LB, Bleecker, E, Boushey, HA, Chmiel, J, Fitzpatrick, AM, Gentile, D, Hundal, M, Israel, E, Kraft, M, Krishnan, JA, LaForce, C, Lazarus, SC, Lemanske, R, Lugogo, N, Martin, RJ, Mauger, DT, Naureckas, E, Peters, SP, Phipatanakul, W, Que, LG, Sheshadri, A, Smith, L, Solway, J, Sullivan-Vedder, L, Sumino, K, Wechsler, ME, Wenzel, S, White, SR, Sutherland, ER, National Heart, Lung, and and Blood Institute’s AsthmaNet, . "Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial." Jama 311, no. 20 (May 2014): 2083-2091.  Full Text
    • Catania, J, Que, LG, Govert, JA, Hollingsworth, JW, and Wolfe, CR. "High intensive care unit admission rate for 2013-2014 influenza is associated with a low rate of vaccination." American Journal of Respiratory and Critical Care Medicine 189, no. 4 (February 2014): 485-487. (Letter)  Full Text
    • Foster, MW, Thompson, JW, Que, LG, Yang, IV, Schwartz, DA, Moseley, MA, and Marshall, HE. "Proteomic analysis of human bronchoalveolar lavage fluid after subsgemental exposure." Journal of Proteome Research 12, no. 5 (May 2013): 2194-2205.  Full Text
    • Foster, MW, Yang, Z, Gooden, DM, Thompson, JW, Ball, CH, Turner, ME, Hou, Y, Pi, J, Moseley, MA, and Que, LG. "Proteomic characterization of the cellular response to nitrosative stress mediated by s-nitrosoglutathione reductase inhibition." Journal of Proteome Research 11, no. 4 (April 2012): 2480-2491.  Full Text
    • Wang, Y, Zhu, Z, Church, TD, Lugogo, NL, Que, LG, Francisco, D, Ingram, JL, Huggins, M, Beaver, DM, Wright, JR, and Kraft, M. "SHP-1 as a critical regulator of Mycoplasma pneumoniae-induced inflammation in human asthmatic airway epithelial cells." J Immunol 188, no. 7 (April 1, 2012): 3371-3381.  Full Text  Link to Item
    • Yang, IV, Tomfohr, J, Singh, J, Foss, CM, Marshall, HE, Que, LG, McElvania-Tekippe, E, Florence, S, Sundy, JS, and Schwartz, DA. "The clinical and environmental determinants of airway transcriptional profiles in allergic asthma." American Journal of Respiratory and Critical Care Medicine 185, no. 6 (March 2012): 620-627.  Full Text
    • Que, LG, and Janssen-Heininger, Y. "Biochemistry of asthma." Biochimica Et Biophysica Acta 1810, no. 11 (November 2011): 1007-null.  Full Text
    • Que, LG, Stiles, JV, Sundy, JS, and Foster, WM. "Pulmonary function, bronchial reactivity, and epithelial permeability are response phenotypes to ozone and develop differentially in healthy humans." Journal of Applied Physiology (Bethesda, Md. : 1985) 111, no. 3 (September 2011): 679-687.  Full Text
    • Norfolk, SG, Hollingsworth, CL, Wolfe, CR, Govert, JA, Que, LG, Cheifetz, IM, and Hollingsworth, JW. "Rescue therapy in adult and pediatric patients with pH1N1 influenza infection: a tertiary center intensive care unit experience from April to October 2009." Critical Care Medicine 38, no. 11 (November 2010): 2103-2107.  Full Text
    • Huang, Y-CT, Schmitt, M, Yang, Z, Que, LG, Stewart, JC, Frampton, MW, and Devlin, RB. "Gene expression profile in circulating mononuclear cells after exposure to ultrafine carbon particles." Inhal Toxicol 22, no. 10 (August 2010): 835-846.  Full Text  Link to Item
    • Choudhry, S, Que, LG, Yang, Z, Liu, L, Eng, C, Kim, SO, Kumar, G, Thyne, S, Chapela, R, Rodriguez-Santana, JR, Rodriguez-Cintron, W, Avila, PC, Stamler, JS, and Burchard, EG. "GSNO reductase and beta2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterol." Pharmacogenetics and Genomics 20, no. 6 (June 2010): 351-358.  Full Text
    • Wahidi, MM, Silvestri, GA, Coakley, RD, Ferguson, JS, Shepherd, RW, Moses, L, Conforti, J, Que, LG, Anstrom, KJ, McGuire, F, Colt, H, and Downie, GH. "A prospective multicenter study of competency metrics and educational interventions in the learning of bronchoscopy among new pulmonary fellows." Chest 137, no. 5 (May 2010): 1040-1049.  Full Text
    • Que, LG, Yang, Z, Stamler, JS, Lugogo, NL, and Kraft, M. "S-nitrosoglutathione reductase: an important regulator in human asthma." American Journal of Respiratory and Critical Care Medicine 180, no. 3 (August 2009): 226-231.  Full Text
    • Chudgar, SM, Cox, CE, Que, LG, Andolsek, K, Knudsen, NW, and Clay, AS. "Current teaching and evaluation methods in critical care medicine: has the Accreditation Council for Graduate Medical Education affected how we practice and teach in the intensive care unit?." Crit Care Med 37, no. 1 (January 2009): 49-60.  Full Text  Link to Item
    • Lugogo, NL, Ginsburg, GS, and Que, LG. "Genetic profiling and tailored therapy in asthma: are we there yet?." Curr Opin Mol Ther 9, no. 6 (December 2007): 528-537. (Review)  Link to Item
    • Clay, AS, Que, LG, Govert, JA, and Andolsek, KM. "“A rose by any other name”? Toward a common terminology in simulation education and assessment." Critical Care Medicine 35, no. 9 (September 2007): 2238-2238.  Full Text
    • Whalen, EJ, Foster, MW, Matsumoto, A, Ozawa, K, Violin, JD, Que, LG, Nelson, CD, Benhar, M, Keys, JR, Rockman, HA, Koch, WJ, Daaka, Y, Lefkowitz, RJ, and Stamler, JS. "Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2." Cell 129, no. 3 (May 4, 2007): 511-522.  Full Text  Link to Item
    • Clay, AS, Que, L, Petrusa, ER, Sebastian, M, and Govert, J. "Debriefing in the intensive care unit: a feedback tool to facilitate bedside teaching." Crit Care Med 35, no. 3 (March 2007): 738-754.  Full Text  Link to Item
    • Que, LG, Liu, L, Yan, Y, Whitehead, GS, Gavett, SH, Schwartz, DA, and Stamler, JS. "Protection from experimental asthma by an endogenous bronchodilator." Science (New York, N.Y.) 308, no. 5728 (June 2005): 1618-1621.  Full Text
    • Liu, L, Yan, Y, Zeng, M, Zhang, J, Hanes, MA, Ahearn, G, McMahon, TJ, Dickfeld, T, Marshall, HE, Que, LG, and Stamler, JS. "Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock." Cell 116, no. 4 (February 2004): 617-628.  Full Text
    • "Adenovirus-mediated gene transfer to nonparenchymal cells in normal and injured liver." American Journal of Physiology Gastrointestinal and Liver Physiology 282, no. 3 45-3 (June 27, 2002).
    • Yu, Q, Que, LG, and Rockey, DC. "Adenovirus-mediated gene transfer to nonparenchymal cells in normal and injured liver." American Journal of Physiology. Gastrointestinal and Liver Physiology 282, no. 3 (March 2002): G565-G572.  Full Text
    • Que, LG, George, SE, Gotoh, T, Mori, M, and Huang, Y-CT. "Effects of arginase isoforms on NO Production by nNOS." Nitric Oxide : Biology and Chemistry 6, no. 1 (February 2002): 1-8.  Full Text
    • Liu, L, Hausladen, A, Zeng, M, Que, L, Heitman, J, and Stamler, JS. "A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans." Nature 410, no. 6827 (March 2001): 490-494.  Full Text
    • Liu, L, Hausladen, A, Zeng, M, Que, L, Heitman, J, Stamler, JS, and Steverding, D. "Nitrosative stress: protection by glutathione-dependent formaldehyde dehydrogenase." Redox Rep 6, no. 4 (2001): 209-210.  Full Text  Link to Item
    • Que, LG, and Tony Huang, YC. "Pharmacologic adjuncts during mechanical ventilation." Semin Respir Crit Care Med 21, no. 3 (2000): 223-232.  Full Text  Link to Item
    • Lau, CL, Bentley, RC, Gockerman, JP, Que, LG, and D'Amico, TA. "Malignant melanoma presenting as a mediastinal mass." The Annals of Thoracic Surgery 67, no. 3 (March 1999): 851-852.  Full Text
    • Que, LG. "Ask the expert." Asthma Magazine 4, no. 5 (1999): 26--.  Full Text
    • Carraway, MS, Welty-Wolf, KE, Kantrow, SP, Huang, YCT, Simonson, SG, Que, LG, Kishimoto, TK, and Piantadosi, CA. "Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons." American Journal of Respiratory and Critical Care Medicine 157, no. 3 PART I (December 1, 1998): 938-949.
    • Que, LG, Kantrow, SP, Jenkinson, CP, Piantadosi, CA, and Huang, YC. "Induction of arginase isoforms in the lung during hyperoxia." The American Journal of Physiology 275, no. 1 Pt 1 (July 1998): L96-102.
    • Que, LG, Kantrow, SP, Jenkinson, CP, Piantadosi, CA, and Huang, YCT. "Induction of arginase isoforms in the lung during hyperoxia." American Journal of Physiology Lung Cellular and Molecular Physiology 275, no. 1 19-1 (July 1, 1998).
    • Que, LG, Kang, BH, Huang, YC, Piantadosi, CA, and Chang, LY. "Anti-intercellular adhesion molecule-1 antibody and intercellular adhesion molecule-1 gene deficiency do not prevent pulmonary neutrophil recruitment in polymicrobial sepsis." Shock 9, no. 4 (April 1998): 304-309.  Link to Item
    • Carraway, MS, Welty-Wolf, KE, Kantrow, SP, Huang, YC, Simonson, SG, Que, LG, Kishimoto, TK, and Piantadosi, CA. "Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons." Am J Respir Crit Care Med 157, no. 3 Pt 1 (March 1998): 938-949.  Full Text  Link to Item

  • Book Sections

    • "S-nitrosothiols in lung inflammation." In Therapeutic Targets in Airway Inflammation, 123-142. January 1, 2003.

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