Loretta Georgina Que | Scholars@Duke

Loretta Georgina Que
Professor of Medicine

My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.

Key words: nitrosative defense, lung injury, nitric oxide

Current Research Interests

Asthma
Obese asthma
Airway inflammation and airway remodeling
Oxidative stress
COPD
Xenon MRI
COVID 19 related lung disease

Current Appointments & Affiliations

Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2019

Contact Information

279 Msrb1, Durham, NC 27710
Duke Box 2629, 203 Research Dr, Durham, NC 27710
loretta.que@duke.edu (919) 681-8551

Background
Education, Training, & Certifications
- Pulmonary Fellow, Medicine, Duke University 1993 - 1996
- Clinical Instructor, Medicine, Yale University 1992 - 1993
- Medical Resident, Medicine, Yale University 1989 - 1992
- M.D., The University of Chicago 1989
Duke Appointment History
- Associate Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2011 - 2019
- Assistant Professor of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 2001 - 2010
- Associate in the Department of Medicine, Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine 1996 - 2001
Research
Selected Grants
- Oxidative Stress and Regional Airway Remodeling and Fibrosis in Obese Asthma awarded by National Institutes of Health 2020 - 2024
- A Longitudinal Prospective Observational Study of the Characteristics, Treatment Patterns and Health Outcomes of Individuals with Severe Asthma in the United States awarded by AstraZeneca Pharmaceuticals, LP 2018 - 2023
- RofLumilast or Azithromycin to preveNt COPD Exacerbations (RELIANCE) awarded by University of Illinois at Chicago 2017 - 2023
- CXCL10/CXCR3 regulation of ozone-induced epithelial permeability awarded by National Institutes of Health 2017 - 2022
- A double-blind, placebo-controlled, multi-centre, clinical trial to investigate the efficacy and safety of therapy with inhaled colistimethate sodium in the treatment of subjects with non-CF bronchiectasis chronically infected with P. aeruginosa awarded by Zambon SpA 2018 - 2021
- Research Training in Allergy and Clinical Immunology awarded by National Institutes of Health 2000 - 2021
- AZ D5180C00018 DESTINATION: A multicentre double blind randomized placebo controlled parallel group phase 3 safety extension study to evaluate safety & tolerability of Tezepelumab awarded by AstraZeneca Pharmaceuticals, LP 2019 - 2021
- Mitochondrial Redox Perturbations in Obese Allergic Asthma awarded by University of Vermont 2020 - 2021
- A Randomized Phase II Clinical Trial of L-Citrulline to Improve Asthma Control in Obese Late Onset Asthma awarded by University of Colorado - Denver 2019 - 2021
- EFC1580 BOREAS: A randomized double blind placebo controlled parallel group 52wk study to assess the efficacy, safety, and tolerability of Dupilumab in patients with moderate to severe COPD w/Type 2 awarded by Sanofi US 2019 - 2021
- American Lung Association (ALA) Novel Digital Diary (ANDDI) Trial awarded by American Lung Association 2019 - 2021
- Mechanisms that Direct Airway Remodeling in Obese Asthma awarded by National Institutes of Health 2017 - 2021
- American Lung Association Airways Clinical Research Centers Network awarded by American Lung Association 2016 - 2021
- Interdisciplinary Training Program in Lung Disease awarded by National Institutes of Health 2009 - 2021
- D5180C00009 SOURCE A multicentre randomized double blind placebo controlled Phase 3 study to evaluate the efficacy and safety of Tezepelumab awarded by AstraZeneca AB 2018 - 2021
- Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRI awarded by National Institutes of Health 2011 - 2021
- Task Area B-D Task Order 16-0058.B1C1D1.0076 awarded by National Institutes of Health 2017 - 2021
- VACCINE AND TREATMENT EVALUATION UNITS (VTEU) PROTOCOL DEVELOPMENT, IMPLEMENTATION AND ASSAYS TASK AREA B-D PHASE 1 PK TRIAL TO EVALUATE FOSFOMYCIN TASK ORDER 16-0058.B1C1D1.0076 awarded by National Institutes of Health 2017 - 2020
- VTEU Task Order 16-0058.B1C1D1.0076 - Task D awarded by National Institutes of Health 2017 - 2020
- Improving Medication Adherence with Telehealthcare Medication Therapy Management to Change Health Outcomes in Adolescents and Young Adults with Asthma (MATCH) awarded by American Lung Association 2019 - 2020
- Asthma BMI Baseline Study (ABBS) awarded by American Lung Association 2018 - 2020
- Trial of Roflumilast in Asthma Management (TRIM) awarded by American Lung Association 2018 - 2020
- Pilot: Zinc Acetate to Treat Chronic Refractory Cough (ZICO) awarded by American Lung Association 2017 - 2020
- A multi-center, randomized, double-blind, placebo controlled, parallel group study to compare cessation versus continuation of long-term mepolizumab treatment in patients with severe eosinophilic asthma (201810) awarded by GlaxoSmithKline 2016 - 2020
- Modulation of Asthma by GSNO-based Therapies awarded by National Institutes of Health 2013 - 2018
- Diesel-induced Alterations of Influenza Infectivity awarded by University of North Carolina - Chapel Hill 2015 - 2017
- Surfactant Protein-A regulation of eosinophil apoptosis in asthma awarded by University of Arizona 2015 - 2017
- HIV and Asthma in the Post- ART Era awarded by National Institutes of Health 2014 - 2016
- The Duke Multidisciplinary Training Program in Pediatric Lung Disease awarded by National Institutes of Health 2010 - 2016
- Clinical Center Core awarded by University of Arizona 2009 - 2016
- Asthma Clinical Research Center of the American Lung Association awarded by American Lung Association 2009 - 2016
- I2PP2A and Asthma awarded by Cognosci, Inc. 2014 - 2015
- Diesel-induced Alterations of Influenza Infectivity awarded by University of North Carolina - Chapel Hill 2013 - 2014
- GSNO Reductase, S-Nitrosothiols, and Asthma awarded by National Institutes of Health 2007 - 2013
- Genetic regulation of O3-induced inflammation in humans awarded by National Institutes of Health 2000 - 2007
- Modulation of NO with Pulmonary Gene Transfer awarded by National Institutes of Health 2000 - 2006
External Relationships
- AstraZeneca
- AstraZeneca (For-Profit, Publicly-traded, Global)
- LPN Research and Development Corporation
- LPN Research and Development Corporation (For-Profit, Non-Publicly-traded, US)
- National Institute of Health
- Robling Medical
- Robling Medical (For-Profit, Publicly-traded, US)
- Sanofi and Regeneron Pharmaceuticals
- Sanofi and Regeneron Pharmaceuticals (For-Profit, Publicly-traded, US)
- Zambon SpA
- Zambon SpA (For-Profit, Publicly-traded, Global)
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Riley, Isaretta L., Bryonna Jackson, Donna Crabtree, Shaun Riebl, Loretta G. Que, Roy Pleasants, and L Ebony Boulware. “A Scoping Review of International Barriers to Asthma Medication Adherence Mapped to the Theoretical Domains Framework.” J Allergy Clin Immunol Pract 9, no. 1 (January 2021): 410-418.e4. https://doi.org/10.1016/j.jaip.2020.08.021.
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  - Yohannes, Abebaw M., Michelle N Eakin, Janet T. Holbrook, Elizabeth A. Sugar, Robert Henderson, Anna M. Baker, Anne S. Casper, et al. “Association of mild cognitive impairment and characteristic of COPD and overall health status in a cohort study.” Expert Rev Respir Med 15, no. 1 (January 2021): 153–59. https://doi.org/10.1080/17476348.2021.1838278.
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  - Holguin, Fernando, Hartmut Grasemann, Sunita Sharma, Daniel Winnica, Karen Wasil, Vong Smith, Margaret H. Cruse, et al. “L-Citrulline increases nitric oxide and improves control in obese asthmatics.” Jci Insight 4, no. 24 (December 19, 2019). https://doi.org/10.1172/jci.insight.131733.
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  - Winnica, Daniel, Catherine Corey, Steven Mullett, Michael Reynolds, Gabrielle Hill, Stacy Wendell, Loretta Que, Fernando Holguin, and Sruti Shiva. “Bioenergetic Differences in the Airway Epithelium of Lean Versus Obese Asthmatics Are Driven by Nitric Oxide and Reflected in Circulating Platelets.” Antioxid Redox Signal 31, no. 10 (October 1, 2019): 673–86. https://doi.org/10.1089/ars.2018.7627.
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  - Wechsler, Michael E., Stanley J. Szefler, Victor E. Ortega, Jacqueline A. Pongracic, Vernon Chinchilli, John J. Lima, Jerry A. Krishnan, et al. “Step-Up Therapy in Black Children and Adults with Poorly Controlled Asthma.” N Engl J Med 381, no. 13 (September 26, 2019): 1227–39. https://doi.org/10.1056/NEJMoa1905560.
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  - Dy, Alane Blythe C., Muhammad Z. Arif, Kenneth J. Addison, Loretta G. Que, Scott Boitano, Monica Kraft, and Julie G. Ledford. “Genetic Variation in Surfactant Protein-A2 Delays Resolution of Eosinophilia in Asthma.” J Immunol 203, no. 5 (September 1, 2019): 1122–30. https://doi.org/10.4049/jimmunol.1900546.
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  - Lazarus, Stephen C., Jerry A. Krishnan, Tonya S. King, Jason E. Lang, Kathryn V. Blake, Ronina Covar, Njira Lugogo, et al. “Mometasone or Tiotropium in Mild Asthma with a Low Sputum Eosinophil Level.” N Engl J Med 380, no. 21 (May 23, 2019): 2009–19. https://doi.org/10.1056/NEJMoa1814917.
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  - Riley, Isaretta L., Beverly Murphy, Zayd Razouki, Jerry A. Krishnan, Andrea Apter, Sande Okelo, Monica Kraft, Cindy Feltner, Loretta G. Que, and L Ebony Boulware. “A Systematic Review of Patient- and Family-Level Inhaled Corticosteroid Adherence Interventions in Black/African Americans.” J Allergy Clin Immunol Pract 7, no. 4 (April 2019): 1184-1193.e3. https://doi.org/10.1016/j.jaip.2018.10.036.
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  - Wu, Jinhong, Jialong Yang, Kai Yang, Hongxia Wang, Balachandra Gorentla, Jinwook Shin, Yurong Qiu, et al. “iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.” J Clin Invest 128, no. 4 (April 2, 2018): 1707–8. https://doi.org/10.1172/JCI120531.
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  - Riley, Isaretta L., L Ebony Boulware, Jie-Lena Sun, Karen Chiswell, Loretta G. Que, Monica Kraft, Jamie L. Todd, Scott M. Palmer, and Monique L. Anderson. “Factors associated with reporting results for pulmonary clinical trials in ClinicalTrials.gov.” Clin Trials 15, no. 1 (February 2018): 87–94. https://doi.org/10.1177/1740774517740352.
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  - Paul, D. W., D. K. Lagat, N. MacIntyre, J. R. Egger, D. M. Murdoch, L. G. Que, and P. S. Kussin. “Validation of spirometry prediction equations in western Kenya.” Int J Tuberc Lung Dis 22, no. 1 (January 1, 2018): 112–18. https://doi.org/10.5588/ijtld.17.0005.
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  - Foster, Matthew W., Zhonghui Yang, David M. Gooden, J Will Thompson, Carol H. Ball, Meredith E. Turner, Yongyong Hou, Jingbo Pi, M Arthur Moseley, and Loretta G. Que. “Correction to "Proteomic Characterization of the Cellular Response to Nitrosative Stress Mediated by S-Nitrosoglutathione Reductase Inhibition".” J Proteome Res 16, no. 7 (July 7, 2017): 2661. https://doi.org/10.1021/acs.jproteome.7b00368.
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  - Durack, Juliana, Susan V. Lynch, Snehal Nariya, Nirav R. Bhakta, Avraham Beigelman, Mario Castro, Anne-Marie Dyer, et al. “Features of the bronchial bacterial microbiome associated with atopy, asthma, and responsiveness to inhaled corticosteroid treatment.” J Allergy Clin Immunol 140, no. 1 (July 2017): 63–75. https://doi.org/10.1016/j.jaci.2016.08.055.
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  - Winnica, D., L. G. Que, C. Baffi, H. Grasemann, K. Fiedler, Z. Yang, E. Etling, et al. “l-citrulline prevents asymmetric dimethylarginine-mediated reductions in nitric oxide and nitrosative stress in primary human airway epithelial cells.” Clin Exp Allergy 47, no. 2 (February 2017): 190–99. https://doi.org/10.1111/cea.12802.
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  - He, Mu, Bastiaan Driehuys, Loretta G. Que, and Yuh-Chin T. Huang. “Using Hyperpolarized 129Xe MRI to Quantify the Pulmonary Ventilation Distribution.” Acad Radiol 23, no. 12 (December 2016): 1521–31. https://doi.org/10.1016/j.acra.2016.07.014.
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  - Ray, Samriddha, Norika Chiba, Changfu Yao, Xiangrong Guan, Alicia M. McConnell, Brian Brockway, Loretta Que, Jonathan L. McQualter, and Barry R. Stripp. “Rare SOX2+ Airway Progenitor Cells Generate KRT5+ Cells that Repopulate Damaged Alveolar Parenchyma following Influenza Virus Infection.” Stem Cell Reports 7, no. 5 (November 8, 2016): 817–25. https://doi.org/10.1016/j.stemcr.2016.09.010.
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  - Baffi, Cynthia W., Lisa Wood, Daniel Winnica, Patrick J. Strollo, Mark T. Gladwin, Loretta G. Que, and Fernando Holguin. “Metabolic Syndrome and the Lung.” Chest 149, no. 6 (June 2016): 1525–34. https://doi.org/10.1016/j.chest.2015.12.034.
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  - Ledford, Julie G., Kenneth J. Addison, Dave Francisco, Matthew W. Foster, Dennis R. Voelker, Loretta G. Que, and Monica Kraft. “Genetic Variation in Surfactant Protein-A2 Results in Altered Regulation of Eosinophil Activities and Enhanced Eosinophilia in Patients with Asthma.” Ann Am Thorac Soc 13 Suppl 1 (March 2016): S101. https://doi.org/10.1513/AnnalsATS.201508-520MG.
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  - Ingram, Jennifer L., David Slade, Tony D. Church, Dave Francisco, Karissa Heck, R Wesley Sigmon, Michael Ghio, et al. “Role of Matrix Metalloproteinases-1 and -2 in Interleukin-13-Suppressed Elastin in Airway Fibroblasts in Asthma.” Am J Respir Cell Mol Biol 54, no. 1 (January 2016): 41–50. https://doi.org/10.1165/rcmb.2014-0290OC.
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  - Yu, Yen-Rei A., Emily G. O’Koren, Danielle F. Hotten, Matthew J. Kan, David Kopin, Erik R. Nelson, Loretta Que, and Michael D. Gunn. “A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues.” Plos One 11, no. 3 (2016): e0150606. https://doi.org/10.1371/journal.pone.0150606.
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  - Lugogo, N. L., J. W. Hollingsworth, D. L. Howell, L. G. Que, D. Francisco, T. D. Church, E. N. Potts-Kant, J. L. Ingram, Y. Wang, and S. H. Jung. “Alveolar Macrophages from Overweight/Obese Subjects with Asthma Demonstrate a Proinflammatory Phenotype (Retraction of vol 186, pg 404, 2012).” American Journal of Respiratory and Critical Care Medicine 192, no. 2 (July 15, 2015): 264–264.
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  - “Retraction. S-nitrosoglutathione supplementation to ovalbumin-sensitized and -challenged mice ameliorates methacholine-induced bronchoconstriction.” Am J Physiol Lung Cell Mol Physiol 308, no. 9 (May 1, 2015): L981. https://doi.org/10.1152/ajplung.zh5-6751-retr.2015.
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  - Schmalbeck, R., L. Faulk, S. Alaimo, K. Gronbjerg, J. Colombo, D. Mason, T. Dearing, et al. “Ask the Experts.” Wallethub, 2015.
  - Mehta, K., E. J. Soderblom, J. W. Thompson, L. G. Que, H. E. Marshall, M. A. Moseley, and M. W. Foster. “Targeted proteomics for unraveling the post-translational regulation of human nitric oxide synthase 2.” Nitric Oxide 42C (November 15, 2014): 132. https://doi.org/10.1016/j.niox.2014.09.100.
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  - Ledford, Julie G., Kenneth J. Addison, Matthew W. Foster, and Loretta G. Que. “Eosinophil-associated lung diseases. A cry for surfactant proteins A and D help?” American Journal of Respiratory Cell and Molecular Biology 51, no. 5 (November 2014): 604–14. https://doi.org/10.1165/rcmb.2014-0095tr.
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  - Castro, Mario, Tonya S. King, Susan J. Kunselman, Michael D. Cabana, Loren Denlinger, Fernando Holguin, Shamsah D. Kazani, et al. “Effect of vitamin D3 on asthma treatment failures in adults with symptomatic asthma and lower vitamin D levels: the VIDA randomized clinical trial.” Jama 311, no. 20 (May 2014): 2083–91. https://doi.org/10.1001/jama.2014.5052.
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  - Catania, Jelena, Loretta G. Que, Joseph A. Govert, John W. Hollingsworth, and Cameron R. Wolfe. “High intensive care unit admission rate for 2013-2014 influenza is associated with a low rate of vaccination.” American Journal of Respiratory and Critical Care Medicine 189, no. 4 (February 2014): 485–87. https://doi.org/10.1164/rccm.201401-0066le.
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  - Foster, Matthew W., J Will Thompson, Loretta G. Que, Ivana V. Yang, David A. Schwartz, M Arthur Moseley, and Harvey E. Marshall. “Proteomic analysis of human bronchoalveolar lavage fluid after subsgemental exposure.” J Proteome Res 12, no. 5 (May 3, 2013): 2194–2205. https://doi.org/10.1021/pr400066g.
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  - Foster, M. W., J. W. Thompson, L. G. Que, I. V. Yang, D. A. Schwartz, M. A. Moseley, and H. E. Marshall. “Proteomic Analysis Of Human Bronchoalveolar Lavage Fluid After Subsegmental Challenge.” American Journal of Respiratory and Critical Care Medicine 187 (2013).
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  - Foster, Matthew W., Zhonghui Yang, David M. Gooden, J Will Thompson, Carol H. Ball, Meredith E. Turner, Yongyong Hou, Jingbo Pi, M Arthur Moseley, and Loretta G. Que. “Proteomic characterization of the cellular response to nitrosative stress mediated by s-nitrosoglutathione reductase inhibition.” J Proteome Res 11, no. 4 (April 6, 2012): 2480–91. https://doi.org/10.1021/pr201180m.
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  - Wang, Ying, Zhou Zhu, Tony D. Church, Njira L. Lugogo, Loretta G. Que, Dave Francisco, Jennifer L. Ingram, et al. “SHP-1 as a critical regulator of Mycoplasma pneumoniae-induced inflammation in human asthmatic airway epithelial cells.” J Immunol 188, no. 7 (April 1, 2012): 3371–81. https://doi.org/10.4049/jimmunol.1100573.
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  - Yang, Ivana V., John Tomfohr, Jaspal Singh, Catherine M. Foss, Harvey E. Marshall, Loretta G. Que, Erin McElvania-Tekippe, Sarita Florence, John S. Sundy, and David A. Schwartz. “The clinical and environmental determinants of airway transcriptional profiles in allergic asthma.” Am J Respir Crit Care Med 185, no. 6 (March 15, 2012): 620–27. https://doi.org/10.1164/rccm.201108-1503OC.
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  - Hsia, Bethany J., Amy M. Pastva, Charles D. Giamberardino, Erin N. Potts-Kant, W Michael Foster, Loretta G. Que, Soman N. Abraham, Jo Rae Wright, and David W. Zaas. “Increased Nitric Oxide Production Prevents Airway Hyperresponsiveness in Caveolin-1 Deficient Mice Following Endotoxin Exposure.” Journal of Allergy & Therapy Suppl 1, no. 4 (January 2012). https://doi.org/10.4172/2155-6121.s1-004.
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  - Que, Loretta G., and Yvonne Janssen-Heininger. “Biochemistry of asthma.” Biochim Biophys Acta 1810, no. 11 (November 2011): 1007. https://doi.org/10.1016/j.bbagen.2011.08.013.
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  - Que, Loretta G., Jane V. Stiles, John S. Sundy, and W Michael Foster. “Pulmonary function, bronchial reactivity, and epithelial permeability are response phenotypes to ozone and develop differentially in healthy humans.” J Appl Physiol (1985) 111, no. 3 (September 2011): 679–87. https://doi.org/10.1152/japplphysiol.00337.2011.
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  - Norfolk, Stephanie G., Caroline L. Hollingsworth, Cameron R. Wolfe, Joseph A. Govert, Loretta G. Que, Ira M. Cheifetz, and John W. Hollingsworth. “Rescue therapy in adult and pediatric patients with pH1N1 influenza infection: a tertiary center intensive care unit experience from April to October 2009.” Crit Care Med 38, no. 11 (November 2010): 2103–7. https://doi.org/10.1097/CCM.0b013e3181f268f1.
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  - Huang, Yuh-Chin T., Michael Schmitt, Zhonghui Yang, Loretta G. Que, Judith C. Stewart, Mark W. Frampton, and Robert B. Devlin. “Gene expression profile in circulating mononuclear cells after exposure to ultrafine carbon particles.” Inhal Toxicol 22, no. 10 (August 2010): 835–46. https://doi.org/10.3109/08958378.2010.486419.
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  - Choudhry, Shweta, Loretta G. Que, Zhonghui Yang, Limin Liu, Celeste Eng, Sung O. Kim, Gunjan Kumar, et al. “GSNO reductase and beta2-adrenergic receptor gene-gene interaction: bronchodilator responsiveness to albuterol.” Pharmacogenet Genomics 20, no. 6 (June 2010): 351–58. https://doi.org/10.1097/FPC.0b013e328337f992.
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  - Wahidi, Momen M., Gerard A. Silvestri, Raymond D. Coakley, J Scott Ferguson, R Wesley Shepherd, Leonard Moses, John Conforti, et al. “A prospective multicenter study of competency metrics and educational interventions in the learning of bronchoscopy among new pulmonary fellows.” Chest 137, no. 5 (May 2010): 1040–49. https://doi.org/10.1378/chest.09-1234.
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  - Pastva, A. M., J. K. L. Walker, S. Mukherjee, C. Giamberardino, B. J. Hsia, E. Potts, J. P. Eu, W. M. Foster, L. G. Que, and J. R. Wright. “In A Model Of Innate Immunity The Interaction Between Inducible Nitric Oxide Synthase And Surfactant Protein-A Regulates Airway Responsiveness.” American Journal of Respiratory and Critical Care Medicine 181 (2010).
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  - Que, Loretta G., Zhonghui Yang, Jonathan S. Stamler, Njira L. Lugogo, and Monica Kraft. “S-nitrosoglutathione reductase: an important regulator in human asthma.” Am J Respir Crit Care Med 180, no. 3 (August 1, 2009): 226–31. https://doi.org/10.1164/rccm.200901-0158OC.
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  - Brown, B. J., A. M. Pastva, B. Lo, W. M. Foster, P. Eu, L. G. Que, S. N. Abraham, J. R. Wright, and D. W. Zaas. “AHR Is Attenuated in Caveolin-1 Deficient Mice.” American Journal of Respiratory and Critical Care Medicine 179 (January 1, 2009).
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  - Chudgar, Saumil M., Christopher E. Cox, Loretta G. Que, Kathryn Andolsek, Nancy W. Knudsen, and Alison S. Clay. “Current teaching and evaluation methods in critical care medicine: has the Accreditation Council for Graduate Medical Education affected how we practice and teach in the intensive care unit?” Crit Care Med 37, no. 1 (January 2009): 49–60. https://doi.org/10.1097/CCM.0b013e31819265c8.
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  - Que, L. G., Z. Yang, T. D. Church, D. M. Beaver, D. Jinwright, N. L. Lugogo, and M. Kraft. “GSNO Reductase Expression and Activity Are Increased in Asthmatic Airway Macrophages.” American Journal of Respiratory and Critical Care Medicine 179 (January 1, 2009).
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  - Lugogo, Njira L., Geoffrey S. Ginsburg, and Loretta G. Que. “Genetic profiling and tailored therapy in asthma: are we there yet?” Curr Opin Mol Ther 9, no. 6 (December 2007): 528–37.
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  - Clay, A. S., L. G. Que, J. A. Govert, and K. M. Andolsek. “"A rose by any other name"? Toward a common terminology in simulation education and assessment [6].” Critical Care Medicine 35, no. 9 (September 1, 2007): 2238. https://doi.org/10.1097/01.CCM.0000281641.66736.90.
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  - Whalen, Erin J., Matthew W. Foster, Akio Matsumoto, Kentaro Ozawa, Jonathan D. Violin, Loretta G. Que, Chris D. Nelson, et al. “Regulation of beta-adrenergic receptor signaling by S-nitrosylation of G-protein-coupled receptor kinase 2.” Cell 129, no. 3 (May 4, 2007): 511–22. https://doi.org/10.1016/j.cell.2007.02.046.
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  - Clay, Alison S., Loretta Que, Emil R. Petrusa, Mark Sebastian, and Joseph Govert. “Debriefing in the intensive care unit: a feedback tool to facilitate bedside teaching.” Crit Care Med 35, no. 3 (March 2007): 738–54. https://doi.org/10.1097/01.CCM.0000257329.22025.18.
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  - Que, Loretta G., Limin Liu, Yun Yan, Gregory S. Whitehead, Stephen H. Gavett, David A. Schwartz, and Jonathan S. Stamler. “Protection from experimental asthma by an endogenous bronchodilator.” Science 308, no. 5728 (June 10, 2005): 1618–21. https://doi.org/10.1126/science.1108228.
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  - Liu, Limin, Yun Yan, Ming Zeng, Jian Zhang, Martha A. Hanes, Gregory Ahearn, Timothy J. McMahon, et al. “Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock.” Cell 116, no. 4 (February 20, 2004): 617–28. https://doi.org/10.1016/s0092-8674(04)00131-x.
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  - Yu, Qing, Loretta G. Que, and Don C. Rockey. “Adenovirus-mediated gene transfer to nonparenchymal cells in normal and injured liver.” Am J Physiol Gastrointest Liver Physiol 282, no. 3 (March 2002): G565–72. https://doi.org/10.1152/ajpgi.00512.2000.
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  - Que, Loretta G., Samuel E. George, Tomomi Gotoh, Masataka Mori, and Yuh-Chin T. Huang. “Effects of arginase isoforms on NO Production by nNOS.” Nitric Oxide 6, no. 1 (February 2002): 1–8. https://doi.org/10.1006/niox.2001.0355.
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  - Liu, L., A. Hausladen, M. Zeng, L. Que, J. Heitman, and J. S. Stamler. “A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans.” Nature 410, no. 6827 (March 22, 2001): 490–94. https://doi.org/10.1038/35068596.
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  - Liu, L., A. Hausladen, M. Zeng, L. Que, J. Heitman, J. S. Stamler, and D. Steverding. “Nitrosative stress: protection by glutathione-dependent formaldehyde dehydrogenase.” Redox Rep 6, no. 4 (2001): 209–10. https://doi.org/10.1179/135100001101536337.
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  - Que, L. G., and Y. C. Tony Huang. “Pharmacologic adjuncts during mechanical ventilation.” Semin Respir Crit Care Med 21, no. 3 (2000): 223–32. https://doi.org/10.1055/s-2000-9848.
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  - Lau, C. L., R. C. Bentley, J. P. Gockerman, L. G. Que, and T. A. D’Amico. “Malignant melanoma presenting as a mediastinal mass.” Ann Thorac Surg 67, no. 3 (March 1999): 851–52. https://doi.org/10.1016/s0003-4975(99)00075-2.
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  - Que, L. G., S. P. Kantrow, C. P. Jenkinson, C. A. Piantadosi, and Y. C. Huang. “Induction of arginase isoforms in the lung during hyperoxia.” Am J Physiol 275, no. 1 (July 1998): L96-102. https://doi.org/10.1152/ajplung.1998.275.1.L96.
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  - Que, L. G., S. P. Kantrow, C. P. Jenkinson, C. A. Piantadosi, and Y. C. T. Huang. “Induction of arginase isoforms in the lung during hyperoxia.” American Journal of Physiology Lung Cellular and Molecular Physiology 275, no. 1 (July 1, 1998): L96–102.
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  - Que, L. G., B. H. Kang, Y. C. Huang, C. A. Piantadosi, and L. Y. Chang. “Anti-intercellular adhesion molecule-1 antibody and intercellular adhesion molecule-1 gene deficiency do not prevent pulmonary neutrophil recruitment in polymicrobial sepsis.” Shock 9, no. 4 (April 1998): 304–9. https://doi.org/10.1097/00024382-199804000-00011.
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  - Carraway, M. S., K. E. Welty-Wolf, S. P. Kantrow, Y. C. Huang, S. G. Simonson, L. G. Que, T. K. Kishimoto, and C. A. Piantadosi. “Antibody to E- and L-selectin does not prevent lung injury or mortality in septic baboons.” American Journal of Respiratory and Critical Care Medicine 157, no. 3 Pt 1 (March 1998): 938–49. https://doi.org/10.1164/ajrccm.157.3.9707129.
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- Book Sections
  - Marshall, H. E., L. G. Que, J. S. Stamler, and B. Gaston. “S-nitrosothiols in lung inflammation.” In Therapeutic Targets in Airway Inflammation, 123–42, 2003.
- Journal Issues
  - Bose, Sonali, Robert J. Henderson, Linda Rogers, Thomas Casale, Gwen Skloot, Xavier Soler, Robert A. Wise, and Loretta G. Que. “Identifying an at-risk population for poor asthma outcomes: Data from the American Lung Association Asthma Clinical Trials Registry.” J Allergy Clin Immunol Pract, November 2019. https://doi.org/10.1016/j.jaip.2019.04.024.
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  - Birukova, Anastasiya, Jaime Cyphert-Daly, Robert Ian Cumming, Yen-Rei Yu, Kymberly M. Gowdy, Loretta G. Que, and Robert M. Tighe. “Sex Modifies Acute Ozone-Mediated Airway Physiologic Responses.” Toxicol Sci, June 1, 2019. https://doi.org/10.1093/toxsci/kfz056.
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  - Yang, Shigao, Alfred T. Harding, Catherine Sweeney, David Miao, Gregory Swan, Connie Zhou, Zhaozhao Jiang, et al. “Control of antiviral innate immune response by protein geranylgeranylation.” Sci Adv, May 2019. https://doi.org/10.1126/sciadv.aav7999.
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  - Tang, Monica, Robert J. Henderson, Janet T. Holbrook, Loretta G. Que, Anne M. Mathews, Robert A. Wise, Anne E. Dixon, et al. “Does Obesity Increase Respiratory Tract Infections in Patients with Asthma?” J Allergy Clin Immunol Pract, March 2019. https://doi.org/10.1016/j.jaip.2018.09.033.
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  - Yang, Zhonghui, Yury A. Bochkov, Dennis R. Voelker, Matthew W. Foster, and Loretta G. Que. “Identification of a Novel Inhibitor of Human Rhinovirus Replication and Inflammation in Airway Epithelial Cells.” Am J Respir Cell Mol Biol, January 2019. https://doi.org/10.1165/rcmb.2018-0058OC.
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  - Baker, Anna M., Janet T. Holbrook, Abebaw M. Yohannes, Michelle N. Eakin, Elizabeth A. Sugar, Robert J. Henderson, Anne S. Casper, et al. “Test Performance Characteristics of the AIR, GAD-7, and HADS-Anxiety Screening Questionnaires for Anxiety in Chronic Obstructive Pulmonary Disease.” Ann Am Thorac Soc, August 2018. https://doi.org/10.1513/AnnalsATS.201708-631OC.
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  - Que, Loretta G., Zhonghui Yang, Njira L. Lugogo, Rohit K. Katial, Steven A. Shoemaker, Janice M. Troha, David M. Rodman, Robert M. Tighe, and Monica Kraft. “Effect of the S-nitrosoglutathione reductase inhibitor N6022 on bronchial hyperreactivity in asthma.” Immun Inflamm Dis, June 2018. https://doi.org/10.1002/iid3.220.
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  - Paul, Devon W., Nigel B. Neely, Meredith Clement, Isaretta Riley, Mashael Al-Hegelan, Matthew Phelan, Monica Kraft, et al. “Development and validation of an electronic medical record (EMR)-based computed phenotype of HIV-1 infection.” J Am Med Inform Assoc, February 1, 2018. https://doi.org/10.1093/jamia/ocx061.
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  - Wu, Jinhong, Jialong Yang, Kai Yang, Hongxia Wang, Balachandra Gorentla, Jinwook Shin, Yurong Qiu, et al. “iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.” J Clin Invest, November 1, 2017. https://doi.org/10.1172/JCI98066.
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  - Suwanpradid, Jutamas, Michael Shih, Lauren Pontius, Bin Yang, Anastasiya Birukova, Emma Guttman-Yassky, David L. Corcoran, Loretta G. Que, Robert M. Tighe, and Amanda S. MacLeod. “Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity.” J Immunol, September 1, 2017. https://doi.org/10.4049/jimmunol.1700739.
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- Conference Papers
  - Daly, J. M., Z. Yang, J. L. Ingram, K. M. Luginbuhl, A. Varanko, R. M. Tighe, A. Chilkoti, and L. G. Que. “Glucagon Like Peptide 1 Attenuates Airway Hyperresponsiveness in a Mouse Model of Obese Allergic Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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  - Duchene, B., S. Caffry, K. Black, J. H. Bates, D. A. Kaminsky, L. G. Que, and A. E. Dixon. “Elevated Airway Oxidative Stress in Obese Asthma Is Correlated with Increased Airway Closure.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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  - Ihrie, M., V. L. McQuade, C. V. Lacuesta, R. M. Tighe, L. G. Que, A. Hedge, J. K. Walker, and J. L. Ingram. “Chronic Leptin Administration in Lean, Allergen-Challenged Female Mice Promotes Small Airway Closure and Airway Fibrosis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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  - Navuluri, N., L. G. Que, D. M. Murdoch, N. Thielman, N. R. MacIntyre, J. A. Krishnan, D. K. Lagat, and P. S. Kussin. “Evaluation of Hypoxemia Among Patients Admitted to a Tertiary Referral Hospital in Western Kenya.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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  - Riley, I. L., L. Svetkey, L. G. Que, and L. Boulware. “Patient, Provider and Community Stakeholder Recommendations for Asthma Interventions in Adult High-Risk Populations.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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  - Riley, I. L., L. Svetkey, L. G. Que, and L. Boulware. “International Patient-Reported Barriers to Asthma Medication Adherence by Countries' Gross National Income and Presence of Universal Health Care.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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  - Ruhl, A., J. M. Jackson, C. J. Carhuas, M. P. Fay, JG Nino de Rivera, J. B. Weinberg, L. G. Que, and H. C. Ackerman. “Alpha Globin Copy Number and Exhaled Nitric Oxide in Black Individuals.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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  - Yang, Z., J. M. Daly, J. L. Ingram, F. Holguin, R. M. Tighe, and L. G. Que. “Deficiency in Paraoxonase 2 Increases Airway Hyper Responsiveness After Ozone Exposure in Mice.” In American Journal of Respiratory and Critical Care Medicine, Vol. 201, 2020.
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  - Cyphert-Daly, Jaime M., Zhonghui Yang, Jennifer L. Ingram, Robert M. Tighe, and Loretta G. Que. “Physiologic response to chronic house dust mite exposure in mice is dependent on lot characteristics.” In J Allergy Clin Immunol, 144:1428-1432.e8, 2019. https://doi.org/10.1016/j.jaci.2019.07.019.
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  - Ihrie, Mark, Victoria McQuade, Akhil Hegde, Jingjing Niu, Jenny Tong, David D’Alessio, Julia K. L. Walker, Loretta G. Que, and Jennifer L. Ingram. “Sleeve gastrectomy surgery reduces airway resistance and inflammation in chronically allergen-challenged obese mice.” In Journal of Allergy and Clinical Immunology, 143:AB307–AB307. Elsevier BV, 2019. https://doi.org/10.1016/j.jaci.2018.12.935.
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  - Holguin, F., S. Sharma, D. E. Winnica, K. Wasil, V. L. Smith, M. H. Cruse, N. Perez, et al. “L-Citrulline as Add-On Therapy to Increase Exhaled Nitric Oxide and Improve Lung Function and Asthma Control in Obese Asthmatics.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.
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  - Riley, I., R. A. Pleasants, D. Crabtree, S. Riebel, L. Svetkey, L. G. Que, M. Handley, A. Cattamanchi, H. Bosworth, and L. E. Boulware. “AdheRence to Inhaled Corticosteroids in Asthma (ARICA): Intervention Development.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.
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  - Winnica, D. E., S. Sharma, L. G. Que, S. Ye, V. L. Smith, M. H. Cruse, N. Perez, and F. Holguin. “Up-Regulation of Paraoxonase 2 in Human Bronchial Epithelial Cells.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.
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  - Yu, Y. A., J. Daly, S. Phelan, R. I. Cumming, A. Birukova, Y. Malakhau, J. L. Ingram, M. D. Gunn, L. G. Que, and R. M. Tighe. “Replacement of Fetal-Derived with Bone Marrow-Derived Pulmonary Resident Macrophages Reduces House Dust Mite-Induced Airway Hyperresponsiveness.” In American Journal of Respiratory and Critical Care Medicine, Vol. 199. AMER THORACIC SOC, 2019.
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  - Holguin, F., C. Liu, S. A. A. Comhair, S. Hazen, E. R. Bleecker, W. W. Busse, W. J. Calhoun, et al. “Upregulation of Paraxonase 1 (PON1) in Severe Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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  - Ingram, J. L., V. McQuade, B. Theriot, J. Niu, J. Daly, J. Wong, J. Tong, R. M. Tighe, L. G. Que, and D. D’Alessio. “Vertical Sleeve Gastrectomy in Allergen-Challenged Obese Mice Is Associated with Reduced Airway Resistance and Fibrosis.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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  - Mathews, A. M., A. M. Baker, J. T. Holbrook, A. M. Yohannes, M. Eakin, E. A. Sugar, R. Henderson, et al. “The Relationship Between Sleep Quality, Age, and Quality of Life in Patients with COPD and Clinical Depression and Anxiety.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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  - Pederson, W., M. Prasetyo, J. M. Cyphert, R. M. Tighe, L. G. Que, and J. G. Ledford. “Genetic Variation in Surfactant Protein-A2 Differentially Mediates Responses to Ozone.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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  - Winnica, D. E., C. Corey, L. G. Que, F. Holguin, and S. Shiva. “Platelet and Airway Epithelium Bioenergetics Are Different in Obese Versus Lean Asthmatics.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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  - Yang, Z., J. Daly, D. E. Winnica, F. Holguin, V. McQuade, J. L. Ingram, R. M. Tighe, and L. G. Que. “Characterization of Paraoxonases in Mice with Obese Allergic Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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  - Yang, Z., Y. A. Bochkov, D. R. Voelker, M. W. Foster, and L. G. Que. “S-Nitrosoglutathione Reductase Inhibitor Blockade of Rhinovirus A16 Replication by Targeting ICAM-1.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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  - Yohannes, A. M., M. Eakin, J. T. Holbrook, E. M. Sugar, R. Henderson, A. M. Baker, D. A. Kaminsky, et al. “Chronic Obstructive Pulmonary Disease Related with Increased Risk of Mild Cognitive Impairment.” In American Journal of Respiratory and Critical Care Medicine, Vol. 197. AMER THORACIC SOC, 2018.
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  - Giovacchini, Coral X., Lauren Pacek, F Joseph McClernon, and Loretta G. Que. “Use and Perceived Risk of Electronic Cigarettes Among North Carolina Middle and High School Students.” In N C Med J, 78:7–13, 2017. https://doi.org/10.18043/ncm.78.1.7.
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  - He, M., S. H. Robertson, J. M. Wang, L. G. Que, K. Mahmood, B. Driehuys, and Y. -. C. Huang. “Characterizing The Ventilation Distribution In Healthy Normal Subjects To Establish Robust Quantitative Analysis Of 129xe Mri.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
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  - Huang, Y. -. C., and L. G. Que. “Clinical Significance Of Isolated Decrease In Single Breath Lung Volume-Total Lung Capacity Ratio (va/tlc).” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
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  - Winnica, D. E., H. Grasemann, L. G. Que, B. Freeman, K. Wasil, S. E. Wenzel, and F. Holguin. “L-Citrulline Prevents Asymmetric Di-Methyl Arginine Uncoupling Of Nitric Oxide Synthase In Primary Human Airway Epithelial Cells.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
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  - Yang, Z., Y. Bochkov, D. R. Voelker, M. W. Foster, and L. G. Que. “A Gsnor Inhibitor Blocks Hrv Infection Of Primary Human Airway Epithelial Cells.” In American Journal of Respiratory and Critical Care Medicine, Vol. 193. AMER THORACIC SOC, 2016.
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  - Ledford, J. G., K. J. Addison, D. C. Francisco, M. W. Foster, D. R. Voelker, L. G. Que, and M. Kraft. “Genetic Variation In Surfactant Protein-A2 Leads To Differential Regulation Of Eosinophil Activities And More Pronounced Eosinophilia In Asthmatics.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.
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  - Ledford, J. G., N. Lugogo, N. Agada, J. Weiss, D. C. Francisco, J. L. Ingram, M. E. Sunday, L. G. Que, and M. Kraft. “Increased Tissue Eosinophilia In Obese Asthma May Be Due To Decreased Surfactant Protein-A Levels.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.
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  - Que, L. G., M. Kraft, N. Lugogo, R. Katial, S. A. Shoemaker, and J. M. Troha. “A Novel Therapeutic Target In Asthma: Translational Evidence For Inhibition Of S-Nitrosoglutathione Reductase.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.
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  - Wang, Y., J. G. Ledford, M. Ghio, D. C. Francisco, K. Addison, L. G. Que, J. W. Hollingsworth, and M. Kraft. “Surfactant Protein A Inhibits Il-13-Induced Inflammatory Response And Mucin Production In Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 191. AMER THORACIC SOC, 2015.
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  - Wang, Y., D. C. Francisco, N. Lugogo, J. Thomas, D. M. Beaver, J. W. Hollingsworth, W. M. Foster, et al. “Genetic Variation In Surfactant Protein A2 Alters Airway Epithelial Response To Mycoplasma Pneumoniae Infection In Asthma.” In American Journal of Respiratory and Critical Care Medicine, Vol. 189. AMER THORACIC SOC, 2014.
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  - Wang, Y., D. Francisco, J. M. Thomas, N. Lugogo, L. G. Que, J. G. Ledford, S. Choudhury, D. Beaver, and M. Kraft. “Surfactant Protein A Inhibits Il-13-Induced Pro-Inflammatory Response In Asthmatic Airway Epithelial Cells.” In American Journal of Respiratory and Critical Care Medicine, Vol. 187. AMER THORACIC SOC, 2013.
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  - Huang, Y. C., M. Schmitt, Z. Yang, L. G. Que, J. Stewart, M. W. Frampton, and R. B. Devlin. “Gene Expression in Circulating Mononuclear Cells after Ultrafine Carbon Particle Exposure.” In American Journal of Respiratory and Critical Care Medicine, Vol. 179. AMER THORACIC SOC, 2009.
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  - Liu, L. M., Y. Yan, M. Zeng, J. Zhang, M. A. Hanes, G. Ahearn, T. J. McMahon, et al. “Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock.” In Nitric Oxide Biology and Chemistry, 11:39–39. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004.
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