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Loretta Georgina Que

Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
Duke Box 2629, 203 Research Dr, Durham, NC 27710
279 MSRB1, Durham, NC 27710

Overview


My research interests focus on studying the role of nitric oxide and related enzymes in the pathogenesis of lung disease, specifically that caused by nitrosative/oxidative stress. Proposed studies are performed in cell culture and applied to animal models of disease, then examined in human disease where relevant. It is our hope that by better understanding the role of NO and reactive nitrogen species in mediating inflammation, and regulating cell signaling, that we will not only help to unravel the basic mechanisms of NO related lung disease, but also provide a rationale for targeted therapeutic use of NO.


Key words: nitrosative defense, lung injury, nitric oxide

Current Appointments & Affiliations


Professor of Medicine · 2019 - Present Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine
Chief, Division of Pulmonary · 2021 - Present Medicine, Pulmonary, Allergy, and Critical Care Medicine, Medicine

In the News


Published March 9, 2022
The Mystery of Long COVID: Brain Fog, Fatigue, Even Sexual Dysfunction
Published April 23, 2021
We Are What We Breathe

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Recent Publications


Leptin augments IL-13-induced airway eotaxins and submucosal eosinophilia in obesity-associated asthma.

Journal Article J Allergy Clin Immunol · March 2025 BACKGROUND: Airway tissue eosinophilia can be an observed feature of obesity-associated type 2 (T2) asthma, but the processes mediating this inflammation are unknown. OBJECTIVE: To investigate a process whereby leptin, an adipokine elevated in obesity, pot ... Full text Link to item Cite

Evaluation of the safety profile and intrapulmonary pharmacokinetics of intravenous fosfomycin in healthy adults.

Journal Article Antimicrob Agents Chemother · February 13, 2025 UNLABELLED: This Phase 1 trial described the intrapulmonary pharmacokinetics and safety profile of IV fosfomycin in healthy participants. Fosfomycin, a broad-spectrum antibiotic mainly used to treat urinary tract infections, is being considered for treatme ... Full text Link to item Cite

Risk of Atherosclerotic Cardiovascular Disease After Chronic Obstructive Pulmonary Disease Hospitalization among Primary and Secondary Prevention Older Adults.

Journal Article J Am Heart Assoc · January 21, 2025 BACKGROUND: Meta-analyses have suggested that the risk of cardiovascular disease events is significantly higher after a chronic obstructive pulmonary disease (COPD) exacerbation, but the populations at highest risk have not been well characterized to date. ... Full text Link to item Cite
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Recent Grants


PROSPERO AZ Pro00115490

Clinical TrialPrincipal Investigator · Awarded by AstraZeneca AB · 2024 - 2029

NICHD Pediatric and Maternal Resource Center: Bridging Pharmacology and the Real World

ResearchCo Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2024 - 2028

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Education, Training & Certifications


The University of Chicago · 1989 M.D.