Research Interests
Asthma
Obese asthma
Airway inflammation and airway remodeling
Oxidative stress
COPD
Xenon MRI
COVID 19 related lung disease
Obese asthma
Airway inflammation and airway remodeling
Oxidative stress
COPD
Xenon MRI
COVID 19 related lung disease
Selected Grants
AMGEN AMG-451 Pro00115602 A Phase 2, Double-blind, Placebo-controlled, Dose Ranging Study Assessing Rocatinlimab in Moderate-to-severe Asthma
Clinical TrialPrincipal Investigator · Awarded by Amgen, Inc. · 2024 - 2029PROSPERO AZ Pro00115490
Clinical TrialPrincipal Investigator · Awarded by AstraZeneca AB · 2024 - 2029NICHD Pediatric and Maternal Resource Center: Bridging Pharmacology and the Real World
ResearchCo Investigator · Awarded by Eunice Kennedy Shriver National Institute of Child Health and Human Development · 2024 - 2028Stimulating Access to Research in Residency (StARR) - NHLBI
Inst. Training Prgm or CMEPreceptor · Awarded by National Heart, Lung, and Blood Institute · 2018 - 2028OBERON - A Phase III, Multicentre, Randomised, Double-blind, Chronic-dosing, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Two Dose Regimens of MEDI3506 in Participants with Symptomatic Chronic Obstructive Pulmonary
Clinical TrialPrincipal Investigator · Awarded by AstraZeneca Pharmaceuticals, LP · 2022 - 2027Duke Program of Training in Pulmonary ReSearch to Promote, Engage and Retain Academic Researchers (PROSPER)
Inst. Training Prgm or CMEPreceptor · Awarded by National Heart, Lung, and Blood Institute · 2022 - 2026Coping with Asthma through Life Management (CALM)
ResearchMentor · Awarded by National Institutes of Health · 2021 - 2026Post-Tuberculosis Lung Disease: Clinical Phenotypes and Barriers to Treatment
ResearchMentor · Awarded by Parker B. Francis Foundation · 2023 - 2026Mechanisms of Nanoparticle Modulation of Allergen-Induced Lung Disease
ResearchCo-Principal Investigator · Awarded by North Carolina State University · 2021 - 2026Peep Mask study
Clinical TrialPrincipal Investigator · Awarded by ProspAir,LLC · 2021 - 2026A Randomized Phase II Clinical Trial of L-Citrulline to Improve Asthma Control in Obese Late Onset Asthma
Clinical TrialPrincipal Investigator · Awarded by University of Colorado - Denver · 2019 - 2026American Lung Association Airways Clinical Research Centers Network
ResearchPrincipal Investigator · Awarded by American Lung Association · 2016 - 2026Hyperpolarized 129Xe MRI to identify structural determinants of low lung function and respiratory symptoms in young adults from the Lung Health Cohort - Fixed Price
ResearchPrincipal Investigator · Awarded by The University of Kansas Medical Center Research Institute, Inc · 2024 - 2026Hyperpolarized 129Xe MRI to identify structural determinants of low lung function and respiratory symptoms in young adults from the Lung Health Cohort
ResearchPrincipal Investigator · Awarded by The University of Kansas Medical Center Research Institute, Inc · 2024 - 2026Regeneron SANOFI Study Dupilumab IL-13Ra2 Signaling
Clinical TrialPrincipal Investigator · Awarded by Regeneron Pharmaceuticals, Inc. · 2022 - 2025A Longitudinal Prospective Observational Study of the Characteristics, Treatment Patterns and Health Outcomes of Individuals with Severe Asthma in the United States
ResearchPrincipal Investigator · Awarded by AstraZeneca Pharmaceuticals, LP · 2018 - 2025ALA-ACRC Lung Health Cohort Deep Phenotyping Ancillary Study
ResearchPrincipal Investigator · Awarded by American Lung Association · 2024 - 2025Influence of omega-3 status on asthma health during pregnancy
ResearchPrincipal Investigator · Awarded by Icahn School of Medicine at Mount Sinai · 2022 - 2025Oxidative Stress and Regional Airway Remodeling and Fibrosis in Obese Asthma
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2025American Lung Association-Airways Clinical Research Center-Lung Health Cohort (ALA-LHC)
ResearchPrincipal Investigator · Awarded by American Lung Association · 2020 - 2025Mitochondrial Redox Perturbations in Obese Allergic Asthma
Clinical TrialPrincipal Investigator · Awarded by University of Vermont · 2018 - 2024The Role of PON2 in the Development of Non-Allergic Asthma in Obesity
FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2024Improving Medication Adherence with Telehealthcare Medication Therapy Management to Change Health Outcomes in Adolescents and Young Adults with Asthma (MATCH)
Clinical TrialPrincipal Investigator · Awarded by American Lung Association · 2019 - 2024EFC1580 BOREAS: A randomized double blind placebo controlled parallel group 52wk study to assess the efficacy, safety, and tolerability of Dupilumab in patients with moderate to severe COPD w/Type 2
Clinical TrialPrincipal Investigator · Awarded by Sanofi US · 2019 - 2024Asthma and Technology in Emerging African American Adults
ResearchPrincipal Investigator · Awarded by University of Michigan · 2023 - 2023Clinical Phenotypes of Chronic Lung Disease and Associated Clinical Implications in Kenya
ResearchMentor · Awarded by University of Arizona · 2023 - 2023R01: CXCL10/CXCR3 regulation of ozone-induced epithelial permeability
ResearchCo Investigator · Awarded by National Institutes of Health · 2017 - 2023A double-blind, placebo-controlled, multi-centre, clinical trial to investigate the efficacy and safety of therapy with inhaled colistimethate sodium in the treatment of subjects with non-CF bronchiectasis chronically infected with P. aeruginosa
Clinical TrialPrincipal Investigator · Awarded by Zambon SpA · 2018 - 2023VTEU Task Order 22 16-0058 - Cost to Complete
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2021 - 2023AZ D5180C00018 DESTINATION: A multicentre double blind randomized placebo controlled parallel group phase 3 safety extension study to evaluate safety & tolerability of Tezepelumab
Clinical TrialPrincipal Investigator · Awarded by AstraZeneca Pharmaceuticals, LP · 2019 - 2023VTEU TO #132 Base - Task Area A - FY.2020.A1B1C1D1.0123 - Option 2.A
ResearchInvestigator · Awarded by National Institutes of Health · 2021 - 2023American Lung Association (ALA) Novel Digital Diary (ANDDI) Trial
Clinical TrialPrincipal Investigator · Awarded by American Lung Association · 2019 - 2023Trial of Roflumilast in Asthma Management (TRIM)
Clinical TrialPrincipal Investigator · Awarded by American Lung Association · 2018 - 2023Mechanisms that Direct Airway Remodeling in Obese Asthma
ResearchCo Investigator · Awarded by National Institutes of Health · 2017 - 2023VTEU Task Order 16-0058.B1C1D1.0076 - Task D
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2017 - 2022VACCINE AND TREATMENT EVALUATION UNITS (VTEU) PROTOCOL DEVELOPMENT, IMPLEMENTATION AND ASSAYS TASK AREA B-D PHASE 1 PK TRIAL TO EVALUATE FOSFOMYCIN TASK ORDER 16-0058.B1C1D1.0076
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2017 - 2022Task Area B-D Task Order 16-0058.B1C1D1.0076
ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2017 - 2022Pilot: Zinc Acetate to Treat Chronic Refractory Cough (ZICO)
Clinical TrialPrincipal Investigator · Awarded by American Lung Association · 2017 - 2022Asthma BMI Baseline Study (ABBS)
Clinical TrialPrincipal Investigator · Awarded by American Lung Association · 2018 - 2021Interdisciplinary Training Program in Lung Disease
Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2009 - 2021D5180C00009 SOURCE A multicentre randomized double blind placebo controlled Phase 3 study to evaluate the efficacy and safety of Tezepelumab
Clinical TrialPrincipal Investigator · Awarded by AstraZeneca AB · 2018 - 2021A multi-center, randomized, double-blind, placebo controlled, parallel group study to compare cessation versus continuation of long-term mepolizumab treatment in patients with severe eosinophilic asthma (201810)
Clinical TrialPrincipal Investigator · Awarded by GlaxoSmithKline · 2016 - 2020Modulation of Asthma by GSNO-based Therapies
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2013 - 2018Diesel-induced Alterations of Influenza Infectivity
ResearchSignificant Contributor · Awarded by University of North Carolina - Chapel Hill · 2015 - 2017Surfactant Protein-A regulation of eosinophil apoptosis in asthma
ResearchPrincipal Investigator · Awarded by University of Arizona · 2015 - 2017HIV and Asthma in the Post- ART Era
ResearchCo Investigator · Awarded by National Institutes of Health · 2014 - 2016The Duke Multidisciplinary Training Program in Pediatric Lung Disease
Inst. Training Prgm or CMEFaculty Member · Awarded by National Institutes of Health · 2010 - 2016Clinical Center Core
ResearchCo Investigator · Awarded by University of Arizona · 2009 - 2016Asthma Clinical Research Center of the American Lung Association
ResearchPrincipal Investigator · Awarded by American Lung Association · 2009 - 2016I2PP2A and Asthma
ResearchPrincipal Investigator · Awarded by Cognosci, Inc. · 2014 - 2015Diesel-induced Alterations of Influenza Infectivity
ResearchCo Investigator · Awarded by University of North Carolina - Chapel Hill · 2013 - 2014GSNO Reductase, S-Nitrosothiols, and Asthma
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2007 - 2013Genetic regulation of O3-induced inflammation in humans
ResearchCo Investigator · Awarded by National Institutes of Health · 2000 - 2007Modulation of NO with Pulmonary Gene Transfer
ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2000 - 2006External Relationships
- American Lung Association
- Amgen, Inc.
- AstraZeneca
- Boehringer Ingelheim
- Merck
- NIH
- Polarean Imaging
- Robling Medical
- Sanofi and Regeneron Pharmaceuticals
- Zambon SpA
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.