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Loretta Georgina Que

Professor of Medicine
Medicine, Pulmonary, Allergy, and Critical Care Medicine
Duke Box 2629, 203 Research Dr, Durham, NC 27710
279 MSRB1, Durham, NC 27710

Research Interests


Asthma
     Obese asthma
     Airway inflammation and airway remodeling
Oxidative stress
COPD
Xenon MRI
COVID 19 related lung disease

Selected Grants


PROSPERO AZ Pro00115490

Clinical TrialPrincipal Investigator · Awarded by AstraZeneca AB · 2024 - 2029

Stimulating Access to Research in Residency (StARR) - NHLBI

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2018 - 2028

Duke Program of Training in Pulmonary ReSearch to Promote, Engage and Retain Academic Researchers (PROSPER)

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2022 - 2026

PROSPERO AZ Pro00115490

Clinical TrialPrincipal Investigator · Awarded by AstraZeneca AB · 2024 - 2029

Stimulating Access to Research in Residency (StARR) - NHLBI

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2018 - 2028

Duke Program of Training in Pulmonary ReSearch to Promote, Engage and Retain Academic Researchers (PROSPER)

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2022 - 2026

Coping with Asthma through Life Management (CALM)

ResearchMentor · Awarded by National Institutes of Health · 2021 - 2026

Post-Tuberculosis Lung Disease: Clinical Phenotypes and Barriers to Treatment

ResearchMentor · Awarded by Parker B. Francis Foundation · 2023 - 2026

Mechanisms of Nanoparticle Modulation of Allergen-Induced Lung Disease

ResearchCo-Principal Investigator · Awarded by North Carolina State University · 2021 - 2026

Regeneron SANOFI Study Dupilumab IL-13Ra2 Signaling

Clinical TrialPrincipal Investigator · Awarded by Regeneron Pharmaceuticals, Inc. · 2022 - 2025

Oxidative Stress and Regional Airway Remodeling and Fibrosis in Obese Asthma

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2020 - 2025

The Role of PON2 in the Development of Non-Allergic Asthma in Obesity

FellowshipPrincipal Investigator · Awarded by National Institutes of Health · 2022 - 2024

Peep Mask study

Clinical TrialPrincipal Investigator · Awarded by ProspAir,LLC · 2021 - 2024

American Lung Association-Airways Clinical Research Center-Lung Health Cohort (ALA-LHC)

ResearchPrincipal Investigator · Awarded by American Lung Association · 2020 - 2024

American Lung Association Airways Clinical Research Centers Network

ResearchPrincipal Investigator · Awarded by American Lung Association · 2016 - 2024

RofLumilast or Azithromycin to preveNt COPD Exacerbations (RELIANCE)

ResearchCo Investigator · Awarded by University of Illinois at Chicago · 2017 - 2024

Asthma and Technology in Emerging African American Adults

ResearchPrincipal Investigator · Awarded by University of Michigan · 2023 - 2023

Clinical Phenotypes of Chronic Lung Disease and Associated Clinical Implications in Kenya

ResearchMentor · Awarded by University of Arizona · 2023 - 2023

R01: CXCL10/CXCR3 regulation of ozone-induced epithelial permeability

ResearchCo Investigator · Awarded by National Institutes of Health · 2017 - 2023

VTEU Task Order 22 16-0058 - Cost to Complete

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2021 - 2023

Mitochondrial Redox Perturbations in Obese Allergic Asthma

Clinical TrialPrincipal Investigator · Awarded by University of Vermont · 2022 - 2023

VTEU TO #132 Base - Task Area A - FY.2020.A1B1C1D1.0123 - Option 2.A

ResearchInvestigator · Awarded by National Institutes of Health · 2021 - 2023

A Randomized Phase II Clinical Trial of L-Citrulline to Improve Asthma Control in Obese Late Onset Asthma

Clinical TrialPrincipal Investigator · Awarded by University of Colorado - Denver · 2019 - 2023

American Lung Association (ALA) Novel Digital Diary (ANDDI) Trial

Clinical TrialPrincipal Investigator · Awarded by American Lung Association · 2019 - 2023

Trial of Roflumilast in Asthma Management (TRIM)

Clinical TrialPrincipal Investigator · Awarded by American Lung Association · 2018 - 2023

Mechanisms that Direct Airway Remodeling in Obese Asthma

ResearchCo Investigator · Awarded by National Institutes of Health · 2017 - 2023

VTEU Task Order 16-0058.B1C1D1.0076 - Task D

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2017 - 2022

Task Area B-D Task Order 16-0058.B1C1D1.0076

ResearchCo-Principal Investigator · Awarded by National Institutes of Health · 2017 - 2022

Pilot: Zinc Acetate to Treat Chronic Refractory Cough (ZICO)

Clinical TrialPrincipal Investigator · Awarded by American Lung Association · 2017 - 2022

Asthma BMI Baseline Study (ABBS)

Clinical TrialPrincipal Investigator · Awarded by American Lung Association · 2018 - 2021

Interdisciplinary Training Program in Lung Disease

Inst. Training Prgm or CMEPreceptor · Awarded by National Institutes of Health · 2009 - 2021

Modulation of Asthma by GSNO-based Therapies

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2013 - 2018

Diesel-induced Alterations of Influenza Infectivity

ResearchSignificant Contributor · Awarded by University of North Carolina - Chapel Hill · 2015 - 2017

Surfactant Protein-A regulation of eosinophil apoptosis in asthma

ResearchPrincipal Investigator · Awarded by University of Arizona · 2015 - 2017

HIV and Asthma in the Post- ART Era

ResearchCo Investigator · Awarded by National Institutes of Health · 2014 - 2016

The Duke Multidisciplinary Training Program in Pediatric Lung Disease

Inst. Training Prgm or CMEFaculty Member · Awarded by National Institutes of Health · 2010 - 2016

Clinical Center Core

ResearchCo Investigator · Awarded by University of Arizona · 2009 - 2016

Asthma Clinical Research Center of the American Lung Association

ResearchPrincipal Investigator · Awarded by American Lung Association · 2009 - 2016

I2PP2A and Asthma

ResearchPrincipal Investigator · Awarded by Cognosci, Inc. · 2014 - 2015

Diesel-induced Alterations of Influenza Infectivity

ResearchCo Investigator · Awarded by University of North Carolina - Chapel Hill · 2013 - 2014

GSNO Reductase, S-Nitrosothiols, and Asthma

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2007 - 2013

Genetic regulation of O3-induced inflammation in humans

ResearchCo Investigator · Awarded by National Institutes of Health · 2000 - 2007

Modulation of NO with Pulmonary Gene Transfer

ResearchPrincipal Investigator · Awarded by National Institutes of Health · 2000 - 2006

External Relationships


  • American Lung Association
  • Amgen, Inc.
  • AstraZeneca
  • Merck
  • NIH
  • American Lung Association
  • Amgen, Inc.
  • AstraZeneca
  • Merck
  • NIH
  • Robling Medical
  • Sanofi and Regeneron Pharmaceuticals
  • Zambon SpA

This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.