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A family of conserved bacterial effectors inhibits salicylic acid-mediated basal immunity and promotes disease necrosis in plants.

Publication ,  Journal Article
DebRoy, S; Thilmony, R; Kwack, Y-B; Nomura, K; He, SY
Published in: Proceedings of the National Academy of Sciences of the United States of America
June 2004

Salicylic acid (SA)-mediated host immunity plays a central role in combating microbial pathogens in plants. Inactivation of SA-mediated immunity, therefore, would be a critical step in the evolution of a successful plant pathogen. It is known that mutations in conserved effector loci (CEL) in the plant pathogens Pseudomonas syringae (the Delta CEL mutation), Erwinia amylovora (the dspA/E mutation), and Pantoea stewartii subsp. stewartii (the wtsE mutation) exert particularly strong negative effects on bacterial virulence in their host plants by unknown mechanisms. We found that the loss of virulence in Delta CEL and dspA/E mutants was linked to their inability to suppress cell wall-based defenses and to cause normal disease necrosis in Arabidopsis and apple host plants. The Delta CEL mutant activated SA-dependent callose deposition in wild-type Arabidopsis but failed to elicit high levels of callose-associated defense in Arabidopsis plants blocked in SA accumulation or synthesis. This mutant also multiplied more aggressively in SA-deficient plants than in wild-type plants. The hopPtoM and avrE genes in the CEL of P. syringae were found to encode suppressors of this SA-dependent basal defense. The widespread conservation of the HopPtoM and AvrE families of effectors in various bacteria suggests that suppression of SA-dependent basal immunity and promotion of host cell death are important virulence strategies for bacterial infection of plants.

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Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

June 2004

Volume

101

Issue

26

Start / End Page

9927 / 9932

Related Subject Headings

  • Virulence
  • Salicylic Acid
  • Pseudomonas syringae
  • Plant Diseases
  • Pantoea
  • Necrosis
  • Mutation
  • Models, Biological
  • Malus
  • MAP Kinase Signaling System
 

Citation

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DebRoy, S., Thilmony, R., Kwack, Y.-B., Nomura, K., & He, S. Y. (2004). A family of conserved bacterial effectors inhibits salicylic acid-mediated basal immunity and promotes disease necrosis in plants. Proceedings of the National Academy of Sciences of the United States of America, 101(26), 9927–9932. https://doi.org/10.1073/pnas.0401601101
DebRoy, Sruti, Roger Thilmony, Yong-Bum Kwack, Kinya Nomura, and Sheng Yang He. “A family of conserved bacterial effectors inhibits salicylic acid-mediated basal immunity and promotes disease necrosis in plants.Proceedings of the National Academy of Sciences of the United States of America 101, no. 26 (June 2004): 9927–32. https://doi.org/10.1073/pnas.0401601101.
DebRoy S, Thilmony R, Kwack Y-B, Nomura K, He SY. A family of conserved bacterial effectors inhibits salicylic acid-mediated basal immunity and promotes disease necrosis in plants. Proceedings of the National Academy of Sciences of the United States of America. 2004 Jun;101(26):9927–32.
DebRoy, Sruti, et al. “A family of conserved bacterial effectors inhibits salicylic acid-mediated basal immunity and promotes disease necrosis in plants.Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 26, June 2004, pp. 9927–32. Epmc, doi:10.1073/pnas.0401601101.
DebRoy S, Thilmony R, Kwack Y-B, Nomura K, He SY. A family of conserved bacterial effectors inhibits salicylic acid-mediated basal immunity and promotes disease necrosis in plants. Proceedings of the National Academy of Sciences of the United States of America. 2004 Jun;101(26):9927–9932.
Journal cover image

Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

June 2004

Volume

101

Issue

26

Start / End Page

9927 / 9932

Related Subject Headings

  • Virulence
  • Salicylic Acid
  • Pseudomonas syringae
  • Plant Diseases
  • Pantoea
  • Necrosis
  • Mutation
  • Models, Biological
  • Malus
  • MAP Kinase Signaling System