A bacterial virulence protein suppresses host innate immunity to cause plant disease.
Published
Journal Article
Plants have evolved a powerful immune system to defend against infection by most microbial organisms. However, successful pathogens, such as Pseudomonas syringae, have developed countermeasures and inject virulence proteins into the host plant cell to suppress immunity and cause devastating diseases. Despite intensive research efforts, the molecular targets of bacterial virulence proteins that are important for plant disease development have remained obscure. Here, we show that a conserved P. syringae virulence protein, HopM1, targets an immunity-associated protein, AtMIN7, in Arabidopsis thaliana. HopM1 mediates the destruction of AtMIN7 via the host proteasome. Our results illustrate a strategy by which a bacterial pathogen exploits the host proteasome to subvert host immunity and causes infection in plants.
Full Text
Duke Authors
Cited Authors
- Nomura, K; Debroy, S; Lee, YH; Pumplin, N; Jones, J; He, SY
Published Date
- July 2006
Published In
Volume / Issue
- 313 / 5784
Start / End Page
- 220 - 223
PubMed ID
- 16840699
Pubmed Central ID
- 16840699
Electronic International Standard Serial Number (EISSN)
- 1095-9203
International Standard Serial Number (ISSN)
- 0036-8075
Digital Object Identifier (DOI)
- 10.1126/science.1129523
Language
- eng