A bacterial virulence protein suppresses host innate immunity to cause plant disease.

Journal Article (Journal Article)

Plants have evolved a powerful immune system to defend against infection by most microbial organisms. However, successful pathogens, such as Pseudomonas syringae, have developed countermeasures and inject virulence proteins into the host plant cell to suppress immunity and cause devastating diseases. Despite intensive research efforts, the molecular targets of bacterial virulence proteins that are important for plant disease development have remained obscure. Here, we show that a conserved P. syringae virulence protein, HopM1, targets an immunity-associated protein, AtMIN7, in Arabidopsis thaliana. HopM1 mediates the destruction of AtMIN7 via the host proteasome. Our results illustrate a strategy by which a bacterial pathogen exploits the host proteasome to subvert host immunity and causes infection in plants.

Full Text

Duke Authors

Cited Authors

  • Nomura, K; Debroy, S; Lee, YH; Pumplin, N; Jones, J; He, SY

Published Date

  • July 2006

Published In

Volume / Issue

  • 313 / 5784

Start / End Page

  • 220 - 223

PubMed ID

  • 16840699

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

International Standard Serial Number (ISSN)

  • 0036-8075

Digital Object Identifier (DOI)

  • 10.1126/science.1129523


  • eng