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Examining the heterogeneity inexcess risks of coronary heart disease, stroke, dialysis, and lower extremity amputation associated with type 2 diabetes mellitus across demographic subgroups in an Asian population: A population-based matched cohort study.

Publication ,  Journal Article
Lim, KK; Lee, VSY; Tan, CS; Kwan, YH; Lim, ZHX; Wee, HL; Østbye, T; Low, LL
Published in: Diabetes Res Clin Pract
January 2021

AIMS: To examine whether the excess risks of coronary heart disease (CHD), stroke, dialysis, and lower extremity amputation (LEA) associated with type 2 diabetes mellitus (T2DM) differ across age, sex, and ethnicity in Singapore. METHODS: Using a 10-year administrative data, we matched individuals with T2DM using nearest neighbour matching, to those without, in 1:2 ratio. To examine whether the excess risks were heterogeneous across age, sex, and ethnicity, we generated interaction terms of age, sex, and ethnicity with T2DM status in Cox proportional hazard (PH) models. RESULTS: The main analyses included ~1 million person years, comprising 66,099 and 120,485 individuals with and without T2DM, respectively. The associations of T2DM with CHD and dialysis, split into two time periods to address violation of PH assumption, were higher with older age in short-term but lower with older age in long-term. The association of T2DM with stroke and LEA were lower with older age. The associations of T2DM with CHD and stroke were also consistently higher in women than men. The associations of T2DM with LEA were higher in ethnic Malays than ethnic Chinese. CONCLUSIONS: The excess risks of CHD, stroke, dialysis, and LEA associated with T2DM were heterogeneous across some demographic subgroups.

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Published In

Diabetes Res Clin Pract

DOI

EISSN

1872-8227

Publication Date

January 2021

Volume

171

Start / End Page

108551

Location

Ireland

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Renal Dialysis
  • Middle Aged
  • Male
  • Lower Extremity
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Diabetes Mellitus, Type 2
 

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Lim, K. K., Lee, V. S. Y., Tan, C. S., Kwan, Y. H., Lim, Z. H. X., Wee, H. L., … Low, L. L. (2021). Examining the heterogeneity inexcess risks of coronary heart disease, stroke, dialysis, and lower extremity amputation associated with type 2 diabetes mellitus across demographic subgroups in an Asian population: A population-based matched cohort study. Diabetes Res Clin Pract, 171, 108551. https://doi.org/10.1016/j.diabres.2020.108551
Lim, Ka Keat, Vivian Shu Yi Lee, Chuen Seng Tan, Yu Heng Kwan, Zoey Hui Xian Lim, Hwee Lin Wee, Truls Østbye, and Lian Leng Low. “Examining the heterogeneity inexcess risks of coronary heart disease, stroke, dialysis, and lower extremity amputation associated with type 2 diabetes mellitus across demographic subgroups in an Asian population: A population-based matched cohort study.Diabetes Res Clin Pract 171 (January 2021): 108551. https://doi.org/10.1016/j.diabres.2020.108551.
Journal cover image

Published In

Diabetes Res Clin Pract

DOI

EISSN

1872-8227

Publication Date

January 2021

Volume

171

Start / End Page

108551

Location

Ireland

Related Subject Headings

  • Young Adult
  • Risk Factors
  • Renal Dialysis
  • Middle Aged
  • Male
  • Lower Extremity
  • Humans
  • Female
  • Endocrinology & Metabolism
  • Diabetes Mellitus, Type 2