Diversity and Convergence of Sodium Channel Mutations Involved in Resistance to Pyrethroids.

Journal Article (Journal Article)

Pyrethroid insecticides target voltage-gated sodium channels, which are critical for electrical signaling in the nervous system. The intensive use of pyrethroids in controlling arthropod pests and disease vectors has led to many instances of pyrethroid resistance around the globe. In the past two decades, studies have identified a large number of sodium channel mutations that are associated with resistance to pyrethroids. The purpose of this review is to summarize both common and unique sodium channel mutations that have been identified in arthropod pests of importance to agriculture or human health. Identification of these mutations provides valuable molecular markers for resistance monitoring in the field and helped the discovery of the elusive pyrethroid receptor site(s) on the sodium channel.

Full Text

Duke Authors

Cited Authors

  • Rinkevich, FD; Du, Y; Dong, K

Published Date

  • July 2013

Published In

Volume / Issue

  • 106 / 3

Start / End Page

  • 93 - 100

PubMed ID

  • 24019556

Pubmed Central ID

  • PMC3765034

Electronic International Standard Serial Number (EISSN)

  • 1095-9939

International Standard Serial Number (ISSN)

  • 0048-3575

Digital Object Identifier (DOI)

  • 10.1016/j.pestbp.2013.02.007


  • eng