Mechanism of action of sodium channel blocker insecticides (SCBIs) on insect sodium channels.

Journal Article (Journal Article)

Sodium channel blocker insecticides (SCBIs) are a relatively new class of insecticides, with a mechanism of action different from those of other classes of insecticides that target voltage-gated sodium channels. These compounds have no effect at hyperpolarized membrane potentials, but cause a voltage-dependent, nearly irreversible block as the membrane potential is depolarized. The mechanism of action of SCBIs is similar to that of local anesthetics (LAs), class I anticonvulsants and class I antiarrhythmics. In this article, we review the physiological actions of these compounds on the whole animal, the nervous system and sodium channels, and also present the results from recent studies that elucidate the receptor site of SCBIs.

Full Text

Duke Authors

Cited Authors

  • Silver, KS; Song, W; Nomura, Y; Salgado, VL; Dong, K

Published Date

  • June 2010

Published In

Volume / Issue

  • 97 / 2

Start / End Page

  • 87 - 92

PubMed ID

  • 24013950

Pubmed Central ID

  • PMC3765036

Electronic International Standard Serial Number (EISSN)

  • 1095-9939

International Standard Serial Number (ISSN)

  • 0048-3575

Digital Object Identifier (DOI)

  • 10.1016/j.pestbp.2009.09.001


  • eng