A voltage-gated calcium-selective channel encoded by a sodium channel-like gene.

Journal Article (Journal Article)

BSC1, which was originally identified by its sequence similarity to voltage-gated Na(+) channels, encodes a functional voltage-gated cation channel whose properties differ significantly from Na(+) channels. BSC1 has slower kinetics of activation and inactivation than Na(+) channels, it is more selective for Ba(2+) than for Na(+), it is blocked by Cd(2+), and Na(+) currents through BSC1 are blocked by low concentrations of Ca(2+). All of these properties are more similar to voltage-gated Ca(2+) channels than to voltage-gated Na(+) channels. The selectivity for Ba(2+) is partially due to the presence of a glutamate in the pore-forming region of domain III, since replacing that residue with lysine (normally present in voltage-gated Na(+) channels) makes the channel more selective for Na(+). BSC1 appears to be the prototype of a novel family of invertebrate voltage-dependent cation channels with a close structural and evolutionary relationship to voltage-gated Na(+) and Ca(2+) channels.

Full Text

Duke Authors

Cited Authors

  • Zhou, W; Chung, I; Liu, Z; Goldin, AL; Dong, K

Published Date

  • April 2004

Published In

Volume / Issue

  • 42 / 1

Start / End Page

  • 101 - 112

PubMed ID

  • 15066268

Pubmed Central ID

  • PMC3065994

Electronic International Standard Serial Number (EISSN)

  • 1097-4199

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/s0896-6273(04)00148-5

Language

  • eng