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Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis.

Publication ,  Journal Article
Andreone, BJ; Chow, BW; Tata, A; Lacoste, B; Ben-Zvi, A; Bullock, K; Deik, AA; Ginty, DD; Clish, CB; Gu, C
Published in: Neuron
May 3, 2017

The blood-brain barrier (BBB) provides a constant homeostatic brain environment that is essential for proper neural function. An unusually low rate of vesicular transport (transcytosis) has been identified as one of the two unique properties of CNS endothelial cells, relative to peripheral endothelial cells, that maintain the restrictive quality of the BBB. However, it is not known how this low rate of transcytosis is achieved. Here we provide a mechanism whereby the regulation of CNS endothelial cell lipid composition specifically inhibits the caveolae-mediated transcytotic route readily used in the periphery. An unbiased lipidomic analysis reveals significant differences in endothelial cell lipid signatures from the CNS and periphery, which underlie a suppression of caveolae vesicle formation and trafficking in brain endothelial cells. Furthermore, lipids transported by Mfsd2a establish a unique lipid environment that inhibits caveolae vesicle formation in CNS endothelial cells to suppress transcytosis and ensure BBB integrity.

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Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

May 3, 2017

Volume

94

Issue

3

Start / End Page

581 / 594.e5

Location

United States

Related Subject Headings

  • Transcytosis
  • Symporters
  • Permeability
  • Neurology & Neurosurgery
  • Microscopy, Electron, Transmission
  • Microscopy, Confocal
  • Mice, Knockout
  • Mice
  • Membrane Transport Proteins
  • Lipid Metabolism
 

Citation

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Andreone, B. J., Chow, B. W., Tata, A., Lacoste, B., Ben-Zvi, A., Bullock, K., … Gu, C. (2017). Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. Neuron, 94(3), 581-594.e5. https://doi.org/10.1016/j.neuron.2017.03.043
Andreone, Benjamin J., Brian Wai Chow, Aleksandra Tata, Baptiste Lacoste, Ayal Ben-Zvi, Kevin Bullock, Amy A. Deik, David D. Ginty, Clary B. Clish, and Chenghua Gu. “Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis.Neuron 94, no. 3 (May 3, 2017): 581-594.e5. https://doi.org/10.1016/j.neuron.2017.03.043.
Andreone BJ, Chow BW, Tata A, Lacoste B, Ben-Zvi A, Bullock K, et al. Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. Neuron. 2017 May 3;94(3):581-594.e5.
Andreone, Benjamin J., et al. “Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis.Neuron, vol. 94, no. 3, May 2017, pp. 581-594.e5. Pubmed, doi:10.1016/j.neuron.2017.03.043.
Andreone BJ, Chow BW, Tata A, Lacoste B, Ben-Zvi A, Bullock K, Deik AA, Ginty DD, Clish CB, Gu C. Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. Neuron. 2017 May 3;94(3):581-594.e5.
Journal cover image

Published In

Neuron

DOI

EISSN

1097-4199

Publication Date

May 3, 2017

Volume

94

Issue

3

Start / End Page

581 / 594.e5

Location

United States

Related Subject Headings

  • Transcytosis
  • Symporters
  • Permeability
  • Neurology & Neurosurgery
  • Microscopy, Electron, Transmission
  • Microscopy, Confocal
  • Mice, Knockout
  • Mice
  • Membrane Transport Proteins
  • Lipid Metabolism