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The Wnt/JNK signaling target gene alcam is required for embryonic kidney development.

Publication ,  Journal Article
Cizelsky, W; Tata, A; Kühl, M; Kühl, SJ
Published in: Development
May 2014

Proper development of nephrons is essential for kidney function. β-Catenin-independent Wnt signaling through Fzd8, Inversin, Daam1, RhoA and Myosin is required for nephric tubule morphogenesis. Here, we provide a novel mechanism through which non-canonical Wnt signaling contributes to tubular development. Using Xenopus laevis as a model system, we found that the cell-adhesion molecule Alcam is required for proper nephrogenesis and functions downstream of Fzd3 during embryonic kidney development. We found alcam expression to be independent of Fzd8 or Inversin, but to be transcriptionally regulated by the β-Catenin-independent Wnt/JNK pathway involving ATF2 and Pax2 in a direct manner. These novel findings indicate that several branches of Wnt signaling are independently required for proximal tubule development. Moreover, our data indicate that regulation of morphogenesis by non-canonical Wnt ligands also involves direct transcriptional responses in addition to the effects on a post-translational level.

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Published In

Development

DOI

EISSN

1477-9129

Publication Date

May 2014

Volume

141

Issue

10

Start / End Page

2064 / 2074

Location

England

Related Subject Headings

  • Xenopus laevis
  • Xenopus Proteins
  • Wnt Signaling Pathway
  • Response Elements
  • Pronephros
  • PAX2 Transcription Factor
  • MAP Kinase Signaling System
  • Kidney
  • Gene Expression Regulation, Developmental
  • Frizzled Receptors
 

Citation

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Cizelsky, W., Tata, A., Kühl, M., & Kühl, S. J. (2014). The Wnt/JNK signaling target gene alcam is required for embryonic kidney development. Development, 141(10), 2064–2074. https://doi.org/10.1242/dev.107938
Cizelsky, Wiebke, Aleksandra Tata, Michael Kühl, and Susanne J. Kühl. “The Wnt/JNK signaling target gene alcam is required for embryonic kidney development.Development 141, no. 10 (May 2014): 2064–74. https://doi.org/10.1242/dev.107938.
Cizelsky W, Tata A, Kühl M, Kühl SJ. The Wnt/JNK signaling target gene alcam is required for embryonic kidney development. Development. 2014 May;141(10):2064–74.
Cizelsky, Wiebke, et al. “The Wnt/JNK signaling target gene alcam is required for embryonic kidney development.Development, vol. 141, no. 10, May 2014, pp. 2064–74. Pubmed, doi:10.1242/dev.107938.
Cizelsky W, Tata A, Kühl M, Kühl SJ. The Wnt/JNK signaling target gene alcam is required for embryonic kidney development. Development. 2014 May;141(10):2064–2074.
Journal cover image

Published In

Development

DOI

EISSN

1477-9129

Publication Date

May 2014

Volume

141

Issue

10

Start / End Page

2064 / 2074

Location

England

Related Subject Headings

  • Xenopus laevis
  • Xenopus Proteins
  • Wnt Signaling Pathway
  • Response Elements
  • Pronephros
  • PAX2 Transcription Factor
  • MAP Kinase Signaling System
  • Kidney
  • Gene Expression Regulation, Developmental
  • Frizzled Receptors