TRPing into excitotoxic neuronal death.

Journal Article (Journal Article)

It is a striking paradox that the activation of NMDA-type glutamate receptors (NMDARs) can both promote neuronal survival and induce excitotoxic cell death. Yet the molecular mechanisms that distinguish these cellular consequences have remained obscure. A recent study by Yan et al. (2020) reveals a novel interaction between NMDARs and TRPM4 that is required for NMDAR-induced neuronal death. Small molecule disruption of this interaction reduces excitotoxicity in stroke without blocking physiological NMDAR signaling.

Full Text

Duke Authors

Cited Authors

  • Green, MV; West, AE

Published Date

  • January 2021

Published In

Volume / Issue

  • 93 /

Start / End Page

  • 102331 -

PubMed ID

  • 33341523

Electronic International Standard Serial Number (EISSN)

  • 1532-1991

Digital Object Identifier (DOI)

  • 10.1016/j.ceca.2020.102331

Language

  • eng

Conference Location

  • Netherlands