TRPing into excitotoxic neuronal death.
Journal Article (Journal Article)
It is a striking paradox that the activation of NMDA-type glutamate receptors (NMDARs) can both promote neuronal survival and induce excitotoxic cell death. Yet the molecular mechanisms that distinguish these cellular consequences have remained obscure. A recent study by Yan et al. (2020) reveals a novel interaction between NMDARs and TRPM4 that is required for NMDAR-induced neuronal death. Small molecule disruption of this interaction reduces excitotoxicity in stroke without blocking physiological NMDAR signaling.
Full Text
Duke Authors
Cited Authors
- Green, MV; West, AE
Published Date
- January 2021
Published In
Volume / Issue
- 93 /
Start / End Page
- 102331 -
PubMed ID
- 33341523
Electronic International Standard Serial Number (EISSN)
- 1532-1991
Digital Object Identifier (DOI)
- 10.1016/j.ceca.2020.102331
Language
- eng
Conference Location
- Netherlands