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A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart.

Publication ,  Journal Article
Tang, J; Vandergriff, A; Wang, Z; Hensley, MT; Cores, J; Allen, TA; Dinh, P-U; Zhang, J; Caranasos, TG; Cheng, K
Published in: Tissue Eng Part C Methods
March 2017

Layering a regenerative polymer scaffold on the surface of the heart, termed as a cardiac patch, has been proven to be effective in preserving cardiac function after myocardial infarction (MI). However, the placement of such a patch on the heart usually needs open-chest surgery, which is traumatic, therefore prevents the translation of this strategy into the clinic. We sought to device a way to apply a cardiac patch by spray painting in situ polymerizable biomaterials onto the heart with a minimally invasive procedure. To prove the concept, we used platelet fibrin gel as the "paint" material in a mouse model of MI. The use of the spraying system allowed for placement of a uniform cardiac patch on the heart in a mini-invasive manner without the need for sutures or glue. The spray treatment promoted cardiac repair and attenuated cardiac dysfunction after MI.

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Published In

Tissue Eng Part C Methods

DOI

EISSN

1937-3392

Publication Date

March 2017

Volume

23

Issue

3

Start / End Page

146 / 155

Location

United States

Related Subject Headings

  • Regeneration
  • Rats, Sprague-Dawley
  • Rats
  • Paintings
  • Myocytes, Cardiac
  • Myocardial Infarction
  • Mice
  • Male
  • Heart
  • Fibrin
 

Citation

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ICMJE
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Tang, J., Vandergriff, A., Wang, Z., Hensley, M. T., Cores, J., Allen, T. A., … Cheng, K. (2017). A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart. Tissue Eng Part C Methods, 23(3), 146–155. https://doi.org/10.1089/ten.TEC.2016.0492
Tang, Junnan, Adam Vandergriff, Zegen Wang, Michael Taylor Hensley, Jhon Cores, Tyler A. Allen, Phuong-Uyen Dinh, Jinying Zhang, Thomas George Caranasos, and Ke Cheng. “A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart.Tissue Eng Part C Methods 23, no. 3 (March 2017): 146–55. https://doi.org/10.1089/ten.TEC.2016.0492.
Tang J, Vandergriff A, Wang Z, Hensley MT, Cores J, Allen TA, et al. A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart. Tissue Eng Part C Methods. 2017 Mar;23(3):146–55.
Tang, Junnan, et al. “A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart.Tissue Eng Part C Methods, vol. 23, no. 3, Mar. 2017, pp. 146–55. Pubmed, doi:10.1089/ten.TEC.2016.0492.
Tang J, Vandergriff A, Wang Z, Hensley MT, Cores J, Allen TA, Dinh P-U, Zhang J, Caranasos TG, Cheng K. A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart. Tissue Eng Part C Methods. 2017 Mar;23(3):146–155.

Published In

Tissue Eng Part C Methods

DOI

EISSN

1937-3392

Publication Date

March 2017

Volume

23

Issue

3

Start / End Page

146 / 155

Location

United States

Related Subject Headings

  • Regeneration
  • Rats, Sprague-Dawley
  • Rats
  • Paintings
  • Myocytes, Cardiac
  • Myocardial Infarction
  • Mice
  • Male
  • Heart
  • Fibrin