A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart.

Journal Article (Journal Article)

Layering a regenerative polymer scaffold on the surface of the heart, termed as a cardiac patch, has been proven to be effective in preserving cardiac function after myocardial infarction (MI). However, the placement of such a patch on the heart usually needs open-chest surgery, which is traumatic, therefore prevents the translation of this strategy into the clinic. We sought to device a way to apply a cardiac patch by spray painting in situ polymerizable biomaterials onto the heart with a minimally invasive procedure. To prove the concept, we used platelet fibrin gel as the "paint" material in a mouse model of MI. The use of the spraying system allowed for placement of a uniform cardiac patch on the heart in a mini-invasive manner without the need for sutures or glue. The spray treatment promoted cardiac repair and attenuated cardiac dysfunction after MI.

Full Text

Duke Authors

Cited Authors

  • Tang, J; Vandergriff, A; Wang, Z; Hensley, MT; Cores, J; Allen, TA; Dinh, P-U; Zhang, J; Caranasos, TG; Cheng, K

Published Date

  • March 2017

Published In

Volume / Issue

  • 23 / 3

Start / End Page

  • 146 - 155

PubMed ID

  • 28068869

Pubmed Central ID

  • PMC5367912

Electronic International Standard Serial Number (EISSN)

  • 1937-3392

International Standard Serial Number (ISSN)

  • 1937-3384

Digital Object Identifier (DOI)

  • 10.1089/ten.tec.2016.0492

Language

  • eng