Evaluating Alzheimer Disease With Flortaucipir and Florbetapir PET: A Clinical Case Series.

Journal Article (Journal Article)

Early, accurate diagnosis of Alzheimer disease (AD) is essential but remains challenging. Neuropathological hallmarks of AD are β-amyloid neuritic plaques and tau protein neurofibrillary tangles. 18F-Florbetapir is one of several available PET tracers for imaging cortical fibrillary β-amyloid plaques. 18F-Flortaucipir PET was recently approved for evaluating the distribution and density of aggregated neurofibrillary tangles. We present cases of mild cognitive impairment or suspected AD to depict the nuances of flortaucipir distribution and scan interpretation as well as how combined information from amyloid and tau PET may help with differential diagnosis and prognosis.

Full Text

Duke Authors

Cited Authors

  • James, OG; Linares, AR; Hellegers, C; Doraiswamy, PM; Wong, TZ

Published Date

  • July 1, 2021

Published In

Volume / Issue

  • 46 / 7

Start / End Page

  • 605 - 608

PubMed ID

  • 33443955

Electronic International Standard Serial Number (EISSN)

  • 1536-0229

Digital Object Identifier (DOI)

  • 10.1097/RLU.0000000000003493


  • eng

Conference Location

  • United States