This dataset was generated from 16 primary and matched recurrent ovarian cancer tissue sets from patients with stage III/IV serous epithelial ovarian cancer who were treated at Duke University Medical Center in Durham, North Carolina. The primary tumor specimens were collected at the time of initial debulking surgery. Recurrent tumor samples were obtained from the same patients during "second-look" surgeries. Samples were obtained and data was generated after patients provided written informed consent under protocols approved by the Duke University Institutional Review Board. Tumor specimens were stored at -80ºC until nucleic acid extraction.