The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets.

Journal Article (Journal Article)

The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the receptor Fzd9, previously identified as a Myc transcriptional target, impairs sustained tumor expansion and β-cell dedifferentiation in a mouse model of Myc-driven insulinoma, allows pancreatic islets to maintain their physiological structure and affects Myc-related global gene expression. Importantly, Wnt signaling inhibition in Fzd9-competent mice largely recapitulates the suppression of proliferation caused by Fzd9 deficiency upon Myc activation. Together, our results indicate that the Wnt signaling receptor Fzd9 is essential for Myc-induced tumorigenesis in pancreatic islets.

Full Text

Duke Authors

Cited Authors

  • Zacarías-Fluck, MF; Jauset, T; Martínez-Martín, S; Kaur, J; Casacuberta-Serra, S; Massó-Vallés, D; Serrano Del Pozo, E; Martín-Fernández, G; González-Larreategui, Í; López-Estévez, S; Brown-Swigart, L; Beaulieu, M-E; Whitfield, JR; Madan, B; Virshup, DM; Evan, GI; Soucek, L

Published Date

  • May 1, 2021

Published In

Volume / Issue

  • 4 / 5

PubMed ID

  • 33653688

Pubmed Central ID

  • PMC8008953

Electronic International Standard Serial Number (EISSN)

  • 2575-1077

Digital Object Identifier (DOI)

  • 10.26508/lsa.201900490

Language

  • eng

Conference Location

  • United States