The Wnt signaling receptor Fzd9 is essential for Myc-driven tumorigenesis in pancreatic islets.
Journal Article (Journal Article)
The huge cadre of genes regulated by Myc has obstructed the identification of critical effectors that are essential for Myc-driven tumorigenesis. Here, we describe how only the lack of the receptor Fzd9, previously identified as a Myc transcriptional target, impairs sustained tumor expansion and β-cell dedifferentiation in a mouse model of Myc-driven insulinoma, allows pancreatic islets to maintain their physiological structure and affects Myc-related global gene expression. Importantly, Wnt signaling inhibition in Fzd9-competent mice largely recapitulates the suppression of proliferation caused by Fzd9 deficiency upon Myc activation. Together, our results indicate that the Wnt signaling receptor Fzd9 is essential for Myc-induced tumorigenesis in pancreatic islets.
Full Text
Duke Authors
Cited Authors
- Zacarías-Fluck, MF; Jauset, T; Martínez-Martín, S; Kaur, J; Casacuberta-Serra, S; Massó-Vallés, D; Serrano Del Pozo, E; Martín-Fernández, G; González-Larreategui, Í; López-Estévez, S; Brown-Swigart, L; Beaulieu, M-E; Whitfield, JR; Madan, B; Virshup, DM; Evan, GI; Soucek, L
Published Date
- May 1, 2021
Published In
Volume / Issue
- 4 / 5
PubMed ID
- 33653688
Pubmed Central ID
- PMC8008953
Electronic International Standard Serial Number (EISSN)
- 2575-1077
Digital Object Identifier (DOI)
- 10.26508/lsa.201900490
Language
- eng
Conference Location
- United States