Scholars@Duke

• Background
• 

  Education, Training, & Certifications

  • Hem/Onc Clinical Fellowship, Pediatric, Johns Hopkins University 1984 - 1985
  • Pediatric Internship & Residency, Pediatrics, Johns Hopkins University 1981 - 1984
  • M.D., Johns Hopkins University 1981
• 

  Duke Appointment History

  • Instructor, Temporary in the Department of Pediatrics, Pediatrics, Clinical Science Departments 2007
• Recognition
• 

  In the News

  • NOV 19, 2013

    Meet the Duke-NUS Faculty: David Virshup
• Research
• 

  External Relationships

  • Experimental Therapeutics Centre Singapore, renamed the Experimental Drug Development Centre
• Publications & Artistic Works
• 

  Selected Publications

  • Academic Articles

    • Zhong, Zheng, Jia Yu, David M. Virshup, and Babita Madan. “Wnts and the hallmarks of cancer.” Cancer Metastasis Rev 39, no. 3 (September 2020): 625–45. https://doi.org/10.1007/s10555-020-09887-6.
       Full Text  Link to Item
    • Masuda, Shusaku, Rajesh Narasimamurthy, Hikari Yoshitane, Jae Kyoung Kim, Yoshitaka Fukada, and David M. Virshup. “Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch.” Proc Natl Acad Sci U S A 117, no. 20 (May 19, 2020): 10888–96. https://doi.org/10.1073/pnas.2000266117.
       Full Text  Link to Item
    • Yu, Jia, Permeen Akhtar Bt Mohamed Yuso, Pamela Goh, Nathan Harmston, David Epstein, David Virshup, and Babita Madan. “The functional landscape of patient derived RNF43 mutations predicts Wnt inhibitor sensitivity,” March 25, 2020. https://doi.org/10.1101/2020.03.25.006999.
       Full Text
    • Liu, Shiyang, Nathan Harmston, Trudy Lee Glaser, Yunka Wong, Zheng Zhong, Babita Madan, David Virshup, and Enrico Petretto. “Wnt-regulated lncRNA discovery enhanced by in vivo identification and CRISPRi functional validation,” February 10, 2020. https://doi.org/10.1101/2020.02.09.941005.
       Full Text
    • Zhong, Zheng, and David M. Virshup. “Wnt Signaling and Drug Resistance in Cancer.” Mol Pharmacol 97, no. 2 (February 2020): 72–89. https://doi.org/10.1124/mol.119.117978.
       Full Text  Link to Item
    • Lee, Kyunghee, Mayumi Kitagawa, Pei Ju Liao, David M. Virshup, and Sang Hyun Lee. “A Ras-LSD1 axis activates PI3K signaling through PIK3IP1 suppression.” Oncogenesis 9, no. 1 (January 2, 2020): 2. https://doi.org/10.1038/s41389-019-0185-4.
       Full Text  Link to Item
    • Masuda, Shusaku, Rajesh Narasimamurthy, Hikari Yoshitane, Jae Kyoung Kim, Yoshitaka Fukada, and David Virshup. “Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch,” December 17, 2019. https://doi.org/10.1101/2019.12.16.876615.
       Full Text
    • Idris, Muhammad, Nathan Harmston, Enrico Petretto, Babita Madan, and David M. Virshup. “Broad regulation of gene isoform expression by Wnt signaling in cancer.” Rna 25, no. 12 (December 2019): 1696–1713. https://doi.org/10.1261/rna.071506.119.
       Full Text  Link to Item
    • Lu, Xiaohan, Nathan P. Rudemiller, Jiafa Ren, Yi Wen, Bo Yang, Robert Griffiths, Jamie R. Privratsky, Babita Madan, David M. Virshup, and Steven D. Crowley. “Opposing actions of renal tubular- and myeloid-derived porcupine in obstruction-induced kidney fibrosis.” Kidney Int 96, no. 6 (December 2019): 1308–19. https://doi.org/10.1016/j.kint.2019.06.020.
       Full Text  Link to Item
    • Zhong, Zheng, Sugunavathi Sepramaniam, Xin Hui Chew, Kris Wood, May Ann Lee, Babita Madan, and David M. Virshup. “PORCN inhibition synergizes with PI3K/mTOR inhibition in Wnt-addicted cancers.” Oncogene 38, no. 40 (October 2019): 6662–77. https://doi.org/10.1038/s41388-019-0908-1.
       Full Text  Link to Item
    • Philpott, Jonathan, Rajesh Narasimamurthy, Clarisse Ricci, Alfred Freeberg, Sabrina Hunt, Lauren Yee, Rebecca Pelofsky, Sarvind Tripathi, David Virshup, and Carrie Partch. “Casein Kinase 1 dynamics underlie the PER2 circadian phosphoswitch,” August 14, 2019. https://doi.org/10.1101/734624.
       Full Text
    • Fadhlullah, Siti Farah Bte, Nurashikin Bte Abdul Halim, Jacqueline Y. T. Yeo, Rachel L. Y. Ho, Phoebe Um, Beng Ti Ang, Carol Tang, Wai H. Ng, David M. Virshup, and Ivy A. W. Ho. “Pathogenic mutations in neurofibromin identifies a leucine-rich domain regulating glioma cell invasiveness.” Oncogene 38, no. 27 (July 2019): 5367–80. https://doi.org/10.1038/s41388-019-0809-3.
       Full Text  Link to Item
    • Greicius, Gediminas, and David M. Virshup. “Stromal control of intestinal development and the stem cell niche.” Differentiation 108 (July 2019): 8–16. https://doi.org/10.1016/j.diff.2019.01.001.
       Full Text  Link to Item
    • Moti, Naushad, Jia Yu, Gaelle Boncompain, Franck Perez, and David M. Virshup. “Wnt traffic from endoplasmic reticulum to filopodia.” Plos One 14, no. 2 (2019): e0212711. https://doi.org/10.1371/journal.pone.0212711.
       Full Text  Link to Item
    • Fu, Nai Yang, Bhupinder Pal, Yunshun Chen, Felicity C. Jackling, Michael Milevskiy, François Vaillant, Bianca D. Capaldo, et al. “Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence.” Dev Cell 47, no. 5 (December 3, 2018): 629-644.e8. https://doi.org/10.1016/j.devcel.2018.10.001.
       Full Text  Link to Item
    • Madan, Babita, Nathan Harmston, Gahyathiri Nallan, Alex Montoya, Peter Faull, Enrico Petretto, and David M. Virshup. “Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axis.” J Clin Invest 128, no. 12 (December 3, 2018): 5620–33. https://doi.org/10.1172/JCI122383.
       Full Text  Link to Item
    • Chee, Yuemin Celina, Jens Pahnke, Ralph Bunte, Vikrant A. Adsool, Babita Madan, and David M. Virshup. “Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche.” Dev Cell 46, no. 6 (September 24, 2018): 681-695.e5. https://doi.org/10.1016/j.devcel.2018.07.023.
       Full Text  Link to Item
    • Kabiri, Zahra, Gediminas Greicius, Hamed Zaribafzadeh, Amanda Hemmerich, Christopher M. Counter, and David M. Virshup. “Wnt signaling suppresses MAPK-driven proliferation of intestinal stem cells.” J Clin Invest 128, no. 9 (August 31, 2018): 3806–12. https://doi.org/10.1172/JCI99325.
       Full Text  Link to Item
    • Mattes, Benjamin, Yonglong Dang, Gediminas Greicius, Lilian Tamara Kaufmann, Benedikt Prunsche, Jakob Rosenbauer, Johannes Stegmaier, et al. “Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates.” Elife 7 (July 31, 2018). https://doi.org/10.7554/eLife.36953.
       Full Text  Link to Item
    • “Correction for Fustin et al., Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock.” Proc Natl Acad Sci U S A 115, no. 27 (July 3, 2018): E6386. https://doi.org/10.1073/pnas.1809838115.
       Full Text  Link to Item
    • Fustin, Jean-Michel, Rika Kojima, Kakeru Itoh, Hsin-Yi Chang, Shiqi Ye, Bowen Zhuang, Asami Oji, et al. “Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock.” Proc Natl Acad Sci U S A 115, no. 23 (June 5, 2018): 5980–85. https://doi.org/10.1073/pnas.1721371115.
       Full Text  Link to Item
    • Narasimamurthy, Rajesh, Sabrina R. Hunt, Yining Lu, Jean-Michel Fustin, Hitoshi Okamura, Carrie L. Partch, Daniel B. Forger, Jae Kyoung Kim, and David M. Virshup. “CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch.” Proc Natl Acad Sci U S A 115, no. 23 (June 5, 2018): 5986–91. https://doi.org/10.1073/pnas.1721076115.
       Full Text  Link to Item
    • Madan, Babita, Nathan Harmston, Gahyathiri Nallan, Alex Montoya, Peter Faull, Enrico Petretto, and David Virshup. “Oncogenic Wnt/STOP signaling regulates ribosome biogenesis in vivo,” May 20, 2018. https://doi.org/10.1101/326819.
       Full Text
    • Moti, Naushad, Jia Yu, Gaelle Boncompain, Franck Perez, and David Virshup. “Visualizing Wnt secretion from Endoplasmic Reticulum to Filopodia,” April 14, 2018. https://doi.org/10.1101/271684.
       Full Text
    • Greicius, Gediminas, Zahra Kabiri, Kristmundur Sigmundsson, Chao Liang, Ralph Bunte, Manvendra K. Singh, and David M. Virshup. “PDGFRα + pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo.” Proc Natl Acad Sci U S A 115, no. 14 (April 3, 2018): E3173–81. https://doi.org/10.1073/pnas.1713510115.
       Full Text  Link to Item
    • Lee, Ha Yin, Yoko Itahana, Stefan Schuechner, Masahiro Fukuda, H Shawn Je, Egon Ogris, David M. Virshup, and Koji Itahana. “Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis.” Sci Signal 11, no. 512 (January 9, 2018). https://doi.org/10.1126/scisignal.aam7893.
       Full Text  Link to Item
    • Madan, Babita, Mitchell J. McDonald, Gabrielle E. Foxa, Cassandra R. Diegel, Bart O. Williams, and David M. Virshup. “Bone loss from Wnt inhibition mitigated by concurrent alendronate therapy.” Bone Res 6 (2018): 17. https://doi.org/10.1038/s41413-018-0017-8.
       Full Text  Link to Item
    • Zhang, F., D. M. Virshup, and J. K. Cheong. “Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis.” Oncogene 37, no. 3 (January 2018): 363–76. https://doi.org/10.1038/onc.2017.334.
       Full Text
    • Ho, Soo Yei, Jenefer Alam, Duraiswamy Athisayamani Jeyaraj, Weiling Wang, Grace Ruiting Lin, Shi Hua Ang, Eldwin Sum Wai Tan, et al. “Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors.” J Med Chem 60, no. 15 (August 10, 2017): 6678–92. https://doi.org/10.1021/acs.jmedchem.7b00662.
       Full Text  Link to Item
    • Narasimamurthy, Rajesh, and David M. Virshup. “A Flick of the Tail Keeps the Circadian Clock in Line.” Mol Cell 66, no. 4 (May 18, 2017): 437–38. https://doi.org/10.1016/j.molcel.2017.05.008.
       Full Text  Link to Item
    • Alok, Anshula, Zhengdeng Lei, N Suhas Jagannathan, Simran Kaur, Nathan Harmston, Steven G. Rozen, Lisa Tucker-Kellogg, and David M. Virshup. “Wnt proteins synergize to activate β-catenin signaling.” J Cell Sci 130, no. 9 (May 1, 2017): 1532–44. https://doi.org/10.1242/jcs.198093.
       Full Text  Link to Item
    • Eng, Gracie Wee Ling, Gracie Wee Ling Edison, and David M. Virshup. “Site-specific phosphorylation of casein kinase 1 δ (CK1δ) regulates its activity towards the circadian regulator PER2.” Plos One 12, no. 5 (2017): e0177834. https://doi.org/10.1371/journal.pone.0177834.
       Full Text  Link to Item
    • Narasimamurthy, Rajesh, and David M. Virshup. “Molecular Mechanisms Regulating Temperature Compensation of the Circadian Clock.” Front Neurol 8 (2017): 161. https://doi.org/10.3389/fneur.2017.00161.
       Full Text  Link to Item
    • Cheong, Jit Kong, and David M. Virshup. “CK1δ: a pharmacologically tractable Achilles' heel of Wnt-driven cancers?” Ann Transl Med 4, no. 21 (November 2016): 433. https://doi.org/10.21037/atm.2016.11.07.
       Full Text  Link to Item
    • Liu, Chang Ching, Dong Liang Ma, Ting-Dong Yan, XiuBo Fan, Zhiyong Poon, Lai-Fong Poon, Su-Ann Goh, et al. “Distinct Responses of Stem Cells to Telomere Uncapping-A Potential Strategy to Improve the Safety of Cell Therapy.” Stem Cells 34, no. 10 (October 2016): 2471–84. https://doi.org/10.1002/stem.2431.
       Full Text  Link to Item
    • Somarelli, J. A., D. Schaeffer, M. S. Marengo, T. Bepler, D. Rouse, K. E. Ware, A. J. Hish, et al. “Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways.” Oncogene 35, no. 33 (August 18, 2016): 4302–11. https://doi.org/10.1038/onc.2015.497.
       Full Text  Open Access Copy  Link to Item
    • Wang, Jiao, Zhizhi Wang, Tingting Yu, Huan Yang, David M. Virshup, Geert J. P. L. Kops, Sang Hyun Lee, et al. “Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization.” Protein Cell 7, no. 7 (July 2016): 516–26. https://doi.org/10.1007/s13238-016-0283-4.
       Full Text  Link to Item
    • Madan, Babita, Matthew P. Walker, Robert Young, Laura Quick, Kelly A. Orgel, Meagan Ryan, Priti Gupta, et al. “USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds.” Proc Natl Acad Sci U S A 113, no. 21 (May 24, 2016): E2945–54. https://doi.org/10.1073/pnas.1605691113.
       Full Text  Link to Item
    • Cheong, Jit Kong, and David M. Virshup. “Keeping autophagy in cheCK1.” Mol Cell Oncol 3, no. 3 (May 2016): e1045117. https://doi.org/10.1080/23723556.2015.1045117.
       Full Text  Link to Item
    • Madan, Babita, Mehul B. Patel, Jiandong Zhang, Ralph M. Bunte, Nathan P. Rudemiller, Robert Griffiths, David M. Virshup, and Steven D. Crowley. “Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis.” Kidney Int 89, no. 5 (May 2016): 1062–74. https://doi.org/10.1016/j.kint.2016.01.017.
       Full Text  Open Access Copy  Link to Item
    • Madan, B., Z. Ke, N. Harmston, S. Y. Ho, A. O. Frois, J. Alam, D. A. Jeyaraj, et al. “Wnt addiction of genetically defined cancers reversed by PORCN inhibition.” Oncogene 35, no. 17 (April 28, 2016): 2197–2207. https://doi.org/10.1038/onc.2015.280.
       Full Text  Link to Item
    • Lo, Kinyui Alice, Pei Yi Ng, Zahra Kabiri, David Virshup, and Lei Sun. “Wnt inhibition enhances browning of mouse primary white adipocytes.” Adipocyte 5, no. 2 (April 2016): 224–31. https://doi.org/10.1080/21623945.2016.1148834.
       Full Text  Link to Item
    • Madan, Babita, Zhiyuan Ke, Zheng Deng Lei, Frois Ashley Oliver, Masanobu Oshima, May Ann Lee, Steve Rozen, and David M. Virshup. “NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition.” Oncotarget 7, no. 11 (March 15, 2016): 12386–92. https://doi.org/10.18632/oncotarget.7157.
       Full Text  Link to Item
    • Xiang, Wei, Jit Kong Cheong, Shi Hui Ang, Bryan Teo, Peng Xu, Kartini Asari, Wen Tian Sun, et al. “Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration.” Oncotarget 6, no. 32 (October 20, 2015): 33769–80. https://doi.org/10.18632/oncotarget.5615.
       Full Text  Link to Item
    • Zhou, Min, Jae Kyoung Kim, Gracie Wee Ling Eng, Daniel B. Forger, and David M. Virshup. “A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period.” Mol Cell 60, no. 1 (October 1, 2015): 77–88. https://doi.org/10.1016/j.molcel.2015.08.022.
       Full Text  Link to Item
    • Kabiri, Zahra, Akihiko Numata, Akira Kawasaki, Akira Edison, Daniel G. Tenen, and David M. Virshup. “Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells.” Blood 126, no. 9 (August 27, 2015): 1086–94. https://doi.org/10.1182/blood-2014-09-598540.
       Full Text  Link to Item
    • Duraiswamy, Athisayamani Jeyaraj, May Ann Lee, Babita Madan, Shi Hua Ang, Eldwin Sum Wai Tan, Wei Wen Vivien Cheong, Zhiyuan Ke, et al. “Discovery and Optimization of a Porcupine Inhibitor.” J Med Chem 58, no. 15 (August 13, 2015): 5889–99. https://doi.org/10.1021/acs.jmedchem.5b00507.
       Full Text  Link to Item
    • Madan, Babita, and David M. Virshup. “Targeting Wnts at the source--new mechanisms, new biomarkers, new drugs.” Mol Cancer Ther 14, no. 5 (May 2015): 1087–94. https://doi.org/10.1158/1535-7163.MCT-14-1038.
       Full Text  Link to Item
    • Ribi, Sebastian, Daniel Baumhoer, Kristy Lee, Kristy Edison, Audrey S. M. Teo, Babita Madan, Kang Zhang, et al. “TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome.” Oncotarget 6, no. 10 (April 10, 2015): 7727–40. https://doi.org/10.18632/oncotarget.3115.
       Full Text  Link to Item
    • Cheong, Jit Kong, Fuquan Zhang, Pei Jou Chua, Boon Huat Bay, Andrew Thorburn, and David M. Virshup. “Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.” J Clin Invest 125, no. 4 (April 2015): 1401–18. https://doi.org/10.1172/JCI78018.
       Full Text  Link to Item
    • Virshup, David M. “Moving upstream in the war on WNTs.” J Clin Invest 125, no. 3 (March 2, 2015): 975–77. https://doi.org/10.1172/JCI80819.
       Full Text  Link to Item
    • Stewart, Jonathan, Jacqueline James, Glenn W. McCluggage, Stephen McQuaid, Kenneth Arthur, David Boyle, Paul Mullan, et al. “Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression.” Mod Pathol 28, no. 3 (March 2015): 428–36. https://doi.org/10.1038/modpathol.2014.114.
       Full Text  Link to Item
    • Yim, D. G. R., S. Ghosh, G. R. Guy, and D. M. Virshup. “Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling.” Oncogene 34, no. 4 (January 22, 2015): 474–84. https://doi.org/10.1038/onc.2013.564.
       Full Text  Link to Item
    • Xu, Peng, David M. Virshup, and Sang Hyun Lee. “B56-PP2A regulates motor dynamics for mitotic chromosome alignment.” J Cell Sci 127, no. Pt 21 (November 1, 2014): 4567–73. https://doi.org/10.1242/jcs.154609.
       Full Text  Link to Item
    • Yu, Jia, and David M. Virshup. “Updating the Wnt pathways.” Biosci Rep 34, no. 5 (October 17, 2014). https://doi.org/10.1042/BSR20140119.
       Full Text  Link to Item
    • Low, Ivan Cherh Chiet, Thomas Loh, Yiqing Huang, David M. Virshup, and Shazib Pervaiz. “Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity.” Blood 124, no. 14 (October 2, 2014): 2223–34. https://doi.org/10.1182/blood-2014-03-563296.
       Full Text  Link to Item
    • Asad, M., M. K. Wong, T. Z. Tan, M. Choolani, J. Low, S. Mori, D. Virshup, J. P. Thiery, and R. Y. -. J. Huang. “FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway.” Cell Death Dis 5 (July 17, 2014): e1346. https://doi.org/10.1038/cddis.2014.302.
       Full Text  Link to Item
    • Zhu, Yunhua, Oleg N. Demidov, Amanda M. Goh, David M. Virshup, David P. Lane, and Dmitry V. Bulavin. “Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging.” J Clin Invest 124, no. 7 (July 2014): 3263–73. https://doi.org/10.1172/JCI73015.
       Full Text  Link to Item
    • MacDonald, Bryan T., Annie Hien, Xinjun Zhang, Oladoyin Iranloye, David M. Virshup, Marian L. Waterman, and Xi He. “Disulfide bond requirements for active Wnt ligands.” J Biol Chem 289, no. 26 (June 27, 2014): 18122–36. https://doi.org/10.1074/jbc.M114.575027.
       Full Text  Link to Item
    • Kabiri, Zahra, Gediminas Greicius, Babita Madan, Steffen Biechele, Zhendong Zhong, Hamed Zaribafzadeh, Hamed Edison, et al. “Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts.” Development 141, no. 11 (June 2014): 2206–15. https://doi.org/10.1242/dev.104976.
       Full Text  Link to Item
    • Yu, Jia, Joanne Chia, Claire Ann Canning, C Michael Jones, Frédéric A. Bard, and David M. Virshup. “WLS retrograde transport to the endoplasmic reticulum during Wnt secretion.” Dev Cell 29, no. 3 (May 12, 2014): 277–91. https://doi.org/10.1016/j.devcel.2014.03.016.
       Full Text  Link to Item
    • Madan, Babita, Zhiyuan Ke, Shermaine Q. Y. Lim, Jenefer Alam, Soo Yei Ho, Duraiswamy A. Jeyaraj, Kakaly Ghosh, et al. “Abstract C248: Novel PORCN inhibitors are safe and effective in the treatment of WNT-dependent cancers.” Therapeutic Agents: Other, November 2013. https://doi.org/10.1158/1535-7163.targ-13-c248.
       Full Text
    • Yim, Daniel G. R., and David M. Virshup. “Unwinding the Wnt action of casein kinase 1.” Cell Res 23, no. 6 (June 2013): 737–38. https://doi.org/10.1038/cr.2013.51.
       Full Text  Link to Item
    • Xu, Peng, Elizabeth A. Raetz, Mayumi Kitagawa, David M. Virshup, and Sang Hyun Lee. “BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression.” Biol Open 2, no. 5 (May 15, 2013): 479–86. https://doi.org/10.1242/bio.20134051.
       Full Text  Open Access Copy  Link to Item
    • Stewart, Jonathan, Jacqueline James, Glenn McCluggage, Stephen McQuaid, David Boyle, Kenneth Arthur, Paul Mullan, et al. “A strong correlation between expression of Wntless and of human epidermal growth factor receptor 2 in gastric, ovarian, and breast cancers suggests a novel-signalling pathway involving NFκB and STAT3.” The Lancet 381 (February 2013): S106–S106. https://doi.org/10.1016/s0140-6736(13)60546-2.
       Full Text
    • Proffitt, Kyle David, Babita Madan, Zhiyuan Ke, Vishal Pendharkar, Lijun Ding, May Ann Lee, Rami N. Hannoush, and David M. Virshup. “Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer.” Cancer Res 73, no. 2 (January 15, 2013): 502–7. https://doi.org/10.1158/0008-5472.CAN-12-2258.
       Full Text  Link to Item
    • Proffitt, Kyle D., and David M. Virshup. “Precise regulation of porcupine activity is required for physiological Wnt signaling.” J Biol Chem 287, no. 41 (October 5, 2012): 34167–78. https://doi.org/10.1074/jbc.M112.381970.
       Full Text  Link to Item
    • Najdi, Rani, Kyle Proffitt, Stephanie Sprowl, Simran Kaur, Jia Yu, Tracy M. Covey, David M. Virshup, and Marian L. Waterman. “A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities.” Differentiation 84, no. 2 (September 2012): 203–13. https://doi.org/10.1016/j.diff.2012.06.004.
       Full Text  Link to Item
    • Coombs, G. S., A. A. Schmitt, C. A. Canning, A. Alok, I. C. C. Low, N. Banerjee, S. Kaur, et al. “Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer.” Oncogene 31, no. 2 (January 12, 2012): 213–25. https://doi.org/10.1038/onc.2011.228.
       Full Text  Link to Item
    • Covey, Tracy M., Simran Kaur, Tina Tan Ong, Kyle D. Proffitt, Yonghui Wu, Patrick Tan, and David M. Virshup. “PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation.” Plos One 7, no. 4 (2012): e34532. https://doi.org/10.1371/journal.pone.0034532.
       Full Text  Link to Item
    • Ooi, Chia Huey, Hue Kian Oh, Hannah Zhu’ai Wang, Angie Lay Keng Tan, Jeanie Wu, Minghui Lee, Sun Young Rha, Hyun Cheol Chung, David Marc Virshup, and Patrick Tan. “A densely interconnected genome-wide network of microRNAs and oncogenic pathways revealed using gene expression signatures.” Plos Genet 7, no. 12 (December 2011): e1002415. https://doi.org/10.1371/journal.pgen.1002415.
       Full Text  Link to Item
    • Cheong, J. K., T. H. Nguyen, H. Wang, P. Tan, P. M. Voorhoeve, S. H. Lee, and D. M. Virshup. “IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation.” Oncogene 30, no. 22 (June 2, 2011): 2558–69. https://doi.org/10.1038/onc.2010.627.
       Full Text  Link to Item
    • Cheong, Jit Kong, and David M. Virshup. “Casein kinase 1: Complexity in the family.” Int J Biochem Cell Biol 43, no. 4 (April 2011): 465–69. https://doi.org/10.1016/j.biocel.2010.12.004.
       Full Text  Link to Item
    • Virshup, David M., and Philipp Kaldis. “Cell biology. Enforcing the Greatwall in mitosis.” Science 330, no. 6011 (December 17, 2010): 1638–39. https://doi.org/10.1126/science.1199898.
       Full Text  Link to Item
    • Covey, Tracy M., Kornelia Edes, Gary S. Coombs, David M. Virshup, and Frank A. Fitzpatrick. “Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer.” Plos One 5, no. 10 (October 21, 2010): e13545. https://doi.org/10.1371/journal.pone.0013545.
       Full Text  Link to Item
    • Coombs, Gary S., Jia Yu, Claire A. Canning, Charles A. Veltri, Tracy M. Covey, Jit K. Cheong, Velani Utomo, et al. “WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification.” J Cell Sci 123, no. Pt 19 (October 1, 2010): 3357–67. https://doi.org/10.1242/jcs.072132.
       Full Text  Link to Item
    • McCulloch, Malcolm W. B., Tim S. Bugni, Gisela P. Concepcion, Gary S. Coombs, Mary Kay Harper, Simran Kaur, Gina C. Mangalindan, et al. “Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp.” J Nat Prod 72, no. 9 (September 2009): 1651–56. https://doi.org/10.1021/np900336f.
       Full Text  Link to Item
    • Wang, C., K. C. Chang, G. Somers, D. Virshup, B. T. Ang, C. Tang, F. Yu, and H. Wang. “Erratum: Protein phosphatase 2A regulates self-renewal of Drosophila neural stem cells (Development (2009) vol. 136 (2287-2296)).” Development 136, no. 17 (September 1, 2009): 3031. https://doi.org/10.1242/dev.042432.
       Full Text
    • Wang, Cheng, Kai Chen Chang, Gregory Somers, David Virshup, Beng Ti Ang, Carol Tang, Fengwei Yu, and Hongyan Wang. “Protein phosphatase 2A regulates self-renewal of Drosophila neural stem cells.” Development 136, no. 13 (July 2009): 2287–96. https://doi.org/10.1242/dev.035758.
       Full Text  Link to Item
    • Virshup, David M., and Daniel B. Forger. “Keeping the beat in the rising heat.” Cell 137, no. 4 (May 15, 2009): 602–4. https://doi.org/10.1016/j.cell.2009.04.051.
       Full Text  Link to Item
    • McCulloch, Malcolm W. B., Gary S. Coombs, Nikhil Banerjee, Tim S. Bugni, Kendell M. Cannon, Mary Kay Harper, Charles A. Veltri, David M. Virshup, and Chris M. Ireland. “Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives.” Bioorg Med Chem 17, no. 6 (March 15, 2009): 2189–98. https://doi.org/10.1016/j.bmc.2008.10.077.
       Full Text  Link to Item
    • Virshup, David M., and Shirish Shenolikar. “From promiscuity to precision: protein phosphatases get a makeover.” Mol Cell 33, no. 5 (March 13, 2009): 537–45. https://doi.org/10.1016/j.molcel.2009.02.015.
       Full Text  Link to Item
    • Coombs, Gary S., Tracy M. Covey, and David M. Virshup. “Wnt signaling in development, disease and translational medicine.” Curr Drug Targets 9, no. 7 (July 2008): 513–31. https://doi.org/10.2174/138945008784911796.
       Full Text  Link to Item
    • Meng, Qing-Jun, Larisa Logunova, Elizabeth S. Maywood, Monica Gallego, Jake Lebiecki, Timothy M. Brown, Martin Sládek, et al. “Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins.” Neuron 58, no. 1 (April 10, 2008): 78–88. https://doi.org/10.1016/j.neuron.2008.01.019.
       Full Text  Link to Item
    • Forester, Craig M., Jessica Maddox, Justin V. Louis, Jozef Goris, and David M. Virshup. “Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1.” Proc Natl Acad Sci U S A 104, no. 50 (December 11, 2007): 19867–72. https://doi.org/10.1073/pnas.0709879104.
       Full Text  Link to Item
    • Forger, Daniel, Didier Gonze, David Virshup, and David K. Welsh. “Beyond intuitive modeling: combining biophysical models with innovative experiments to move the circadian clock field forward.” J Biol Rhythms 22, no. 3 (June 2007): 200–210. https://doi.org/10.1177/0748730407301823.
       Full Text  Link to Item
    • Virshup, David M., and Daniel B. Forger. “After hours keeps clock researchers CRYing Overtime.” Cell 129, no. 5 (June 1, 2007): 857–59. https://doi.org/10.1016/j.cell.2007.05.015.
       Full Text  Link to Item
    • Luo, Wen, Annita Peterson, Benjamin A. Garcia, Gary Coombs, Bente Kofahl, Reinhart Heinrich, Jeffrey Shabanowitz, Donald F. Hunt, H Joseph Yost, and David M. Virshup. “Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex.” Embo J 26, no. 6 (March 21, 2007): 1511–21. https://doi.org/10.1038/sj.emboj.7601607.
       Full Text  Link to Item
    • Tsai, I-Chun, Jeffrey D. Amack, Zhong-Hua Gao, Vimla Band, H Joseph Yost, and David M. Virshup. “A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein.” Dev Cell 12, no. 3 (March 2007): 335–47. https://doi.org/10.1016/j.devcel.2007.02.009.
       Full Text  Link to Item
    • Tsai, I-Chun, Margaret Woolf, Deborah W. Neklason, William W. Branford, H Joseph Yost, Randall W. Burt, and David M. Virshup. “Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism.” Int J Cancer 120, no. 5 (March 1, 2007): 1005–12. https://doi.org/10.1002/ijc.22368.
       Full Text  Link to Item
    • Gallego, Monica, and David M. Virshup. “Post-translational modifications regulate the ticking of the circadian clock.” Nat Rev Mol Cell Biol 8, no. 2 (February 2007): 139–48. https://doi.org/10.1038/nrm2106.
       Full Text  Link to Item
    • Saraf, Amit, David M. Virshup, and Stefan Strack. “Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis.” J Biol Chem 282, no. 1 (January 5, 2007): 573–80. https://doi.org/10.1074/jbc.M607407200.
       Full Text  Link to Item
    • Virshup, D. M., E. J. Eide, D. B. Forger, M. Gallego, and E Vielhaber Harnish. “Reversible protein phosphorylation regulates circadian rhythms.” Cold Spring Harb Symp Quant Biol 72 (2007): 413–20. https://doi.org/10.1101/sqb.2007.72.048.
       Full Text  Link to Item
    • Margolis, Seth S., Jennifer A. Perry, Craig M. Forester, Leta K. Nutt, Yanxiang Guo, Melanie J. Jardim, Michael J. Thomenius, et al. “Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis.” Cell 127, no. 4 (November 17, 2006): 759–73. https://doi.org/10.1016/j.cell.2006.10.035.
       Full Text  Link to Item
    • Gallego, Monica, Heeseog Kang, and David M. Virshup. “Protein phosphatase 1 regulates the stability of the circadian protein PER2.” Biochem J 399, no. 1 (October 1, 2006): 169–75. https://doi.org/10.1042/BJ20060678.
       Full Text  Link to Item
    • Klimowski, Laura K., Benjamin A. Garcia, Jeffrey Shabanowitz, Donald F. Hunt, and David M. Virshup. “Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling.” Febs J 273, no. 20 (October 2006): 4594–4602. https://doi.org/10.1111/j.1742-4658.2006.05462.x.
       Full Text  Link to Item
    • Gallego, Monica, Erik J. Eide, Margaret F. Woolf, David M. Virshup, and Daniel B. Forger. “An opposite role for tau in circadian rhythms revealed by mathematical modeling.” Proc Natl Acad Sci U S A 103, no. 28 (July 11, 2006): 10618–23. https://doi.org/10.1073/pnas.0604511103.
       Full Text  Link to Item
    • Swiatek, Wojciech, Heeseog Kang, Benjamin A. Garcia, Jeffery Shabanowitz, Gary S. Coombs, Donald F. Hunt, and David M. Virshup. “Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation.” J Biol Chem 281, no. 18 (May 5, 2006): 12233–41. https://doi.org/10.1074/jbc.M510580200.
       Full Text  Link to Item
    • Eide, Erik J., Margaret F. Woolf, Heeseog Kang, Peter Woolf, William Hurst, Fernando Camacho, Erica L. Vielhaber, Andrew Giovanni, and David M. Virshup. “Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation.” Mol Cell Biol 25, no. 7 (April 2005): 2795–2807. https://doi.org/10.1128/MCB.25.7.2795-2807.2005.
       Full Text  Link to Item
    • Firulli, Beth A., Dayana Krawchuk, Victoria E. Centonze, Neil Vargesson, David M. Virshup, Simon J. Conway, Peter Cserjesi, Ed Laufer, and Anthony B. Firulli. “Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities.” Nat Genet 37, no. 4 (April 2005): 373–81. https://doi.org/10.1038/ng1525.
       Full Text  Link to Item
    • Gallego, Monica, and David M. Virshup. “Protein serine/threonine phosphatases: life, death, and sleeping.” Curr Opin Cell Biol 17, no. 2 (April 2005): 197–202. https://doi.org/10.1016/j.ceb.2005.01.002.
       Full Text  Link to Item
    • Eide, Erik J., Heeseog Kang, Stephanie Crapo, Monica Gallego, and David M. Virshup. “Casein kinase I in the mammalian circadian clock.” Methods Enzymol 393 (2005): 408–18. https://doi.org/10.1016/S0076-6879(05)93019-X.
       Full Text  Link to Item
    • Okamura, Heidi, Carmen Garcia-Rodriguez, Holly Martinson, Jun Qin, David M. Virshup, and Anjana Rao. “A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1.” Mol Cell Biol 24, no. 10 (May 2004): 4184–95. https://doi.org/10.1128/mcb.24.10.4184-4195.2004.
       Full Text  Link to Item
    • Swiatek, Wojciech, I-Chun Tsai, Laura Klimowski, Andrea Pepler, Janet Barnette, H Joseph Yost, and David M. Virshup. “Regulation of casein kinase I epsilon activity by Wnt signaling.” J Biol Chem 279, no. 13 (March 26, 2004): 13011–17. https://doi.org/10.1074/jbc.M304682200.
       Full Text  Link to Item
    • Firulli, Beth A., David M. Virshup, and Anthony B. Firulli. “Phosphopeptide mapping of proteins ectopically expressed in tissue culture cell lines.” Biol Proced Online 6 (2004): 16–22. https://doi.org/10.1251/bpo69.
       Full Text  Link to Item
    • Firulli, Beth A., Marthe J. Howard, Jennifer R. McDaid, Leanne McIlreavey, Karen M. Dionne, Victoria E. Centonze, Peter Cserjesi, David M. Virshup, and Anthony B. Firulli. “PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation.” Mol Cell 12, no. 5 (November 2003): 1225–37. https://doi.org/10.1016/s1097-2765(03)00425-8.
       Full Text  Link to Item
    • Liu, Feng, David M. Virshup, Angus C. Nairn, and Paul Greengard. “Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors.” J Biol Chem 277, no. 47 (November 22, 2002): 45393–99. https://doi.org/10.1074/jbc.M204499200.
       Full Text  Link to Item
    • Liu, Ying, David M. Virshup, Raymond L. White, and Lih-Ching Hsu. “Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha.” Cancer Res 62, no. 22 (November 15, 2002): 6357–61.
       Link to Item
    • Raetz, Elizabeth A., Sherrie L. Perkins, Marlee A. Carlson, Kevin P. Schooler, William L. Carroll, and David M. Virshup. “The nucleophosmin-anaplastic lymphoma kinase fusion protein induces c-Myc expression in pediatric anaplastic large cell lymphomas.” Am J Pathol 161, no. 3 (September 2002): 875–83. https://doi.org/10.1016/S0002-9440(10)64248-4.
       Full Text  Link to Item
    • Li, Xinghai, Anne Scuderi, Anthea Letsou, and David M. Virshup. “B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster.” Mol Cell Biol 22, no. 11 (June 2002): 3674–84. https://doi.org/10.1128/mcb.22.11.3674-3684.2002.
       Full Text  Link to Item
    • Eide, Erik J., Erica L. Vielhaber, William A. Hinz, and David M. Virshup. “The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon.” J Biol Chem 277, no. 19 (May 10, 2002): 17248–54. https://doi.org/10.1074/jbc.M111466200.
       Full Text  Link to Item
    • Toh, K. L., C. Thulin, Y. H. Fu, L. J. Ptacek, and D. M. Virshup. “Sequential multisite phosphorylation by casein kinase I epsilon (CKI epsilon).” Faseb Journal 16, no. 5 (March 22, 2002): A917–A917.
       Link to Item
    • Slayton, William B., Gerald J. Spangrude, Zhong Chen, Wayne F. Greene, and David Virshup. “Lineage-specific trisomy 21 in a neonate with resolving transient myeloproliferative syndrome.” J Pediatr Hematol Oncol 24, no. 3 (March 2002): 224–26. https://doi.org/10.1097/00043426-200203000-00013.
       Full Text  Link to Item
    • Gao, Zhong-Hua, Joni M. Seeling, Virginia Hill, April Yochum, and David M. Virshup. “Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex.” Proc Natl Acad Sci U S A 99, no. 3 (February 5, 2002): 1182–87. https://doi.org/10.1073/pnas.032468199.
       Full Text  Link to Item
    • Li, Xinghai, and David M. Virshup. “Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A.” Eur J Biochem 269, no. 2 (January 2002): 546–52. https://doi.org/10.1046/j.0014-2956.2001.02680.x.
       Full Text  Link to Item
    • Vielhaber, E. L., D. Duricka, K. S. Ullman, and D. M. Virshup. “Nuclear export of mammalian PERIOD proteins.” J Biol Chem 276, no. 49 (December 7, 2001): 45921–27. https://doi.org/10.1074/jbc.M107726200.
       Full Text  Link to Item
    • Li, X., H. J. Yost, D. M. Virshup, and J. M. Seeling. “Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus.” Embo J 20, no. 15 (August 1, 2001): 4122–31. https://doi.org/10.1093/emboj/20.15.4122.
       Full Text  Link to Item
    • Seeling, J. M., X. Li, H. J. Yost, and D. M. Virshup. “PP2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus.” Developmental Biology 235, no. 1 (July 1, 2001): 254–254.
       Link to Item
    • Eide, E. J., and D. M. Virshup. “Casein kinase I: another cog in the circadian clockworks.” Chronobiol Int 18, no. 3 (May 2001): 389–98. https://doi.org/10.1081/cbi-100103963.
       Full Text  Link to Item
    • Toh, K. L., C. R. Jones, Y. He, E. J. Eide, W. A. Hinz, D. M. Virshup, L. J. Ptácek, and Y. H. Fu. “An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome.” Science 291, no. 5506 (February 9, 2001): 1040–43. https://doi.org/10.1126/science.1057499.
       Full Text  Link to Item
    • Camacho, F., M. Cilio, Y. Guo, D. M. Virshup, K. Patel, O. Khorkova, S. Styren, B. Morse, Z. Yao, and G. A. Keesler. “Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2.” Febs Lett 489, no. 2–3 (February 2, 2001): 159–65. https://doi.org/10.1016/s0014-5793(00)02434-0.
       Full Text  Link to Item
    • Kornberg, A. “Public funding of understanding nature.” Iubmb Life 51, no. 2 (February 2001): 71–72. https://doi.org/10.1080/15216540117461.
       Full Text  Link to Item
    • Raetz, E. A., S. L. Perkins, M. A. Carlson, K. P. Schooler, and D. M. Virshup. “Pediatric ALK-positive lymphomas coexpress c-Myc.” Blood 96, no. 11 (November 16, 2000): 128A-128A.
       Link to Item
    • Vielhaber, E., E. Eide, A. Rivers, Z. H. Gao, and D. M. Virshup. “Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon.” Mol Cell Biol 20, no. 13 (July 2000): 4888–99. https://doi.org/10.1128/mcb.20.13.4888-4899.2000.
       Full Text  Link to Item
    • Keesler, G. A., F. Camacho, Y. Guo, D. Virshup, C. Mondadori, and Z. Yao. “Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon.” Neuroreport 11, no. 5 (April 7, 2000): 951–55. https://doi.org/10.1097/00001756-200004070-00011.
       Full Text  Link to Item
    • Virshup, D. M. “Protein phosphatase 2A: a panoply of enzymes.” Curr Opin Cell Biol 12, no. 2 (April 2000): 180–85. https://doi.org/10.1016/s0955-0674(99)00074-5.
       Full Text  Link to Item
    • Gao, Z. H., J. Metherall, and D. M. Virshup. “Identification of casein kinase I substrates by in vitro expression cloning screening.” Biochem Biophys Res Commun 268, no. 2 (February 16, 2000): 562–66. https://doi.org/10.1006/bbrc.2000.2168.
       Full Text  Link to Item
    • Gietzen, K. F., and D. M. Virshup. “Identification of inhibitory autophosphorylation sites in casein kinase I epsilon.” J Biol Chem 274, no. 45 (November 5, 1999): 32063–70. https://doi.org/10.1074/jbc.274.45.32063.
       Full Text  Link to Item
    • Goldsby, R. E., S. L. Perkins, D. M. Virshup, A. R. Brothman, and C. S. Bruggers. “Lymphoblastic lymphoma and excessive toxicity from chemotherapy: an unusual presentation for Fanconi anemia.” J Pediatr Hematol Oncol 21, no. 3 (May 1999): 240–43. https://doi.org/10.1097/00043426-199905000-00014.
       Full Text  Link to Item
    • Honeggar, M., J. Krall, D. M. Virshup, and M. A. Movsesian. “Expression of multiple PP2A serine/threonine phosphatase B56 (B ') subunit isoforms in human cardiac and vascular smooth muscle myocytes.” Journal of Investigative Medicine 47, no. 4 (April 1, 1999): 194A-194A.
       Link to Item
    • Seeling, J. M., J. R. Miller, R. Gil, R. T. Moon, R. White, and D. M. Virshup. “Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A.” Science 283, no. 5410 (March 26, 1999): 2089–91. https://doi.org/10.1126/science.283.5410.2089.
       Full Text  Link to Item
    • Honeggar, M., J. Krall, D. M. Virshup, and M. A. Movsesian. “Expression of multiple PP2A serine/threonine phosphatase B56 (B ') subunit isoforms in human cardiac and vascular smooth muscle myocytes.” Faseb Journal 13, no. 4 (March 12, 1999): A468–A468.
       Link to Item
    • Rivers, A., K. F. Gietzen, E. Vielhaber, and D. M. Virshup. “Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle.” J Biol Chem 273, no. 26 (June 26, 1998): 15980–84. https://doi.org/10.1074/jbc.273.26.15980.
       Full Text  Link to Item
    • McDonald, J. M., E. C. Douglass, R. Fisher, C. F. Geiser, C. E. Krill, L. C. Strong, D. Virshup, and V. Huff. “Linkage of familial Wilms' tumor predisposition to chromosome 19 and a two-locus model for the etiology of familial tumors.” Cancer Res 58, no. 7 (April 1, 1998): 1387–90.
       Link to Item
    • Cegielska, A., K. F. Gietzen, A. Rivers, and D. M. Virshup. “Autoinhibition of casein kinase I epsilon (CKI epsilon) is relieved by protein phosphatases and limited proteolysis.” J Biol Chem 273, no. 3 (January 16, 1998): 1357–64. https://doi.org/10.1074/jbc.273.3.1357.
       Full Text  Link to Item
    • McCright, B., and D. M. Virshup. “Identifying protein phosphatase 2A interacting proteins using the yeast two-hybrid method.” Methods Mol Biol 93 (1998): 263–77. https://doi.org/10.1385/0-89603-468-2:263.
       Full Text  Link to Item
    • Gietzen, K. J., and D. M. Virshup. “Determinants of casein kinase i epsilon (ckir) autoinhibition.” Faseb Journal 11, no. 9 (December 1, 1997).
    • Virshup, D., K. Oietzen, A. Rivers, and U. Utah. “Regulation of casein kinase i.” Faseb Journal 11, no. 9 (December 1, 1997).
    • Gietzen, K. J., and D. M. Virshup. “Determinants of casein kinase I epsilon (CKI epsilon) autoinhibition.” Faseb Journal 11, no. 9 (July 31, 1997): A1356–A1356.
       Link to Item
    • McCright, B., A. M. Rivers, S. Audlin, and D. M. Virshup. “The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm.” J Biol Chem 271, no. 36 (September 6, 1996): 22081–89. https://doi.org/10.1074/jbc.271.36.22081.
       Full Text  Link to Item
    • McCright, B., A. R. Brothman, and D. M. Virshup. “Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12.” Genomics 36, no. 1 (August 15, 1996): 168–70. https://doi.org/10.1006/geno.1996.0438.
       Full Text  Link to Item
    • McCright, B., and D. M. Virshup. “Identification of a new family of protein phosphatase 2A regulatory subunits.” J Biol Chem 270, no. 44 (November 3, 1995): 26123–28. https://doi.org/10.1074/jbc.270.44.26123.
       Full Text  Link to Item
    • Fish, K. J., A. Cegielska, M. E. Getman, G. M. Landes, and D. M. Virshup. “Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family.” J Biol Chem 270, no. 25 (June 23, 1995): 14875–83. https://doi.org/10.1074/jbc.270.25.14875.
       Full Text  Link to Item
    • Sivak, L. E., and D. M. Virshup. “Occurrence of Henoch-Schönlein purpura in a child with Wilms' tumor.” Med Pediatr Oncol 24, no. 3 (March 1995): 213–14. https://doi.org/10.1002/mpo.2950240314.
       Full Text  Link to Item
    • Cegielska, A., S. Shaffer, R. Derua, J. Goris, and D. M. Virshup. “Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication.” Mol Cell Biol 14, no. 7 (July 1994): 4616–23. https://doi.org/10.1128/mcb.14.7.4616.
       Full Text  Link to Item
    • Cegielska, A., I. Moarefi, E. Fanning, and D. M. Virshup. “T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123.” J Virol 68, no. 1 (January 1994): 269–75. https://doi.org/10.1128/JVI.68.1.269-275.1994.
       Full Text  Link to Item
    • Coombs, R. H., and B. B. Virshup. “Enhancing the psychological health of medical students: the student well-being committee.” Med Educ 28, no. 1 (January 1994): 47–54. https://doi.org/10.1111/j.1365-2923.1994.tb02684.x.
       Full Text  Link to Item
    • Cegielska, A., and D. M. Virshup. “Control of simian virus 40 DNA replication by the HeLa cell nuclear kinase casein kinase I.” Mol Cell Biol 13, no. 2 (February 1993): 1202–11. https://doi.org/10.1128/mcb.13.2.1202.
       Full Text  Link to Item
    • VIRSHUP, D. M., A. CEGIELSKA, K. FISH, S. SHAFFER, and D. HILLAM. “CONTROL OF SV40 DNA-REPLICATION BY THE RECIPROCAL ACTION OF CASEIN KINASE-I AND PROTEIN PHOSPHATASE 2AC.” Journal of Cellular Biochemistry, January 9, 1993, 305–305.
       Link to Item
    • Virshup, D. M., A. A. Russo, and T. J. Kelly. “Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A.” Mol Cell Biol 12, no. 11 (November 1992): 4883–95. https://doi.org/10.1128/mcb.12.11.4883.
       Full Text  Link to Item
    • Modlin, J. F., R. Dagan, L. E. Berlin, D. M. Virshup, R. H. Yolken, and M. Menegus. “Focal encephalitis with enterovirus infections.” Pediatrics 88, no. 4 (October 1991): 841–45.
       Link to Item
    • Scheidtmann, K. H., D. M. Virshup, and T. J. Kelly. “Protein phosphatase 2A dephosphorylates simian virus 40 large T antigen specifically at residues involved in regulation of DNA-binding activity.” J Virol 65, no. 4 (April 1991): 2098–2101. https://doi.org/10.1128/JVI.65.4.2098-2101.1991.
       Full Text  Link to Item
    • ERDILE, L. F., K. L. COLLINS, A. RUSSO, P. SIMANCEK, D. SMALL, C. UMBRICHT, D. VIRSHUP, et al. “INITIATION OF SV40 DNA-REPLICATION - MECHANISM AND CONTROL.” Cold Spring Harbor Symposia on Quantitative Biology 56 (January 1, 1991): 303–13.
       Link to Item
    • Erdile, L. F., K. L. Collins, A. Russo, P. Simancek, D. Small, C. Umbricht, D. Virshup, L. Cheng, S. Randall, and D. Weinberg. “Initiation of SV40 DNA replication: mechanism and control.” Cold Spring Harb Symp Quant Biol 56 (1991): 303–13. https://doi.org/10.1101/sqb.1991.056.01.037.
       Full Text  Link to Item
    • Weinberg, D. H., K. L. Collins, P. Simancek, A. Russo, M. S. Wold, D. M. Virshup, and T. J. Kelly. “Reconstitution of simian virus 40 DNA replication with purified proteins.” Proc Natl Acad Sci U S A 87, no. 22 (November 1990): 8692–96. https://doi.org/10.1073/pnas.87.22.8692.
       Full Text  Link to Item
    • Virshup, D. M. “DNA replication.” Curr Opin Cell Biol 2, no. 3 (June 1990): 453–60. https://doi.org/10.1016/0955-0674(90)90127-z.
       Full Text  Link to Item
    • Moo-Penn, W. F., D. C. Swan, T. K. Hine, R. M. Baine, D. L. Jue, J. M. Benson, M. H. Johnson, D. M. Virshup, and W. H. Zinkham. “Hb Catonsville (glutamic acid inserted between Pro-37(C2)alpha and Thr-38(C3)alpha). Nonallelic gene conversion in the globin system?” J Biol Chem 264, no. 36 (December 25, 1989): 21454–57.
       Link to Item
    • Virshup, D. M., M. G. Kauffman, and T. J. Kelly. “Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A.” Embo J 8, no. 12 (December 1, 1989): 3891–98.
       Link to Item
    • Virshup, D. M., and T. J. Kelly. “Purification of replication protein C, a cellular protein involved in the initial stages of simian virus 40 DNA replication in vitro.” Proc Natl Acad Sci U S A 86, no. 10 (May 1989): 3584–88. https://doi.org/10.1073/pnas.86.10.3584.
       Full Text  Link to Item
    • Wold, M. S., D. H. Weinberg, D. M. Virshup, J. J. Li, and T. J. Kelly. “Identification of cellular proteins required for simian virus 40 DNA replication.” J Biol Chem 264, no. 5 (February 15, 1989): 2801–9.
       Link to Item
    • Virshup, D. M., and V. Bennett. “Clathrin-coated vesicle assembly polypeptides: physical properties and reconstitution studies with brain membranes.” J Cell Biol 106, no. 1 (January 1988): 39–50. https://doi.org/10.1083/jcb.106.1.39.
       Full Text  Link to Item
    • Jerdan, M. S., R. S. Shapiro, N. B. Smith, D. M. Virshup, and A. F. Hood. “Cutaneous manifestations of Corynebacterium group JK sepsis.” J Am Acad Dermatol 16, no. 2 Pt 2 (February 1987): 444–47. https://doi.org/10.1016/s0190-9622(87)70058-9.
       Full Text  Link to Item
    • VIRSHUP, D. M., and V. BENNETT. “CLATHRIN-COATED VESICLE ASSEMBLY POLYPEPTIDES - PHYSICAL-PROPERTIES AND IDENTIFICATION OF A NEW SUBUNIT.” Journal of Cell Biology 103, no. 5 (November 1, 1986): A53–A53.
       Link to Item
    • Agre, P., D. Virshup, and V. Bennett. “Bepridil and cetiedil. Vasodilators which inhibit Ca2+-dependent calmodulin interactions with erythrocyte membranes.” J Clin Invest 74, no. 3 (September 1984): 812–20. https://doi.org/10.1172/JCI111497.
       Full Text  Link to Item
    • Virshup, D. M., W. H. Zinkham, R. L. Sirota, and W. S. Caughey. “Unique sensitivity of Hb Zürich to oxidative injury by phenazopyridine: reversal of the effects by elevating carboxyhemoglobin levels in vivo and in vitro.” Am J Hematol 14, no. 4 (June 1983): 315–24. https://doi.org/10.1002/ajh.2830140402.
       Full Text  Link to Item
    • Virshup, D. M., H. Zinkham Wm., R. L. Sirota, and W. S. Caughey. “Unique sensitivity of HB Zurich to oxidative injury by phenazopyridine: Reversal of the effect by elevating carboxyhemoglobin levels in vivo and in vitro.” Pediatric Research 16, no. 4 II (January 1, 1982).
    • Kaur, Amanpreet, Sugunavathi Sepramaniam, Jun Yi Stanley Lim, Siddhi Patnaik, Nathan Harmston, May Ann Lee, Enrico Petretto, David M. Virshup, and Babita Madan. “WNT inhibition creates a BRCA-like state in Wnt-addicted cancer,” n.d. https://doi.org/10.1101/2020.06.17.157024.
       Full Text

  • Conference Papers

    • Ricci, Clarisse Gravina, Jonathan M. Philpott, Rajesh Narasimamurthy, Alfred M. Freeberg, Sabrina R. Hunt, Lauren E. Yee, Rebecca S. Pelofsky, Sarvind Tripathi, David M. Virshup, and Carrie L. Partch. “Free Energy Landscape of Casein Kinase Delta and its Implications for Circadian Rhythm.” In Biophysical Journal, 118:207A-208A. CELL PRESS, 2020.
       Link to Item
    • Tan, D., M. Ng, V. Subbiah, W. Messersmith, V. Teneggi, V. Diermayr, K. Ethirajulu, et al. “Phase I extension study of ETC-159 an oral PORCN inhibitor administered with bone protective treatment, in patients with advanced solid tumours.” In Annals of Oncology : Official Journal of the European Society for Medical Oncology, 29:ix23–24, 2018. https://doi.org/10.1093/annonc/mdy430.002.
       Full Text
    • Cai, W., J. K. Cheong, E. Edison, A. Banerjee, T. Z. Tan, L. Gaboury, E. M. Yousef, et al. “Abstract P4-08-03: DEAD-box RNA helicase DP103 as a novel regulator of Wnt/β-catenin signaling pathway and promotes cancer stem cell-like behavior in triple negative breast cancers.” In Poster Session Abstracts. American Association for Cancer Research, 2016. https://doi.org/10.1158/1538-7445.sabcs15-p4-08-03.
       Full Text
    • Ke, Zhiyuan, Babita Madan, Shermaine Q. Y. Lim, Sifang Wang, Jenefer Alam, Soo Yei Ho, Duraiswamy Athisayamani Jeyaraj, et al. “Abstract 4449: A novel Porcupine inhibitor is effective in the treatment of cancers with RNF43 mutations.” In Experimental and Molecular Therapeutics. American Association for Cancer Research, 2015. https://doi.org/10.1158/1538-7445.am2015-4449.
       Full Text
    • Ke, Z., S. Lim, S. Wang, J. Fulwood, K. Proffitt, B. Madan, M. Choong, H. Flotow, D. Virshup, and M. Lee. “172 Identification of Small Molecule Inhibitors of Wnt Secretion.” In European Journal of Cancer, 48:52–53. Elsevier BV, 2012. https://doi.org/10.1016/s0959-8049(12)71970-6.
       Full Text
    • Cheong, Jit Kong, and David M. Virshup. “Abstract B264: IC261 induces cell cycle arrest and apoptosis of human cancer cells via a CK1δ/ε independent mechanism.” In Therapeutic Agents  Small Molecule Kinase Inhibitors. American Association for Cancer Research, 2009. https://doi.org/10.1158/1535-7163.targ-09-b264.
       Full Text
    • Wang, Cheng, Kaichen Chang, Greory Somers, David Virshup, Beng Ti Ang, Carol Tang, Fengwei Yu, and Hongyan Wang. “08-P022 Protein phosphatase 2A regulates self-renewal of Drosophila neural stem cells.” In Mechanisms of Development, 126:S150–S150. Elsevier BV, 2009. https://doi.org/10.1016/j.mod.2009.06.329.
       Full Text
    • Laufer, E., B. Firulli, D. Krawchuk, V. Centonze, D. Virshup, S. Conway, P. Cserjesi, and A. Firulli. “Hand2 and Twist1 interact antagonistically in the vertebrate limb.” In Developmental Biology, 271:590–590. ACADEMIC PRESS INC ELSEVIER SCIENCE, 2004.
       Link to Item
    • Tsai, I. C., M. Woolf, D. Neklason, R. Burt, and D. M. Virshup. “A disease-associated casein kinase 1 delta mutation alters its physiological roles and may promote adenomatous polyps via wnt/beta-catenin independent mechanism.” In Faseb Journal, 18:C299–C299. FEDERATION AMER SOC EXP BIOL, 2004.
       Link to Item
    • Fu, Y., C. R. Jones, K. Toh, D. Virshup, and L. J. Ptacek. “An hPer2 phosphorylation site mutation in familial Advanced Sleep-Phase Syndrome.” In American Journal of Human Genetics, 69:597–597. UNIV CHICAGO PRESS, 2001.
       Link to Item
    • Slayton, W. B., G. J. Spangrude, Z. Chen, and D. Virshup. “Residual trisomic cells in a patient with resolving transient myeloproliferative disorder and trisomy 21 mosaicism.” In Blood, 94:291B-291B. AMER SOC HEMATOLOGY, 1999.
       Link to Item
    • Vielhaber, E., and D. Virshup. “Identification of Casein Kinase I epsilon (CKI epsilon) substrates using a membrane based kinase assay.” In Faseb Journal, 11:A1359–A1359. FEDERATION AMER SOC EXP BIOL, 1997.
       Link to Item
    • Virshup, D., K. Gietzen, and A. Rivers. “Regulation of casein kinase I epsilon.” In Faseb Journal, 11:A1359–A1359. FEDERATION AMER SOC EXP BIOL, 1997.
       Link to Item
    • Goldsby, R. E., D. Carlson, E. D. Swalberg, and D. Virshup. “Comparing effects on temperature of early versus late leukodepletion in platelet transfusions.” In Blood, 86:1397–1397. W B SAUNDERS CO, 1995.
       Link to Item
    • VIRSHUP, D. M., M. S. WOLD, D. H. WEINBERG, M. G. KAUFFMAN, and T. J. KELLY. “CELLULAR PROTEINS INVOLVED IN SV40 DNA-REPLICATION INVITRO.” In Molecular Mechanisms in Dna Replication and Recombination, edited by C. C. RICHARDSON and I. R. LEHMAN, 127:303–14. WILEY-LISS, INC, 1990.
       Link to Item

Some information on this profile has been compiled automatically from Duke databases and external sources. (Our About page explains how this works.) If you see a problem with the information, please write to Scholars@Duke and let us know. We will reply promptly.