David Marc Virshup | Scholars@Duke

David Marc Virshup
Professor of Pediatrics

Wnt Signaling and Cancer Biology; Circadian Rhythms; Pediatric Hematology/Oncology

Current Appointments & Affiliations

Professor of Pediatrics, Pediatrics, Clinical Science Departments 2007
Member of the Duke Cancer Institute, Duke Cancer Institute, Institutes and Centers 2007

Contact Information

128 Davison Bldg, Durham, NC 27710
Box 2927 Med Ctr, Durham, NC 27710
david.virshup@duke.edu (919) 684-0190

Background
Education, Training, & Certifications
- Hem/Onc Clinical Fellowship, Pediatric, Johns Hopkins University 1984 - 1985
- Pediatric Internship & Residency, Pediatrics, Johns Hopkins University 1981 - 1984
- M.D., Johns Hopkins University 1981
Duke Appointment History
- Instructor, Temporary in the Department of Pediatrics, Pediatrics, Clinical Science Departments 2007
Recognition
In the News
- NOV 19, 2013
  
  Meet the Duke-NUS Faculty: David Virshup
Publications & Artistic Works
Selected Publications
- Academic Articles
  - Fu, NY, Pal, B, Chen, Y, Jackling, FC, Milevskiy, M, Vaillant, F, Capaldo, BD, Guo, F, Liu, KH, Rios, AC, Lim, N, Kueh, AJ, Virshup, DM, Herold, MJ, Tucker, HO, Smyth, GK, Lindeman, GJ, and Visvader, JE. "Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence." Developmental Cell 47, no. 5 (December 2018): 629-644.e8. Full Text
  - Madan, B, Harmston, N, Nallan, G, Montoya, A, Faull, P, Petretto, E, and Virshup, DM. "Temporal dynamics of Wnt-dependent transcriptome reveal an oncogenic Wnt/MYC/ribosome axis." The Journal of Clinical Investigation 128, no. 12 (December 2018): 5620-5633. Full Text
  - Chee, YC, Pahnke, J, Bunte, R, Adsool, VA, Madan, B, and Virshup, DM. "Intrinsic Xenobiotic Resistance of the Intestinal Stem Cell Niche." Developmental Cell 46, no. 6 (September 2018): 681-695.e5. Full Text
  - Kabiri, Z, Greicius, G, Zaribafzadeh, H, Hemmerich, A, Counter, CM, and Virshup, DM. "Wnt signaling suppresses MAPK-driven proliferation of intestinal stem cells." The Journal of Clinical Investigation 128, no. 9 (August 2018): 3806-3812. Full Text
  - Mattes, B, Dang, Y, Greicius, G, Kaufmann, LT, Prunsche, B, Rosenbauer, J, Stegmaier, J, Mikut, R, Özbek, S, Nienhaus, GU, Schug, A, Virshup, DM, and Scholpp, S. "Wnt/PCP controls spreading of Wnt/β-catenin signals by cytonemes in vertebrates." Elife 7 (July 31, 2018). Full Text
  - "Correction for Fustin et al., TwoCk1δtranscripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock." Proceedings of the National Academy of Sciences 115, no. 27 (July 3, 2018): E6386-E6386. Full Text
  - Fustin, J-M, Kojima, R, Itoh, K, Chang, H-Y, Ye, S, Zhuang, B, Oji, A, Gibo, S, Narasimamurthy, R, Virshup, D, Kurosawa, G, Doi, M, Manabe, I, Ishihama, Y, Ikawa, M, and Okamura, H. "Two Ck1δ transcripts regulated by m6A methylation code for two antagonistic kinases in the control of the circadian clock." Proceedings of the National Academy of Sciences of the United States of America 115, no. 23 (June 2018): 5980-5985. Full Text
  - Narasimamurthy, R, Hunt, SR, Lu, Y, Fustin, J-M, Okamura, H, Partch, CL, Forger, DB, Kim, JK, and Virshup, DM. "CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch." Proceedings of the National Academy of Sciences of the United States of America 115, no. 23 (June 2018): 5986-5991. Full Text
  - Madan, B, HARMSTON, NATHAN, Nallan, G, Montoya, A, Faull, P, Petretto, E, and Virshup, D. "Oncogenic Wnt/STOP signaling regulates ribosome biogenesis in vivo." (May 20, 2018). Full Text
  - Moti, N, Yu, J, Boncompain, G, Perez, F, and Virshup, D. "Visualizing Wnt secretion from endoplasmic reticulum to filopodia." (April 14, 2018). Full Text
  - Greicius, G, Kabiri, Z, Sigmundsson, K, Liang, C, Bunte, R, Singh, MK, and Virshup, DM. "PDGFRα+ pericryptal stromal cells are the critical source of Wnts and RSPO3 for murine intestinal stem cells in vivo." Proceedings of the National Academy of Sciences of the United States of America 115, no. 14 (April 2018): E3173-E3181. Full Text
  - Lee, HY, Itahana, Y, Schuechner, S, Fukuda, M, Je, HS, Ogris, E, Virshup, DM, and Itahana, K. "Ca2+-dependent demethylation of phosphatase PP2Ac promotes glucose deprivation-induced cell death independently of inhibiting glycolysis." Science Signaling 11, no. 512 (January 9, 2018). Full Text
  - Madan, B, McDonald, MJ, Foxa, GE, Diegel, CR, Williams, BO, and Virshup, DM. "Bone loss from Wnt inhibition mitigated by concurrent alendronate therapy." Bone Research 6 (January 2018): 17-null. Full Text
  - Zhang, F, Virshup, DM, and Cheong, JK. "Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis." Oncogene 37, no. 3 (January 2018): 363-376. Full Text
  - Ho, SY, Alam, J, Jeyaraj, DA, Wang, W, Lin, GR, Ang, SH, Tan, ESW, Lee, MA, Ke, Z, Madan, B, Virshup, DM, Ding, LJ, Manoharan, V, Chew, YS, Low, CB, Pendharkar, V, Sangthongpitag, K, Hill, J, Keller, TH, and Poulsen, A. "Scaffold Hopping and Optimization of Maleimide Based Porcupine Inhibitors." Journal of Medicinal Chemistry 60, no. 15 (August 2017): 6678-6692. Full Text
  - Alok, A, Lei, Z, Jagannathan, NS, Kaur, S, Harmston, N, Rozen, SG, Tucker-Kellogg, L, and Virshup, DM. "Wnt proteins synergize to activate β-catenin signaling." Journal of Cell Science 130, no. 9 (May 2017): 1532-1544. Full Text
  - Narasimamurthy, R, and Virshup, DM. "A Flick of the Tail Keeps the Circadian Clock in Line." Molecular cell 66, no. 4 (May 2017): 437-438. Full Text
  - Eng, GWL, Edison, , and Virshup, DM. "Site-specific phosphorylation of casein kinase 1 δ (CK1δ) regulates its activity towards the circadian regulator PER2." PloS one 12, no. 5 (January 2017): e0177834-. Full Text
  - Narasimamurthy, R, and Virshup, DM. "Molecular Mechanisms Regulating Temperature Compensation of the Circadian Clock." Frontiers in neurology 8 (January 2017): 161-. (Review) Full Text
  - Cheong, JK, and Virshup, DM. "CK1δ: a pharmacologically tractable Achilles' heel of Wnt-driven cancers?." Annals of translational medicine 4, no. 21 (November 2016): 433-. Full Text
  - Lim, SK, Lu, SY, Kang, S-A, Tan, HJ, Li, Z, Adrian Wee, ZN, Guan, JS, Reddy Chichili, VP, Sivaraman, J, Putti, T, Thike, AA, Tan, PH, Sudol, M, Virshup, DM, Chan, SW, Hong, W, and Lim, YP. "Wnt Signaling Promotes Breast Cancer by Blocking ITCH-Mediated Degradation of YAP/TAZ Transcriptional Coactivator WBP2." Cancer Research 76, no. 21 (November 2016): 6278-6289. Full Text
  - Liu, CC, Ma, DL, Yan, T-D, Fan, X, Poon, Z, Poon, L-F, Goh, S-A, Rozen, SG, Hwang, WYK, Tergaonkar, V, Tan, P, Ghosh, S, Virshup, DM, Goh, ELK, and Li, S. "Distinct Responses of Stem Cells to Telomere Uncapping-A Potential Strategy to Improve the Safety of Cell Therapy." Stem Cells (Dayton, Ohio) 34, no. 10 (October 2016): 2471-2484. Full Text
  - Somarelli, JA, Schaeffer, D, Marengo, MS, Bepler, T, Rouse, D, Ware, KE, Hish, AJ, Zhao, Y, Buckley, AF, Epstein, JI, Armstrong, AJ, Virshup, DM, and Garcia-Blanco, MA. "Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways." Oncogene 35, no. 33 (August 2016): 4302-4311. Full Text Open Access Copy
  - Wang, J, Wang, Z, Yu, T, Yang, H, Virshup, DM, Kops, GJPL, Lee, SH, Zhou, W, Li, X, Xu, W, and Rao, Z. "Crystal structure of a PP2A B56-BubR1 complex and its implications for PP2A substrate recruitment and localization." Protein & cell 7, no. 7 (July 2016): 516-526. Full Text
  - Madan, B, Walker, MP, Young, R, Quick, L, Orgel, KA, Ryan, M, Gupta, P, Henrich, IC, Ferrer, M, Marine, S, Roberts, BS, Arthur, WT, Berndt, JD, Oliveira, AM, Moon, RT, Virshup, DM, Chou, MM, and Major, MB. "USP6 oncogene promotes Wnt signaling by deubiquitylating Frizzleds." Proceedings of the National Academy of Sciences of the United States of America 113, no. 21 (May 9, 2016): E2945-E2954. Full Text
  - Cheong, JK, and Virshup, DM. "Keeping autophagy in cheCK1." Molecular & Cellular Oncology 3, no. 3 (May 2016): e1045117-null. Full Text
  - Madan, B, Patel, MB, Zhang, J, Bunte, RM, Rudemiller, NP, Griffiths, R, Virshup, DM, and Crowley, SD. "Experimental inhibition of porcupine-mediated Wnt O-acylation attenuates kidney fibrosis." Kidney international 89, no. 5 (May 2016): 1062-1074. Full Text Open Access Copy
  - Lo, KA, Ng, PY, Kabiri, Z, Virshup, D, and Sun, L. "Wnt inhibition enhances browning of mouse primary white adipocytes." Adipocyte 5, no. 2 (April 2016): 224-231. Full Text
  - Madan, B, Ke, Z, Harmston, N, Ho, SY, Frois, AO, Alam, J, Jeyaraj, DA, Pendharkar, V, Ghosh, K, Virshup, IH, Manoharan, V, Ong, EHQ, Sangthongpitag, K, Hill, J, Petretto, E, Keller, TH, Lee, MA, Matter, A, and Virshup, DM. "Wnt addiction of genetically defined cancers reversed by PORCN inhibition." Oncogene 35, no. 17 (April 2016): 2197-2207. Full Text
  - Madan, B, Ke, Z, Lei, ZD, Oliver, FA, Oshima, M, Lee, MA, Rozen, S, and Virshup, DM. "NOTUM is a potential pharmacodynamic biomarker of Wnt pathway inhibition." Oncotarget 7, no. 11 (March 2016): 12386-12392. Full Text
  - Xiang, W, Cheong, JK, Ang, SH, Teo, B, Xu, P, Asari, K, Sun, WT, Than, H, Bunte, RM, Virshup, DM, and Chuah, C. "Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration." Oncotarget 6, no. 32 (October 2015): 33769-33780. Full Text
  - Zhou, M, Kim, JK, Eng, GWL, Forger, DB, and Virshup, DM. "A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period." Molecular Cell 60, no. 1 (October 2015): 77-88. Full Text
  - Duraiswamy, AJ, Lee, MA, Madan, B, Ang, SH, Tan, ESW, Cheong, WWV, Ke, Z, Pendharkar, V, Ding, LJ, Chew, YS, Manoharan, V, Sangthongpitag, K, Alam, J, Poulsen, A, Ho, SY, Virshup, DM, and Keller, TH. "Discovery and Optimization of a Porcupine Inhibitor." Journal of Medicinal Chemistry 58, no. 15 (August 2015): 5889-5899. Full Text
  - Kabiri, Z, Numata, A, Kawasaki, A, Edison, , Tenen, DG, and Virshup, DM. "Wnts are dispensable for differentiation and self-renewal of adult murine hematopoietic stem cells." Blood 126, no. 9 (August 2015): 1086-1094. Full Text
  - Madan, B, and Virshup, DM. "Targeting Wnts at the source--new mechanisms, new biomarkers, new drugs." Molecular cancer therapeutics 14, no. 5 (May 2015): 1087-1094. (Review) Full Text
  - Cheong, JK, Zhang, F, Chua, PJ, Bay, BH, Thorburn, A, and Virshup, DM. "Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers." The Journal of Clinical Investigation 125, no. 4 (April 2015): 1401-1418. Full Text
  - Ribi, S, Baumhoer, D, Lee, K, Edison, , Teo, ASM, Madan, B, Zhang, K, Kohlmann, WK, Yao, F, Lee, WH, Hoi, Q, Cai, S, Woo, XY, Tan, P, Jundt, G, Smida, J, Nathrath, M, Sung, W-K, Schiffman, JD, Virshup, DM, and Hillmer, AM. "TP53 intron 1 hotspot rearrangements are specific to sporadic osteosarcoma and can cause Li-Fraumeni syndrome." Oncotarget 6, no. 10 (April 2015): 7727-7740. Full Text
  - Stewart, J, James, J, McCluggage, GW, McQuaid, S, Arthur, K, Boyle, D, Mullan, P, McArt, D, Yan, B, Irwin, G, Harkin, DP, Zhengdeng, L, Ong, C-W, Yu, J, Virshup, DM, and Salto-Tellez, M. "Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression." Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc 28, no. 3 (March 2015): 428-436. Full Text
  - Virshup, DM. "Moving upstream in the war on WNTs." The Journal of Clinical Investigation 125, no. 3 (March 2015): 975-977. Full Text
  - Yim, DGR, Ghosh, S, Guy, GR, and Virshup, DM. "Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling." Oncogene 34, no. 4 (January 22, 2015): 474-484. Full Text
  - Stewart, J, James, J, McCluggage, GW, McQuaid, S, Arthur, K, Boyle, D, Mullan, P, McArt, D, Yan, B, Irwin, G, Harkin, DP, Zhengdeng, L, Ong, CW, Yu, J, Virshup, DM, and Salto-Tellez, M. "Analysis of wntless (WLS) expression in gastric, ovarian, and breast cancers reveals a strong association with HER2 overexpression." Modern Pathology 28, no. 3 (January 1, 2015): 428-436. Full Text
  - Yim, DGR, Ghosh, S, Guy, GR, and Virshup, DM. "Casein kinase 1 regulates Sprouty2 in FGF-ERK signaling." Oncogene 34, no. 4 (January 2015): 474-484. Full Text
  - Xu, P, Virshup, DM, and Lee, SH. "B56-PP2A regulates motor dynamics for mitotic chromosome alignment." Journal of cell science 127, no. Pt 21 (November 2014): 4567-4573. Full Text
  - Yu, J, and Virshup, DM. "Updating the Wnt pathways." Bioscience Reports 34, no. 5 (October 17, 2014). Full Text
  - Low, ICC, Loh, T, Huang, Y, Virshup, DM, and Pervaiz, S. "Ser70 phosphorylation of Bcl-2 by selective tyrosine nitration of PP2A-B56δ stabilizes its antiapoptotic activity." Blood 124, no. 14 (October 2014): 2223-2234. Full Text
  - Zhu, Y, Demidov, ON, Goh, AM, Virshup, DM, Lane, DP, and Bulavin, DV. "Phosphatase WIP1 regulates adult neurogenesis and WNT signaling during aging." The Journal of Clinical Investigation 124, no. 7 (July 2014): 3263-3273. Full Text
  - Kabiri, Z, Greicius, G, Madan, B, Biechele, S, Zhong, Z, Zaribafzadeh, H, Edison, , Aliyev, J, Wu, Y, Bunte, R, Williams, BO, Rossant, J, and Virshup, DM. "Stroma provides an intestinal stem cell niche in the absence of epithelial Wnts." Development (Cambridge, England) 141, no. 11 (June 2014): 2206-2215. Full Text
  - MacDonald, BT, Hien, A, Zhang, X, Iranloye, O, Virshup, DM, Waterman, ML, and He, X. "Disulfide bond requirements for active Wnt ligands." The Journal of Biological Chemistry 289, no. 26 (June 2014): 18122-18136. Full Text
  - Virshup, DM. "WLS Retrograde transport to the endoplasmic reticulum during Wnt secretion." Developmental Cell 29, no. 3 (May 12, 2014): 277-291. Full Text
  - Yu, J, Chia, J, Canning, CA, Jones, CM, Bard, FA, and Virshup, DM. "WLS retrograde transport to the endoplasmic reticulum during Wnt secretion." Developmental Cell 29, no. 3 (May 2014): 277-291. Full Text
  - Asad, M, Wong, MK, Tan, TZ, Choolani, M, Low, J, Mori, S, Virshup, D, Thiery, JP, and Huang, RY-J. "FZD7 drives in vitro aggressiveness in Stem-A subtype of ovarian cancer via regulation of non-canonical Wnt/PCP pathway." Cell Death & Disease 5 (January 2014): e1346-null. Full Text
  - Madan, B, Ke, Z, Lim, SQY, Alam, J, Ho, SY, Jeyaraj, DA, Ghosh, K, Chew, YS, Aliyev, J, Ding, LJ, Pendharkar, V, Wang, S, Sangthongpitag, K, Keller, T, Lee, MA, and Virshup, DM. "Abstract C248: Novel PORCN inhibitors are safe and effective in the treatment of WNT-dependent cancers." Molecular Cancer Therapeutics 12, no. 11_Supplement (November 1, 2013): C248-C248. Full Text
  - Yim, DGR, and Virshup, DM. "Unwinding the Wnt action of casein kinase 1." Cell Res 23, no. 6 (June 2013): 737-738. Full Text Link to Item
  - Xu, P, Raetz, EA, Kitagawa, M, Virshup, DM, and Lee, SH. "BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression." Biology Open 2, no. 5 (May 2013): 479-486. Full Text Open Access Copy
  - Stewart, J, James, J, McCluggage, G, McQuaid, S, Boyle, D, Arthur, K, Mullan, P, Kidson, C, McCabe, N, Kennedy, R, McArt, D, Carson, A, Yan, B, Zhengdeng, L, Tan, P, Virshup, D, and Salto-Tellez, M. "A strong correlation between expression of Wntless and of human epidermal growth factor receptor 2 in gastric, ovarian, and breast cancers suggests a novel-signalling pathway involving NFκB and STAT3." The Lancet 381 (February 2013): S106-S106. Full Text
  - Proffitt, KD, Madan, B, Ke, Z, Pendharkar, V, Ding, L, Lee, MA, Hannoush, RN, and Virshup, DM. "Pharmacological inhibition of the Wnt acyltransferase PORCN prevents growth of WNT-driven mammary cancer." Cancer Research 73, no. 2 (January 2013): 502-507. Full Text
  - Yim, DGR, and Virshup, DM. "Unwinding the Wnt action of casein kinase 1." Cell Research 23, no. 6 (2013): 737-738. Full Text
  - Proffitt, KD, and Virshup, DM. "Precise regulation of porcupine activity is required for physiological Wnt signaling." The Journal of Biological Chemistry 287, no. 41 (October 2012): 34167-34178. Full Text
  - Najdi, R, Proffitt, K, Sprowl, S, Kaur, S, Yu, J, Covey, TM, Virshup, DM, and Waterman, ML. "A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities." Differentiation 84, no. 2 (September 2012): 203-213. Full Text Link to Item
  - Coombs, GS, Schmitt, AA, Canning, CA, Alok, A, Low, ICC, Banerjee, N, Kaur, S, Utomo, V, Jones, CM, Pervaiz, S, Toone, EJ, and Virshup, DM. "Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer." Oncogene 31, no. 2 (January 2012): 213-225. Full Text
  - Covey, TM, Kaur, S, Tan Ong, T, Proffitt, KD, Wu, Y, Tan, P, and Virshup, DM. "PORCN moonlights in a Wnt-independent pathway that regulates cancer cell proliferation." PLoS One 7, no. 4 (2012): e34532-. Full Text Link to Item
  - Ooi, CH, Oh, HK, Wang, HZ, Tan, ALK, Wu, J, Lee, M, Rha, SY, Chung, HC, Virshup, DM, and Tan, P. "A densely interconnected genome-wide network of microRNAs and oncogenic pathways revealed using gene expression signatures." PLoS Genet 7, no. 12 (December 2011): e1002415-. Full Text Link to Item
  - Cheong, JK, Nguyen, TH, Wang, H, Tan, P, Voorhoeve, PM, Lee, SH, and Virshup, DM. "IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation." Oncogene 30, no. 22 (June 2011): 2558-2569. Full Text
  - Cheong, JK, and Virshup, DM. "Casein kinase 1: Complexity in the family." The International Journal of Biochemistry & Cell Biology 43, no. 4 (April 2011): 465-469. (Review) Full Text
  - Virshup, DM, and Kaldis, P. "Cell biology. Enforcing the Greatwall in mitosis." Science 330, no. 6011 (December 17, 2010): 1638-1639. Full Text Link to Item
  - Covey, TM, Edes, K, Coombs, GS, Virshup, DM, and Fitzpatrick, FA. "Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer. (Published online)" PLoS One 5, no. 10 (October 21, 2010): e13545-. Full Text Link to Item
  - Coombs, GS, Yu, J, Canning, CA, Veltri, CA, Covey, TM, Cheong, JK, Utomo, V, Banerjee, N, Zhang, ZH, Jadulco, RC, Concepcion, GP, Bugni, TS, Harper, MK, Mihalek, I, Jones, CM, Ireland, CM, and Virshup, DM. "WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification." J Cell Sci 123, no. Pt 19 (October 1, 2010): 3357-3367. Full Text Link to Item
  - McCulloch, MWB, Bugni, TS, Concepcion, GP, Coombs, GS, Harper, MK, Kaur, S, Mangalindan, GC, Mutizwa, MM, Veltri, CA, Virshup, DM, and Ireland, CM. "Carteriosulfonic acids A-C, GSK-3beta inhibitors from a Carteriospongia sp." J Nat Prod 72, no. 9 (September 2009): 1651-1656. Full Text Link to Item
  - Wang, C, Chang, KC, Somers, G, Virshup, D, Ang, BT, Tang, C, Yu, F, and Wang, H. "Protein phosphatase 2A regulates self-renewal of Drosophila neural stem cells." Development 136, no. 17 (September 1, 2009): 3031-3031. Full Text
  - Wang, C, Chang, KC, Somers, G, Virshup, D, Ang, BT, Tang, C, Yu, F, and Wang, H. "Protein phosphatase 2A regulates self-renewal of Drosophila neural stem cells." Development 136, no. 13 (July 2009): 2287-2296. Full Text Link to Item
  - Virshup, DM, and Forger, DB. "Keeping the beat in the rising heat." Cell 137, no. 4 (May 15, 2009): 602-604. Full Text Link to Item
  - McCulloch, MWB, Coombs, GS, Banerjee, N, Bugni, TS, Cannon, KM, Harper, MK, Veltri, CA, Virshup, DM, and Ireland, CM. "Psammaplin A as a general activator of cell-based signaling assays via HDAC inhibition and studies on some bromotyrosine derivatives." Bioorganic & Medicinal Chemistry 17, no. 6 (March 2009): 2189-2198. Full Text
  - Virshup, DM, and Shenolikar, S. "From promiscuity to precision: protein phosphatases get a makeover." Molecular Cell 33, no. 5 (March 2009): 537-545. (Review) Full Text
  - Coombs, GS, Covey, TM, and Virshup, DM. "Wnt signaling in development, disease and translational medicine." Curr Drug Targets 9, no. 7 (July 2008): 513-531. (Review) Link to Item
  - Meng, Q-J, Logunova, L, Maywood, ES, Gallego, M, Lebiecki, J, Brown, TM, Sládek, M, Semikhodskii, AS, Glossop, NRJ, Piggins, HD, Chesham, JE, Bechtold, DA, Yoo, S-H, Takahashi, JS, Virshup, DM, Boot-Handford, RP, Hastings, MH, and Loudon, ASI. "Setting clock speed in mammals: the CK1 epsilon tau mutation in mice accelerates circadian pacemakers by selectively destabilizing PERIOD proteins." Neuron 58, no. 1 (April 2008): 78-88. Full Text
  - Forester, CM, Maddox, J, Louis, JV, Goris, J, and Virshup, DM. "Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1." Proceedings of the National Academy of Sciences of the United States of America 104, no. 50 (December 4, 2007): 19867-19872. Full Text
  - Forger, D, Gonze, D, Virshup, D, and Welsh, DK. "Beyond intuitive modeling: combining biophysical models with innovative experiments to move the circadian clock field forward." Journal of Biological Rhythms 22, no. 3 (June 2007): 200-210. (Review) Full Text
  - Virshup, DM, and Forger, DB. "After hours keeps clock researchers CRYing Overtime." Cell 129, no. 5 (June 1, 2007): 857-859. Full Text Link to Item
  - Luo, W, Peterson, A, Garcia, BA, Coombs, G, Kofahl, B, Heinrich, R, Shabanowitz, J, Hunt, DF, Yost, HJ, and Virshup, DM. "Protein phosphatase 1 regulates assembly and function of the beta-catenin degradation complex." The Embo Journal 26, no. 6 (March 2007): 1511-1521. Full Text
  - Tsai, I-C, Amack, JD, Gao, Z-H, Band, V, Yost, HJ, and Virshup, DM. "A Wnt-CKIvarepsilon-Rap1 pathway regulates gastrulation by modulating SIPA1L1, a Rap GTPase activating protein." Developmental Cell 12, no. 3 (March 2007): 335-347. Full Text
  - Tsai, I-C, Woolf, M, Neklason, DW, Branford, WW, Yost, HJ, Burt, RW, and Virshup, DM. "Disease-associated casein kinase I delta mutation may promote adenomatous polyps formation via a Wnt/beta-catenin independent mechanism." International Journal of Cancer 120, no. 5 (March 2007): 1005-1012. Full Text
  - Gallego, M, and Virshup, DM. "Post-translational modifications regulate the ticking of the circadian clock." Nature Reviews. Molecular Cell Biology 8, no. 2 (February 2007): 139-148. (Review) Full Text
  - Saraf, A, Virshup, DM, and Strack, S. "Differential expression of the B'beta regulatory subunit of protein phosphatase 2A modulates tyrosine hydroxylase phosphorylation and catecholamine synthesis." The Journal of Biological Chemistry 282, no. 1 (January 2007): 573-580. Full Text
  - Virshup, DM, Eide, EJ, Forger, DB, Gallego, M, and Harnish, EV. "Reversible protein phosphorylation regulates circadian rhythms." Cold Spring Harb Symp Quant Biol 72 (2007): 413-420. (Review) Full Text Link to Item
  - Margolis, SS, Perry, JA, Forester, CM, Nutt, LK, Guo, Y, Jardim, MJ, Thomenius, MJ, Freel, CD, Darbandi, R, Ahn, J-H, Arroyo, JD, Wang, X-F, Shenolikar, S, Nairn, AC, Dunphy, WG, Hahn, WC, Virshup, DM, and Kornbluth, S. "Role for the PP2A/B56delta phosphatase in regulating 14-3-3 release from Cdc25 to control mitosis." Cell 127, no. 4 (November 2006): 759-773. Full Text
  - Gallego, M, Kang, H, and Virshup, DM. "Protein phosphatase 1 regulates the stability of the circadian protein PER2." The Biochemical Journal 399, no. 1 (October 2006): 169-175. Full Text
  - Klimowski, LK, Garcia, BA, Shabanowitz, J, Hunt, DF, and Virshup, DM. "Site-specific casein kinase 1epsilon-dependent phosphorylation of Dishevelled modulates beta-catenin signaling." The Febs Journal 273, no. 20 (October 2006): 4594-4602. Full Text
  - Gallego, M, Eide, EJ, Woolf, MF, Virshup, DM, and Forger, DB. "An opposite role for tau in circadian rhythms revealed by mathematical modeling." Proceedings of the National Academy of Sciences of the United States of America 103, no. 28 (July 3, 2006): 10618-10623. Full Text
  - Swiatek, W, Kang, H, Garcia, BA, Shabanowitz, J, Coombs, GS, Hunt, DF, and Virshup, DM. "Negative regulation of LRP6 function by casein kinase I epsilon phosphorylation." The Journal of Biological Chemistry 281, no. 18 (May 2006): 12233-12241. Full Text
  - Eide, EJ, Woolf, MF, Kang, H, Woolf, P, Hurst, W, Camacho, F, Vielhaber, EL, Giovanni, A, and Virshup, DM. "Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation." Molecular and Cellular Biology 25, no. 7 (April 2005): 2795-2807. Full Text
  - Firulli, BA, Krawchuk, D, Centonze, VE, Vargesson, N, Virshup, DM, Conway, SJ, Cserjesi, P, Laufer, E, and Firulli, AB. "Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities." Nature Genetics 37, no. 4 (April 2005): 373-381. Full Text
  - Gallego, M, and Virshup, DM. "Protein serine/threonine phosphatases: life, death, and sleeping." Curr Opin Cell Biol 17, no. 2 (April 2005): 197-202. (Review) Full Text Link to Item
  - Eide, EJ, Kang, H, Crapo, S, Gallego, M, and Virshup, DM. "Casein kinase I in the mammalian circadian clock." Methods in Enzymology 393 (January 2005): 408-418. Full Text
  - Okamura, H, Garcia-Rodriguez, C, Martinson, H, Qin, J, Virshup, DM, and Rao, A. "A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1." Molecular and Cellular Biology 24, no. 10 (May 2004): 4184-4195. Full Text
  - Swiatek, W, Tsai, I-C, Klimowski, L, Pepler, A, Barnette, J, Yost, HJ, and Virshup, DM. "Regulation of casein kinase I epsilon activity by Wnt signaling." J Biol Chem 279, no. 13 (March 26, 2004): 13011-13017. Full Text Link to Item
  - Firulli, BA, Virshup, DM, and Firulli, AB. "Phosphopeptide mapping of proteins ectopically expressed in tissue culture cell lines." Biol Proced Online 6 (2004): 16-22. Full Text Link to Item
  - Firulli, BA, Howard, MJ, McDaid, JR, McIlreavey, L, Dionne, KM, Centonze, VE, Cserjesi, P, Virshup, DM, and Firulli, AB. "PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation." Molecular Cell 12, no. 5 (November 2003): 1225-1237. Full Text
  - Liu, Y, Virshup, DM, White, RL, and Hsu, L-C. "Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1alpha." Cancer Res 62, no. 22 (November 15, 2002): 6357-6361. Link to Item
  - Liu, F, Virshup, DM, Nairn, AC, and Greengard, P. "Mechanism of regulation of casein kinase I activity by group I metabotropic glutamate receptors." The Journal of Biological Chemistry 277, no. 47 (November 2002): 45393-45399. Full Text
  - Raetz, EA, Perkins, SL, Carlson, MA, Schooler, KP, Carroll, WL, and Virshup, DM. "The nucleophosmin-anaplastic lymphoma kinase fusion protein induces c-Myc expression in pediatric anaplastic large cell lymphomas." The American Journal of Pathology 161, no. 3 (September 2002): 875-883. Full Text
  - Li, X, Scuderi, A, Letsou, A, and Virshup, DM. "B56-associated protein phosphatase 2A is required for survival and protects from apoptosis in Drosophila melanogaster." Molecular and Cellular Biology 22, no. 11 (June 2002): 3674-3684. Full Text
  - Eide, EJ, Vielhaber, EL, Hinz, WA, and Virshup, DM. "The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon." The Journal of Biological Chemistry 277, no. 19 (May 2002): 17248-17254. Full Text
  - Toh, KL, Thulin, C, Fu, YH, Ptacek, LJ, and Virshup, DM. "Sequential multisite phosphorylation by casein kinase I epsilon (CKI epsilon)." FASEB JOURNAL 16, no. 5 (March 22, 2002): A917-A917. Link to Item
  - Slayton, WB, Spangrude, GJ, Chen, Z, Greene, WF, and Virshup, D. "Lineage-specific trisomy 21 in a neonate with resolving transient myeloproliferative syndrome." J Pediatr Hematol Oncol 24, no. 3 (March 2002): 224-226. Link to Item
  - Gao, Z-H, Seeling, JM, Hill, V, Yochum, A, and Virshup, DM. "Casein kinase I phosphorylates and destabilizes the beta-catenin degradation complex." Proceedings of the National Academy of Sciences of the United States of America 99, no. 3 (February 2002): 1182-1187. Full Text
  - Li, X, and Virshup, DM. "Two conserved domains in regulatory B subunits mediate binding to the A subunit of protein phosphatase 2A." European Journal of Biochemistry 269, no. 2 (January 2002): 546-552. Full Text
  - Vielhaber, EL, Duricka, D, Ullman, KS, and Virshup, DM. "Nuclear export of mammalian PERIOD proteins." The Journal of Biological Chemistry 276, no. 49 (December 2001): 45921-45927. Full Text
  - Li, X, Yost, HJ, Virshup, DM, and Seeling, JM. "Protein phosphatase 2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus." The Embo Journal 20, no. 15 (August 2001): 4122-4131. Full Text
  - Seeling, JM, Li, X, Yost, HJ, and Virshup, DM. "PP2A and its B56 regulatory subunit inhibit Wnt signaling in Xenopus." DEVELOPMENTAL BIOLOGY 235, no. 1 (July 1, 2001): 254-254. Link to Item
  - Eide, EJ, and Virshup, DM. "Casein kinase I: another cog in the circadian clockworks." Chronobiol Int 18, no. 3 (May 2001): 389-398. (Review) Link to Item
  - Camacho, F, Cilio, M, Guo, Y, Virshup, DM, Patel, K, Khorkova, O, Styren, S, Morse, B, Yao, Z, and Keesler, GA. "Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2." FEBS Lett 489, no. 2-3 (February 2, 2001): 159-165. Link to Item
  - Toh, KL, Jones, CR, He, Y, Eide, EJ, Hinz, WA, Virshup, DM, Ptácek, LJ, and Fu, YH. "An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome." Science (New York, N.Y.) 291, no. 5506 (February 2001): 1040-1043. Full Text
  - Vielhaber, E, and Virshup, DM. "Casein kinase I: from obscurity to center stage." Iubmb Life 51, no. 2 (February 2001): 73-78. (Review) Full Text
  - Raetz, EA, Perkins, SL, Carlson, MA, Schooler, KP, and Virshup, DM. "Pediatric ALK-positive lymphomas coexpress c-Myc." BLOOD 96, no. 11 (November 16, 2000): 128A-128A. Link to Item
  - Vielhaber, E, Eide, E, Rivers, A, Gao, ZH, and Virshup, DM. "Nuclear entry of the circadian regulator mPER1 is controlled by mammalian casein kinase I epsilon." Molecular and Cellular Biology 20, no. 13 (July 2000): 4888-4899. Full Text
  - Keesler, GA, Camacho, F, Guo, Y, Virshup, D, Mondadori, C, and Yao, Z. "Phosphorylation and destabilization of human period I clock protein by human casein kinase I epsilon." Neuroreport 11, no. 5 (April 2000): 951-955. Full Text
  - Virshup, DM. "Protein phosphatase 2A: a panoply of enzymes." Curr Opin Cell Biol 12, no. 2 (April 2000): 180-185. (Review) Link to Item
  - Gao, ZH, Metherall, J, and Virshup, DM. "Identification of casein kinase I substrates by in vitro expression cloning screening." Biochem Biophys Res Commun 268, no. 2 (February 16, 2000): 562-566. Full Text Link to Item
  - Gietzen, KF, and Virshup, DM. "Identification of inhibitory autophosphorylation sites in casein kinase I epsilon." The Journal of Biological Chemistry 274, no. 45 (November 1999): 32063-32070. Full Text
  - Goldsby, RE, Perkins, SL, Virshup, DM, Brothman, AR, and Bruggers, CS. "Lymphoblastic lymphoma and excessive toxicity from chemotherapy: an unusual presentation for Fanconi anemia." J Pediatr Hematol Oncol 21, no. 3 (May 1999): 240-243. Link to Item
  - Honeggar, M, Krall, J, Virshup, DM, and Movsesian, MA. "Expression of multiple PP2A serine/threonine phosphatase B56 (B ') subunit isoforms in human cardiac and vascular smooth muscle myocytes." JOURNAL OF INVESTIGATIVE MEDICINE 47, no. 4 (April 1999): 194A-194A. Link to Item
  - Honeggar, M, Krall, J, Virshup, DM, and Movsesian, MA. "Expression of multiple PP2A serine/threonine phosphatase B56 (B ') subunit isoforms in human cardiac and vascular smooth muscle myocytes." FASEB JOURNAL 13, no. 4 (March 12, 1999): A468-A468. Link to Item
  - Seeling, JM, Miller, JR, Gil, R, Moon, RT, White, R, and Virshup, DM. "Regulation of beta-catenin signaling by the B56 subunit of protein phosphatase 2A." Science (New York, N.Y.) 283, no. 5410 (March 1999): 2089-2091. Full Text
  - Rivers, A, Gietzen, KF, Vielhaber, E, and Virshup, DM. "Regulation of casein kinase I epsilon and casein kinase I delta by an in vivo futile phosphorylation cycle." J Biol Chem 273, no. 26 (June 26, 1998): 15980-15984. Link to Item
  - McDonald, JM, Douglass, EC, Fisher, R, Geiser, CF, Krill, CE, Strong, LC, Virshup, D, and Huff, V. "Linkage of familial Wilms' tumor predisposition to chromosome 19 and a two-locus model for the etiology of familial tumors." Cancer Research 58, no. 7 (April 1998): 1387-1390.
  - Cegielska, A, Gietzen, KF, Rivers, A, and Virshup, DM. "Autoinhibition of casein kinase I epsilon (CKI epsilon) is relieved by protein phosphatases and limited proteolysis." J Biol Chem 273, no. 3 (January 16, 1998): 1357-1364. Link to Item
  - McCright, B, and Virshup, DM. "Identifying protein phosphatase 2A interacting proteins using the yeast two-hybrid method." Methods Mol Biol 93 (1998): 263-277. Full Text Link to Item
  - "Determinants of casein kinase i epsilon (ckir) autoinhibition." Faseb Journal 11, no. 9 (December 1, 1997).
  - "Regulation of casein kinase i." Faseb Journal 11, no. 9 (December 1, 1997).
  - Gietzen, KJ, and Virshup, DM. "Determinants of casein kinase I epsilon (CKI epsilon) autoinhibition." FASEB JOURNAL 11, no. 9 (July 31, 1997): A1356-A1356. Link to Item
  - McCright, B, Rivers, AM, Audlin, S, and Virshup, DM. "The B56 family of protein phosphatase 2A (PP2A) regulatory subunits encodes differentiation-induced phosphoproteins that target PP2A to both nucleus and cytoplasm." The Journal of Biological Chemistry 271, no. 36 (September 1996): 22081-22089. Full Text
  - McCright, B, Brothman, AR, and Virshup, DM. "Assignment of human protein phosphatase 2A regulatory subunit genes b56alpha, b56beta, b56gamma, b56delta, and b56epsilon (PPP2R5A-PPP2R5E), highly expressed in muscle and brain, to chromosome regions 1q41, 11q12, 3p21, 6p21.1, and 7p11.2 --> p12." Genomics 36, no. 1 (August 1996): 168-170. Full Text
  - McCright, B, and Virshup, DM. "Identification of a new family of protein phosphatase 2A regulatory subunits." The Journal of Biological Chemistry 270, no. 44 (November 1995): 26123-26128. Full Text
  - Fish, KJ, Cegielska, A, Getman, ME, Landes, GM, and Virshup, DM. "Isolation and characterization of human casein kinase I epsilon (CKI), a novel member of the CKI gene family." The Journal of Biological Chemistry 270, no. 25 (June 1995): 14875-14883. Full Text
  - Sivak, LE, and Virshup, DM. "Occurrence of Henoch-Schönlein purpura in a child with Wilms' tumor." Med Pediatr Oncol 24, no. 3 (March 1995): 213-214. Link to Item
  - Cegielska, A, Shaffer, S, Derua, R, Goris, J, and Virshup, DM. "Different oligomeric forms of protein phosphatase 2A activate and inhibit simian virus 40 DNA replication." Mol Cell Biol 14, no. 7 (July 1994): 4616-4623. Link to Item
  - Cegielska, A, Moarefi, I, Fanning, E, and Virshup, DM. "T-antigen kinase inhibits simian virus 40 DNA replication by phosphorylation of intact T antigen on serines 120 and 123." J Virol 68, no. 1 (January 1994): 269-275. Link to Item
  - Coombs, RH, and Virshup, BB. "Enhancing the psychological health of medical students: the student well-being committee." Medical education 28, no. 1 (January 1994): 47-54. Full Text
  - Cegielska, A, and Virshup, DM. "Control of simian virus 40 DNA replication by the HeLa cell nuclear kinase casein kinase I." Mol Cell Biol 13, no. 2 (February 1993): 1202-1211. Link to Item
  - VIRSHUP, DM, CEGIELSKA, A, FISH, K, SHAFFER, S, and HILLAM, D. "CONTROL OF SV40 DNA-REPLICATION BY THE RECIPROCAL ACTION OF CASEIN KINASE-I AND PROTEIN PHOSPHATASE 2AC." JOURNAL OF CELLULAR BIOCHEMISTRY (January 9, 1993): 305-305. Link to Item
  - Virshup, DM, Russo, AA, and Kelly, TJ. "Mechanism of activation of simian virus 40 DNA replication by protein phosphatase 2A." Mol Cell Biol 12, no. 11 (November 1992): 4883-4895. Link to Item
  - Modlin, JF, Dagan, R, Berlin, LE, Virshup, DM, Yolken, RH, and Menegus, M. "Focal encephalitis with enterovirus infections." Pediatrics 88, no. 4 (October 1991): 841-845. Link to Item
  - Scheidtmann, KH, Virshup, DM, and Kelly, TJ. "Protein phosphatase 2A dephosphorylates simian virus 40 large T antigen specifically at residues involved in regulation of DNA-binding activity." Journal of Virology 65, no. 4 (April 1991): 2098-2101.
  - ERDILE, LF, COLLINS, KL, RUSSO, A, SIMANCEK, P, SMALL, D, UMBRICHT, C, VIRSHUP, D, CHENG, L, RANDALL, S, WEINBERG, D, MOAREFI, I, FANNING, E, and KELLY, T. "INITIATION OF SV40 DNA-REPLICATION - MECHANISM AND CONTROL." Cold Spring Harbor Symposia on Quantitative Biology 56 (January 1, 1991): 303-313. (Academic Article) Link to Item
  - Erdile, LF, Collins, KL, Russo, A, Simancek, P, Small, D, Umbricht, C, Virshup, D, Cheng, L, Randall, S, and Weinberg, D. "Initiation of SV40 DNA replication: mechanism and control." Cold Spring Harbor Symposia on Quantitative Biology 56 (January 1991): 303-313. (Review) Full Text
  - Weinberg, DH, Collins, KL, Simancek, P, Russo, A, Wold, MS, Virshup, DM, and Kelly, TJ. "Reconstitution of simian virus 40 DNA replication with purified proteins." Proceedings of the National Academy of Sciences of the United States of America 87, no. 22 (November 1990): 8692-8696. Full Text
  - Virshup, DM. "DNA replication." Curr Opin Cell Biol 2, no. 3 (June 1990): 453-460. (Review) Link to Item
  - Moo-Penn, WF, Swan, DC, Hine, TK, Baine, RM, Jue, DL, Benson, JM, Johnson, MH, Virshup, DM, and Zinkham, WH. "Hb Catonsville (glutamic acid inserted between Pro-37(C2)alpha and Thr-38(C3)alpha). Nonallelic gene conversion in the globin system?." J Biol Chem 264, no. 36 (December 25, 1989): 21454-21457. Link to Item
  - Virshup, DM, Kauffman, MG, and Kelly, TJ. "Activation of SV40 DNA replication in vitro by cellular protein phosphatase 2A." The Embo Journal 8, no. 12 (December 1989): 3891-3898. Full Text
  - Virshup, DM, and Kelly, TJ. "Purification of replication protein C, a cellular protein involved in the initial stages of simian virus 40 DNA replication in vitro." Proc Natl Acad Sci U S A 86, no. 10 (May 1989): 3584-3588. Link to Item
  - Wold, MS, Weinberg, DH, Virshup, DM, Li, JJ, and Kelly, TJ. "Identification of cellular proteins required for simian virus 40 DNA replication." The Journal of Biological Chemistry 264, no. 5 (February 1989): 2801-2809.
  - Virshup, DM, and Bennett, V. "Clathrin-coated vesicle assembly polypeptides: physical properties and reconstitution studies with brain membranes." The Journal of Cell Biology 106, no. 1 (January 1988): 39-50. Full Text
  - JERDAN, MS, SHAPIRO, RS, SMITH, NB, VIRSHUP, DM, and HOOD, AF. "CUTANEOUS MANIFESTATIONS OF CORYNEBACTERIUM GROUP JK SEPSIS." JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY 16, no. 2 (February 1987): 444-447. Full Text Link to Item
  - Jerdan, MS, Shapiro, RS, Smith, NB, Virshup, DM, and Hood, AF. "Cutaneous manifestations of Corynebacterium group JK sepsis." J Am Acad Dermatol 16, no. 2 Pt 2 (February 1987): 444-447. Link to Item
  - Virshup, DM, and Hood, AF. "Cutaneous manifestations of Corynebacterium group JK sepsis." Journal of the American Academy of Dermatology 16, no. 2 (January 1, 1987): 444-447. Full Text
  - VIRSHUP, DM, and BENNETT, V. "CLATHRIN-COATED VESICLE ASSEMBLY POLYPEPTIDES - PHYSICAL-PROPERTIES AND IDENTIFICATION OF A NEW SUBUNIT." JOURNAL OF CELL BIOLOGY 103, no. 5 (November 1986): A53-A53. Link to Item
  - Agre, P, Virshup, D, and Bennett, V. "Bepridil and cetiedil. Vasodilators which inhibit Ca2+-dependent calmodulin interactions with erythrocyte membranes." J Clin Invest 74, no. 3 (September 1984): 812-820. Full Text Link to Item
  - Virshup, DM, Zinkham, WH, Sirota, RL, and Caughey, WS. "Unique sensitivity of Hb Zürich to oxidative injury by phenazopyridine: reversal of the effects by elevating carboxyhemoglobin levels in vivo and in vitro." American Journal of Hematology 14, no. 4 (June 1983): 315-324. Full Text
  - "Unique sensitivity of HB Zurich to oxidative injury by phenazopyridine: Reversal of the effect by elevating carboxyhemoglobin levels in vivo and in vitro." Pediatric Research 16, no. 4 II (January 1, 1982).
- Conference Papers
  - Cai, W, Cheong, J, Edison, E, Banerjee, A, Tan, T, Gaboury, L, Yousef, E, Thiery, J, Lobie, P, Virshup, D, Yap, C, and Kumar, A. "Abstract P4-08-03: DEAD-box RNA helicase DP103 as a novel regulator of Wnt/β-catenin signaling pathway and promotes cancer stem cell-like behavior in triple negative breast cancers." February 15, 2016. Full Text
  - Ke, Z, Madan, B, Lim, SQY, Wang, S, Alam, J, Ho, SY, Jeyaraj, DA, Ghosh, K, Chew, YS, Ding, LJ, Monoharan, V, Pendharkar, V, Ong, E, Hill, J, Sangthongpitag, K, Keller, T, Lee, MA, and Virshup, DM. "Abstract 4449: A novel Porcupine inhibitor is effective in the treatment of cancers with RNF43 mutations." : American Association for Cancer Research (AACR), August 1, 2015. Full Text
  - Ke, Z, Lim, S, Wang, S, Fulwood, J, Proffitt, K, Madan, B, Choong, M, Flotow, H, Virshup, D, and Lee, M. "172 Identification of Small Molecule Inhibitors of Wnt Secretion." November 2012. Full Text
  - Cheong, JK, and Virshup, DM. "Abstract B264: IC261 induces cell cycle arrest and apoptosis of human cancer cells via a CK1 / independent mechanism." December 10, 2009. Full Text
  - Wang, C, Chang, K, Somers, G, Virshup, D, Ti Ang, B, Tang, C, Yu, F, and Wang, H. "08-P022 Protein phosphatase 2A regulates self-renewal of Drosophila neural stem cells." August 2009. Full Text
  - Laufer, E, Firulli, B, Krawchuk, D, Centonze, V, Virshup, D, Conway, S, Cserjesi, P, and Firulli, A. "Hand2 and Twist1 interact antagonistically in the vertebrate limb." July 15, 2004. Link to Item
  - Tsai, IC, Woolf, M, Neklason, D, Burt, R, and Virshup, DM. "A disease-associated casein kinase 1 delta mutation alters its physiological roles and may promote adenomatous polyps via wnt/beta-catenin independent mechanism." May 14, 2004. Link to Item
  - Fu, Y, Jones, CR, Toh, K, Virshup, D, and Ptacek, LJ. "An hPer2 phosphorylation site mutation in familial Advanced Sleep-Phase Syndrome." October 2001. Link to Item
  - Slayton, WB, Spangrude, GJ, Chen, Z, and Virshup, D. "Residual trisomic cells in a patient with resolving transient myeloproliferative disorder and trisomy 21 mosaicism." November 15, 1999. Link to Item
  - Vielhaber, E, and Virshup, D. "Identification of Casein Kinase I epsilon (CKI epsilon) substrates using a membrane based kinase assay." July 31, 1997. Link to Item
  - Virshup, D, Gietzen, K, and Rivers, A. "Regulation of casein kinase I epsilon." July 31, 1997. Link to Item
  - Goldsby, RE, Carlson, D, Swalberg, ED, and Virshup, D. "Comparing effects on temperature of early versus late leukodepletion in platelet transfusions." November 15, 1995. Link to Item
  - VIRSHUP, DM, WOLD, MS, WEINBERG, DH, KAUFFMAN, MG, and KELLY, TJ. "CELLULAR PROTEINS INVOLVED IN SV40 DNA-REPLICATION INVITRO." 1990. Link to Item

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