Overview
Current Appointments & Affiliations
Professor of Pediatrics
·
2007 - Present
Pediatrics,
Clinical Science Departments
Member of the Duke Cancer Institute
·
2007 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Markovian state models uncover casein kinase 1 dynamics that govern circadian period.
Journal Article Biophys J · September 18, 2025 Circadian rhythms in mammals are tightly regulated through phosphorylation of period (PER) proteins by casein kinase 1 (CK1, subtypes δ and ε). CK1 acts on at least two different regions of PER with opposing effects: phosphorylation of phosphodegron region ... Full text Link to item CiteTelocytes deliver essential Wnts directly to murine intestinal stem cells via synapse-like contacts.
Journal Article Dev Cell · July 19, 2025 Spatial and temporal control of Wnt delivery to the intestinal stem cell niche regulates intestinal homeostasis. Telocytes, specialized stromal cells with characteristic long, thin cytoplasmic protrusions, produce essential Wnts for the development and mai ... Full text Link to item CiteSelf-maintenance of zonal hepatocytes during adult homeostasis and their complex plasticity upon distinct liver injuries.
Journal Article Cell Rep · January 28, 2025 Hepatocytes are organized into distinct zonal subsets across the liver lobule, yet their contributions to liver homeostasis and regeneration remain controversial. Here, we developed multiple genetic lineage-tracing mouse models to systematically address th ... Full text Link to item CiteEducation, Training & Certifications
Johns Hopkins University ·
1981
M.D.