Overview
Current Appointments & Affiliations
Professor of Pediatrics
·
2007 - Present
Pediatrics,
Clinical Science Departments
Professor in Pharmacology and Cancer Biology
·
2026 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2007 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Oncogenic KRAS/ERK/JUNB signaling suppresses differentiation regulator GATA6 in pancreatic cancer.
Journal Article J Clin Invest · February 2, 2026 GATA6 is a master regulator of differentiation in the pancreas, and its expression levels determine the 2 main molecular subtypes of pancreatic cancer. High GATA6 levels contribute to the classical pancreatic cancer subtype, which is associated with a high ... Full text Link to item CiteIdentification of Wnt-regulated genes that are repressed by, or independent of, β-catenin.
Journal Article FEBS J · January 28, 2026 Wnt signaling regulates metazoan development and homeostasis, in part by β-catenin-dependent activation and repression of a large number of genes. However, Wnt signaling also regulates genes independent of β-catenin, genes that are less well-characterized. ... Full text Link to item CiteSecreted frizzled-related proteins in angiogenesis: molecular mechanisms and clinical implications.
Journal Article Angiogenesis · December 19, 2025 Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is essential for tissue homeostasis, development, and repair. Dysregulation of this tightly regulated process contributes to a wide range of diseases, including cancer, ischemi ... Full text Link to item CiteRecent Grants
Molecular Mechanisms of Wnt Transport
ResearchPrincipal Investigator · Awarded by The Trustees of Columbia University · 2025 - 2028View All Grants
Education
Johns Hopkins University ·
1981
M.D.