Overview
Current Appointments & Affiliations
Professor of Pediatrics
·
2007 - Present
Pediatrics,
Clinical Science Departments
Professor in Pharmacology and Cancer Biology
·
2026 - Present
Pharmacology & Cancer Biology,
Basic Science Departments
Member of the Duke Cancer Institute
·
2007 - Present
Duke Cancer Institute,
Institutes and Centers
Recent Publications
Secreted frizzled-related proteins in angiogenesis: molecular mechanisms and clinical implications.
Journal Article Angiogenesis · December 19, 2025 Angiogenesis, the formation of new blood vessels from pre-existing vasculature, is essential for tissue homeostasis, development, and repair. Dysregulation of this tightly regulated process contributes to a wide range of diseases, including cancer, ischemi ... Full text Link to item CiteOncogenic KRAS/ERK/JUNB signaling suppresses differentiation regulator GATA6 in pancreatic cancer.
Journal Article J Clin Invest · December 2, 2025 GATA6 is a master regulator of differentiation in the pancreas and its expression levels determine the two main molecular subtypes of pancreatic cancer. High GATA6 contributes to the "classical" pancreatic cancer subtype, which is associated with a higher ... Full text Link to item CiteMicroproteins Simba1 and Simba2 activate Wingless signaling during the reactivation of neural stem cells in Drosophila.
Journal Article Nat Commun · November 26, 2025 The ability of neural stem cells (NSCs) to switch between quiescent and proliferative states is fundamental for adult neurogenesis and regeneration. Microproteins or short open reading frame (sORF)-encoded peptides (SEPs), are highly abundant yet largely u ... Full text Link to item CiteEducation, Training & Certifications
Johns Hopkins University ·
1981
M.D.