Research Interests
From 2007-2025 my laboratory at Duke-NUS Medical School in Singapore focused on signal transduction, with an emphasis on both Wnt signaling and circadian rhythms. In the Wnt field, we studied how Wnts are delivered from producing to sending cells. Exploiting a small molecule inhibitor of Wnt secretion co-developed in Singapore, we uncovered Wnt-activated and Wnt-repressed pathways that function to maintain stem cells and drive cancer. In 2025 I returned to Duke in Durham to continue studies on Wnt delivery.
External Relationships
- Albatroz Therapeutics
- Ambagon
- CasInvent Pharma
- Duke-NUS
- Parabilis Medicines
This faculty member (or a member of their immediate family) has reported outside activities with the companies, institutions, or organizations listed above. This information is available to institutional leadership and, when appropriate, management plans are in place to address potential conflicts of interest.