The role of Sfrp and DKK proteins in cardiomyocyte development.

Journal Article (Journal Article;Review)

In this review, we summarize the role of Wnt proteins in cardiomyogenesis. More specifically, we focus on how the development of cardiomyocytes from precursor cells involves a complex interplay between Wnt canonical β-catenin signaling pathways and Wnt noncanonical signaling pathways involving PCP and JNK. We also describe recent literature which suggests that endogenous Wnt inhibitors such as the Sfrp and DKK proteins play important roles in regulating the cardiomyocyte differentiation.

Full Text

Duke Authors

Cited Authors

  • Hsueh, Y-C; Hodgkinson, CP; Gomez, JA

Published Date

  • February 2021

Published In

Volume / Issue

  • 9 / 3

Start / End Page

  • e14678 -

PubMed ID

  • 33587322

Pubmed Central ID

  • PMC7883806

Electronic International Standard Serial Number (EISSN)

  • 2051-817X

Digital Object Identifier (DOI)

  • 10.14814/phy2.14678


  • eng

Conference Location

  • United States